Lista de obras - Giles E. Hardingham - Dominio Público Uruguay

2B synaptic or extrasynaptic determines signalling from the NMDA receptor

artículo científico publicado en 2006

A Bi-fluorescence complementation system to detect associations between the Endoplasmic reticulum and mitochondria

artículo científico publicado en 2017

A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication

artículo científico publicado en 2001

Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response.

artículo científico publicado en 2012

Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning

artículo científico

Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity

artículo científico publicado en 2009

Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes

artículo científico publicado en 2016

Altered dendritic spine function and integration in a mouse model of Fragile X Syndrome

Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion

scientific article published in Scientific Reports

Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

artículo científico publicado en 2018

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

artículo científico publicado en 2018

CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.

artículo científico publicado en 1998

CNS peroxiredoxins and their regulation in health and disease

artículo científico publicado en 2011

CREB Regulates Distinct Adaptive Transcriptional Programs in Astrocytes and Neurons

artículo científico

Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

artículo científico publicado en 2017

Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals

artículo científico publicado en 2006

Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

artículo científico publicado en 2013

Compartmentalized NMDA receptor signalling to survival and death

article by Francesc X Soriano & Giles E. Hardingham published 15 October 2007 in Journal of Physiology

Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels

artículo científico publicado en 1999

Corrigendum to “Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response” [Exp. Neurol. 237/2 (2012) 396–406]

scholarly article published in Experimental Neurology

Corrigendum: Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

artículo científico publicado en 2017

Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated

artículo científico publicado en 2002

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

artículo científico publicado en 2009

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators.

artículo científico publicado en 2017

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

artículo científico publicado en 2012

Effect of a GRIN2A de novo mutation associated with epilepsy and intellectual disability on NMDA receptor currents and Mg(2+) block in cultured primary cortical neurons

artículo científico publicado en 2015

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

scientific article published on October 2016

Excitotoxic insults lead to peroxiredoxin hyperoxidation

artículo científico publicado en 2009

Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling

artículo científico publicado en 2016

Functional assessment of the NMDA receptor variant GluN2A R586K.

artículo científico publicado en 2017

Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy

artículo científico publicado en 2019

Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.

artículo científico publicado en 2015

GRIN2A-related disorders: genotype and functional consequence predict phenotype

artículo científico publicado en 2019

Gene regulation by nuclear and cytoplasmic calcium signals.

artículo científico publicado en 1997

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

artículo científico publicado en 2017

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.

artículo científico publicado en 2011

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration

artículo científico publicado en 2010

Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration

artículo científico

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

artículo científico publicado en 2015

Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-D-aspartate receptors

scientific journal article

Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons

artículo científico publicado en 2010

In Cortical Neurons HDAC3 Activity Suppresses RD4-Dependent SMRT Export ⬇️

artículo científico publicado el 9 de junio de 2011

In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death

artículo científico publicado en 2008

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.

artículo científico publicado en 2008

Influence of GluN2 subunit identity on NMDA receptor function.

artículo científico

Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression.

artículo científico publicado en 2009

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

artículo científico publicado en 2012

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones

artículo científico publicado en 2014

Lineage divergence of activity-driven transcription and evolution of cognitive ability

artículo científico publicado en 2017

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

artículo científico publicado en 2016

Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes

artículo científico publicado en 2016

Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons

artículo científico publicado en 2014

Mechanisms controlling gene expression by nuclear calcium signals.

artículo científico publicado en 1998

Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes

artículo científico publicado en 2021

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.

artículo científico publicado en 2010

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

artículo científico publicado en 2013

Mixed-species RNA-seq for elucidation of non-cell-autonomous control of gene transcription

article

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

artículo científico publicado en 2012

NMDA receptor C-terminal signaling in development, plasticity, and disease

artículo científico publicado en 2019

NMDA receptor expression and activity in osteoarthritic human articular chondrocytes

artículo científico publicado en 2008

NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons

artículo científico publicado en 2013

Neuronal Activity and Its Role in Controlling Antioxidant Genes

artículo científico publicado en 2020

Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-γ coactivator-1α and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses.

artículo científico publicado en 2011

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 ⬇️

artículo científico publicado en 2015

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

artículo científico publicado en 2017

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes.

artículo científico publicado en 2014

Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness.

artículo científico publicado en 2005

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

artículo científico publicado en 2001

PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity

scientific journal article

Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy

artículo científico publicado en 2014

Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells

scientific article published on 17 January 2014

Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1.

artículo científico publicado en 2011

Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability

artículo científico publicado en 2006

Presynaptic efficacy directs normalization of synaptic strength in layer 2/3 rat neocortex after paired activity

artículo científico publicado en 2007

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

artículo científico publicado en 2017

Pro-survival signalling from the NMDA receptor.

