Lista de obras - Stephen J. Yarwood - Dominio Público Uruguay

Activation of protein kinase Calpha by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein beta-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells.

artículo científico publicado en 2009

Adhesion and migration of cells responding to microtopography.

artículo científico publicado en 2014

Cyclic AMP modulates adipogenesis in 3T3-F442A cells

artículo científico publicado en 1995

Cyclic AMP potentiates growth hormone-dependent differentiation of 3T3-F442A preadipocytes: possible involvement of the transcription factor CREB.

artículo científico publicado en 1998

Cyclic AMP stimulates the phosphorylation and activation of p42 and p44 mitogen-activated protein kinases in 3T3-F442A preadipocytes

artículo científico publicado en 1996

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.

artículo científico publicado en 2002

Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation

artículo científico publicado en 2016

Effect of cellular uptake of gelatin nanoparticles on adhesion, morphology and cytoskeleton organisation of human fibroblasts

artículo científico publicado en 2004

Elevation of cyclic AMP in Jurkat T-cells provokes distinct transcriptional responses through the protein kinase A (PKA) and exchange protein activated by cyclic AMP (EPAC) pathways

artículo científico publicado en 2005

Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition

artículo científico publicado en 2016

Exchange protein directly activated by cyclic AMP-1-regulated recruitment of CCAAT/enhancer-binding proteins to the suppressor of cytokine signaling-3 promoter

scientific article published on 01 January 2012

Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors

artículo científico publicado en 2012

Fibroblast signaling events in response to nanotopography: a gene array study

artículo científico publicado en 2002

Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.

artículo científico publicado en 2013

Genome-Wide Mapping Defines a Role for C/EBPβ and c-Jun in Non-Canonical Cyclic AMP Signalling

scientific article published on 14 October 2019

Growth hormone-dependent differentiation of 3T3-F442A preadipocytes requires Janus kinase/signal transducer and activator of transcription but not mitogen-activated protein kinase or p70 S6 kinase signaling.

artículo científico publicado en 1999

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

artículo científico publicado en 2019

Identification of CCAAT/enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene

artículo científico publicado en 2008

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1.

artículo científico publicado en 2017

In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting

artículo científico publicado en 2002

Increasing fibroblast response to materials using nanotopography: morphological and genetic measurements of cell response to 13-nm-high polymer demixed islands

artículo científico publicado en 2002

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C ⬇️

artículo científico publicado el 15 de noviembre de 2010

Interactions between Epac1 and ezrin in the control of endothelial barrier function.

artículo científico

Intracellular compartmentalization of PDE4 cyclic AMP-specific phosphodiesterases.

artículo científico publicado en 1998

Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist

scientific article published on 16 April 2020

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms

artículo científico publicado en 2016

Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting

scientific journal article

Mimitin - a novel cytokine-regulated mitochondrial protein

artículo científico publicado en 2009

Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency.

artículo científico publicado en 2016

Nanotopology potentiates growth hormone signalling and osteogenesis of mesenchymal stem cells

artículo científico publicado en 2014

Novel control of cAMP-regulated transcription in vascular endothelial cells

artículo científico publicado en 2012

Nucleus alignment and cell signaling in fibroblasts: response to a micro-grooved topography

artículo científico publicado en 2003

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

artículo científico publicado en 2015

Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4.

artículo científico publicado en 2017

Protease inhibitors prevent the protein kinase A-dependent loss of Rap1 GTPase from the particulate fraction of COS1 cells

artículo científico publicado en 2004

Regulation of the inflammatory response of vascular endothelial cells by EPAC1.

artículo científico

Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3.

artículo científico publicado en 2009

Selective small-molecule EPAC activators

scientific article published on 01 October 2019

Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation

artículo científico publicado en 2015

Special Issue on "New Advances in Cyclic AMP Signalling"-An Editorial Overview

scientific article published on 12 October 2020

Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes ⬇️

artículo científico publicado el 31 de marzo de 1998

Synthesis and Biochemical Evaluation of Non-Cyclic Nucleotide Exchange Protein Directly Activated by cAMP 1 (EPAC1) Regulators

scientific article published on 28 April 2020

The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation

artículo científico publicado en 2017

The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

artículo científico publicado en 2002

The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal.

