Lista de obras - Jacek Zielonka - Dominio Público Uruguay

"ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"--a critical commentary

artículo científico publicado en 2008

1-Methyl-3-nitropyridine: an efficient oxidant of NADH in non-enzymatic and enzyme-mediated processes.

artículo científico publicado en 2003

1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin.

artículo científico publicado en 2003

20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.

artículo científico publicado en 2008

A Critical Review of Methodologies to Detect Reactive Oxygen and Nitrogen Species Stimulated by NADPH Oxidase Enzymes: Implications in Pesticide Toxicity

artículo científico publicado en 2016

A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease

artículo científico publicado en 2014

A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds

artículo científico publicado en 2017

Alcohol-induced CYP2E1, Mitochondrial Dynamics and Retrograde Signaling in Human Hepatic 3D Organoids

artículo científico publicado en 2020

Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation

artículo científico publicado en 2012

Anthralin: primary products of its redox reactions.

artículo científico publicado en 2006

Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism

artículo científico publicado en 2015

Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides.

artículo científico publicado en 2012

Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology

artículo científico publicado en 2020

Corrigendum to 'A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds' [REDOX 14C (2017) 316-327].

artículo científico publicado en 2018

Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity.

artículo científico publicado en 2006

Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia

scientific article published on 01 September 2020

Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers

artículo científico publicado en 2007

Cytokines and lipopolysaccharides induce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes

artículo científico publicado en 2008

Detection and Characterization of Reactive Oxygen and Nitrogen Species in Biological Systems by Monitoring Species-Specific Products

artículo científico publicado en 2017

Detection and differentiation between peroxynitrite and hydroperoxides using mitochondria-targeted arylboronic acid.

artículo científico publicado en 2015

Detection and identification of oxidants formed during •NO/O2•⁻ reaction: a multi-well plate CW-EPR spectroscopy combined with HPLC analyses.

artículo científico publicado en 2014

Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine.

artículo científico publicado en 2008

Detection of mitochondria-generated reactive oxygen species in cells using multiple probes and methods: Potentials, pitfalls, and the future.

artículo científico publicado en 2018

Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse

artículo científico publicado en 2013

Direct oxidation of boronates by peroxynitrite: mechanism and implications in fluorescence imaging of peroxynitrite.

artículo científico publicado en 2009

Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q

artículo científico publicado en 2009

Effect of heparin on viologen-stimulated enzymatic NADH depletion

artículo científico publicado en 2006

Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals

scientific article published on 10 June 2019

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

artículo científico publicado en 2017

Foreword to the Free Radical Biology and Medicine Special Issue on ¨Current fluorescence and chemiluminescence approaches in free radical and redox biology¨

artículo científico publicado en 2018

Global profiling of reactive oxygen and nitrogen species in biological systems: high-throughput real-time analyses

artículo científico publicado en 2011

Green fluorescent proteins induce oxidative stress in cells: A worrisome new wrinkle in the application of the GFP reporter system to biological systems?

artículo científico publicado en 2017

H2O2 generation by bacillus Calmette-Guérin induces the cellular oxidative stress response required for bacillus Calmette-Guérin direct effects on urothelial carcinoma biology

artículo científico publicado en 2014

HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements

artículo científico publicado en 2008

HPLC-Based Monitoring of Oxidation of Hydroethidine for the Detection of NADPH Oxidase-Derived Superoxide Radical Anion

artículo científico publicado en 2019

HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes--the ultimate approach for intra- and extracellular superoxide detection.

artículo científico

High-Throughput Screening of NOX Inhibitors

artículo científico publicado en 2019

High-throughput assays for superoxide and hydrogen peroxide: design of a screening workflow to identify inhibitors of NADPH oxidases.

artículo científico publicado en 2014

Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth

artículo científico publicado en 2010

Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response

artículo científico publicado en 2007

Hydropropidine: a novel, cell-impermeant fluorogenic probe for detecting extracellular superoxide.

artículo científico publicado en 2012

Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses

artículo científico publicado en 2019

Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells.

artículo científico publicado en 2014

Kindlin-3 negatively regulates the release of neutrophil extracellular traps.

