Lista de obras - Roberta Fruttero - Dominio Público Uruguay

(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins

artículo científico publicado en 2009

1,2,5-Oxadiazole analogues of leflunomide and related compounds

artículo científico publicado en 2010

13C and 15N solution and solid-state nuclear magnetic resonance study of the intermolecular interactions in the 1 : 1 trimethoprim sulphamethoxazole complex

4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues

artículo científico publicado en 2010

6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity

artículo científico publicado en 2013

A multi-photoresponsive molecular-hybrid for dual-modal photoinactivation of cancer cells

scholarly article in RSC Advances, vol. 4 no. 84, 2014

A new class of NO-donor H3-antagonists

artículo científico publicado en 2004

A new class of ibuprofen derivatives with reduced gastrotoxicity

artículo científico publicado en 2001

A new furoxan NO-donor rabeprazole derivative and related compounds

artículo científico publicado en 2003

A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity

artículo científico publicado en 2009

A nitric oxide-donor furoxan moiety improves the efficacy of edaravone against early renal dysfunction and injury evoked by ischemia/reperfusion

artículo científico publicado en 2015

A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

artículo científico publicado en 2008

A rapid screening for cytochrome P450 catalysis on new chemical entities: cytochrome P450 BM3 and 1,2,5-oxadiazole derivatives

artículo científico publicado en 2012

Acyclic analogs of classical H2-antagonists: synthesis and activity of dialkylamioalkyl substituted ethers and oximes

Amodiaquine analogues containing NO-donor substructures: synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria

artículo científico publicado en 2011

Amphiphilic NO-Donor Antioxidants

artículo científico publicado en 2007

Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin

artículo científico publicado en 2003

Benzofurazanyl- and benzofuroxanyl-1,4-dihydropyridines: synthesis, structure and calcium entry blocker activity

Carnosine analogues containing NO-donor substructures: synthesis, physico-chemical characterization and preliminary pharmacological profile

artículo científico publicado en 2012

Characterization of a new compound, S35b, as a guanylate cyclase activator in human platelets

scientific article published on 01 March 1992

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells.

artículo científico publicado en 2011

Corrigendum: Designing Multitarget Anti-inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists-COX-2 Inhibitors

scholarly article by Massimo Bertinaria et al published 26 November 2012 in ChemMedChem

Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors

artículo científico publicado en 2012

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants.

artículo científico publicado en 2004

Dipole moments and electron distribution of furoxans and furazans

Doxorubicin-antioxidant co-drugs

artículo científico publicado en 2013

Edaravone derivatives containing NO-donor functions

artículo científico publicado en 2009

Effect of the leaving group on the electrodic reduction mechanism of anti-Helicobacter pylori metronidazole derivatives, in aprotic and protic media.

artículo científico publicado en 2004

Electrochemical studies of biologically active arylazoxy compounds. The relationship between redox potentials and molluscicidal activities

Evidence of self-protonation on the electrodic reduction mechanism of an anti-Helicobacter pylori metronidazole isotere

Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents

artículo científico publicado en 2014

Furoxan analogues of the histamine H3-receptor antagonist imoproxifan and related furazan derivatives

artículo científico publicado en 2005

Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

artículo científico publicado en 2006

Identification of 2,3-diaminophenazine and of o-benzoquinone dioxime as the major in vitro metabolites of benzofuroxan

artículo científico publicado en 2004

In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition.

artículo científico publicado en 2015

Inhibition of human alpha-, beta- and gamma-thrombin by mono-, bis-, tris- and tetra-benzamidine structures: thermodynamic study

artículo científico publicado en 1992

Ionic Partition Diagram of the Zwitterionic Antihistamine Cetirizine

Leishmanicidal activities of novel synthetic furoxan and benzofuroxan derivatives

artículo científico publicado en 2014

Lipophilicity behaviour of the Zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems

artículo científico publicado en 2001

Liposomal nitrooxy-doxorubicin: one step over caelyx in drug-resistant human cancer cells

artículo científico publicado en 2014

Liposome/water lipophilicity: methods, information content, and pharmaceutical applications

artículo científico publicado en 2004

Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets

artículo científico publicado en 2006

Mesomeric dipole moments. Part 12

Michael addition of Grignard reagents to tetraethyl ethenylidenebisphosphonate

article

Mitochondrial-targeting nitrooxy-doxorubicin: a new approach to overcome drug resistance

artículo científico publicado en 2012

Molecular factors influencing retention on immobilized artifical membranes (IAM) compared to partitioning in liposomes and n-octanol

artículo científico publicado en 2002

Molecular-Dynamics and NMR Investigation of the Property Space of the Zwitterionic Antihistamine Cetirizine

Multitarget drugs: Focus on the NO-donor hybrid drugs

Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities

artículo científico publicado en 2010

N-Substituted analogues of S-nitroso-N-acetyl-D,L-penicillamine: chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries

artículo científico publicado en 1999

NO donor and biological properties of different benzofuroxans

artículo científico publicado en 1999

NO release regulated by doxorubicin as the green light-harvesting antenna

scientific article published on 21 May 2020

NO-Donor COX-2 Inhibitors. New Nitrooxy-Substituted 1,5-Diarylimidazoles Endowed with COX-2 Inhibitory and Vasodilator Properties

scientific article published on 03 March 2007

NO-Donor Phenols: A New Class of Products Endowed with Antioxidant and Vasodilator Properties

scientific article published on 01 May 2006

NO-donor melatonin derivatives: synthesis and in vitro pharmacological characterization

artículo científico publicado en 2007

NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease

artículo científico publicado en 2015

New 1,4-dihydropyridines endowed with NO-donor and calcium channel agonist properties

artículo científico publicado en 2004

New Nitric Oxide or Hydrogen Sulfide Releasing Aspirins

artículo científico publicado en 2011

New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold

scientific article published on 03 January 2012

New potential uroselective NO-donor alpha1-antagonists

artículo científico publicado en 2003

New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni

artículo científico publicado en 2014

New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands

scientific article published on 03 April 2018

Nicorandil analogues containing NO-donor furoxans and related furazans

artículo científico publicado en 2000

Nitric Oxide Donor β2-Agonists: Furoxan Derivatives Containing the Fenoterol Moiety and Related Furazans

artículo científico publicado en 2007

Nitric oxide donor doxorubicins accumulate into Doxorubicin-resistant human colon cancer cells inducing cytotoxicity

artículo científico publicado en 2011

Nitroanilines are the reduction products of benzofuroxan system by oxyhemoglobin (HbO2 2+).

artículo científico publicado en 2001

Nitrooxyacyl derivatives of salicylic acid: aspirin-like molecules that covalently inactivate cyclooxygenase-1.

artículo científico publicado en 2011

Nitrooxymethyl-substituted analogues of celecoxib: synthesis and pharmacological characterization

artículo científico publicado en 2009

Nitrooxymethyl-substituted analogues of rofecoxib: synthesis and pharmacological characterization

artículo científico publicado en 2010

No-Mimetic Furoxans: Arylsulphonylfuroxans and Related Compounds

scientific article published on 01 October 1993

Non-imidazole histamine NO-donor H3-antagonists

artículo científico publicado en 2005

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.

artículo científico publicado en 2013

Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties

artículo científico publicado en 2008

Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors

artículo científico publicado en 2012

On the self-condensation of aminoguanidine leading to 1,1,4,10,10-pentaamino-2,3,5,6,8,9-hexaazadeca-1,3,5,7,9-pentaene (structure elucidation through X-ray powder diffraction)

Oximation of acetyl(hydroxyimino)acetone: nuclear magnetic resonance spectroscopic, chemical, and X-ray crystallographic studies of the reaction products

Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein

artículo científico publicado en 2010

Physicochemical Profiling of Sartans: A Detailed Study of Ionization Constants and Distribution Coefficients

Physicochemical profile and in vitro permeation behavior of a new class of non-steroidal anti-inflammatory drug candidates

artículo científico publicado en 2010

Platelet antiaggregatory effects and haemodynamic activity of two terfuroxan isomer pairs

artículo científico publicado en 2002

Reversed-phase high-performance liquid chromatographic study of the lipophilicity of a series of analogues of the antibiotic “calvatic acid”

S35b, a new phenylsulfonylfuroxan compound, inhibits thrombin-induced synthesis of platelet-activating factor and prostacyclin in human endothelial cells

artículo científico publicado en 1993

Searching for balanced hybrid NO-donor 1,4-dihydropyridines with basic properties.

artículo científico publicado en 2001

Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans

artículo científico publicado en 2011

Searching for new NO-donor aspirin-like molecules: a new class of nitrooxy-acyl derivatives of salicylic acid

artículo científico publicado en 2008

Structural investigation of Ca 2+ antagonists benzofurazanyl and benzofuroxanyl-1,4-dihydropyridines

Structure-Property Relationships in the Basicity and Lipophilicity of Arylalkylamine Oxides

Structure-antioxidant activity relationships in a series of NO-donor phenols

artículo científico publicado en 2008

Studies of the potential genotoxic effects of furoxans: the case of CAS 1609 and of the water-soluble analogue of CHF 2363.

