Lista de obras - Karen N. Allen - Dominio Público Uruguay

A Central Region of NF-κB Essential Modulator Is Required for IKKβ-Induced Conformational Change and for Signal Propagation

scientific article published on 18 June 2019

A Structural Element That Facilitates Proton-Coupled Electron Transfer in Oxalate Decarboxylase

artículo científico publicado en 2012

A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action ⬇️

artículo científico publicado el 4 de enero de 2011

Assigning the EPR Fine Structure Parameters of the Mn(II) Centers in Bacillus subtilis Oxalate Decarboxylase by Site-Directed Mutagenesis and DFT/MM Calculations

artículo científico publicado en 2014

Binding Energy and Catalysis by d -Xylose Isomerase: Kinetic, Product, and X-ray Crystallographic Analysis of Enzyme-Catalyzed Isomerization of ( R )-Glyceraldehyde

artículo científico publicado en 2011

Catalytic cycling in beta-phosphoglucomutase: a kinetic and structural analysis

artículo científico publicado en 2005

Catalytic scaffolds for phosphoryl group transfer

artículo científico publicado en 2016

Caught in the act: the structure of phosphorylated beta-phosphoglucomutase from Lactococcus lactis

artículo científico publicado en 2002

Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase

artículo científico publicado en 2005

Chemical-modification rescue assessed by mass spectrometry demonstrates that gamma-thia-lysine yields the same activity as lysine in aldolase

artículo científico publicado en 2002

Co-evolution of HAD phosphatase and hotdog-fold thioesterase domain function in the menaquinone-pathway fusion proteins BF1314 and PG1653.

scientific article published on 10 July 2013

Conformational Cycling in β-Phosphoglucomutase Catalysis: Reorientation of the β-d-Glucose 1,6-(Bis)phosphate Intermediate†

artículo científico publicado en 2006

Consequences of domain insertion on sequence-structure divergence in a superfold

scientific article published on 19 August 2013

Conservation and Covariance in Small Bacterial Phosphoglycosyltransferases Identify the Functional Catalytic Core

artículo científico publicado en 2015

Crystallization and preliminary X-ray diffraction studies of beta-phosphoglucomutase from Lactococcus lactus

artículo científico publicado en 2002

Crystallization and preliminary crystallographic analysis of phosphonoacetaldehyde hydrolase

Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme

artículo científico publicado en 2018

Design of a heterospecific, tetrameric, 21-residue miniprotein with mixed alpha/beta structure.

artículo científico publicado en 2005

Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO).

artículo científico publicado en 2014

Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage

artículo científico publicado en 2006

Double-lanthanide-binding tags for macromolecular crystallographic structure determination

artículo científico publicado en 2007

Encoded loop-lanthanide-binding tags for long-range distance measurements in proteins by NMR and EPR spectroscopy

scientific article published on 04 September 2015

Engineering encodable lanthanide-binding tags into loop regions of proteins

artículo científico publicado en 2011

Enzymatic synthesis of radiolabeled phosphonoacetaldehyde

artículo científico publicado en 2003

Enzyme Substrate Specificity Conferred by Distinct Conformational Pathways

artículo científico publicado en 2015

Enzyme promiscuity: engine of evolutionary innovation.

artículo científico publicado en 2014

Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies ⬇️

artículo científico publicado el 20 de diciembre de 2012

Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes

artículo científico publicado en 2006

Form finds function

artículo científico publicado en 2007

HAD superfamily phosphotransferase substrate diversification: structure and function analysis of HAD subclass IIB sugar phosphatase BT4131.

artículo científico publicado en 2005

Intein-mediated purification of a recombinantly expressed peptide

scientific article published on 23 September 2004

Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2)

scientific article published on 02 January 2020

Investigation of metal ion binding in phosphonoacetaldehyde hydrolase identifies sequence markers for metal-activated enzymes of the HAD enzyme superfamily

artículo científico publicado en 2004

Lanthanide-Binding Tags for 3D X-ray Imaging of Proteins in Cells at Nanoscale Resolution

scientific article published on 21 January 2020

Mechanism of Substrate Recognition and Catalysis of the Haloalkanoic Acid Dehalogenase Family Member α-Phosphoglucomutase

scientific article published on 13 July 2018

Membrane association of monotopic phosphoglycosyl transferase underpins function

artículo científico publicado en 2018

Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.

artículo científico publicado en 2017

Monotopic Membrane Proteins Join the Fold

artículo científico publicado en 2018

Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.

artículo científico publicado en 2013

Neutron diffraction studies towards deciphering the protonation state of catalytic residues in the bacterial KDN9P phosphatase.

artículo científico publicado en 2013

New superfamily members identified for Schiff-base enzymes based on verification of catalytically essential residues.

artículo científico publicado en 2006

Panoramic view of a superfamily of phosphatases through substrate profiling

artículo científico publicado en 2015

Quaternary ammonium oxidative demethylation: X-ray crystallographic, resonance Raman, and UV-visible spectroscopic analysis of a Rieske-type demethylase

artículo científico publicado en 2012

Snapshots of Catalysis: the Structure of Fructose-1,6-(bis)phosphate Aldolase Covalently Bound to the Substrate Dihydroxyacetone Phosphate, ⬇️

artículo científico publicado el 20 de noviembre de 2001

Spatial clustering of isozyme-specific residues reveals unlikely determinants of isozyme specificity in fructose-1,6-bisphosphate aldolase

artículo científico publicado en 2003

Structural Basis for the Divergence of Substrate Specificity and Biological Function within HAD Phosphatases in Lipopolysaccharide and Sialic Acid Biosynthesis

artículo científico publicado en 2013

Structural Basis of the Molecular Switch between Phosphatase and Mutase Functions of Human Phosphomannomutase 1 under Ischemic Conditions

scientific article published on 11 May 2018

Structural Origin of the High Affinity of a Chemically Evolved Lanthanide-Binding Peptide

artículo científico publicado en 2004

Structural and mechanistic themes in glycoconjugate biosynthesis at membrane interfaces

scientific article published on 16 April 2019

Structure and activity analyses of Escherichia coli K-12 NagD provide insight into the evolution of biochemical function in the haloalkanoic acid dehalogenase superfamily

artículo científico publicado en 2006

Structure of a fructose-1,6-bis(phosphate) aldolase liganded to its natural substrate in a cleavage-defective mutant at 2.3 A(,)

artículo científico publicado en 1999

Structure of a rabbit muscle fructose-1,6-bisphosphate aldolase A dimer variant

artículo científico publicado en 2008

Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs

artículo científico publicado en 2014

Structure-Function Analysis of 2-Keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate Phosphatase Defines Specificity Elements in Type C0 Haloalkanoate Dehalogenase Family Members

artículo científico publicado en 2009

Structure-Guided Insight into the Specificity and Mechanism of a Parasitic Nucleoside Hydrolase

artículo científico publicado en 2022

Structure-guided approach for detecting large domain inserts in protein sequences as illustrated using the haloacid dehalogenase superfamily.

artículo científico publicado en 2014

Substrate Binding Mode and Molecular Basis of a Specificity Switch in Oxalate Decarboxylase.

artículo científico publicado en 2016

The 2.1 A structure of Torpedo californica creatine kinase complexed with the ADP-Mg(2+)-NO(3)(-)-creatine transition-state analogue complex

artículo científico publicado en 2002

The Enzyme Function Initiative

artículo científico publicado en 2011

The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a

artículo científico publicado en 2006

The X-ray crystallographic structure and activity analysis of a Pseudomonas-specific subfamily of the HAD enzyme superfamily evidences a novel biochemical function

artículo científico publicado en 2008

The X‐ray crystallographic structure and specificity profile of HAD superfamily phosphohydrolase BT1666: Comparison of paralogous functions in B. thetaiotaomicron ⬇️

artículo científico publicado el 30 de agosto de 2011

The origin of the electrostatic perturbation in acetoacetate decarboxylase

artículo científico publicado en 2009

X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily

artículo científico publicado en 2004

X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture.

scholarly article

Lista de obras de Karen N. Allen

A Central Region of NF-κB Essential Modulator Is Required for IKKβ-Induced Conformational Change and for Signal Propagation

A Structural Element That Facilitates Proton-Coupled Electron Transfer in Oxalate Decarboxylase

A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action ⬇️

Assigning the EPR Fine Structure Parameters of the Mn(II) Centers in Bacillus subtilis Oxalate Decarboxylase by Site-Directed Mutagenesis and DFT/MM Calculations

Binding Energy and Catalysis by d -Xylose Isomerase: Kinetic, Product, and X-ray Crystallographic Analysis of Enzyme-Catalyzed Isomerization of ( R )-Glyceraldehyde

Catalytic cycling in beta-phosphoglucomutase: a kinetic and structural analysis

Catalytic scaffolds for phosphoryl group transfer

Caught in the act: the structure of phosphorylated beta-phosphoglucomutase from Lactococcus lactis

Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase

Chemical-modification rescue assessed by mass spectrometry demonstrates that gamma-thia-lysine yields the same activity as lysine in aldolase

Co-evolution of HAD phosphatase and hotdog-fold thioesterase domain function in the menaquinone-pathway fusion proteins BF1314 and PG1653.

Conformational Cycling in β-Phosphoglucomutase Catalysis: Reorientation of the β-d-Glucose 1,6-(Bis)phosphate Intermediate†

Consequences of domain insertion on sequence-structure divergence in a superfold

Conservation and Covariance in Small Bacterial Phosphoglycosyltransferases Identify the Functional Catalytic Core

Crystallization and preliminary X-ray diffraction studies of beta-phosphoglucomutase from Lactococcus lactus

Crystallization and preliminary crystallographic analysis of phosphonoacetaldehyde hydrolase

Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme

Design of a heterospecific, tetrameric, 21-residue miniprotein with mixed alpha/beta structure.

Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO).

Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage

Double-lanthanide-binding tags for macromolecular crystallographic structure determination

Encoded loop-lanthanide-binding tags for long-range distance measurements in proteins by NMR and EPR spectroscopy

Engineering encodable lanthanide-binding tags into loop regions of proteins

Enzymatic synthesis of radiolabeled phosphonoacetaldehyde

Enzyme Substrate Specificity Conferred by Distinct Conformational Pathways

Enzyme promiscuity: engine of evolutionary innovation.

Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies ⬇️

Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes

Form finds function

HAD superfamily phosphotransferase substrate diversification: structure and function analysis of HAD subclass IIB sugar phosphatase BT4131.

Intein-mediated purification of a recombinantly expressed peptide

Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2)

Investigation of metal ion binding in phosphonoacetaldehyde hydrolase identifies sequence markers for metal-activated enzymes of the HAD enzyme superfamily

Lanthanide-Binding Tags for 3D X-ray Imaging of Proteins in Cells at Nanoscale Resolution

Mechanism of Substrate Recognition and Catalysis of the Haloalkanoic Acid Dehalogenase Family Member α-Phosphoglucomutase

Membrane association of monotopic phosphoglycosyl transferase underpins function

Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.

Monotopic Membrane Proteins Join the Fold

Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.

Neutron diffraction studies towards deciphering the protonation state of catalytic residues in the bacterial KDN9P phosphatase.

New superfamily members identified for Schiff-base enzymes based on verification of catalytically essential residues.

Panoramic view of a superfamily of phosphatases through substrate profiling

Quaternary ammonium oxidative demethylation: X-ray crystallographic, resonance Raman, and UV-visible spectroscopic analysis of a Rieske-type demethylase

Snapshots of Catalysis: the Structure of Fructose-1,6-(bis)phosphate Aldolase Covalently Bound to the Substrate Dihydroxyacetone Phosphate, ⬇️

Spatial clustering of isozyme-specific residues reveals unlikely determinants of isozyme specificity in fructose-1,6-bisphosphate aldolase

Structural Basis for the Divergence of Substrate Specificity and Biological Function within HAD Phosphatases in Lipopolysaccharide and Sialic Acid Biosynthesis

Structural Basis of the Molecular Switch between Phosphatase and Mutase Functions of Human Phosphomannomutase 1 under Ischemic Conditions

Structural Origin of the High Affinity of a Chemically Evolved Lanthanide-Binding Peptide

Structural and mechanistic themes in glycoconjugate biosynthesis at membrane interfaces

Structure and activity analyses of Escherichia coli K-12 NagD provide insight into the evolution of biochemical function in the haloalkanoic acid dehalogenase superfamily

Structure of a fructose-1,6-bis(phosphate) aldolase liganded to its natural substrate in a cleavage-defective mutant at 2.3 A(,)

Structure of a rabbit muscle fructose-1,6-bisphosphate aldolase A dimer variant

Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs

Structure-Function Analysis of 2-Keto-3-deoxy-D-glycero-D-galactonononate-9-phosphate Phosphatase Defines Specificity Elements in Type C0 Haloalkanoate Dehalogenase Family Members

Structure-Guided Insight into the Specificity and Mechanism of a Parasitic Nucleoside Hydrolase

Structure-guided approach for detecting large domain inserts in protein sequences as illustrated using the haloacid dehalogenase superfamily.

Substrate Binding Mode and Molecular Basis of a Specificity Switch in Oxalate Decarboxylase.

The 2.1 A structure of Torpedo californica creatine kinase complexed with the ADP-Mg(2+)-NO(3)(-)-creatine transition-state analogue complex

The Enzyme Function Initiative

The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a

The X-ray crystallographic structure and activity analysis of a Pseudomonas-specific subfamily of the HAD enzyme superfamily evidences a novel biochemical function

The X‐ray crystallographic structure and specificity profile of HAD superfamily phosphohydrolase BT1666: Comparison of paralogous functions in B. thetaiotaomicron ⬇️

The origin of the electrostatic perturbation in acetoacetate decarboxylase

X-ray crystal structure of the hypothetical phosphotyrosine phosphatase MDP-1 of the haloacid dehalogenase superfamily

X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture.