Lista de obras - Shin-Ichiro Takahashi - Dominio Público Uruguay

A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes.

artículo científico publicado en 2016

Amino acid regulation of gene transcription of rat insulin-like growth factor-binding protein-1.

artículo científico publicado en 2000

Analysis of insulin receptor substrate signaling dynamics on microstructured surfaces

artículo científico publicado en 2015

Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos.

artículo científico publicado en 2013

Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats

artículo científico publicado en 2017

Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene

artículo científico publicado en 2003

Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling

artículo científico publicado en 2016

Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts ⬇️

artículo científico publicado en 2011

Creation of an autocrine model of insulin-like growth factor-I action in transfected FRTL-5 cells

artículo científico publicado el 1 de junio de 1992

Dietary protein deprivation decreases the serine phosphorylation of insulin receptor substrate-1 in rat skeletal muscle

artículo científico publicado en 2004

Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver

artículo científico publicado en 2010

Dietary restriction of single essential amino acids reduces plasma insulin-like growth factor-I (IGF-I) but does not affect plasma IGF-binding protein-1 in rats

artículo científico publicado en 2000

Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin beta

artículo científico publicado en 2008

Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells.

artículo científico publicado en 2008

Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans

artículo científico publicado en 2012

Familial dysautonomia (Riley-Day syndrome)

scientific article published on 01 March 1994

Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation

scientific article published on 30 September 2013

Familial short stature with IGF-I receptor gene anomaly.

artículo científico

Glucose deprivation attenuates sortilin levels in skeletal muscle cells

artículo científico publicado en 2016

Growth hormone (GH) or insulin-like growth factor (IGF)-I represses 11beta-hydroxysteroid dehydrogenase type 1 (HSD1) mRNA expression in 3T3-L1 cells and its activity in their homogenates.

artículo científico publicado en 2009

Growth hormone inhibition of glucose uptake in adipocytes occurs without affecting GLUT4 translocation through an insulin receptor substrate-2-phosphatidylinositol 3-kinase-dependent pathway

artículo científico publicado en 2009

HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells

scientific journal article

Helicobacter pylori eradication therapy for gastric ulcer in elderly

artículo científico publicado en 2010

IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response.

scientific article published on August 2009

IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells

artículo científico publicado en 2012

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

artículo científico publicado en 2018

In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains

artículo científico publicado en 2017

Influence of fabrication errors on wölter mirror imaging performance

artículo científico publicado en 1998

Insulin injection restored increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but did not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats.

artículo científico publicado en 2014

Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes

artículo científico publicado en 2013

Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis

scientific article published on 04 March 2014

Insulin receptor substrate-3 functions as transcriptional activator in the nucleus

scientific journal article

Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity

artículo científico publicado en 2010

Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.

artículo científico publicado en 2010

Insulin-Like Growth Factor-l Potentiates Protein Synthesis Induced by Thyrotropin in FRTL-5 Cells: Comparison of Induction of Protein Synthesis and DNA Synthesis ⬇️

artículo científico publicado el 1 de abril de 1998

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs

artículo científico publicado en 2012

Integrator complex plays an essential role in adipose differentiation.

artículo científico publicado en 2013

KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.

artículo científico publicado en 2011

LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8

artículo científico publicado en 2012

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.

artículo científico publicado en 2015

Long-term hormonal regulation of the cAMP-specific phosphodiesterases in cultured FRTL-5 thyroid cells.

artículo científico publicado en 2001

Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2.

artículo científico publicado en 2003

Microinjection of endogenous and exogenous proteins into primary cultures of rat hepatocytes and the degradation of the injected proteins

artículo científico publicado en 1989

Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression

artículo científico publicado en 2004

Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation

artículo científico publicado en 2005

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.

artículo científico publicado en 2015

Negative regulation of adipogenesis from human mesenchymal stem cells by Jun N-terminal kinase.

artículo científico publicado en 2005

New approach for the establishment of an hepatocyte cell line derived from rat early embryonic stem cells.

artículo científico publicado en 2003

Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation.

artículo científico publicado en 2012

Novel repressor regulates insulin sensitivity through interaction with Foxo1

artículo científico publicado en 2012

PKCα suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation

artículo científico publicado en 2012

Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.

artículo científico publicado en 2010

Phosphatidylinositol 3-Kinase-Associated Protein (PI3KAP)/XB130 Crosslinks Actin Filaments through Its Actin Binding and Multimerization Properties In Vitro and Enhances Endocytosis in HEK293 Cells

artículo científico publicado en 2016

Phosphatidylinositol 3-Kinase-Binding Protein, PI3KAP/XB130, Is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells ⬇️

artículo científico publicado el 11 de abril de 2012

Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.

artículo científico publicado en 2012

Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity

artículo científico publicado en 2010

Preoperative second-derivative of photoplethysmography measurement predicts the hemodynamic response to general anaesthesia induction

artículo científico publicado en 2009

Primary marginal zone lymphoma of the thymus accompanied by chromosomal anomaly 46,X,dup(X)(p11p22).

artículo científico publicado en 2002

Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit

artículo científico publicado en 2015

RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates

artículo científico publicado en 2015

Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism - ERRATUM

artículo científico publicado en 2015

Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism.

artículo científico

Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model

artículo científico publicado en 2012

Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues.

artículo científico publicado en 2016

Runx1 promotes angiogenesis by downregulation of insulin-like growth factor-binding protein-3.

artículo científico publicado en 2005

Short term feedback regulation of cAMP in FRTL-5 thyroid cells. Role of PDE4D3 phosphodiesterase activation.

