Lista de obras - José J. Lucas - Dominio Público Uruguay

A mouse model to study tau pathology related with tau phosphorylation and assembly

artículo científico publicado en 2007

A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer's disease

artículo científico publicado en 2021

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

artículo científico publicado en 2009

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

artículo científico publicado en 2010

Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels.

artículo científico publicado en 2012

Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome.

artículo científico publicado en 2015

Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration.

artículo científico publicado en 2009

Assembly in vitro of tau protein and its implications in Alzheimer's disease.

artículo científico publicado en 2004

BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease

artículo científico publicado en 2007

Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

artículo científico publicado en 2004

CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures

artículo científico publicado en 2013

Centro de Biologia Molecular "Severo Ochoa": a center for basic research into Alzheimer's disease.

artículo científico publicado en 2010

Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.

artículo científico publicado en 2006

Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration

artículo científico publicado en 2005

Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.

artículo científico publicado en 2015

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

artículo científico publicado en 2001

Effects of partial suppression of parkin on huntingtin mutant R6/1 mice.

artículo científico publicado en 2009

Enhanced induction of the immunoproteasome by interferon gamma in neurons expressing mutant Huntingtin.

artículo científico publicado en 2004

FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain

artículo científico publicado en 2001

Faulty splicing and cytoskeleton abnormalities in Huntington's disease

artículo científico publicado en 2016

Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington's disease.

artículo científico publicado en 2005

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

artículo científico publicado en 2006

GSK3 and tau: two convergence points in Alzheimer's disease.

artículo científico

GSK3: a possible link between beta amyloid peptide and tau protein.

artículo científico publicado en 2009

GSK3β overexpression induces neuronal death and a depletion of the neurogenic niches in the dentate gyrus.

artículo científico publicado en 2010

Glycogen synthase kinase-3 inhibition is integral to long-term potentiation

artículo científico publicado en 2007

Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease

artículo científico publicado en 2003

Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta.

artículo científico publicado en 2008

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6

artículo científico publicado en 2021

Huntington's disease is a four-repeat tauopathy with tau nuclear rods.

artículo científico publicado en 2014

Huntington's disease-specific mis-splicing unveils key effector genes and altered splicing factors

artículo científico publicado en 2021

Impaired ATF6α processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease.

artículo científico publicado en 2010

Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice

artículo científico publicado en 2015

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases.

artículo científico publicado en 2011

In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning.

artículo científico publicado en 2014

Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease

artículo científico publicado en 2011

Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor

artículo científico publicado en 1998

Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain

artículo científico publicado en 2006

Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons.

artículo científico publicado en 2008

Is the ubiquitin-proteasome system impaired in Huntington's disease?

artículo científico publicado en 2007

Looking for novel functions of tau.

artículo científico

Loss of mRNA levels, binding and activation of GTP-binding proteins for cannabinoid CB1 receptors in the basal ganglia of a transgenic model of Huntington's disease

artículo científico publicado en 2002

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease.

artículo científico publicado en 2010

MAP2 Splicing is Altered in Huntington's Disease.

artículo científico publicado en 2016

Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus

artículo científico publicado en 2014

Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders

artículo científico publicado en 2014

Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists.

artículo científico publicado en 2000

Molecular mechanisms of pain: serotonin1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons

scientific article published on 01 April 1993

Mutant huntingtin affects endocytosis in striatal cells by altering the binding of AP-2 to membranes

artículo científico publicado en 2012

N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation

artículo científico publicado en 2007

NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy

scientific journal article

Neuronal apoptosis and motor deficits in mice with genetic inhibition of GSK-3 are Fas-dependent

artículo científico publicado en 2013

Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice.

artículo científico publicado en 2007

Nuclear localization of N-terminal mutant huntingtin is cell cycle dependent

artículo científico publicado en 2002

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice

artículo científico publicado en 2013

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.

artículo científico publicado en 2009

Pathogenic Mis-splicing of CPEB4 in Schizophrenia

artículo científico publicado en 2023

Peripheral noxious stimulation induces CREM expression in dorsal horn: involvement of glutamate

scientific article published on 01 December 1997

Presynaptic dysfunction in Huntington's disease.

artículo científico publicado en 2010

Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system

artículo científico publicado en 2015

Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus.

artículo científico publicado en 2013

Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism

artículo científico publicado en 2010

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

artículo científico publicado en 2009

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

artículo científico publicado en 2006

Reduced striatal dopamine DA D2 receptor function in dominant-negative GSK-3 transgenic mice

artículo científico publicado en 2014

Regulation of proteasome activity by P2Y2 receptor underlies the neuroprotective effects of extracellular nucleotides.

artículo científico publicado en 2016

Role of tau protein in both physiological and pathological conditions.

artículo científico publicado en 2004

Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments

artículo científico publicado en 2002

Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury

artículo científico publicado en 2017

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity

artículo científico publicado en 2011

Sulfo-glycosaminoglycan content affects PHF-tau solubility and allows the identification of different types of PHFs

artículo científico publicado en 2002

Tau kinase I overexpression induces dentate gyrus degeneration

artículo científico publicado en 2010

Tau phosphorylation in hippocampus results in toxic gain-of-function.

scientific article published on August 2010

Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits

artículo científico publicado en 2009

Tau-positive nuclear indentations in P301S tauopathy mice.

artículo científico publicado en 2016

Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options.

artículo científico publicado en 2009

Testing the ubiquitin-proteasome hypothesis of neurodegeneration in vivo.

artículo científico publicado en 2004

The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington's disease

artículo científico publicado en 2017

The role of GSK3 in Alzheimer disease.

scientific article published on 27 May 2009

The ubiquitin-proteasome system in Huntington's disease.

artículo científico publicado en 2005

Ubiquitin-proteasome system involvement in Huntington's disease

artículo científico publicado en 2014

α-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease.

artículo científico publicado en 2011

Lista de obras de José J. Lucas

A mouse model to study tau pathology related with tau phosphorylation and assembly

A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer's disease

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels.

Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome.

Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration.

Assembly in vitro of tau protein and its implications in Alzheimer's disease.

BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease

Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures

Centro de Biologia Molecular "Severo Ochoa": a center for basic research into Alzheimer's disease.

Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.

Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration

Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease.

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

Effects of partial suppression of parkin on huntingtin mutant R6/1 mice.

Enhanced induction of the immunoproteasome by interferon gamma in neurons expressing mutant Huntingtin.

FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain

Faulty splicing and cytoskeleton abnormalities in Huntington's disease

Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington's disease.

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3.

GSK3 and tau: two convergence points in Alzheimer's disease.

GSK3: a possible link between beta amyloid peptide and tau protein.

GSK3β overexpression induces neuronal death and a depletion of the neurogenic niches in the dentate gyrus.

Glycogen synthase kinase-3 inhibition is integral to long-term potentiation

Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease

Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta.

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6

Huntington's disease is a four-repeat tauopathy with tau nuclear rods.

Huntington's disease-specific mis-splicing unveils key effector genes and altered splicing factors

Impaired ATF6α processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease.

Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases.

In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning.

Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease

Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor

Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain

Inhibition of the ATP-gated P2X7 receptor promotes axonal growth and branching in cultured hippocampal neurons.

Is the ubiquitin-proteasome system impaired in Huntington's disease?

Looking for novel functions of tau.

Loss of mRNA levels, binding and activation of GTP-binding proteins for cannabinoid CB1 receptors in the basal ganglia of a transgenic model of Huntington's disease

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease.

MAP2 Splicing is Altered in Huntington's Disease.

Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus

Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders

Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists.

Molecular mechanisms of pain: serotonin1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons

Mutant huntingtin affects endocytosis in striatal cells by altering the binding of AP-2 to membranes

N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation

NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy

Neuronal apoptosis and motor deficits in mice with genetic inhibition of GSK-3 are Fas-dependent

Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice.

Nuclear localization of N-terminal mutant huntingtin is cell cycle dependent

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.

Pathogenic Mis-splicing of CPEB4 in Schizophrenia

Peripheral noxious stimulation induces CREM expression in dorsal horn: involvement of glutamate

Presynaptic dysfunction in Huntington's disease.

Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system

Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus.

Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

Reduced striatal dopamine DA D2 receptor function in dominant-negative GSK-3 transgenic mice

Regulation of proteasome activity by P2Y2 receptor underlies the neuroprotective effects of extracellular nucleotides.

Role of tau protein in both physiological and pathological conditions.

Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments

Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity

Sulfo-glycosaminoglycan content affects PHF-tau solubility and allows the identification of different types of PHFs

Tau kinase I overexpression induces dentate gyrus degeneration

Tau phosphorylation in hippocampus results in toxic gain-of-function.

Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits

Tau-positive nuclear indentations in P301S tauopathy mice.

Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options.

Testing the ubiquitin-proteasome hypothesis of neurodegeneration in vivo.

The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington's disease

The role of GSK3 in Alzheimer disease.