Lista de obras - Juan Bueren - Dominio Público Uruguay

A Short and Efficient Transduction Protocol for Mouse Hematopoietic Stem Cells with Lentiviral Vectors.

artículo científico publicado en 2017

A common founder mutation in FANCA underlies the world's highest prevalence of Fanconi anemia in Gypsy families from Spain

artículo científico publicado en 2004

A new approach to evaluate the total reserve of hematopoietic progenitors after acute irradiation

artículo científico publicado en 2004

A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice.

artículo científico publicado en 2011

A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells.

artículo científico publicado en 2010

A simplified approach to improve the efficiency and safety of ex vivo hematopoietic gene therapy in fanconi anemia patients

artículo científico publicado en 2006

AM218, a new polyanionic polysaccharide, induces radioprotection in mice when administered shortly before irradiation

scientific article published on 01 January 1997

Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease

artículo científico publicado en 2006

Adipose-derived mesenchymal stromal cells modulate experimental autoimmune arthritis by inducing an early regulatory innate cell signature.

artículo científico publicado en 2016

Analysis of hematopoiesis in mice irradiated with 500 mGy of X rays at different stages of development

artículo científico publicado en 1995

Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics

artículo científico publicado en 2003

BCR-JAK2 drives a myeloproliferative neoplasm in transplanted mice.

artículo científico publicado en 2015

Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells

artículo científico publicado en 2010

Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells

artículo científico publicado en 2010

Biodistribution and Efficacy of Human Adipose-Derived Mesenchymal Stem Cells Following Intranodal Administration in Experimental Colitis.

artículo científico publicado en 2017

Brief report: impaired cell reprogramming in nonhomologous end joining deficient cells.

artículo científico publicado en 2013

Brief report: reduced expression of CD18 leads to the in vivo expansion of hematopoietic stem cells in mouse bone marrow.

artículo científico publicado en 2014

Chromosome fragility in patients with Fanconi anaemia: diagnostic implications and clinical impact

artículo científico publicado en 2011

Conversion of human fibroblasts into monocyte-like progenitor cells

artículo científico publicado en 2014

Correction of SCID-X1 using an enhancerless Vav promoter.

artículo científico publicado en 2011

Cytotoxic infection of hematopoietic stem and committed progenitor cells by the parvovirus minute virus of mice. Propagation of an acute myelosuppression in culture

artículo científico publicado en 1991

Detectable clonal mosaicism in blood as a biomarker of cancer risk in Fanconi anemia

artículo científico publicado en 2017

Development of a web course on gene therapy by the international consortium of gene therapy

artículo científico publicado en 2014

Development of an in vitro model for the simultaneous study of the efficacy and hematotoxicity of antileukemic compounds.

artículo científico publicado en 2010

Development of lentiviral vectors with optimized transcriptional activity for the gene therapy of patients with Fanconi anemia

artículo científico publicado en 2010

Differential sensitivity to hyperthermia of mouse normal haemopoietic stem cells related to proliferation activity and organ source

scientific article published on 01 July 1987

Direct Conversion of Fibroblasts to Megakaryocyte Progenitors

artículo científico publicado en 2016

Down-regulated expression of hsa-miR-181c in Fanconi anemia patients: implications in TNFα regulation and proliferation of hematopoietic progenitor cells

artículo científico publicado en 2012

Efficient engraftment of in utero transplanted mice with retrovirally transduced hematopoietic stem cells

artículo científico publicado en 2005

Engraftment and in vivo proliferation advantage of gene corrected mobilized CD34(+) cells from Fanconi anemia patients.

artículo científico

Engraftment kinetics of human CD34+ cells from cord blood and mobilized peripheral blood co-transplanted into NOD/SCID mice

artículo científico publicado en 2005

Epigenetic Alterations in Fanconi Anaemia: Role in Pathophysiology and Therapeutic Potential.

artículo científico publicado en 2015

Ex vivo expansion and selection of retrovirally transduced bone marrow: an efficient methodology for gene-transfer to murine lympho-haemopoietic stem cells

artículo científico publicado en 1994

Ex vivo expansion of umbilical cord blood (UCB) CD34(+) cells alters the expression and function of alpha 4 beta 1 and alpha 5 beta 1 integrins

scientific article published on 01 October 2001

Exploring the link between MORF4L1 and risk of breast cancer

artículo científico publicado en 2011

Fanconi anaemia: from a monogenic disease to sporadic cancer ⬇️

artículo científico publicado el 1 de abril de 2011

Functional and phenotypic variations in human T cells subjected to retroviral-mediated gene transfer

artículo científico publicado en 2004

Gene therapy for Fanconi anemia: one step closer to the clinic.

artículo científico publicado en 2012

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.

artículo científico publicado en 2015

Generation of functional neutrophils from a mouse model of X-linked chronic granulomatous disorder using induced pluripotent stem cells

artículo científico publicado en 2011

Generation of iPSCs from genetically corrected Brca2 hypomorphic cells: implications in cell reprogramming and stem cell therapy

artículo científico publicado en 2014

Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion

artículo científico publicado en 2006

Human Adipose-Derived Mesenchymal Stem Cells Modulate Experimental Autoimmune Arthritis by Modifying Early Adaptive T Cell Responses.

artículo científico publicado en 2015

Immunoresponse against the transgene limits hematopoietic engraftment of mice transplanted in utero with virally transduced fetal liver.

artículo científico publicado en 2010

Improved Hematopoietic Gene Therapy in a Mouse Model of Fanconi Anemia Mediated by Mesenchymal Stromal Cells

artículo científico publicado en 2017

In vitro and in vivo susceptibility of mouse megakaryocytic progenitors to strain i of parvovirus minute virus of mice.

artículo científico publicado en 2001

In vitro hematotoxicity of Aplidine on human bone marrow and cord blood progenitor cells

artículo científico publicado en 2001

In vitro toxicity of ET-743 and aplidine, two marine-derived antineoplastics, on human bone marrow haematopoietic progenitors. comparison with the clinical results

artículo científico publicado en 2002

In vitro toxicity of three new antitumoral drugs (trabectedin, aplidin, and kahalalide F) on hematopoietic progenitors and stem cells

artículo científico publicado en 2003

In vivo imaging of lung inflammation with neutrophil-specific 68Ga nano-radiotracer

artículo científico publicado en 2017

Inhibitory effects of marine-derived DNA-binding anti-tumour tetrahydroisoquinolines on the Fanconi anaemia pathway

artículo científico publicado en 2013

Intralymphatic Administration of Adipose Mesenchymal Stem Cells Reduces the Severity of Collagen-Induced Experimental Arthritis

artículo científico publicado en 2017

Jun N-terminal kinase activity and early growth-response factor-1 gene expression are down-regulated in Fanconi anemia group A lymphoblasts.

artículo científico publicado en 2003

Kinetic studies of pyruvate kinase during in vitro differentiation of GM-CFC haemopoietic precursor and bone marrow cells in mice

artículo científico publicado en 1990

Latent hematopoietic stem cell toxicity associated with protracted drug administration

artículo científico publicado en 2001

Lentiviral Vector-Mediated Correction of a Mouse Model of Leukocyte Adhesion Deficiency Type I.

artículo científico publicado en 2016

Lentiviral vector integration sites in human NOD/SCID repopulating cells

artículo científico publicado en 2006

Lentiviral-Mediated Gene Therapy in Fanconi Anemia-A Mice Reveals Long-Term Engraftment and Continuous Turnover of Corrected HSCs.

artículo científico publicado en 2015

Lessons Learned from Two Decades of Clinical Trial Experience in Gene Therapy for Fanconi Anemia

artículo científico publicado en 2017

Long-term skin regeneration in xenografts from iPSC teratoma-derived human keratinocytes.

artículo científico publicado en 2016

Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent

artículo científico publicado en 2017

Mechanisms towards compensation of long-term haemopoietic injury in mice after 5 Gy irradiation: in vivo and in vitro enhancement of superoxide anion production by granulocytes

artículo científico publicado en 1992

Mesenchymal stromal cells enhance the engraftment of hematopoietic stem cells in an autologous mouse transplantation model

artículo científico publicado en 2015

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs

artículo científico publicado en 2014

Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia

artículo científico publicado en 2013

Non-homologous end-joining defect in fanconi anemia hematopoietic cells exposed to ionizing radiation

artículo científico publicado en 2005

Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations

artículo científico publicado en 2011

Parvovirus infection suppresses long-term repopulating hematopoietic stem cells

artículo científico publicado en 2003

Perspectives on gene therapy for Fanconi anemia

article

Preserved long-term repopulation and differentiation properties of hematopoietic grafts subjected to ex vivo expansion with stem cell factor and interleukin 11

scientific article published on 01 May 1999

Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay.

artículo científico publicado en 2001

Production of humoral factors that stimulate spleen colony-forming units in mice irradiated with moderate doses of X rays

artículo científico publicado en 1990

Prostaglandin E2 plays a key role in the immunosuppressive properties of adipose and bone marrow tissue-derived mesenchymal stromal cells.

artículo científico publicado en 2010

Purging of leukemia-contaminated bone marrow grafts using suicide adenoviral vectors: an in vivo murine experimental model.

artículo científico publicado en 2003

Pyruvate kinase during in vitro differentiation of GM-CFC haemopoietic precursor in mice: modulation by L-alanine and L-phenylalanine

artículo científico publicado en 1989

Quantitative PCR analysis reveals a high incidence of large intragenic deletions in the FANCA gene in Spanish Fanconi anemia patients.

artículo científico publicado en 2004

Radioprotection mediated by the haemopoietic stimulation conferred by AM5: a protein-associated polysaccharide

scientific article published on 01 July 1992

Reduced efficacy of mesenchymal stromal cells in preventing graft-versus-host disease in an in vivo model of haploidentical bone marrow transplant with leukemia

artículo científico publicado en 2012

Regulatory elements of the vav gene drive transgene expression in hematopoietic stem cells from adult mice

artículo científico publicado en 2004

Residual damage of lymphohematopoietic repopulating cells after irradiation of mice at different stages of development

artículo científico

Residual haematopoietic damage in adult and 8 day-old mice exposed to 7 Gy of X-rays

scientific article published on 01 January 1993

Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency

artículo científico publicado en 2016

Safety of retroviral gene marking with a truncated NGF receptor

scientific article published on 01 April 2003

Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting.

artículo científico publicado en 2011

Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia

scientific article published on 09 September 2019

The mobilization of hematopoietic progenitors to peripheral blood is predictive of the hematopoietic syndrome after total or partial body irradiation of mice

artículo científico publicado en 2006

Therapeutic gene editing in CD34+ hematopoietic progenitors from Fanconi anemia patients.

artículo científico publicado en 2017

Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase

artículo científico publicado en 2012

Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases

artículo científico publicado en 2013

Transplantation of marrow cells from children with standard risk-acute lymphoblastic leukemia at the end of therapy into NOD/SCID mice for detecting residual leukemic cells with in vivo growth potential

scientific article published on 01 December 2003

Unraveling the role of FANCD2 in chronic myeloid leukemia

artículo científico publicado en 2012

Use of CFU-GM assay for prediction of human maximum tolerated dose of a new antitumoral drug: Yondelis (ET-743).

artículo científico publicado en 2003

Lista de obras de Juan Bueren

A Short and Efficient Transduction Protocol for Mouse Hematopoietic Stem Cells with Lentiviral Vectors.

A common founder mutation in FANCA underlies the world's highest prevalence of Fanconi anemia in Gypsy families from Spain

A new approach to evaluate the total reserve of hematopoietic progenitors after acute irradiation

A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice.

A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells.

A simplified approach to improve the efficiency and safety of ex vivo hematopoietic gene therapy in fanconi anemia patients

AM218, a new polyanionic polysaccharide, induces radioprotection in mice when administered shortly before irradiation

Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease

Adipose-derived mesenchymal stromal cells modulate experimental autoimmune arthritis by inducing an early regulatory innate cell signature.

Analysis of hematopoiesis in mice irradiated with 500 mGy of X rays at different stages of development

Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics

BCR-JAK2 drives a myeloproliferative neoplasm in transplanted mice.

Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells

Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells

Biodistribution and Efficacy of Human Adipose-Derived Mesenchymal Stem Cells Following Intranodal Administration in Experimental Colitis.

Brief report: impaired cell reprogramming in nonhomologous end joining deficient cells.

Brief report: reduced expression of CD18 leads to the in vivo expansion of hematopoietic stem cells in mouse bone marrow.

Chromosome fragility in patients with Fanconi anaemia: diagnostic implications and clinical impact

Conversion of human fibroblasts into monocyte-like progenitor cells

Correction of SCID-X1 using an enhancerless Vav promoter.

Cytotoxic infection of hematopoietic stem and committed progenitor cells by the parvovirus minute virus of mice. Propagation of an acute myelosuppression in culture

Detectable clonal mosaicism in blood as a biomarker of cancer risk in Fanconi anemia

Development of a web course on gene therapy by the international consortium of gene therapy

Development of an in vitro model for the simultaneous study of the efficacy and hematotoxicity of antileukemic compounds.

Development of lentiviral vectors with optimized transcriptional activity for the gene therapy of patients with Fanconi anemia

Differential sensitivity to hyperthermia of mouse normal haemopoietic stem cells related to proliferation activity and organ source

Direct Conversion of Fibroblasts to Megakaryocyte Progenitors

Down-regulated expression of hsa-miR-181c in Fanconi anemia patients: implications in TNFα regulation and proliferation of hematopoietic progenitor cells

Efficient engraftment of in utero transplanted mice with retrovirally transduced hematopoietic stem cells

Engraftment and in vivo proliferation advantage of gene corrected mobilized CD34(+) cells from Fanconi anemia patients.

Engraftment kinetics of human CD34+ cells from cord blood and mobilized peripheral blood co-transplanted into NOD/SCID mice

Epigenetic Alterations in Fanconi Anaemia: Role in Pathophysiology and Therapeutic Potential.

Ex vivo expansion and selection of retrovirally transduced bone marrow: an efficient methodology for gene-transfer to murine lympho-haemopoietic stem cells

Ex vivo expansion of umbilical cord blood (UCB) CD34(+) cells alters the expression and function of alpha 4 beta 1 and alpha 5 beta 1 integrins

Exploring the link between MORF4L1 and risk of breast cancer

Fanconi anaemia: from a monogenic disease to sporadic cancer ⬇️

Functional and phenotypic variations in human T cells subjected to retroviral-mediated gene transfer

Gene therapy for Fanconi anemia: one step closer to the clinic.

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.

Generation of functional neutrophils from a mouse model of X-linked chronic granulomatous disorder using induced pluripotent stem cells

Generation of iPSCs from genetically corrected Brca2 hypomorphic cells: implications in cell reprogramming and stem cell therapy

Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion

Human Adipose-Derived Mesenchymal Stem Cells Modulate Experimental Autoimmune Arthritis by Modifying Early Adaptive T Cell Responses.

Immunoresponse against the transgene limits hematopoietic engraftment of mice transplanted in utero with virally transduced fetal liver.

Improved Hematopoietic Gene Therapy in a Mouse Model of Fanconi Anemia Mediated by Mesenchymal Stromal Cells

In vitro and in vivo susceptibility of mouse megakaryocytic progenitors to strain i of parvovirus minute virus of mice.

In vitro hematotoxicity of Aplidine on human bone marrow and cord blood progenitor cells

In vitro toxicity of ET-743 and aplidine, two marine-derived antineoplastics, on human bone marrow haematopoietic progenitors. comparison with the clinical results

In vitro toxicity of three new antitumoral drugs (trabectedin, aplidin, and kahalalide F) on hematopoietic progenitors and stem cells

In vivo imaging of lung inflammation with neutrophil-specific 68Ga nano-radiotracer

Inhibitory effects of marine-derived DNA-binding anti-tumour tetrahydroisoquinolines on the Fanconi anaemia pathway

Intralymphatic Administration of Adipose Mesenchymal Stem Cells Reduces the Severity of Collagen-Induced Experimental Arthritis

Jun N-terminal kinase activity and early growth-response factor-1 gene expression are down-regulated in Fanconi anemia group A lymphoblasts.

Kinetic studies of pyruvate kinase during in vitro differentiation of GM-CFC haemopoietic precursor and bone marrow cells in mice

Latent hematopoietic stem cell toxicity associated with protracted drug administration

Lentiviral Vector-Mediated Correction of a Mouse Model of Leukocyte Adhesion Deficiency Type I.

Lentiviral vector integration sites in human NOD/SCID repopulating cells

Lentiviral-Mediated Gene Therapy in Fanconi Anemia-A Mice Reveals Long-Term Engraftment and Continuous Turnover of Corrected HSCs.

Lessons Learned from Two Decades of Clinical Trial Experience in Gene Therapy for Fanconi Anemia

Long-term skin regeneration in xenografts from iPSC teratoma-derived human keratinocytes.

Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent

Mechanisms towards compensation of long-term haemopoietic injury in mice after 5 Gy irradiation: in vivo and in vitro enhancement of superoxide anion production by granulocytes

Mesenchymal stromal cells enhance the engraftment of hematopoietic stem cells in an autologous mouse transplantation model

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs

Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia

Non-homologous end-joining defect in fanconi anemia hematopoietic cells exposed to ionizing radiation

Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations

Parvovirus infection suppresses long-term repopulating hematopoietic stem cells

Perspectives on gene therapy for Fanconi anemia

Preserved long-term repopulation and differentiation properties of hematopoietic grafts subjected to ex vivo expansion with stem cell factor and interleukin 11

Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay.

Production of humoral factors that stimulate spleen colony-forming units in mice irradiated with moderate doses of X rays

Prostaglandin E2 plays a key role in the immunosuppressive properties of adipose and bone marrow tissue-derived mesenchymal stromal cells.

Purging of leukemia-contaminated bone marrow grafts using suicide adenoviral vectors: an in vivo murine experimental model.

Pyruvate kinase during in vitro differentiation of GM-CFC haemopoietic precursor in mice: modulation by L-alanine and L-phenylalanine

Quantitative PCR analysis reveals a high incidence of large intragenic deletions in the FANCA gene in Spanish Fanconi anemia patients.

Radioprotection mediated by the haemopoietic stimulation conferred by AM5: a protein-associated polysaccharide

Reduced efficacy of mesenchymal stromal cells in preventing graft-versus-host disease in an in vivo model of haploidentical bone marrow transplant with leukemia

Regulatory elements of the vav gene drive transgene expression in hematopoietic stem cells from adult mice