artículo científico publicado en 2000

Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation

artículo científico publicado en 2013

Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters

artículo científico publicado en 2013

Supplemental arginine above the requirement during suckling causes obesity and insulin resistance in rats

artículo científico publicado en 2016

The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation

artículo científico publicado en 2013

The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes

scientific journal article

The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins

artículo científico publicado en 2015

The Short-Stature Homeobox-Containing Gene (shox/SHOX) Is Required for the Regulation of Cell Proliferation and Bone Differentiation in Zebrafish Embryo and Human Mesenchymal Stem Cells

artículo científico publicado en 2017

The Third International Congress of the GRS and the IGF Society, November 11-15, 2006, Kobe, Japan

artículo científico publicado en 2007

The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats

artículo científico publicado en 2006

Thyroglobulin (Tg) activates MAPK pathway to induce thyroid cell growth in the absence of TSH, insulin and serum.

artículo científico publicado en 2012

Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats

artículo científico publicado en 2014

Triglyceride synthesis in hepatocytes isolated from rats fed a low-protein diet is enhanced independently of upregulation of insulin signaling

artículo científico publicado en 2017

Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes

artículo científico publicado en 2015

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination

artículo científico publicado en 2017

Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma.

artículo científico publicado en 2017

Virtual pancreatoscopy of pancreatic cancer

artículo científico publicado en 2003

[Insulin-like growth factor-I controls animal growth]

artículo científico publicado en 1996

[Legislation of MEXT guidelines for research involving recombinant DNA molecules]

artículo científico publicado en 2004

Lista de obras de Shin-Ichiro Takahashi

A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes.

Amino acid regulation of gene transcription of rat insulin-like growth factor-binding protein-1.

Analysis of insulin receptor substrate signaling dynamics on microstructured surfaces

Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos.

Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats

Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene

Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling

Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts ⬇️

Creation of an autocrine model of insulin-like growth factor-I action in transfected FRTL-5 cells

Dietary protein deprivation decreases the serine phosphorylation of insulin receptor substrate-1 in rat skeletal muscle

Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver

Dietary restriction of single essential amino acids reduces plasma insulin-like growth factor-I (IGF-I) but does not affect plasma IGF-binding protein-1 in rats

Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin beta

Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells.

Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans

Familial dysautonomia (Riley-Day syndrome)

Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation

Familial short stature with IGF-I receptor gene anomaly.

Glucose deprivation attenuates sortilin levels in skeletal muscle cells

Growth hormone (GH) or insulin-like growth factor (IGF)-I represses 11beta-hydroxysteroid dehydrogenase type 1 (HSD1) mRNA expression in 3T3-L1 cells and its activity in their homogenates.

Growth hormone inhibition of glucose uptake in adipocytes occurs without affecting GLUT4 translocation through an insulin receptor substrate-2-phosphatidylinositol 3-kinase-dependent pathway

HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells

Helicobacter pylori eradication therapy for gastric ulcer in elderly

IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response.

IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains

Influence of fabrication errors on wölter mirror imaging performance

Insulin injection restored increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but did not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats.

Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes

Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis

Insulin receptor substrate-3 functions as transcriptional activator in the nucleus

Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity

Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.

Insulin-Like Growth Factor-l Potentiates Protein Synthesis Induced by Thyrotropin in FRTL-5 Cells: Comparison of Induction of Protein Synthesis and DNA Synthesis ⬇️

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs

Integrator complex plays an essential role in adipose differentiation.

KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.

LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.

Long-term hormonal regulation of the cAMP-specific phosphodiesterases in cultured FRTL-5 thyroid cells.

Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2.

Microinjection of endogenous and exogenous proteins into primary cultures of rat hepatocytes and the degradation of the injected proteins

Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression

Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.

Negative regulation of adipogenesis from human mesenchymal stem cells by Jun N-terminal kinase.

New approach for the establishment of an hepatocyte cell line derived from rat early embryonic stem cells.

Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation.

Novel repressor regulates insulin sensitivity through interaction with Foxo1

PKCα suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation

Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.

Phosphatidylinositol 3-Kinase-Associated Protein (PI3KAP)/XB130 Crosslinks Actin Filaments through Its Actin Binding and Multimerization Properties In Vitro and Enhances Endocytosis in HEK293 Cells

Phosphatidylinositol 3-Kinase-Binding Protein, PI3KAP/XB130, Is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells ⬇️

Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.

Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity

Preoperative second-derivative of photoplethysmography measurement predicts the hemodynamic response to general anaesthesia induction

Primary marginal zone lymphoma of the thymus accompanied by chromosomal anomaly 46,X,dup(X)(p11p22).

Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit

RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates

Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism - ERRATUM

Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism.

Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model

Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues.

Runx1 promotes angiogenesis by downregulation of insulin-like growth factor-binding protein-3.

Short term feedback regulation of cAMP in FRTL-5 thyroid cells. Role of PDE4D3 phosphodiesterase activation.

Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation

Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters

Supplemental arginine above the requirement during suckling causes obesity and insulin resistance in rats

The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation

The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes

The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins

The Short-Stature Homeobox-Containing Gene (shox/SHOX) Is Required for the Regulation of Cell Proliferation and Bone Differentiation in Zebrafish Embryo and Human Mesenchymal Stem Cells

The Third International Congress of the GRS and the IGF Society, November 11-15, 2006, Kobe, Japan

The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats

Thyroglobulin (Tg) activates MAPK pathway to induce thyroid cell growth in the absence of TSH, insulin and serum.

Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats

Triglyceride synthesis in hepatocytes isolated from rats fed a low-protein diet is enhanced independently of upregulation of insulin signaling

Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes