Lista de obras - David J Vocadlo - Dominio Público Uruguay

6''-Azido-6''-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate

artículo científico publicado en 2010

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases

artículo científico publicado en 2007

A Chemical Genetic Method for Monitoring Genome-Wide Dynamics of -GlcNAc Turnover on Chromatin-Associated Proteins

artículo científico publicado en 2019

A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors

artículo científico publicado en 2015

A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High-Throughput Screening: Application to O-GlcNAc Transferase

artículo científico publicado en 2020

A case for reverse protonation: identification of Glu160 as an acid/base catalyst in Thermoanaerobacterium saccharolyticum beta-xylosidase and detailed kinetic analysis of a site-directed mutant.

artículo científico publicado en 2002

A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase.

artículo científico publicado en 2006

A highly concise preparation of O-deacetylated arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl chloride and aryl thiols or disulfides

artículo científico publicado en 2006

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

scientific article published on 04 September 2018

A mechanism-based inactivator of glycoside hydrolases involving formation of a transient non-classical carbocation

scientific article published on 05 December 2014

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

artículo científico publicado en 2008

A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells.

artículo científico publicado en 2009

A strategy for functional proteomic analysis of glycosidase activity from cell lysates.

artículo científico publicado en 2004

AmpG inactivation restores susceptibility of pan-beta-lactam-resistant Pseudomonas aeruginosa clinical strains

artículo científico publicado en 2011

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

artículo científico publicado en 2007

Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state

artículo científico publicado en 2002

Carbohydrate Bis-acetal-Based Substrates as Tunable Fluorescence-Quenched Probes for Monitoring exo-Glycosidase Activity

artículo científico publicado en 2017

Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate

artículo científico publicado en 2001

Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose

artículo científico publicado en 2016

Characterization and downstream mannose phosphorylation of human recombinant α‐L‐iduronidase produced in Arabidopsis complex glycan‐deficient (cgl) seeds ⬇️

artículo científico publicado el 31 de julio de 2013

Characterization of a beta-N-acetylhexosaminidase and a beta-N-acetylglucosaminidase/beta-glucosidase from Cellulomonas fimi

artículo científico publicado en 2006

Characterization of the Glu and Asp residues in the active site of human beta-hexosaminidase B

artículo científico publicado en 2001

Conformational Itinerary of Pseudomonas aeruginosa 1,6-Anhydro- N -acetylmuramic Acid Kinase during Its Catalytic Cycle

artículo científico publicado en 2014

Crystal structure of beta-D-xylosidase from Thermoanaerobacterium saccharolyticum, a family 39 glycoside hydrolase

artículo científico publicado en 2004

Crystal structure of the AmpR effector binding domain provides insight into the molecular regulation of inducible ampc beta-lactamase

artículo científico publicado en 2010

Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase

artículo científico publicado en 2001

Cura Annonae-Chemically Boosting Crop Yields Through Metabolic Feeding of a Plant Signaling Precursor

artículo científico publicado en 2017

Detailed comparative analysis of the catalytic mechanisms of beta-N-acetylglucosaminidases from families 3 and 20 of glycoside hydrolases.

artículo científico publicado en 2005

Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology.

artículo científico

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation ⬇️

artículo científico publicado el 19 de abril de 2012

Differential Recognition and Hydrolysis of Host Carbohydrate Antigens by Streptococcus pneumoniae Family 98 Glycoside Hydrolases

artículo científico publicado en 2009

Direct one-step fluorescent labeling of O-GlcNAc modified proteins in live cells using metabolic intermediates

artículo científico publicado en 2018

Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

scientific article published on 29 September 2019

Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).

artículo científico publicado en 2009

Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance

artículo científico publicado en 2008

Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis

artículo científico publicado en 2010

Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase

artículo científico publicado en 2009

Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity

artículo científico publicado en 2015

Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase

artículo científico publicado en 2006

Functional proteomic profiling of glycan-processing enzymes

artículo científico publicado en 2006

Genome-wide chemical mapping of O-GlcNAcylated proteins in Drosophila melanogaster

artículo científico publicado en 2016

HCF-1 Is Cleaved in the Active Site of O-GlcNAc Transferase

artículo científico publicado en 2013

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells.

artículo científico publicado en 2011

How to make a difference: mechanisms of protein and nucleic acid modifying enzymes

artículo científico publicado en 2012

Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells

artículo científico publicado en 2013

Identification of Glu-277 as the catalytic nucleophile of Thermoanaerobacterium saccharolyticum β-xylosidase using electrospray MS ⬇️

artículo científico publicado el 15 de octubre de 1998

In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation.

artículo científico publicado en 2008

Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa

artículo científico publicado en 2009

Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase.

artículo científico publicado en 2009

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

artículo científico publicado en 2012

Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes

artículo científico publicado en 2010

Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc–imidazole hybrid inhibitor

artículo científico publicado en 2006

Inhibition of the family 20 glycoside hydrolase catalytic modules in the Streptococcus pneumoniae exo-β-D-N-acetylglucosaminidase, StrH

artículo científico publicado en 2013

Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis

artículo científico publicado en 2011

Insight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ

artículo científico publicado en 2009

Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates.

artículo científico publicado en 2012

Mammalian Notch is modified by D-Xyl-alpha1-3-D-Xyl-alpha1-3-D-Glc-beta1-O-Ser: implementation of a method to study O-glucosylation

artículo científico publicado en 2009

Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

artículo científico publicado en 2010

Mechanism of action and identification of Asp242 as the catalytic nucleophile of Vibrio furnisii N-acetyl-beta-D-glucosaminidase using 2-acetamido-2-deoxy-5-fluoro-alpha-L-idopyranosyl fluoride

artículo científico publicado en 2000

Mechanistic insights into glycosidase chemistry

artículo científico publicado en 2008

Metabolic Inhibitors of O-GlcNAc Transferase That Act In Vivo Implicate Decreased O-GlcNAc Levels in Leptin-Mediated Nutrient Sensing

artículo científico publicado en 2018

Metabolic inhibition of sialyl-Lewis X biosynthesis by 5-thiofucose remodels the cell surface and impairs selectin-mediated cell adhesion.

artículo científico publicado en 2012

Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: INTRACELLULAR -O-LINKED N-GLYCOLYLGLUCOSAMINE (GlcNGc), UDP-GlcNGc, AND THE BIOCHEMICAL AND STRUCTURAL RATIONALE FOR THE SUBSTRATE TOLERANCE OF -O-LINKED -N-ACETYLGLUCOSAMINIDASE

artículo científico publicado en 2012

Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine

artículo científico publicado en 2012

Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS.

artículo científico publicado en 2009

Molecular Basis of 1,6-Anhydro Bond Cleavage and Phosphoryl Transfer by Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase

artículo científico publicado en 2011

Molecular basis for G protein control of the prokaryotic ATP sulfurylase

artículo científico publicado en 2006

Molecular basis for inhibition of GH84 glycoside hydrolases by substituted azepanes: conformational flexibility enables probing of substrate distortion

artículo científico publicado en 2009

NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa

artículo científico publicado en 2010

O-GLcNAc post-translational modifications regulate the entry of neurons into an axon branching program

artículo científico publicado en 2009

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.

artículo científico

O-GlcNAc modification of tau directly inhibits its aggregation without perturbing the conformational properties of tau monomers

artículo científico publicado en 2014

O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains

artículo científico publicado en 2015

O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation.

artículo científico publicado en 2012

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

artículo científico publicado en 2005

O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.

artículo científico publicado en 2014

Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein pre-formed-fibrils

artículo científico publicado en 2020

Pharmacological inhibition of O-GlcNAcase (OGA) enhances autophagy in brain through an mTOR-independent pathway.

artículo científico publicado en 2018

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.

artículo científico publicado en 2014

Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter

artículo científico publicado en 2015

Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships

artículo científico publicado en 2009

Production of α-L-iduronidase in maize for the potential treatment of a human lysosomal storage disease

scientific article published in Nature Communications

Providing β-lactams a helping hand: targeting the AmpC β-lactamase induction pathway.