artículo científico publicado en 2015

The cyclic AMP phosphodiesterase 4D5 (PDE4D5)/receptor for activated C-kinase 1 (RACK1) signalling complex as a sensor of the extracellular nano-environment

artículo científico publicado en 2017

The future of EPAC-targeted therapies: agonism versus antagonism

artículo científico publicado en 2015

The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs)

article

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun.

artículo científico publicado en 2012

The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs ⬇️

artículo científico publicado en 2014

Use of an activation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation by forskolin in rat1 cells

artículo científico publicado en 2000

Lista de obras de Stephen J. Yarwood

Activation of protein kinase Calpha by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein beta-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells.

Adhesion and migration of cells responding to microtopography.

Cyclic AMP modulates adipogenesis in 3T3-F442A cells

Cyclic AMP potentiates growth hormone-dependent differentiation of 3T3-F442A preadipocytes: possible involvement of the transcription factor CREB.

Cyclic AMP stimulates the phosphorylation and activation of p42 and p44 mitogen-activated protein kinases in 3T3-F442A preadipocytes

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.

Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation

Effect of cellular uptake of gelatin nanoparticles on adhesion, morphology and cytoskeleton organisation of human fibroblasts

Elevation of cyclic AMP in Jurkat T-cells provokes distinct transcriptional responses through the protein kinase A (PKA) and exchange protein activated by cyclic AMP (EPAC) pathways

Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition

Exchange protein directly activated by cyclic AMP-1-regulated recruitment of CCAAT/enhancer-binding proteins to the suppressor of cytokine signaling-3 promoter

Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors

Fibroblast signaling events in response to nanotopography: a gene array study

Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.

Genome-Wide Mapping Defines a Role for C/EBPβ and c-Jun in Non-Canonical Cyclic AMP Signalling

Growth hormone-dependent differentiation of 3T3-F442A preadipocytes requires Janus kinase/signal transducer and activator of transcription but not mitogen-activated protein kinase or p70 S6 kinase signaling.

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

Identification of CCAAT/enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1.

In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting

Increasing fibroblast response to materials using nanotopography: morphological and genetic measurements of cell response to 13-nm-high polymer demixed islands

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C ⬇️

Interactions between Epac1 and ezrin in the control of endothelial barrier function.

Intracellular compartmentalization of PDE4 cyclic AMP-specific phosphodiesterases.

Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms

Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting

Mimitin - a novel cytokine-regulated mitochondrial protein

Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency.

Nanotopology potentiates growth hormone signalling and osteogenesis of mesenchymal stem cells

Novel control of cAMP-regulated transcription in vascular endothelial cells

Nucleus alignment and cell signaling in fibroblasts: response to a micro-grooved topography

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4.

Protease inhibitors prevent the protein kinase A-dependent loss of Rap1 GTPase from the particulate fraction of COS1 cells

Regulation of the inflammatory response of vascular endothelial cells by EPAC1.

Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3.

Selective small-molecule EPAC activators

Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation

Special Issue on "New Advances in Cyclic AMP Signalling"-An Editorial Overview

Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes ⬇️

Synthesis and Biochemical Evaluation of Non-Cyclic Nucleotide Exchange Protein Directly Activated by cAMP 1 (EPAC1) Regulators

The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation

The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal.

The cyclic AMP phosphodiesterase 4D5 (PDE4D5)/receptor for activated C-kinase 1 (RACK1) signalling complex as a sensor of the extracellular nano-environment

The future of EPAC-targeted therapies: agonism versus antagonism

The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs)

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun.

The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs ⬇️

Use of an activation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation by forskolin in rat1 cells