artículo científico publicado en 2008

Studies on agents with mixed NO-dependent and calcium channel antagonistic vasodilating activities.

artículo científico publicado en 2001

Studies on agents with mixed NO-dependent vasodilating and beta-blocking activities

artículo científico publicado en 1997

Synthesis and Biological Evaluation of N(2) -Substituted 2,4-Diamino-6-cyclohexylmethoxy-5-nitrosopyrimidines and Related 5-Cyano-NNO-azoxy Derivatives as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors

artículo científico publicado en 2016

Synthesis and Biological Evaluation of the First Example of NO-Donor Histone Deacetylase Inhibitor

artículo científico publicado en 2013

Synthesis and anti-Helicobacter pylori properties of NO-donor/metronidazole hybrids and related compounds

Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives

scientific article published on 05 April 2011

Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues

artículo científico publicado en 2012

Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).

artículo científico publicado en 2010

Synthesis and vasodilating properties of N-alkylamide derivatives of 4-amino-3-furoxancarboxylic acid and related azo derivatives.

artículo científico publicado en 2003

Synthesis and voltage-clamp studies of methyl 1,4-dihydro-2, 6-dimethyl-5-nitro-4-(benzofurazanyl)pyridine-3-carboxylate racemates and enantiomers and of their benzofuroxanyl analogues.

artículo científico publicado en 1999

Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption.

artículo científico publicado en 2005

Synthesis of new bicyclic analogues of glutamic acid

Synthesis of some novel organic nitrates and comparative in vitro study of their vasodilator profile

artículo científico publicado en 2009

Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs

scientific article published on 08 December 2011

Synthesis, Physicochemical Characterization, and Biological Activities of New Carnosine Derivatives Stable in Human Serum As Potential Neuroprotective Agents

artículo científico publicado en 2010

Synthesis, chiral HPLC resolution and configuration assignment of 1-phenylglyceryl trinitrate stereomers

artículo científico publicado en 2006

The Furoxan System: Design of Selective Nitric Oxide (NO) Donor Inhibitors of COX-2 Endowed with Anti-Aggregatory and Vasodilating Activities

artículo científico publicado en 2005

The Lipophilicity Behavior of Three Catechol-O-methyltransferase (COMT) Inhibitors and Simple Analogues

artículo científico publicado en 2006

The relationship between redox potentials and substituent constants in biologically active arylazoxy compounds

The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors ⬇️

artículo científico publicado el 10 de noviembre de 2012

Thermolysis of 4-(2-azido-3-nitrophenyl)-1,4-dihydropyridines as source of β-carboline derivatives and some related compounds

Thymopentin down-regulates both activity and expression of iNOS in blood cells of Sézary syndrome patients

artículo científico publicado en 2012

Tuning the Hydrophobicity of a Mitochondria-Targeted NO Photodonor

artículo científico publicado en 2018

Unsymmetrically substituted furoxans. Part 19. Methyl and phenylfuroxansulfonic acids and related sulfonamides

Water Soluble Furoxan Derivatives as NO Prodrugs

artículo científico publicado en 1997

Water-Soluble Nitric-Oxide-Releasing Acetylsalicylic Acid (ASA) Prodrugs

artículo científico publicado en 2013

[3-(1H-imidazol-4-yl)propyl]guanidines containing furoxan moieties: a new class of H3-antagonists endowed with NO-donor properties

artículo científico publicado en 2003

α1-Adrenoceptor Blocking Activity of Some Ring-open Analogues of Prazosin

scientific article published on 01 October 1994

Lista de obras de Roberta Fruttero

(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins

1,2,5-Oxadiazole analogues of leflunomide and related compounds

13C and 15N solution and solid-state nuclear magnetic resonance study of the intermolecular interactions in the 1 : 1 trimethoprim sulphamethoxazole complex

4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues

6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity

A multi-photoresponsive molecular-hybrid for dual-modal photoinactivation of cancer cells

A new class of NO-donor H3-antagonists

A new class of ibuprofen derivatives with reduced gastrotoxicity

A new furoxan NO-donor rabeprazole derivative and related compounds

A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity

A nitric oxide-donor furoxan moiety improves the efficacy of edaravone against early renal dysfunction and injury evoked by ischemia/reperfusion

A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

A rapid screening for cytochrome P450 catalysis on new chemical entities: cytochrome P450 BM3 and 1,2,5-oxadiazole derivatives

Acyclic analogs of classical H2-antagonists: synthesis and activity of dialkylamioalkyl substituted ethers and oximes

Amodiaquine analogues containing NO-donor substructures: synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria

Amphiphilic NO-Donor Antioxidants

Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin

Benzofurazanyl- and benzofuroxanyl-1,4-dihydropyridines: synthesis, structure and calcium entry blocker activity

Carnosine analogues containing NO-donor substructures: synthesis, physico-chemical characterization and preliminary pharmacological profile

Characterization of a new compound, S35b, as a guanylate cyclase activator in human platelets

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells.

Corrigendum: Designing Multitarget Anti-inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists-COX-2 Inhibitors

Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants.

Dipole moments and electron distribution of furoxans and furazans

Doxorubicin-antioxidant co-drugs

Edaravone derivatives containing NO-donor functions

Effect of the leaving group on the electrodic reduction mechanism of anti-Helicobacter pylori metronidazole derivatives, in aprotic and protic media.

Electrochemical studies of biologically active arylazoxy compounds. The relationship between redox potentials and molluscicidal activities

Evidence of self-protonation on the electrodic reduction mechanism of an anti-Helicobacter pylori metronidazole isotere

Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents

Furoxan analogues of the histamine H3-receptor antagonist imoproxifan and related furazan derivatives

Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

Identification of 2,3-diaminophenazine and of o-benzoquinone dioxime as the major in vitro metabolites of benzofuroxan

In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition.

Inhibition of human alpha-, beta- and gamma-thrombin by mono-, bis-, tris- and tetra-benzamidine structures: thermodynamic study

Ionic Partition Diagram of the Zwitterionic Antihistamine Cetirizine

Leishmanicidal activities of novel synthetic furoxan and benzofuroxan derivatives

Lipophilicity behaviour of the Zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems

Liposomal nitrooxy-doxorubicin: one step over caelyx in drug-resistant human cancer cells

Liposome/water lipophilicity: methods, information content, and pharmaceutical applications

Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets

Mesomeric dipole moments. Part 12

Michael addition of Grignard reagents to tetraethyl ethenylidenebisphosphonate

Mitochondrial-targeting nitrooxy-doxorubicin: a new approach to overcome drug resistance

Molecular factors influencing retention on immobilized artifical membranes (IAM) compared to partitioning in liposomes and n-octanol

Molecular-Dynamics and NMR Investigation of the Property Space of the Zwitterionic Antihistamine Cetirizine

Multitarget drugs: Focus on the NO-donor hybrid drugs

Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities

N-Substituted analogues of S-nitroso-N-acetyl-D,L-penicillamine: chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries

NO donor and biological properties of different benzofuroxans

NO release regulated by doxorubicin as the green light-harvesting antenna

NO-Donor COX-2 Inhibitors. New Nitrooxy-Substituted 1,5-Diarylimidazoles Endowed with COX-2 Inhibitory and Vasodilator Properties

NO-Donor Phenols: A New Class of Products Endowed with Antioxidant and Vasodilator Properties

NO-donor melatonin derivatives: synthesis and in vitro pharmacological characterization

NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease

New 1,4-dihydropyridines endowed with NO-donor and calcium channel agonist properties

New Nitric Oxide or Hydrogen Sulfide Releasing Aspirins

New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold

New potential uroselective NO-donor alpha1-antagonists

New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni

New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands

Nicorandil analogues containing NO-donor furoxans and related furazans

Nitric Oxide Donor β2-Agonists: Furoxan Derivatives Containing the Fenoterol Moiety and Related Furazans

Nitric oxide donor doxorubicins accumulate into Doxorubicin-resistant human colon cancer cells inducing cytotoxicity

Nitroanilines are the reduction products of benzofuroxan system by oxyhemoglobin (HbO2 2+).

Nitrooxyacyl derivatives of salicylic acid: aspirin-like molecules that covalently inactivate cyclooxygenase-1.

Nitrooxymethyl-substituted analogues of celecoxib: synthesis and pharmacological characterization

Nitrooxymethyl-substituted analogues of rofecoxib: synthesis and pharmacological characterization

No-Mimetic Furoxans: Arylsulphonylfuroxans and Related Compounds

Non-imidazole histamine NO-donor H3-antagonists

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.

Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties

Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors

On the self-condensation of aminoguanidine leading to 1,1,4,10,10-pentaamino-2,3,5,6,8,9-hexaazadeca-1,3,5,7,9-pentaene (structure elucidation through X-ray powder diffraction)

Oximation of acetyl(hydroxyimino)acetone: nuclear magnetic resonance spectroscopic, chemical, and X-ray crystallographic studies of the reaction products

Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein

Physicochemical Profiling of Sartans: A Detailed Study of Ionization Constants and Distribution Coefficients

Physicochemical profile and in vitro permeation behavior of a new class of non-steroidal anti-inflammatory drug candidates