Lista de obras - Sheena McGowan - Dominio Público Uruguay

<i>Toxoplasma gondii</i> Toxolysin 4 Contributes to Efficient Parasite Egress from Host Cells

artículo científico publicado en 2021

A pharmacological and biochemical examination of the geographical variation of Chironex fleckeri venom.

artículo científico publicado en 2009

Active site metals mediate an oligomeric equilibrium in <i>Plasmodium</i> M17 aminopeptidases

scientific article published on 10 December 2020

Aminopeptidase N1 (EtAPN1), an M1 metalloprotease of the apicomplexan parasite Eimeria tenella, participates in parasite development ⬇️

artículo científico publicado en 2014

An overview of the serpin superfamily

artículo científico publicado en 2006

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

artículo científico publicado en 2011

Catalytic diversity and cell wall binding repeats in the phage-encoded endolysins

scientific article published on 13 November 2018

Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection

scientific article published on 12 August 2019

Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract.

artículo científico publicado en 2018

Component Parts of Bacteriophage Virions Accurately Defined by a Machine-Learning Approach Built on Evolutionary Features

artículo científico publicado en 2021

Conformational change in the chromatin remodelling protein MENT

artículo científico publicado en 2009

Crystal structure of the inhibitor-free form of the serine protease kallikrein-4

scientific article published on 16 July 2019

DNA accelerates the inhibition of human cathepsin V by serpins

artículo científico publicado en 2007

Dynamic Motion and Communication in the Streptococcal C1 Phage Lysin, PlyC

artículo científico publicado en 2015

Federated repositories of X-ray diffraction images

artículo científico publicado en 2008

Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum

artículo científico publicado en 2012

From crystal to compound: structure-based antimalarial drug discovery

artículo científico publicado en 2014

Functional analysis of the VirSR phosphorelay from Clostridium perfringens

artículo científico publicado en 2009

Generation of AMBER force field parameters for zinc centres of M1 and M17 family aminopeptidases

artículo científico publicado en 2017

Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases

artículo científico publicado en 2019

Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening

artículo científico publicado en 2015

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

scientific article published on 13 February 2019

Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases

artículo científico publicado en 2015

Isolation and characterization of the nuclear serpin MENT.

artículo científico publicado en 2011

M1 aminopeptidases as drug targets: broad applications or therapeutic niche?

artículo científico publicado en 2017

M17 aminopeptidases diversify function by moderating their macromolecular assemblies and active site environment

scientific article published on 14 January 2019

Mapping the pathway and dynamics of bestatin inhibition of the Plasmodium falciparum M1 aminopeptidase, PfA-M1

article

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide ⬇️

artículo científico publicado en 2014

Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions

scientific article published on 18 July 2019

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

artículo científico publicado en 2016

Operation of the Australian Store.Synchrotron for macromolecular crystallography

artículo científico publicado en 2014

Oxidative Deselenization of Selenocysteine: Applications for Programmed Ligation at Serine.

artículo científico publicado en 2015

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

scientific article published on 30 September 2009

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

artículo científico publicado en 2016

Reactive centre loop dynamics and serpin specificity

artículo científico publicado en 2019

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

artículo científico publicado en 2015

Serpins in Prokaryotes

Sitagliptin does not inhibit the M1 alanyl aminopeptidase from Plasmodium falciparum

artículo científico publicado en 2013

Smoothing a rugged protein folding landscape by sequence-based redesign

artículo científico publicado en 2016

Stonefish toxin defines an ancient branch of the perforin-like superfamily.