artículo científico publicado en 2018

Low-Temperature EPR Spectroscopy as a Probe-Free Technique for Monitoring Oxidants Formed in Tumor Cells and Tissues: Implications in Drug Resistance and OXPHOS-Targeted Therapies

scientific article published on 26 September 2018

Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I

artículo científico publicado en 2020

Mechanism of oxidative conversion of Amplex® Red to resorufin: Pulse radiolysis and enzymatic studies.

artículo científico publicado en 2016

Mechanistic similarities between oxidation of hydroethidine by Fremy's salt and superoxide: stopped-flow optical and EPR studies.

artículo científico publicado en 2005

Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation.

artículo científico publicado en 2016

Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice

artículo científico publicado en 2017

Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model

artículo científico publicado en 2013

Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells

artículo científico publicado en 2016

Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity

scientific article published on 22 April 2018

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. ⬇️

artículo científico publicado en 2017

Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death

artículo científico publicado en 2012

Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells

scientific article published on 17 September 2020

Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms.

artículo científico publicado en 2017

Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells

artículo científico publicado en 2011

Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon

artículo científico publicado en 2020

Mitochondria-targeted spin traps: synthesis, superoxide spin trapping, and mitochondrial uptake

artículo científico publicado en 2014

Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death

artículo científico publicado en 2013

Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy

artículo científico publicado en 2011

Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies.

artículo científico publicado en 2017

MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries

artículo científico publicado en 2008

Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH. Biological Implications.

artículo científico publicado en 2014

On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation

artículo científico publicado en 2013

On the use of fluorescence lifetime imaging and dihydroethidium to detect superoxide in intact animals and ex vivo tissues: a reassessment.

artículo científico publicado en 2013

On the use of peroxy-caged luciferin (PCL-1) probe for bioluminescent detection of inflammatory oxidants in vitro and in vivo - Identification of reaction intermediates and oxidant-specific minor products.

artículo científico publicado en 2016

Oxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide

artículo científico publicado en 2020

Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: direct reaction with boronate-based fluorescent probe

artículo científico publicado en 2010

Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation.

artículo científico publicado en 2014

Pulse radiolysis and steady-state analyses of the reaction between hydroethidine and superoxide and other oxidants.

artículo científico publicado en 2006

Radical scavenging and NO-releasing properties of selected beta-adrenoreceptor antagonists

artículo científico publicado en 2006

Radical scavenging properties of genistein.

artículo científico publicado en 2003

Reaction between peroxynitrite and boronates: EPR spin-trapping, HPLC Analyses, and quantum mechanical study of the free radical pathway

artículo científico publicado en 2011

Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications

artículo científico publicado en 2013

Real-time measurements of amino acid and protein hydroperoxides using coumarin boronic acid.

artículo científico publicado en 2014

Real-time monitoring of reactive oxygen and nitrogen species in a multiwell plate using the diagnostic marker products of specific probes.

artículo científico publicado en 2013

Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases.

artículo científico publicado en 2017

Recent developments in detection of superoxide radical anion and hydrogen peroxide: Opportunities, challenges, and implications in redox signaling.

artículo científico publicado en 2016

Reply to Jourd'heuil: Peroxynitrite Is the Major Species Formed from Different Flux Ratios of Co-generated Nitric Oxide and Superoxide.

artículo científico publicado en 2010

Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning.

scientific article published on February 2009

SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer

artículo científico publicado en 2019

Small-molecule luminescent probes for the detection of cellular oxidizing and nitrating species.

artículo científico publicado en 2018

Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators

artículo científico publicado en 2019

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis

artículo científico publicado en 2019

Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies

artículo científico publicado en 2017

The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone

artículo científico publicado en 2010

The confounding effects of light, sonication, and Mn(III)TBAP on quantitation of superoxide using hydroethidine.

artículo científico publicado en 2006

The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism?

artículo científico publicado en 2008

The iron-chelating drug triapine causes pronounced mitochondrial thiol redox stress

artículo científico publicado en 2010

Toward selective detection of reactive oxygen and nitrogen species with the use of fluorogenic probes--Limitations, progress, and perspectives.

artículo científico

Tracking isotopically labeled oxidants using boronate-based redox probes

artículo científico publicado en 2020

Transient species in the stepwise interconversion of NADH and NAD+.

artículo científico publicado en 2004

Lista de obras de Jacek Zielonka

"ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"--a critical commentary

1-Methyl-3-nitropyridine: an efficient oxidant of NADH in non-enzymatic and enzyme-mediated processes.

