Lista de obras - R Largo - Dominio Público Uruguay

6-Shogaol inhibits chondrocytes' innate immune responses and cathepsin-K activity

artículo científico publicado en 2013

A fibrin based model for rheumatoid synovitis.

artículo científico publicado en 2003

A subgroup of lupus patients with nephritis, innate T cell activation and low vitamin D is identified by the enhancement of circulating MHC class I-related chain A

scientific article published on 27 February 2019

ACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritis

scientific article published on 01 December 1995

Activation of NF-kappaB in tubular epithelial cells of rats with intense proteinuria: role of angiotensin II and endothelin-1.

artículo científico publicado en 2001

An OA phenotype may obtain major benefit from bone-acting agents

artículo científico publicado en 2013

An orally active ETA/ETB receptor antagonist ameliorates proteinuria and glomerular lesions in rats with proliferative nephritis

scientific article published on 01 September 1996

An update on the up and coming therapies to treat osteoarthritis, a multifaceted disease.

artículo científico publicado en 2016

Angiotensin-converting enzyme is upregulated in the proximal tubules of rats with intense proteinuria

scientific article published on 01 February 1999

Aromatase expression in human chondrocytes: An induction due to culture

artículo científico publicado en 2015

Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis

artículo científico publicado en 2008

Bone mineral density and joint cartilage: four clinical settings of a complex relationship in osteoarthritis.

artículo científico publicado en 2011

Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits.

artículo científico publicado en 2005

Characterization of a new experimental model of osteoporosis in rabbits

artículo científico publicado en 2008

Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis.

artículo científico publicado en 2015

Chondrocyte enlargement is a marker of osteoarthritis severity

scientific article published on 30 April 2019

Chondroitin sulfate improves synovitis in rabbits with chronic antigen-induced arthritis

artículo científico publicado en 2010

Chronic arthritis aggravates vascular lesions in rabbits with atherosclerosis: a novel model of atherosclerosis associated with chronic inflammation

artículo científico publicado en 2008

Científicos españoles con los Dres. Greg Winter y Richard A. Lerner, premios Príncipe de Asturias en Investigación Científica y Técnica 2012

article

Combined Treatment With Chondroitin Sulfate and Glucosamine Sulfate Shows No Superiority Over Placebo for Reduction of Joint Pain and Functional Impairment in Patients With Knee Osteoarthritis: A Six-Month Multicenter, Randomized, Double-Blind, Plac

artículo científico publicado en 2016

Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis.

artículo científico publicado en 2017

Corrigendum: The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction

artículo científico publicado en 2016

Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study

artículo científico publicado en 2020

DXA in the assessment of subchondral bone mineral density in knee osteoarthritis--A semi-standardized protocol after systematic review

artículo científico

Diacerein has a weak effect on the catabolic pathway of human osteoarthritis synovial fibroblast--comparison to its effects on osteoarthritic chondrocytes.

artículo científico publicado en 2008

Differential effects of the antioxidant n-acetylcysteine on the production of catabolic mediators in IL-1beta-stimulated human osteoarthritic synoviocytes and chondrocytes.

artículo científico publicado en 2009

Does oral glucosamine prevent subchondral bone loss in an animal model of osteoarthritis? Comment on the article by Wang et al.

artículo científico publicado en 2008

EP2/EP4 signalling inhibits monocyte chemoattractant protein-1 production induced by interleukin 1beta in synovial fibroblasts.

artículo científico publicado en 2004

Effect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritis.

artículo científico publicado en 2009

Effects and interactions of endothelin-1 and angiotensin II on matrix protein expression and synthesis and mesangial cell growth

scientific article published on 01 April 1996

Effects of PTH [1-34] on synoviopathy in an experimental model of osteoarthritis preceded by osteoporosis

artículo científico publicado en 2012

Effects of estrogen deficiency and low bone mineral density on healthy knee cartilage in rabbits

scientific article published on 01 June 2010

Endothelin-1 expression during early response after antigen challenge in brown-norway rats

artículo científico publicado en 1998

Endothelin-1 upregulation in the kidney of uninephrectomized spontaneously hypertensive rats and its modification by the angiotensin-converting enzyme inhibitor quinapril

scientific article published on 01 May 1997

Expression of the peptide C4b-binding protein beta in the arthritic joint

artículo científico publicado en 2006

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

artículo científico publicado en 2022

Fibrin generated in the synovial fluid activates intimal cells from their apical surface: a sequential morphological study in antigen-induced arthritis

artículo científico publicado en 2003

Glomerular up-regulation of EIIIA and V120 fibronectin isoforms in proliferative immune complex nephritis

scientific article published on 01 September 1996

Glucosamine and O-GlcNAcylation: a novel immunometabolic therapeutic target for OA and chronic, low-grade systemic inflammation?

scientific article published on 18 June 2020

Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes

artículo científico publicado en 2003

Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis

scientific article published on 01 November 2004

Hypercholesterolemia boosts joint destruction in chronic arthritis. An experimental model aggravated by foam macrophage infiltration

artículo científico publicado en 2013

Improvement of experimental accelerated atherosclerosis by chondroitin sulphate.

artículo científico publicado en 2010

Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis.

artículo científico publicado en 2011

Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis

artículo científico publicado en 2017

Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis

artículo científico publicado en 2019

Interaction of intimal fibroblasts with intracavitary fibrin: a morphologic follow up in ovalbumin arthritis.

artículo científico publicado en 2002

Is lecturing in Rheumatology Satellite Symposia a male attribute?

artículo científico publicado en 2013

Lipid transport and metabolism in healthy and osteoarthritic cartilage

artículo científico publicado en 2013

Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis

artículo científico publicado en 2008

Mediators and Patterns of Muscle Loss in Chronic Systemic Inflammation.

artículo científico publicado en 2018

Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure

artículo científico publicado en 2001

Mycophenolate mofetil prevents salt-sensitive hypertension resulting from nitric oxide synthesis inhibition

artículo científico publicado en 2001

Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis.

artículo científico publicado en 2010

O-linked N-acetylglucosamine (O-GlcNAc) protein modification is increased in the cartilage of patients with knee osteoarthritis.

artículo científico publicado en 2013

Osteoarthritis: Chondroitin sulfate - CONCEPT clear, uncertainties unchanged

scientific article published on 17 August 2017

Osteoarthritis: a progressive disease with changing phenotypes.

artículo científico publicado en 2013

Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits.

artículo científico publicado en 2006

Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis

artículo científico

PTH increases jaw mineral density in a rabbit model of osteoporosis

artículo científico publicado en 2010

Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains.

artículo científico publicado en 2018

Platelet-activating factor stimulates gene expression and synthesis of matrix proteins in cultured rat and human mesangial cells: role of TGF-beta

scientific article published on 01 August 1997

Prostaglandin E2 receptors EP1 and EP4 are up-regulated in rabbit chondrocytes by IL-1beta, but not by TNFalpha

scientific article published on 31 March 2007

Quinapril decreases renal endothelin-1 expression and synthesis in a normotensive model of immune-complex nephritis

scientific article published on 01 May 1997

RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis

artículo científico publicado en 2012

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy

scientific article published in Nature Communications

Renal expression of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor in a rat model of tubulointerstitial damage

scientific article published on 01 January 1999

Reply

artículo científico publicado en 2017

SDF-1 signaling: a promising target in rheumatic diseases

artículo científico publicado en 2014

Selective estrogen receptor modulators (SERMs): new alternatives for osteoarthritis?

artículo científico

Sequential changes of parathyroid hormone related protein (PTHrP) in articular cartilage during progression of inflammatory and degenerative arthritis

artículo científico publicado en 2004

Studies of piroxicam absorption by oral mucosa.

artículo científico publicado en 2002

Subchondral bone as a key target for osteoarthritis treatment.

artículo científico

Subchondral bone remodelling and osteoarthritis

artículo científico publicado en 2012

TLR4 signalling in osteoarthritis--finding targets for candidate DMOADs.

artículo científico publicado en 2014

Targeting chronic innate inflammatory pathways, the main road to prevention of osteoarthritis progression

scientific article published on 27 February 2019

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

artículo científico publicado en 2018

Tenofovir Causes Bone Loss via Decreased Bone Formation and Increased Bone Resorption, Which Can Be Counteracted by Dipyridamole in Mice

scientific article published on 25 February 2019

The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction.

artículo científico publicado en 2016

The combined therapy with chondroitin sulfate plus glucosamine sulfate or chondroitin sulfate plus glucosamine hydrochloride does not improve joint damage in an experimental model of knee osteoarthritis in rabbits

artículo científico publicado en 2016

Tight blood pressure control decreases apoptosis during renal damage

artículo científico publicado en 2004

Tofacitinib restores the inhibition of reverse cholesterol transport induced by inflammation: understanding the lipid paradox associated with rheumatoid arthritis

artículo científico publicado en 2017

Treating osteoporotic osteoarthritis, or the art of cutting a balding man's hair

scientific article published on 18 December 2019

Unexpected Bone Formation Produced by RANKL Blockade.

artículo científico publicado en 2017

Up-regulation of parathyroid hormone-related protein in folic acid-induced acute renal failure

artículo científico publicado en 2001

Validation of Musculoskeletal Ultrasound in the Assessment of Experimental Gout Synovitis

artículo científico publicado en 2018

Lista de obras de R Largo

6-Shogaol inhibits chondrocytes' innate immune responses and cathepsin-K activity

A fibrin based model for rheumatoid synovitis.

A subgroup of lupus patients with nephritis, innate T cell activation and low vitamin D is identified by the enhancement of circulating MHC class I-related chain A

ACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritis

Activation of NF-kappaB in tubular epithelial cells of rats with intense proteinuria: role of angiotensin II and endothelin-1.

An OA phenotype may obtain major benefit from bone-acting agents

An orally active ETA/ETB receptor antagonist ameliorates proteinuria and glomerular lesions in rats with proliferative nephritis

An update on the up and coming therapies to treat osteoarthritis, a multifaceted disease.

Angiotensin-converting enzyme is upregulated in the proximal tubules of rats with intense proteinuria

Aromatase expression in human chondrocytes: An induction due to culture

Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis

Bone mineral density and joint cartilage: four clinical settings of a complex relationship in osteoarthritis.

Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits.

Characterization of a new experimental model of osteoporosis in rabbits

Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis.

Chondrocyte enlargement is a marker of osteoarthritis severity

Chondroitin sulfate improves synovitis in rabbits with chronic antigen-induced arthritis

Chronic arthritis aggravates vascular lesions in rabbits with atherosclerosis: a novel model of atherosclerosis associated with chronic inflammation

Científicos españoles con los Dres. Greg Winter y Richard A. Lerner, premios Príncipe de Asturias en Investigación Científica y Técnica 2012

Combined Treatment With Chondroitin Sulfate and Glucosamine Sulfate Shows No Superiority Over Placebo for Reduction of Joint Pain and Functional Impairment in Patients With Knee Osteoarthritis: A Six-Month Multicenter, Randomized, Double-Blind, Plac

Compensatory anabolic signaling in the sarcopenia of experimental chronic arthritis.

Corrigendum: The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction

Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study

DXA in the assessment of subchondral bone mineral density in knee osteoarthritis--A semi-standardized protocol after systematic review

Diacerein has a weak effect on the catabolic pathway of human osteoarthritis synovial fibroblast--comparison to its effects on osteoarthritic chondrocytes.

Differential effects of the antioxidant n-acetylcysteine on the production of catabolic mediators in IL-1beta-stimulated human osteoarthritic synoviocytes and chondrocytes.

Does oral glucosamine prevent subchondral bone loss in an animal model of osteoarthritis? Comment on the article by Wang et al.

EP2/EP4 signalling inhibits monocyte chemoattractant protein-1 production induced by interleukin 1beta in synovial fibroblasts.

Effect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritis.

Effects and interactions of endothelin-1 and angiotensin II on matrix protein expression and synthesis and mesangial cell growth

Effects of PTH [1-34] on synoviopathy in an experimental model of osteoarthritis preceded by osteoporosis

Effects of estrogen deficiency and low bone mineral density on healthy knee cartilage in rabbits

Endothelin-1 expression during early response after antigen challenge in brown-norway rats

Endothelin-1 upregulation in the kidney of uninephrectomized spontaneously hypertensive rats and its modification by the angiotensin-converting enzyme inhibitor quinapril

Expression of the peptide C4b-binding protein beta in the arthritic joint

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Fibrin generated in the synovial fluid activates intimal cells from their apical surface: a sequential morphological study in antigen-induced arthritis

Glomerular up-regulation of EIIIA and V120 fibronectin isoforms in proliferative immune complex nephritis

Glucosamine and O-GlcNAcylation: a novel immunometabolic therapeutic target for OA and chronic, low-grade systemic inflammation?

Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes

Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis

Hypercholesterolemia boosts joint destruction in chronic arthritis. An experimental model aggravated by foam macrophage infiltration

Improvement of experimental accelerated atherosclerosis by chondroitin sulphate.

Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis.

Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis

Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis

Interaction of intimal fibroblasts with intracavitary fibrin: a morphologic follow up in ovalbumin arthritis.

Is lecturing in Rheumatology Satellite Symposia a male attribute?

Lipid transport and metabolism in healthy and osteoarthritic cartilage

Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis

Mediators and Patterns of Muscle Loss in Chronic Systemic Inflammation.

Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure

Mycophenolate mofetil prevents salt-sensitive hypertension resulting from nitric oxide synthesis inhibition

Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis.

O-linked N-acetylglucosamine (O-GlcNAc) protein modification is increased in the cartilage of patients with knee osteoarthritis.

Osteoarthritis: Chondroitin sulfate - CONCEPT clear, uncertainties unchanged

Osteoarthritis: a progressive disease with changing phenotypes.

Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits.

Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis

PTH increases jaw mineral density in a rabbit model of osteoporosis

Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains.

Platelet-activating factor stimulates gene expression and synthesis of matrix proteins in cultured rat and human mesangial cells: role of TGF-beta

Prostaglandin E2 receptors EP1 and EP4 are up-regulated in rabbit chondrocytes by IL-1beta, but not by TNFalpha

Quinapril decreases renal endothelin-1 expression and synthesis in a normotensive model of immune-complex nephritis

RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy

Renal expression of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor in a rat model of tubulointerstitial damage

Reply

SDF-1 signaling: a promising target in rheumatic diseases

Selective estrogen receptor modulators (SERMs): new alternatives for osteoarthritis?

Sequential changes of parathyroid hormone related protein (PTHrP) in articular cartilage during progression of inflammatory and degenerative arthritis

Studies of piroxicam absorption by oral mucosa.

Subchondral bone as a key target for osteoarthritis treatment.

Subchondral bone remodelling and osteoarthritis

TLR4 signalling in osteoarthritis--finding targets for candidate DMOADs.

Targeting chronic innate inflammatory pathways, the main road to prevention of osteoarthritis progression

Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

Tenofovir Causes Bone Loss via Decreased Bone Formation and Increased Bone Resorption, Which Can Be Counteracted by Dipyridamole in Mice

The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction.