Lista de obras - Wei-Jen Tang - Dominio Público Uruguay

A 1.3-Å Structure of Zinc-bound N-terminal Domain of Calmodulin Elucidates Potential Early Ion-binding Step

artículo científico publicado en 2007

A fluorimetric assay for real-time monitoring of adenylyl cyclase activity based on terbium norfloxacin

artículo científico publicado en 2008

A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase

artículo científico publicado en 2004

ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

artículo científico publicado en 2017

Adenylyl cyclases.

artículo científico publicado en 1992

An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis.

artículo científico publicado en 2000

Anthrax edema factor potency depends on mode of cell entry.

artículo científico publicado en 2005

Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells

artículo científico publicado en 2005

Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1

scientific article published on 09 May 2007

Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin

artículo científico publicado en 2007

Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage

artículo científico publicado en 2007

Anthrax toxins induce shock in rats by depressed cardiac ventricular function

artículo científico publicado en 2007

Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling

artículo científico publicado en 2005

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

artículo científico publicado en 2014

Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus

artículo científico publicado en 2008

Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice

artículo científico publicado en 2005

Bacillus anthracis edema toxin impairs neutrophil actin-based motility

artículo científico publicado en 2009

Bis-halogen-anthraniloyl-substituted nucleoside 5'-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin

artículo científico publicado en 2010

Calcium dependence of the interaction between calmodulin and anthrax edema factor

artículo científico publicado en 2003

Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.

artículo científico publicado en 2005

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

artículo científico publicado en 2015

Cellular Functions and X-ray Structure of Anthrolysin O, a Cholesterol-dependent Cytolysin Secreted by Bacillus anthracis

artículo científico publicado en 2009

Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor

artículo científico publicado en 2004

Comparison of three anthrax toxin neutralization assays

artículo científico publicado en 2010

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

artículo científico publicado en 2013

Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase

artículo científico publicado en 2002

Contributions of edema factor and protective antigen to the induction of protective immunity by Bacillus anthracis edema toxin as an intranasal adjuvant

artículo científico publicado en 2010

Coordinate regulation of G protein signaling via dynamic interactions of receptor and GAP

artículo científico publicado en 2008

Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin.

artículo científico publicado en 2001

Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA.

artículo científico publicado en 2010

Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation

artículo científico publicado en 2014

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

artículo científico publicado en 2010

Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor

artículo científico publicado en 2015

Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin

artículo científico publicado en 2004

Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor.

artículo científico publicado en 2009

Empirical valence bond simulations of the chemical mechanism of ATP to cAMP conversion by anthrax edema factor.

artículo científico publicado en 2013

Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.

artículo científico publicado en 2018

Erratum: ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

artículo científico publicado en 2017

Expression and Purification of Soluble Adenylyl Cyclase from Escherichia coli

artículo científico publicado el 1 de enero de 2004

Expression and purification of recombinant adenylyl cyclases in Sf9 cells.

artículo científico publicado en 1994

Expression of alpha subunit of Gs in Escherichia coli

artículo científico publicado en 2002

Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues

artículo científico publicado en 2008

Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

artículo científico publicado en 2004

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

artículo científico publicado en 2011

Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL.

artículo científico publicado en 2016

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

artículo científico publicado en 2014

Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines

artículo científico publicado en 2008

In vivo epidermal migration requires focal adhesion targeting of ACF7

artículo científico publicado en 2016

Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates

artículo científico publicado en 2011

Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors

artículo científico publicado en 2007

Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response

artículo científico publicado en 2010

Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: comparison with membranous adenylyl cyclase I.

artículo científico publicado en 2012

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction

scientific article published on 01 May 2007

Modular total chemical synthesis of a human immunodeficiency virus type 1 protease

artículo científico publicado en 2007

Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification

artículo científico publicado en 2013

Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †

artículo científico publicado en 2008

Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme

artículo científico publicado en 2010

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

artículo científico publicado en 2009

Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease

artículo científico publicado en 2014

Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides

artículo científico publicado en 2007

Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides.

artículo científico publicado en 2008

Noninvasive imaging technologies reveal edema toxin as a key virulence factor in anthrax

artículo científico publicado en 2011

Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor

artículo científico publicado en 2013

Pathophysiology of anthrax

artículo científico publicado en 2009

Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities

artículo científico publicado en 2005

Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins

artículo científico publicado en 2002

Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme

artículo científico publicado en 2010

Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine

artículo científico publicado en 2011

Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation

artículo científico publicado en 2009

Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently

artículo científico publicado en 2008

Pseudomonas aeruginosa exoenzyme Y directly bundles actin filaments

scientific article published on 04 February 2020

Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin

scientific article published on 19 June 2019

Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction

artículo científico publicado en 2004

Reinvestigating the synthesis and efficacy of small benzimidazole derivatives as presequence protease enhancers

scientific article published on 01 October 2019

Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection

artículo científico publicado en 2004

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

artículo científico publicado en 2009

Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'

artículo científico publicado en 2008

Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.

artículo científico publicado en 2004

Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin

artículo científico publicado en 2002

Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin

artículo científico publicado en 2005

Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme

scientific article published on 07 July 2009

Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction

artículo científico publicado en 2011

Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site

artículo científico publicado en 2004

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

artículo científico publicado en 2007

Structure, function, and regulation of insulin-degrading enzyme

artículo científico publicado en 2009

Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.

artículo científico publicado en 2014

Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough

artículo científico publicado en 2003

Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme

artículo científico publicado en 2015

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

artículo científico publicado en 2006

Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus

artículo científico publicado en 2015

The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition.

artículo científico publicado en 2006

The C2 catalytic domain of adenylyl cyclase contains the second metal ion (Mn2+) binding site

scientific article published on 01 November 1998

The adenylyl cyclase activity of anthrax edema factor

artículo científico publicado en 2009

The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor

artículo científico publicado en 2007

The case for developing consensus standards for research in microbial pathogenesis: Bacillus anthracis toxins as an example

artículo científico publicado en 2009

The conserved asparagine and arginine are essential for catalysis of mammalian adenylyl cyclase

scientific article published on 01 May 1997

Three discrete regions of mammalian adenylyl cyclase form a site for Gsalpha activation.

artículo científico publicado en 1997

Truncation and alanine-scanning mutants of type I adenylyl cyclase.

artículo científico publicado en 1995

Two Cytoplasmic Domains of Mammalian Adenylyl Cyclase Form a G- and Forskolin-activated Enzymein Vitro

artículo científico publicado en 1996

Ubiquitin is a novel substrate for human insulin-degrading enzyme

artículo científico publicado en 2011

Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor.

artículo científico publicado en 2010

Lista de obras de Wei-Jen Tang

A 1.3-Å Structure of Zinc-bound N-terminal Domain of Calmodulin Elucidates Potential Early Ion-binding Step

A fluorimetric assay for real-time monitoring of adenylyl cyclase activity based on terbium norfloxacin

A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase

ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

Adenylyl cyclases.

An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis.

Anthrax edema factor potency depends on mode of cell entry.

Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells

Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1

Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin

Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage

Anthrax toxins induce shock in rats by depressed cardiac ventricular function

Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus

Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice

Bacillus anthracis edema toxin impairs neutrophil actin-based motility

Bis-halogen-anthraniloyl-substituted nucleoside 5'-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin

Calcium dependence of the interaction between calmodulin and anthrax edema factor

Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Cellular Functions and X-ray Structure of Anthrolysin O, a Cholesterol-dependent Cytolysin Secreted by Bacillus anthracis

Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor

Comparison of three anthrax toxin neutralization assays

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase

Contributions of edema factor and protective antigen to the induction of protective immunity by Bacillus anthracis edema toxin as an intranasal adjuvant

Coordinate regulation of G protein signaling via dynamic interactions of receptor and GAP

Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin.

Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA.

Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor

Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin

Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor.

Empirical valence bond simulations of the chemical mechanism of ATP to cAMP conversion by anthrax edema factor.

Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.

Erratum: ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

Expression and Purification of Soluble Adenylyl Cyclase from Escherichia coli

Expression and purification of recombinant adenylyl cyclases in Sf9 cells.

Expression of alpha subunit of Gs in Escherichia coli

Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues

Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL.

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines

In vivo epidermal migration requires focal adhesion targeting of ACF7

Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates

Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors

Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response

Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: comparison with membranous adenylyl cyclase I.

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction

Modular total chemical synthesis of a human immunodeficiency virus type 1 protease

Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification

Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †

Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease

Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides

Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides.

Noninvasive imaging technologies reveal edema toxin as a key virulence factor in anthrax

Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor

Pathophysiology of anthrax

Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities

Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins

Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme

Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine

Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation

Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently

Pseudomonas aeruginosa exoenzyme Y directly bundles actin filaments

Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin

Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction

Reinvestigating the synthesis and efficacy of small benzimidazole derivatives as presequence protease enhancers

Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'

Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.

Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin