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Lista de obras de Susan M. Lea

A Comparative Structure/Function Analysis of Two Type IV Pilin DNA Receptors Defines a Novel Mode of DNA Binding

artículo científico publicado en 2016

A complex iron-calcium cofactor catalyzing phosphotransfer chemistry

artículo científico publicado en 2014

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

artículo científico publicado en 2008

A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies

artículo científico publicado en 2017

A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi.

artículo científico publicado en 2005

A novel inhibitor of complement C5 provides structural insights into activation

A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase.

artículo científico publicado en 2017

A structural study of the interaction between the Dr haemagglutinin DraE and derivatives of chloramphenicol

artículo científico publicado en 2009

An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction

artículo científico publicado en 2005

An atomic resolution model for assembly, architecture, and function of the Dr adhesins.

artículo científico publicado en 2004

An inhibitor of complement C5 provides structural insights into activation

scientific article published on 23 December 2019

Analysis of antigenic surfaces of proteins

scientific article published on 01 January 1995

Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites.

artículo científico publicado en 1994

Architecture of the major component of the type III secretion system export apparatus

artículo científico publicado en 2013

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

artículo científico publicado en 2012

Author Correction: Structure of the core of the type III secretion system export apparatus

scientific article published on 01 August 2018

Author Correction: Structures of the stator complex that drives rotation of the bacterial flagellum

scientific article published on 09 November 2020

Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS).

artículo científico publicado en 2014

Bifunctional Lipocalin Ameliorates Murine Immune Complex-induced Acute Lung Injury

artículo científico publicado en 2013

Biological activity, membrane-targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli.

artículo científico publicado en 2004

Building a secreting nanomachine: a structural overview of the T3SS.

artículo científico

Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS.

artículo científico publicado en 2015

Characterizing sequence variation in the VP1 capsid proteins of foot and mouth disease virus (serotype 0) with respect to virion structure

artículo científico publicado en 1998

Chicken TAP genes are polymorphic and co-evolve with the dominantly-expressed class I gene

article

Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility

artículo científico publicado en 2014

Complement Factor H: Using Atomic Resolution Structure to Illuminate Disease Mechanisms

Complement factor H: using atomic resolution structure to illuminate disease mechanisms

artículo científico publicado en 2008

Complement factor I in health and disease

artículo científico publicado en 2011

Complement regulation at the molecular level: The structure of decay-accelerating factor

artículo científico publicado en 2004

Correction: Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules

artículo científico publicado en 2013

Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target

scholarly article

Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals

scholarly article

Crystal Structure and Functional Characterization of the Complement Regulator Mannose-binding Lectin (MBL)/Ficolin-associated Protein-1 (MAP-1)

artículo científico publicado en 2012

Crystal structure of Spa40, the specificity switch for theShigella flexneritype III secretion system

artículo científico publicado en 2008

Crystal structure of the Bacillus subtilis phosphodiesterase PhoD reveals an iron and calcium-containing active site

artículo científico publicado en 2014

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

artículo científico publicado en 2013

Crystallization and preliminary X-ray analysis of three serotypes of foot-and-mouth disease virus

artículo científico publicado en 1992

Crystallization and preliminary X-ray diffraction analysis of a biologically active fragment of CD55

artículo científico publicado en 1999

Crystallization and preliminary X-ray diffraction analysis of three EGF domains of EMR2, a 7TM immune-system molecule.

artículo científico publicado en 2004

Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferi

artículo científico publicado en 2004

Crystallographic studies of human complement factor I

Decay-accelerating factor must bind both components of the complement alternative pathway C3 convertase to mediate efficient decay

scientific journal article

Deconvolution of fully overlapped reflections from crystals of foot-and-mouth disease virus O1 G67.

artículo científico publicado en 1995

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

artículo científico publicado en 2013

Delivering a toxic metal to the active site of urease

scholarly article

Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules

artículo científico publicado en 2012

Determination of the affinity and kinetic constants for the interaction between the human virus echovirus 11 and its cellular receptor, CD55.

artículo científico publicado en 1998

Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection

artículo científico publicado en 2002

Different modes of variation for each BG lineage suggest different functions

artículo científico publicado en 2016

Dimerization of complement factor H-related proteins modulates complement activation in vivo

artículo científico publicado en 2013

Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus ⬇️

artículo científico publicado el 1 de diciembre de 1997

Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein

artículo científico publicado en 2013

ErpC, a member of the complement regulator-acquiring family of surface proteins fromBorrelia burgdorferi, possesses an architecture previously unseen in this protein family

artículo científico publicado en 2013

Erratum: Corrigendum: Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout

scholarly article published in Nature Structural & Molecular Biology

Erratum: Structure of and influence of a tick complement inhibitor on human complement component 5

scholarly article published in Nature Immunology

EspM2 is a RhoA guanine nucleotide exchange factor

artículo científico publicado en 2009

Expanding the Huntington’s disease research toolbox; validated subdomain protein constructs for biochemical and structural investigation of huntingtin

preprint

Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

artículo científico publicado en 2015

Expression, limited proteolysis and preliminary crystallographic analysis of IpaD, a component of the Shigella flexneri type III secretion system

artículo científico publicado en 2006

Expression, purification, cocrystallization and preliminary crystallographic analysis of sucrose octasulfate/human complement regulator factor H SCRs 6-8.

artículo científico publicado en 2007

Expression, purification, crystallization and preliminary crystallographic analysis of BipD, a component of the Burkholderia pseudomallei type III secretion system

artículo científico publicado en 2006

Expression, purification, crystallization and preliminary crystallographic analysis of MxiH, a subunit of the Shigella flexneri type III secretion system needle

artículo científico publicado en 2006

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.

artículo científico publicado en 2017

Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation

artículo científico publicado en 2015

Factor I autoantibodies are associated with atypical haemolytic uraemic syndrome

scholarly article by David Kavanagh et al published August 2010 in Molecular Immunology

Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon?

artículo científico publicado en 2012

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

artículo científico publicado en 2014

Functional analysis of the interdependence between DNA uptake sequence and its cognate ComP receptor during natural transformation in Neisseria species

artículo científico publicado en 2013

Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) ofBorrelia burgdorferi

artículo científico publicado en 2013

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

preprint

Helical Packing of Needles from Functionally Altered Shigella Type III Secretion Systems

article

Helical structure of the needle of the type III secretion system of Shigella flexneri

artículo científico publicado en 2003

High resolution studies of the Afa/Dr adhesin DraE and its interaction with chloramphenicol

artículo científico publicado en 2004

High-resolution structures of bacterially expressed soluble human CD59

artículo científico publicado en 2007

His-384 Allotypic Variant of Factor H Associated with Age-related Macular Degeneration Has Different Heparin Binding Properties from the Non-disease-associated Form

artículo científico publicado en 2006

Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides.

artículo científico publicado en 2006

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

artículo científico publicado en 2021

Hydrophilic domain II of Escherichia coli Dr fimbriae facilitates cell invasion

artículo científico publicado en 2005

Identification and characterization of the ‘missing’ terminal enzyme for siroheme biosynthesis in α-proteobacteria

artículo científico publicado en 2014

Identification of Jagged1 as a novel ligand for CD46: An interaction required for normal induction and regulation of human TH1 responses

article

Identifying factors which enhance capacity to engage in clinical education among podiatry practitioners: an action research project

artículo científico publicado en 2015

Interactions of CD55 with non-C ligands

scientific article published in 2002

Interactions of CD55 with non-complement ligands

artículo científico publicado en 2002

Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites

artículo científico publicado en 2004

Intersubunit allosteric communication mediated by a conserved loop in the MCM helicase

scholarly article

Investigating the structure of the factor B vWF-A domain/CD55 protein-protein complex using DEER spectroscopy: successes and pitfalls

artículo científico publicado en 2013

Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A

artículo científico publicado en 2003

Mechanism for the Hydrolysis of a Sulfur-Sulfur Bond Based on the Crystal Structure of the Thiosulfohydrolase SoxB

artículo científico publicado en 2009

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

artículo científico publicado en 2021

Mechanism of thiosulfate oxidation in the SoxA family of cysteine-ligated cytochromes

artículo científico publicado en 2015

Model of the equine rhinitis A virus capsid: identification of a major neutralizing immunogenic site

artículo científico publicado en 2003

Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.

artículo científico publicado en 2001

Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor

artículo científico publicado en 2013

Molecular basis for redox control by the human cystine/glutamate antiporter system xc−

artículo científico publicado en 2021

Molecular basis for redox control by the human cystine/glutamate antiporter system xc−

preprint

Molecular dissection of interactions between components of the alternative pathway of complement and decay accelerating factor (CD55).

artículo científico publicado en 2004

Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection

artículo científico publicado en 2011

Molecular model of a type III secretion system needle: Implications for host-cell sensing

artículo científico publicado en 2006

Molecular structure of the intact bacterial flagellar basal body

artículo científico publicado en 2021

Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H

artículo científico publicado en 2009

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

artículo científico publicado en 2009

Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies

artículo científico publicado en 2016

Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein

scholarly article

Nonfunctional variant 3 factor H binding proteins as meningococcal vaccine candidates

artículo científico publicado en 2013

Notch receptor-ligand binding and activation: insights from molecular studies

artículo científico publicado en 2012

On the state of crystallography at the dawn of the electron microscopy revolution

artículo científico publicado en 2017

Polymorphisms in the Human Inhibitory Signal-regulatory Protein   Do Not Affect Binding to Its Ligand CD47

artículo científico publicado en 2014

Putting the structure into complement ⬇️

artículo científico publicado el 1 de noviembre de 2012

Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT

artículo científico publicado en 2004

Rev binds specifically to a purine loop in the SL1 region of the HIV-1 leader RNA

artículo científico publicado en 2003

SAS-6 oligomerization: the key to the centriole?

artículo científico publicado en 2011

SIMPLE 3.0. Stream single-particle cryo-EM analysis in real time

artículo científico publicado en 2020

SIMPLE 3.0. Stream single-particle cryo-EM analysis in real time

scientific article published on 07 November 2020

Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD.

artículo científico publicado en 2006

Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP

artículo científico publicado en 2012

SepL resembles an aberrant effector in binding to a class 1 type III secretion chaperone and carrying an N-terminal secretion signal

artículo científico publicado en 2010

Shigella flexneri Spa15 Crystal Structure Verified in Solution by Double Electron Electron Resonance

artículo científico publicado en 2011

Specific DNA recognition mediated by a type IV pilin

artículo científico publicado en 2013

Specificity and mechanism of assembly of C4b binding protein

Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands

artículo científico publicado en 2013

Structural Basis for Mitotic Centrosome Assembly in Flies

artículo científico publicado en 2017

Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59

artículo científico publicado en 2013

Structural Insights into Notch Receptor-Ligand Interactions

Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system

scholarly article

Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus

artículo científico publicado en 2016

Structural and Functional Studies on the N-terminal Domain of the Shigella Type III Secretion Protein MxiG

artículo científico publicado en 2011

Structural and functional characteristics of MBL/Ficolin-associated Protein-1 (MAP-1)

Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55

artículo científico publicado en 2007

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

artículo científico publicado en 2017

Structural and functional insights into the interaction of echoviruses and decay-accelerating factor

artículo científico publicado en 2005

Structural basis for complement factor H linked age-related macular degeneration

artículo científico publicado en 2007

Structural basis for complement factor I control and its disease-associated sequence polymorphisms

artículo científico publicado en 2011

Structural basis for specificity and promiscuity in a carrier protein/enzyme system from the sulfur cycle

artículo científico publicado en 2015

Structural basis for therapeutic inhibition of complement C5

artículo científico publicado en 2016

Structural basis of antifolate recognition and transport by PCFT

scholarly article

Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks.

artículo científico publicado en 2017

Structural biology of Tat protein transport

artículo científico

Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1.

artículo científico publicado en 2005

Structural comparison of two strains of foot-and-mouth disease virus subtype O1 and a laboratory antigenic variant, G67.

artículo científico publicado en 1995

Structural findings in complement factor H-related proteins unravel the pathogenesis of C3 glomerulopathy

Structure and function of a family of tick-derived complement inhibitors targeting properdin

artículo científico publicado en 2022

Structure and mechanism of the proton-driven motor that powers type 9 secretion and gliding motility

artículo científico publicado en 2021

Structure of Foot-and-mouth disease virus serotype A10 61 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation

artículo científico publicado en 2005

Structure of a major immunogenic site on foot-and-mouth disease virus

artículo científico publicado en 1993

Structure of and influence of a tick complement inhibitor on human complement component 5

artículo científico publicado en 2008

Structure of human complement C8, a precursor to membrane attack

artículo científico publicado en 2010

Structure of the TatC core of the twin-arginine protein transport system

artículo científico publicado en 2012

Structure of the core of the type III secretion system export apparatus

artículo científico publicado en 2018

Structure-based design of chimeric antigens for multivalent protein vaccines.

artículo científico publicado en 2018

Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi.

artículo científico publicado en 2006

Structures of CD200/CD200 Receptor Family and Implications for Topology, Regulation, and Evolution

artículo científico publicado en 2013

Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction

artículo científico publicado en 2015

Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold

artículo científico publicado en 2020

Structures of the Shigella flexneri Type 3 Secretion System Protein MxiC Reveal Conformational Variability Amongst Homologues

artículo científico publicado en 2008

Structures of the Type IX Secretion/Gliding Motility Motor from across the Phylum

scholarly article

Structures of the Type IX Secretion/gliding motility motor from across the phylum Bacteroidetes

scholarly article

Structures of the rat complement regulator CrrY

artículo científico publicado en 2011

Structures of the stator complex that drives rotation of the bacterial flagellum

scientific article published on 14 September 2020

Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation

artículo científico publicado en 2020

TatBC, TatB, and TatC form structurally autonomous units within the twin arginine protein transport system of Escherichia coli

artículo científico publicado en 2007

Tetartohedral twinning could happen to you too

artículo científico

The CD46-Jagged1 interaction is critical for human TH1 immunity

artículo científico publicado en 2012

The Escherichia coli Cell Division Protein and Model Tat Substrate SufI (FtsP) Localizes to the Septal Ring and Has a Multicopper Oxidase-Like Structure

artículo científico publicado en 2009

The S. Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin

artículo científico publicado en 2019

The Salmonella type III secretion system inner rod protein PrgJ is partially folded.

artículo científico publicado en 2012

The Structure of OMCI, a Novel Lipocalin Inhibitor of the Complement System

artículo científico publicado en 2007

The Structure of an Injectisome Export Gate Demonstrates Conservation of Architecture in the Core Export Gate between Flagellar and Virulence Type III Secretion Systems

artículo científico publicado en 2019

The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation.

artículo científico publicado en 2014

The characterization of weak protein-protein interactions: evidence from DEER for the trimerization of a von Willebrand Factor A domain in solution.

artículo científico publicado en 2006

The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies

artículo científico publicado en 2015

The structure and antigenicity of a type C foot-and-mouth disease virus

artículo científico publicado en 1994

The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex.

artículo científico publicado en 1999

The structure of an immunodominant loop on foot and mouth disease virus, serotype O1, determined under reducing conditions

artículo científico publicado en 1994

The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55)

artículo científico publicado en 2004

The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion

artículo científico publicado en 2020

The type III needle and the damage done

artículo científico publicado en 2005

Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout

artículo científico publicado en 2009

Timing is everything: the regulation of type III secretion

artículo científico publicado en 2010

Towards a structural basis for complement factor H linked age-related macular degeneration

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties

Type 9 secretion system structures reveal a new protein transport mechanism

scientific article published in Nature

What's the point of the type III secretion system needle?

artículo científico publicado en 2008

With phases: how two wrongs can sometimes make a right

artículo científico publicado en 2010

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