artículo científico publicado en 2006

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

artículo científico publicado en 2022

Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure

artículo científico publicado en 2013

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer's disease

scholarly article published 16 August 2018

Regulation of Neuronal Oxidative and Nitrosative Stress by Endogenous Protective Pathways and Disease Processes

scientific article published on 28 February 2011

Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging

Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2.

artículo científico publicado en 2009

SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites

artículo científico publicado en 2012

Secondary injury and inflammation after intracerebral haemorrhage: a systematic review and meta-analysis of molecular markers in patient brain tissue

publication published on 06 August 2021

Selective dendritic susceptibility to bioenergetic, excitotoxic and redox perturbations in cortical neurons

artículo científico publicado en 2014

Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand

artículo científico publicado en 2008

Suppression of the intrinsic apoptosis pathway by synaptic activity.

artículo científico publicado en 2010

Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome

artículo científico publicado en 2019

SynGAP isoforms exert opposing effects on synaptic strength

artículo científico publicado en 2012

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

artículo científico publicado en 2008

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

artículo científico publicado en 2015

Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene

artículo científico publicado en 2009

Synaptic activity induces signalling to CREB without increasing global levels of cAMP in hippocampal neurons

artículo científico publicado en 2003

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

artículo científico publicado en 2010

Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

artículo científico publicado en 2017

TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner ⬇️

artículo científico publicado el 1 de mayo de 2012

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences

article

The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases

artículo científico publicado en 2020

The Yin and Yang of NMDA receptor signalling

artículo científico publicado en 2003

The dichotomy of NMDA receptor signaling.

artículo científico publicado en 2007

The human NMDA receptor GluN2AN615K variant influences channel blocker potency.

artículo científico publicado en 2019

The influence of synaptic activity on neuronal health

artículo científico publicado en 2011

The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults

artículo científico publicado en 2012

To die or not to die? Current questions in cell death signalling

artículo científico publicado en 2010

Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin

artículo científico publicado en 2009

Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory

artículo científico publicado en 2017

Transfection in Primary Cultured Neuronal Cells.

artículo científico publicado en 2017

c-Jun functions as a calcium-regulated transcriptional activator in the absence of JNK/SAPK1 activation.

artículo científico publicado en 1999

Lista de obras de Giles E. Hardingham

2B synaptic or extrasynaptic determines signalling from the NMDA receptor

A Bi-fluorescence complementation system to detect associations between the Endoplasmic reticulum and mitochondria

A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication

Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response.

Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning

Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity

Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes

Altered dendritic spine function and integration in a mouse model of Fragile X Syndrome

Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion

Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.

CNS peroxiredoxins and their regulation in health and disease

CREB Regulates Distinct Adaptive Transcriptional Programs in Astrocytes and Neurons

Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals

Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

Compartmentalized NMDA receptor signalling to survival and death

Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels

Corrigendum to “Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response” [Exp. Neurol. 237/2 (2012) 396–406]

Corrigendum: Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators.

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

Effect of a GRIN2A de novo mutation associated with epilepsy and intellectual disability on NMDA receptor currents and Mg(2+) block in cultured primary cortical neurons

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

Excitotoxic insults lead to peroxiredoxin hyperoxidation

Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling

Functional assessment of the NMDA receptor variant GluN2A R586K.

Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy

Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells.

GRIN2A-related disorders: genotype and functional consequence predict phenotype

Gene regulation by nuclear and cytoplasmic calcium signals.

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.

Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration

Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-D-aspartate receptors

Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons

In Cortical Neurons HDAC3 Activity Suppresses RD4-Dependent SMRT Export ⬇️

In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.

Influence of GluN2 subunit identity on NMDA receptor function.

Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression.

Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis

Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones

Lineage divergence of activity-driven transcription and evolution of cognitive ability

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes

Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons

Mechanisms controlling gene expression by nuclear calcium signals.

Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

Mixed-species RNA-seq for elucidation of non-cell-autonomous control of gene transcription

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

NMDA receptor C-terminal signaling in development, plasticity, and disease

NMDA receptor expression and activity in osteoarthritic human articular chondrocytes

NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons

Neuronal Activity and Its Role in Controlling Antioxidant Genes

Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-γ coactivator-1α and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses.

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 ⬇️

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes.

Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness.

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity

Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy

Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells

Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1.

Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability

Presynaptic efficacy directs normalization of synaptic strength in layer 2/3 rat neocortex after paired activity

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.

Pro-survival signalling from the NMDA receptor.

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer's disease