artículo científico publicado en 2015

Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain

artículo científico publicado en 2015

Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate

artículo científico publicado en 2015

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

artículo científico publicado en 2009

Structural mechanisms of inactivation in scabies mite serine protease paralogues

artículo científico publicado en 2009

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO

artículo científico publicado en 2014

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

artículo científico publicado en 2010

Structure-Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction

artículo científico publicado en 2016

Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from Plasmodium falciparum

artículo científico publicado en 2013

Synthesis of New (−)-Bestatin-Based Inhibitor Libraries Reveals a Novel Binding Mode in the S1 Pocket of the Essential Malaria M1 Metalloaminopeptidase

artículo científico publicado en 2011

Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials

artículo científico publicado en 2014

The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis

artículo científico publicado en 2007

The FxRxHrS motif: a conserved region essential for DNA binding of the VirR response regulator from Clostridium perfringens

artículo científico publicado en 2002

The SKHR motif is required for biological function of the VirR response regulator from Clostridium perfringens

artículo científico publicado en 2003

The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates

artículo científico publicado en 2010

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors

artículo científico publicado en 2014

Working in concert: the metalloaminopeptidases from Plasmodium falciparum

artículo científico publicado en 2013

X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP

artículo científico publicado en 2012

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

artículo científico publicado en 2006

X-ray crystal structure of the streptococcal specific phage lysin PlyC. ⬇️

artículo científico publicado en 2012

X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17

artículo científico publicado en 2015

Lista de obras de Sheena McGowan

<i>Toxoplasma gondii</i> Toxolysin 4 Contributes to Efficient Parasite Egress from Host Cells

A pharmacological and biochemical examination of the geographical variation of Chironex fleckeri venom.

Active site metals mediate an oligomeric equilibrium in <i>Plasmodium</i> M17 aminopeptidases

Aminopeptidase N1 (EtAPN1), an M1 metalloprotease of the apicomplexan parasite Eimeria tenella, participates in parasite development ⬇️

An overview of the serpin superfamily

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

Catalytic diversity and cell wall binding repeats in the phage-encoded endolysins

Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection

Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract.

Component Parts of Bacteriophage Virions Accurately Defined by a Machine-Learning Approach Built on Evolutionary Features

Conformational change in the chromatin remodelling protein MENT

Crystal structure of the inhibitor-free form of the serine protease kallikrein-4

DNA accelerates the inhibition of human cathepsin V by serpins

Dynamic Motion and Communication in the Streptococcal C1 Phage Lysin, PlyC

Federated repositories of X-ray diffraction images

Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum

From crystal to compound: structure-based antimalarial drug discovery

Functional analysis of the VirSR phosphorelay from Clostridium perfringens

Generation of AMBER force field parameters for zinc centres of M1 and M17 family aminopeptidases

Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases

Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases

Isolation and characterization of the nuclear serpin MENT.

M1 aminopeptidases as drug targets: broad applications or therapeutic niche?

M17 aminopeptidases diversify function by moderating their macromolecular assemblies and active site environment

Mapping the pathway and dynamics of bestatin inhibition of the Plasmodium falciparum M1 aminopeptidase, PfA-M1

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide ⬇️

Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Operation of the Australian Store.Synchrotron for macromolecular crystallography

Oxidative Deselenization of Selenocysteine: Applications for Programmed Ligation at Serine.

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

Reactive centre loop dynamics and serpin specificity

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

Serpins in Prokaryotes

Sitagliptin does not inhibit the M1 alanyl aminopeptidase from Plasmodium falciparum

Smoothing a rugged protein folding landscape by sequence-based redesign

Stonefish toxin defines an ancient branch of the perforin-like superfamily.

Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain

Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

Structural mechanisms of inactivation in scabies mite serine protease paralogues

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

Structure-Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction

Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from Plasmodium falciparum

Synthesis of New (−)-Bestatin-Based Inhibitor Libraries Reveals a Novel Binding Mode in the S1 Pocket of the Essential Malaria M1 Metalloaminopeptidase

Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials

The 1.6 A crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis

The FxRxHrS motif: a conserved region essential for DNA binding of the VirR response regulator from Clostridium perfringens

The SKHR motif is required for biological function of the VirR response regulator from Clostridium perfringens

The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors

Working in concert: the metalloaminopeptidases from Plasmodium falciparum

X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

X-ray crystal structure of the streptococcal specific phage lysin PlyC. ⬇️

X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17