1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin.

20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.

A Critical Review of Methodologies to Detect Reactive Oxygen and Nitrogen Species Stimulated by NADPH Oxidase Enzymes: Implications in Pesticide Toxicity

A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease

A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds

Alcohol-induced CYP2E1, Mitochondrial Dynamics and Retrograde Signaling in Human Hepatic 3D Organoids

Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation

Anthralin: primary products of its redox reactions.

Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism

Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides.

Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology

Corrigendum to 'A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds' [REDOX 14C (2017) 316-327].

Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity.

Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia

Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers

Cytokines and lipopolysaccharides induce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes

Detection and Characterization of Reactive Oxygen and Nitrogen Species in Biological Systems by Monitoring Species-Specific Products

Detection and differentiation between peroxynitrite and hydroperoxides using mitochondria-targeted arylboronic acid.

Detection and identification of oxidants formed during •NO/O2•⁻ reaction: a multi-well plate CW-EPR spectroscopy combined with HPLC analyses.

Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine.

Detection of mitochondria-generated reactive oxygen species in cells using multiple probes and methods: Potentials, pitfalls, and the future.

Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse

Direct oxidation of boronates by peroxynitrite: mechanism and implications in fluorescence imaging of peroxynitrite.

Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q

Effect of heparin on viologen-stimulated enzymatic NADH depletion

Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Foreword to the Free Radical Biology and Medicine Special Issue on ¨Current fluorescence and chemiluminescence approaches in free radical and redox biology¨

Global profiling of reactive oxygen and nitrogen species in biological systems: high-throughput real-time analyses

Green fluorescent proteins induce oxidative stress in cells: A worrisome new wrinkle in the application of the GFP reporter system to biological systems?

H2O2 generation by bacillus Calmette-Guérin induces the cellular oxidative stress response required for bacillus Calmette-Guérin direct effects on urothelial carcinoma biology

HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements

HPLC-Based Monitoring of Oxidation of Hydroethidine for the Detection of NADPH Oxidase-Derived Superoxide Radical Anion

HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes--the ultimate approach for intra- and extracellular superoxide detection.

High-Throughput Screening of NOX Inhibitors

High-throughput assays for superoxide and hydrogen peroxide: design of a screening workflow to identify inhibitors of NADPH oxidases.

Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth

Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response

Hydropropidine: a novel, cell-impermeant fluorogenic probe for detecting extracellular superoxide.

Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses

Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells.

Kindlin-3 negatively regulates the release of neutrophil extracellular traps.

Low-Temperature EPR Spectroscopy as a Probe-Free Technique for Monitoring Oxidants Formed in Tumor Cells and Tissues: Implications in Drug Resistance and OXPHOS-Targeted Therapies

Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I

Mechanism of oxidative conversion of Amplex® Red to resorufin: Pulse radiolysis and enzymatic studies.

Mechanistic similarities between oxidation of hydroethidine by Fremy's salt and superoxide: stopped-flow optical and EPR studies.

Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation.

Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice

Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model

Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells

Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity

Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. ⬇️

Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death

Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells

Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms.

Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells

Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon

Mitochondria-targeted spin traps: synthesis, superoxide spin trapping, and mitochondrial uptake

Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death

Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy

Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies.

MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries

Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH. Biological Implications.

On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation

On the use of fluorescence lifetime imaging and dihydroethidium to detect superoxide in intact animals and ex vivo tissues: a reassessment.

On the use of peroxy-caged luciferin (PCL-1) probe for bioluminescent detection of inflammatory oxidants in vitro and in vivo - Identification of reaction intermediates and oxidant-specific minor products.

Oxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide

Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: direct reaction with boronate-based fluorescent probe

Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation.

Pulse radiolysis and steady-state analyses of the reaction between hydroethidine and superoxide and other oxidants.

Radical scavenging and NO-releasing properties of selected beta-adrenoreceptor antagonists

Radical scavenging properties of genistein.

Reaction between peroxynitrite and boronates: EPR spin-trapping, HPLC Analyses, and quantum mechanical study of the free radical pathway

Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications

Real-time measurements of amino acid and protein hydroperoxides using coumarin boronic acid.

Real-time monitoring of reactive oxygen and nitrogen species in a multiwell plate using the diagnostic marker products of specific probes.

Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases.