Lista de obras - Nuala A Helsby - Dominio Público Uruguay

2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT.

artículo científico publicado en 2004

A case-control study to assess the ability of the thymine challenge test to predict patients with severe to life threatening fluoropyrimidine-induced gastrointestinal toxicity

scientific article published on 12 December 2019

A high incidence of polymorphic CYP2C19 variants in archival blood samples from Papua New Guinea.

artículo científico

A higher throughput assay for quantification of melphalan-induced DNA damage in peripheral blood mononuclear cells

scientific article published on 11 December 2019

A simple ex vivo bioassay for 5-FU transport into healthy buccal mucosal cells

scientific article published on 19 July 2019

Aerobic 2- and 4-nitroreduction of CB 1954 by human liver

artículo científico publicado en 2005

Allantoin as A Biomarker of Inflammation in an Inflammatory Bowel Disease Mouse Model: NMR Analysis of Urine

scholarly article by Philippa A. Dryland et al published 3 June 2008 in The Open Bioactive Compounds Journal

Antimutagenic effects of wheat bran diet through modification of xenobiotic metabolising enzymes

artículo científico publicado en 2000

Association between the low-dose irinotecan regimen-induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers.

artículo científico publicado en 2014

Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.

artículo científico publicado en 2004

Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards.

artículo científico publicado en 2007

CYP2 family: physiological enzymes subset in GtoPdb v.2021.2

artículo científico publicado en 2021

CYP2C19 and CYP2D6 genotypes in Pacific peoples

artículo científico publicado en 2016

CYP2C19 genotype-phenotype discordance in patients with multiple myeloma leads to an acquired loss of drug-metabolising activity

artículo científico publicado en 2014

Can in vitro drug metabolism studies with human tissue replace in vivo animal studies? ⬇️

artículo científico publicado el 2 de agosto de 2005

Comparison of a thymine challenge test and endogenous uracil–dihydrouracil levels for assessment of fluoropyrimidine toxicity risk

artículo científico publicado en 2021

Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX(®) ADME PGx Panel for Pharmacogenomic Profiling

artículo científico publicado en 2016

Cyclophosphamide bioactivation pharmacogenetics in breast cancer patients

artículo científico publicado en 2021

Cytochrome P450 (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

artículo científico publicado en 2019

Cytochrome P450 in GtoPdb v.2021.2

artículo científico publicado en 2021

DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHY ASSAY FOR THE DETERMINATION OF A FLUORINATED ANALOGUE OF THALIDOMIDE, N-(2,6-DIOXOPIPERIDIN-3-YL)-3,4,5,6-TETRAFLUOROPHTHALAMIC ACID, AND LENALIDOMIDE

artículo científico publicado en 2011

Do 5-fluorouracil therapies alter CYP2C19 metaboliser status?

artículo científico publicado en 2010

Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.

artículo científico publicado en 2003

Effects of quercetin on drug metabolizing enzymes and oxidation of 2',7-dichlorofluorescin in HepG2 cells

artículo científico publicado en 1997

Evaluating aziridinyl nitrobenzamide compounds as leishmanicidal prodrugs

artículo científico publicado en 2013

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin

artículo científico publicado en 2013

Hepatic cytochrome P450 CYP2C activity in psoriasis: studies using proguanil as a probe compound: Investigative reports

artículo científico publicado en 1998

Hepatic nitroreduction, toxicity and toxicokinetics of the anti-tumour prodrug CB 1954 in mouse and rat

artículo científico publicado en 2007

High CYP2C19 phenotypic variability in gastrointestinal cancer patients

artículo científico publicado en 2015

Hydrolysis of dinitrobenzamide phosphate prodrugs: the role of alkaline phosphatase

artículo científico publicado en 2009

Indirect regulation of CYP2C19 gene expression via DNA methylation.

artículo científico publicado en 2017

Influence of mustard group structure on pathways of in vitro metabolism of anticancer N-(2-hydroxyethyl)-3,5-dinitrobenzamide 2-mustard prodrugs

artículo científico publicado en 2007

Inhibition of mouse and human CYP 1A- and 2E1-dependent substrate metabolism by the isoflavonoids genistein and equol.

artículo científico publicado en 1998

Inter-individual variation in the metabolic activation of the antimalarial biguanides

artículo científico publicado en 1991

Intracellular activation of 4-hydroxycyclophosphamide into a DNA-alkylating agent in human leucocytes

artículo científico publicado en 2021

Is the prevalence of CYP2C19 genetic variants different in Pacific people than in New Zealand Europeans?

artículo científico publicado en 2010

Leaving group effects in reductively triggered fragmentation of 4-nitrobenzyl carbamates †

artículo científico publicado en 2000

Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases

artículo científico publicado en 2008

Metabolism of thalidomide in liver microsomes of mice, rabbits, and humans

artículo científico publicado en 2004

Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease

artículo científico publicado en 2010

Metabolomic analysis reveals differences in urinary excretion of kiwifruit-derived metabolites in a mouse model of inflammatory bowel disease.

artículo científico publicado en 2011

Molecular mechanisms of genetic variation and transcriptional regulation of CYP2C19 ⬇️

artículo científico publicado el 10 de octubre de 2012

Nontargeted urinary metabolite profiling of a mouse model of Crohn's disease.

artículo científico publicado en 2009

Omeprazole-induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype.

artículo científico publicado en 2010

Pharmacogenetics of drug-metabolizing enzymes: the prodrug hypothesis.

artículo científico publicado en 2012

Pharmacogenomics in Papua New Guineans: unique profiles and implications for enhancing drug efficacy while improving drug safety

artículo científico publicado en 2018

Pheno- or genotype for the CYP2C19 drug metabolism polymorphism: the influence of disease.

artículo científico publicado en 2008

Preliminary Evidence for Enhanced Thymine Absorption: A Putative New Phenotype Associated With Fluoropyrimidine Toxicity in Cancer Patients

scientific article published on 01 August 2018

Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.

artículo científico publicado en 2002

Regulation of cytosolic phospholipase A2 expression by cytokines in human amnion cells

artículo científico publicado en 1999

Severe 5-Fluorouracil-Associated Gastrointestinal Toxicity Unexplained by Dihydropyrimidine Dehydrogenase Deficiency and Renal Impairment: Should We Be Investigating Other Elimination Pathways to Assess the Risk of 5-Fluorouracil Toxicity?

artículo científico publicado en 2021

Single-nucleotide polymorphisms and copy number variations of the FCGR2A and FCGR3A genes in healthy Japanese subjects.

artículo científico publicado en 2013

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

The Prevalence, Impact, and Risk Factors for Persistent Pain After Breast Cancer Surgery in a New Zealand Population

artículo científico publicado en 2019

The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study

artículo científico publicado en 1991

The association between heterozygosity for UGT1A16, UGT1A128, and variation in the serum total-bilirubin level in healthy young Japanese adults

artículo científico publicado en 2013

The combined impact of CYP2C19 and CYP2B6 pharmacogenetics on cyclophosphamide bioactivation

artículo científico publicado en 2010

The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes

scientific article published on 22 July 2019

The importance of correct assignment of CYP2B6 genetic variants with respect to cyclophosphamide metabolizer status ⬇️

artículo científico publicado el 1 de abril de 2011

The isoflavones equol and genistein do not induce xenobiotic-metabolizing enzymes in mouse and in human cells

scientific article published on 01 June 1997

The multiple dose pharmacokinetics of proguanil

artículo científico publicado en 1993

The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism

artículo científico publicado en 1990

The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents

scientific article published on 26 August 2014

The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution

artículo científico publicado en 1988

The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides

artículo científico publicado en 1995

Towards a test to predict 5-fluorouracil toxicity: Pharmacokinetic data for thymine and two sequential metabolites following oral thymine administration to healthy adult males.

artículo científico publicado en 2015

Trypanocidal activity of aziridinyl nitrobenzamide prodrugs

artículo científico publicado en 2010

Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.

artículo científico publicado en 2015

Using metabolomic analysis to understand inflammatory bowel diseases.

scientific article published on April 2011

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

artículo científico publicado en 2021

Which CYP2B6 Variants Have Functional Consequences for Cyclophosphamide Bioactivation?

artículo científico publicado en 2011

Lista de obras de Nuala A Helsby

2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT.

A case-control study to assess the ability of the thymine challenge test to predict patients with severe to life threatening fluoropyrimidine-induced gastrointestinal toxicity

A high incidence of polymorphic CYP2C19 variants in archival blood samples from Papua New Guinea.

A higher throughput assay for quantification of melphalan-induced DNA damage in peripheral blood mononuclear cells

A simple ex vivo bioassay for 5-FU transport into healthy buccal mucosal cells

Aerobic 2- and 4-nitroreduction of CB 1954 by human liver

Allantoin as A Biomarker of Inflammation in an Inflammatory Bowel Disease Mouse Model: NMR Analysis of Urine

Antimutagenic effects of wheat bran diet through modification of xenobiotic metabolising enzymes

Association between the low-dose irinotecan regimen-induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers.

Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.

Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards.

CYP2 family: physiological enzymes subset in GtoPdb v.2021.2

CYP2C19 and CYP2D6 genotypes in Pacific peoples

CYP2C19 genotype-phenotype discordance in patients with multiple myeloma leads to an acquired loss of drug-metabolising activity

Can in vitro drug metabolism studies with human tissue replace in vivo animal studies? ⬇️

Comparison of a thymine challenge test and endogenous uracil–dihydrouracil levels for assessment of fluoropyrimidine toxicity risk

Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX(®) ADME PGx Panel for Pharmacogenomic Profiling

Cyclophosphamide bioactivation pharmacogenetics in breast cancer patients

Cytochrome P450 (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Cytochrome P450 in GtoPdb v.2021.2

DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHY ASSAY FOR THE DETERMINATION OF A FLUORINATED ANALOGUE OF THALIDOMIDE, N-(2,6-DIOXOPIPERIDIN-3-YL)-3,4,5,6-TETRAFLUOROPHTHALAMIC ACID, AND LENALIDOMIDE

Do 5-fluorouracil therapies alter CYP2C19 metaboliser status?

Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.

Effects of quercetin on drug metabolizing enzymes and oxidation of 2',7-dichlorofluorescin in HepG2 cells

Evaluating aziridinyl nitrobenzamide compounds as leishmanicidal prodrugs

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin

Hepatic cytochrome P450 CYP2C activity in psoriasis: studies using proguanil as a probe compound: Investigative reports

Hepatic nitroreduction, toxicity and toxicokinetics of the anti-tumour prodrug CB 1954 in mouse and rat

High CYP2C19 phenotypic variability in gastrointestinal cancer patients

Hydrolysis of dinitrobenzamide phosphate prodrugs: the role of alkaline phosphatase

Indirect regulation of CYP2C19 gene expression via DNA methylation.

Influence of mustard group structure on pathways of in vitro metabolism of anticancer N-(2-hydroxyethyl)-3,5-dinitrobenzamide 2-mustard prodrugs

Inhibition of mouse and human CYP 1A- and 2E1-dependent substrate metabolism by the isoflavonoids genistein and equol.

Inter-individual variation in the metabolic activation of the antimalarial biguanides

Intracellular activation of 4-hydroxycyclophosphamide into a DNA-alkylating agent in human leucocytes

Is the prevalence of CYP2C19 genetic variants different in Pacific people than in New Zealand Europeans?

Leaving group effects in reductively triggered fragmentation of 4-nitrobenzyl carbamates †

Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases

Metabolism of thalidomide in liver microsomes of mice, rabbits, and humans

Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease

Metabolomic analysis reveals differences in urinary excretion of kiwifruit-derived metabolites in a mouse model of inflammatory bowel disease.

Molecular mechanisms of genetic variation and transcriptional regulation of CYP2C19 ⬇️

Nontargeted urinary metabolite profiling of a mouse model of Crohn's disease.

Omeprazole-induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype.

Pharmacogenetics of drug-metabolizing enzymes: the prodrug hypothesis.

Pharmacogenomics in Papua New Guineans: unique profiles and implications for enhancing drug efficacy while improving drug safety

Pheno- or genotype for the CYP2C19 drug metabolism polymorphism: the influence of disease.

Preliminary Evidence for Enhanced Thymine Absorption: A Putative New Phenotype Associated With Fluoropyrimidine Toxicity in Cancer Patients

Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.

Regulation of cytosolic phospholipase A2 expression by cytokines in human amnion cells

Severe 5-Fluorouracil-Associated Gastrointestinal Toxicity Unexplained by Dihydropyrimidine Dehydrogenase Deficiency and Renal Impairment: Should We Be Investigating Other Elimination Pathways to Assess the Risk of 5-Fluorouracil Toxicity?

Single-nucleotide polymorphisms and copy number variations of the FCGR2A and FCGR3A genes in healthy Japanese subjects.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

The Prevalence, Impact, and Risk Factors for Persistent Pain After Breast Cancer Surgery in a New Zealand Population

The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study

The association between heterozygosity for UGT1A1*6, UGT1A1*28, and variation in the serum total-bilirubin level in healthy young Japanese adults

The combined impact of CYP2C19 and CYP2B6 pharmacogenetics on cyclophosphamide bioactivation

The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes

The importance of correct assignment of CYP2B6 genetic variants with respect to cyclophosphamide metabolizer status ⬇️

The isoflavones equol and genistein do not induce xenobiotic-metabolizing enzymes in mouse and in human cells

The multiple dose pharmacokinetics of proguanil

The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism

The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents

The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution

The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides

Towards a test to predict 5-fluorouracil toxicity: Pharmacokinetic data for thymine and two sequential metabolites following oral thymine administration to healthy adult males.

Trypanocidal activity of aziridinyl nitrobenzamide prodrugs

Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.

Using metabolomic analysis to understand inflammatory bowel diseases.

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

Which CYP2B6 Variants Have Functional Consequences for Cyclophosphamide Bioactivation?

The association between heterozygosity for UGT1A16, UGT1A128, and variation in the serum total-bilirubin level in healthy young Japanese adults