Lista de obras - Mikael Simons - Dominio Público Uruguay

A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons

artículo científico publicado en 2013

A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production

artículo científico publicado en 2013

A size barrier limits protein diffusion at the cell surface to generate lipid-rich myelin-membrane sheets

artículo científico publicado en 2011

A unified cell biological perspective on axon-myelin injury

artículo científico

Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system.

artículo científico publicado en 2015

Actomyosin contractility controls cell surface area of oligodendrocytes

artículo científico publicado en 2009

Adenovirus-mediated gene transfer of inhibitors of apoptosis protein delays apoptosis in cerebellar granule neurons.

artículo científico publicado en 1999

Age-related myelin degradation burdens the clearance function of microglia during aging.

artículo científico publicado en 2016

Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons

artículo científico publicado en 1996

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

artículo científico publicado en 2017

Antioxidative strategies in cognitive impairment: a novel connection between biliverdin-reductase and statins

Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains

artículo científico publicado en 2000

Atomic resolution view into the structure–function relationships of the human myelin peripheral membrane protein P2

artículo científico publicado en 2014

Axonal selection and myelin sheath generation in the central nervous system

artículo científico

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions

artículo científico publicado en 2017

Catching filopodia: Exosomes surf on fast highways to enter cells

artículo científico publicado en 2016

Cell polarity in myelinating glia: from membrane flow to diffusion barriers

artículo científico

Cell type- and brain region-resolved mouse brain proteome.

artículo científico publicado en 2015

Cell visco-elasticity measured with AFM and optical trapping at sub-micrometer deformations

artículo científico publicado en 2012

Central nervous system myelin: structure, synthesis and assembly

artículo científico publicado en 2011

Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses

scientific article published on February 2014

Cholesterol and myelin biogenesis

artículo científico publicado en 2010

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons ⬇️

artículo científico publicado el 26 de mayo de 1998

Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

artículo científico publicado en 2006

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

artículo científico publicado en 2013

Chronic progressive multiple sclerosis - pathogenesis of neurodegeneration and therapeutic strategies

artículo científico publicado en 2010

Control of oligodendroglial cell number by the miR-17-92 cluster

artículo científico publicado en 2010

Defective cholesterol clearance limits remyelination in the aged central nervous system

artículo científico publicado en 2018

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

scientific article published on 20 February 2021

Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing

artículo científico publicado en 2021

Dynamics of the Peripheral Membrane Protein P2 from Human Myelin Measured by Neutron Scattering--A Comparison between Wild-Type Protein and a Hinge Mutant

artículo científico publicado en 2015

Editorial overview: Cellular neuroscience

artículo científico publicado en 2016

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

artículo científico publicado en 2008

Erythropoietin attenuates neurological and histological consequences of toxic demyelination in mice

artículo científico publicado en 2012

Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B.

artículo científico publicado en 2011

Exogenous administration of gangliosides displaces GPI-anchored proteins from lipid microdomains in living cells

artículo científico publicado en 1999

Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease

artículo científico publicado en 2010

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

artículo científico publicado en 2013

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

artículo científico publicado en 2015

Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.

artículo científico publicado en 2008

Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension

artículo científico publicado en 2013

Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.

artículo científico publicado en 2017

Grey matter myelination

artículo científico publicado en 2019

Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis

artículo científico publicado en 2004

Identification of Tmem10/Opalin as a novel marker for oligodendrocytes using gene expression profiling

artículo científico publicado en 2008

Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles

artículo científico publicado en 2010

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

artículo científico publicado en 1997

Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendrites

Intracerebral Injections and Ultrastructural Analysis of High-Pressure Frozen Brain Tissue

artículo científico publicado en 2017

Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila

artículo científico publicado en 2012

Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis

artículo científico publicado en 2012

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

artículo científico publicado en 2016

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

artículo científico publicado en 2021

Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system

artículo científico publicado en 2013

Metabolism and functions of lipids in myelin

artículo científico

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

artículo científico publicado en 2020

Myelin architecture: zippering membranes tightly together

artículo científico

Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin

artículo científico publicado en 2006

Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork

artículo científico publicado en 2013

Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue

artículo científico publicado en 2014

Myelination at a glance

artículo científico

Myelinophagy: Schwann cells dine in.

artículo científico publicado en 2015

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model

artículo científico publicado en 2016

Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites

artículo científico publicado en 2006

Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis

artículo científico publicado en 2006

Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer's disease.

artículo científico publicado en 1996

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

artículo científico publicado en 2020

Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication

artículo científico publicado en 2013

Oligodendrocytes: Myelination and Axonal Support

artículo científico

Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease

artículo científico publicado en 2002

Palmitoylation is a sorting determinant for transport to the myelin membrane

artículo científico publicado en 2005

Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium.

artículo científico publicado en 2009

Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

artículo científico publicado en 2020

Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence ⬇️

artículo científico publicado el 16 de octubre de 1995

Prox1 Is Required for Oligodendrocyte Cell Identity in Adult Neural Stem Cells of the Subventricular Zone

artículo científico publicado en 2016

Quantified CSF antibody reactivity against myelin in multiple sclerosis

artículo científico publicado en 2015

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.

artículo científico publicado en 2010

Reorganization of Lipid Diffusion by Myelin Basic Protein as Revealed by STED Nanoscopy

artículo científico publicado en 2016

Rho Regulates Membrane Transport in the Endocytic Pathway to Control Plasma Membrane Specialization in Oligodendroglial Cells

scientific article published on 01 March 2007

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

scientific article published in 2011

Self-segregation of myelin membrane lipids in model membranes

artículo científico publicado en 2011

Subcortical cytoskeleton periodicity throughout the nervous system

artículo científico publicado en 2016

TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination

artículo científico publicado en 2021

Targeted ablation of oligodendrocytes triggers axonal damage

artículo científico publicado en 2011

Tau deposition patterns are associated with functional connectivity in primary tauopathies

artículo científico publicado en 2022

Teaching NeuroImages: Ma2 encephalitis presenting as acute panhypopituitarism in a young man.

artículo científico publicado en 2013

The emerging functions of oligodendrocytes in regulating neuronal network behaviour

artículo científico publicado en 2014

The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells

artículo científico publicado en 2012

The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane

scientific journal article

The logistics of myelin biogenesis in the central nervous system

artículo científico publicado en 2017

Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia

artículo científico publicado en 2012

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

artículo científico publicado en 2002

Two-dimensional gel mapping of the processing of the human amyloid precursor protein in rat hippocampal neurons.

artículo científico publicado en 1995

Wrapping it up: the cell biology of myelination

artículo científico publicado en 2007

Lista de obras de Mikael Simons

A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons

A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production

A size barrier limits protein diffusion at the cell surface to generate lipid-rich myelin-membrane sheets

A unified cell biological perspective on axon-myelin injury

Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system.

Actomyosin contractility controls cell surface area of oligodendrocytes

Adenovirus-mediated gene transfer of inhibitors of apoptosis protein delays apoptosis in cerebellar granule neurons.

Age-related myelin degradation burdens the clearance function of microglia during aging.

Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

Antioxidative strategies in cognitive impairment: a novel connection between biliverdin-reductase and statins

Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains

Atomic resolution view into the structure–function relationships of the human myelin peripheral membrane protein P2

Axonal selection and myelin sheath generation in the central nervous system

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions

Catching filopodia: Exosomes surf on fast highways to enter cells

Cell polarity in myelinating glia: from membrane flow to diffusion barriers

Cell type- and brain region-resolved mouse brain proteome.

Cell visco-elasticity measured with AFM and optical trapping at sub-micrometer deformations

Central nervous system myelin: structure, synthesis and assembly

Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses

Cholesterol and myelin biogenesis

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons ⬇️

Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

Chronic progressive multiple sclerosis - pathogenesis of neurodegeneration and therapeutic strategies

Control of oligodendroglial cell number by the miR-17-92 cluster

Defective cholesterol clearance limits remyelination in the aged central nervous system

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing

Dynamics of the Peripheral Membrane Protein P2 from Human Myelin Measured by Neutron Scattering--A Comparison between Wild-Type Protein and a Hinge Mutant

Editorial overview: Cellular neuroscience

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

Erythropoietin attenuates neurological and histological consequences of toxic demyelination in mice

Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B.

Exogenous administration of gangliosides displaces GPI-anchored proteins from lipid microdomains in living cells

Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.

Functional and structural evaluation of lamotrigine treatment in rat models of acute and chronic ocular hypertension

Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.

Grey matter myelination

Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis

Identification of Tmem10/Opalin as a novel marker for oligodendrocytes using gene expression profiling

Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendrites

Intracerebral Injections and Ultrastructural Analysis of High-Pressure Frozen Brain Tissue

Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila

Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system

Metabolism and functions of lipids in myelin

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Myelin architecture: zippering membranes tightly together

Myelin basic protein-dependent plasma membrane reorganization in the formation of myelin

Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork

Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue

Myelination at a glance

Myelinophagy: Schwann cells dine in.

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model

Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites

Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis

Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer's disease.

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication

Oligodendrocytes: Myelination and Axonal Support

Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease

Palmitoylation is a sorting determinant for transport to the myelin membrane

Phosphatidylinositol 4,5-bisphosphate-dependent interaction of myelin basic protein with the plasma membrane in oligodendroglial cells and its rapid perturbation by elevated calcium.

Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence ⬇️

Prox1 Is Required for Oligodendrocyte Cell Identity in Adult Neural Stem Cells of the Subventricular Zone

Quantified CSF antibody reactivity against myelin in multiple sclerosis

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.

Reorganization of Lipid Diffusion by Myelin Basic Protein as Revealed by STED Nanoscopy

Rho Regulates Membrane Transport in the Endocytic Pathway to Control Plasma Membrane Specialization in Oligodendroglial Cells