artículo científico

Reduced protein O-glycosylation in the nervous system of the mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis

artículo científico publicado en 2012

Role of beta Arg211 in the active site of human beta-hexosaminidase B.

artículo científico publicado en 2000

Selective Fluorogenic β-Glucocerebrosidase Substrates for Convenient Analysis of Enzyme Activity in Cell and Tissue Homogenates

artículo científico publicado en 2020

Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams

artículo científico publicado en 2013

Software for rapid time dependent ChIP-sequencing analysis (TDCA).

artículo científico publicado en 2017

Streptococcus pneumoniae endohexosaminidase D; feasibility of using N-glycan oxazoline donors for synthetic glycosylation of a GlcNAc-asparagine acceptor

artículo científico publicado en 2010

Structural Analysis of a Family 101 Glycoside Hydrolase in Complex with Carbohydrates Reveals Insights into Its Mechanism

artículo científico publicado en 2015

Structural and functional insight into human O-GlcNAcase ⬇️

artículo científico publicado en 2017

Structural snapshots of the reaction coordinate for O-GlcNAc transferase

artículo científico publicado en 2012

Structural, mechanistic, and computational analysis of the effects of anomeric fluorines on anomeric fluoride departure in 5-fluoroxylosyl fluorides

scientific article published on 19 September 2011

Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation

artículo científico publicado en 2008

Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms

artículo científico publicado en 2015

Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2

artículo científico publicado en 2014

Synthesis of 4-methylumbelliferyl α-d-mannopyranosyl-(1→6)-β-d-mannopyranoside and development of a coupled fluorescent assay for GH125 exo-α-1,6-mannosidases.

artículo científico publicado en 2013

Tandem Bioorthogonal Labeling Uncovers Endogenous Cotranslationally O-GlcNAc Modified Nascent Proteins

scientific article published on 01 September 2020

The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to β-Lactams

artículo científico publicado en 2013

The chemical synthesis of 2-deoxy-2-fluorodisaccharide probes of the hen egg white lysozyme mechanism.

artículo científico publicado en 2005

The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor

artículo científico publicado en 2011

The emerging link between O-GlcNAc and Alzheimer disease.

artículo científico publicado en 2014

The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila

artículo científico publicado en 2020

The β-lactamase gene regulator AmpR is a tetramer that recognizes and binds the D-Ala-D-Ala motif of its repressor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide

artículo científico publicado en 2014

Tools for probing and perturbing O-GlcNAc in cells and in vivo ⬇️

artículo científico publicado el 30 de julio de 2013

Visualizing the reaction coordinate of an O-GlcNAc hydrolase

artículo científico publicado en 2010

mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer.

artículo científico publicado en 2015

Lista de obras de David J Vocadlo

6''-Azido-6''-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases

A Chemical Genetic Method for Monitoring Genome-Wide Dynamics of -GlcNAc Turnover on Chromatin-Associated Proteins

A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors

A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High-Throughput Screening: Application to O-GlcNAc Transferase

A case for reverse protonation: identification of Glu160 as an acid/base catalyst in Thermoanaerobacterium saccharolyticum beta-xylosidase and detailed kinetic analysis of a site-directed mutant.

A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase.

A highly concise preparation of O-deacetylated arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl chloride and aryl thiols or disulfides

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

A mechanism-based inactivator of glycoside hydrolases involving formation of a transient non-classical carbocation

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells.

A strategy for functional proteomic analysis of glycosidase activity from cell lysates.

AmpG inactivation restores susceptibility of pan-beta-lactam-resistant Pseudomonas aeruginosa clinical strains

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state

Carbohydrate Bis-acetal-Based Substrates as Tunable Fluorescence-Quenched Probes for Monitoring exo-Glycosidase Activity

Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate

Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose

Characterization and downstream mannose phosphorylation of human recombinant α‐L‐iduronidase produced in Arabidopsis complex glycan‐deficient (cgl) seeds ⬇️

Characterization of a beta-N-acetylhexosaminidase and a beta-N-acetylglucosaminidase/beta-glucosidase from Cellulomonas fimi

Characterization of the Glu and Asp residues in the active site of human beta-hexosaminidase B

Conformational Itinerary of Pseudomonas aeruginosa 1,6-Anhydro- N -acetylmuramic Acid Kinase during Its Catalytic Cycle

Crystal structure of beta-D-xylosidase from Thermoanaerobacterium saccharolyticum, a family 39 glycoside hydrolase

Crystal structure of the AmpR effector binding domain provides insight into the molecular regulation of inducible ampc beta-lactamase

Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase

Cura Annonae-Chemically Boosting Crop Yields Through Metabolic Feeding of a Plant Signaling Precursor

Detailed comparative analysis of the catalytic mechanisms of beta-N-acetylglucosaminidases from families 3 and 20 of glycoside hydrolases.

Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology.

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation ⬇️

Differential Recognition and Hydrolysis of Host Carbohydrate Antigens by Streptococcus pneumoniae Family 98 Glycoside Hydrolases

Direct one-step fluorescent labeling of O-GlcNAc modified proteins in live cells using metabolic intermediates

Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).

Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance

Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis

Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase

Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity

Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase

Functional proteomic profiling of glycan-processing enzymes

Genome-wide chemical mapping of O-GlcNAcylated proteins in Drosophila melanogaster

HCF-1 Is Cleaved in the Active Site of O-GlcNAc Transferase

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells.

How to make a difference: mechanisms of protein and nucleic acid modifying enzymes

Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells

Identification of Glu-277 as the catalytic nucleophile of Thermoanaerobacterium saccharolyticum β-xylosidase using electrospray MS ⬇️

In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation.

Inactivation of the glycoside hydrolase NagZ attenuates antipseudomonal beta-lactam resistance in Pseudomonas aeruginosa

Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase.

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes

Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc–imidazole hybrid inhibitor

Inhibition of the family 20 glycoside hydrolase catalytic modules in the Streptococcus pneumoniae exo-β-D-N-acetylglucosaminidase, StrH

Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis

Insight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ

Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates.

Mammalian Notch is modified by D-Xyl-alpha1-3-D-Xyl-alpha1-3-D-Glc-beta1-O-Ser: implementation of a method to study O-glucosylation

Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

Mechanism of action and identification of Asp242 as the catalytic nucleophile of Vibrio furnisii N-acetyl-beta-D-glucosaminidase using 2-acetamido-2-deoxy-5-fluoro-alpha-L-idopyranosyl fluoride

Mechanistic insights into glycosidase chemistry

Metabolic Inhibitors of O-GlcNAc Transferase That Act In Vivo Implicate Decreased O-GlcNAc Levels in Leptin-Mediated Nutrient Sensing

Metabolic inhibition of sialyl-Lewis X biosynthesis by 5-thiofucose remodels the cell surface and impairs selectin-mediated cell adhesion.

Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: INTRACELLULAR -O-LINKED N-GLYCOLYLGLUCOSAMINE (GlcNGc), UDP-GlcNGc, AND THE BIOCHEMICAL AND STRUCTURAL RATIONALE FOR THE SUBSTRATE TOLERANCE OF -O-LINKED -N-ACETYLGLUCOSAMINIDASE

Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine

Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS.

Molecular Basis of 1,6-Anhydro Bond Cleavage and Phosphoryl Transfer by Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase

Molecular basis for G protein control of the prokaryotic ATP sulfurylase

Molecular basis for inhibition of GH84 glycoside hydrolases by substituted azepanes: conformational flexibility enables probing of substrate distortion

NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa

O-GLcNAc post-translational modifications regulate the entry of neurons into an axon branching program

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.

O-GlcNAc modification of tau directly inhibits its aggregation without perturbing the conformational properties of tau monomers

O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains

O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation.

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.

Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein pre-formed-fibrils

Pharmacological inhibition of O-GlcNAcase (OGA) enhances autophagy in brain through an mTOR-independent pathway.

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.