Lista de obras - Michael Gotthardt - Dominio Público Uruguay

A proteome map of murine heart and skeletal muscle

artículo científico publicado en 2008

Adaptations in titin's spring elements in normal and cardiomyopathic hearts.

artículo científico publicado en 2003

Altered contractility of skeletal muscle in mice deficient in titin's M-band region

artículo científico publicado en 2009

Axial tubule junctions control rapid calcium signaling in atria

artículo científico publicado en 2016

CAR-diology--a virus receptor in the healthy and diseased heart

artículo científico publicado en 2009

Calcium sensitivity and myofilament lattice structure in titin N2B KO mice

artículo científico publicado en 2012

Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice

artículo científico publicado en 2010

Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo

artículo científico publicado en 2009

Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region

artículo científico publicado en 2007

Cellular signalling by lipoprotein receptors

artículo científico publicado en 2000

Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure

artículo científico publicado en 2002

Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1.

artículo científico publicado en 2011

Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia

artículo científico publicado en 2014

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice

scientific article published on 19 June 2020

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome

artículo científico publicado en 2021

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes

artículo científico publicado en 2019

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics

artículo científico publicado en 2014

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

artículo científico publicado en 2018

Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure

artículo científico publicado en 2009

Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness

artículo científico publicado en 2009

Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP.

artículo científico publicado en 2017

Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle

scholarly article by Henk Granzier et al published August 2007 in American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

artículo científico publicado en 1998

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling

scientific journal article

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

artículo científico publicado en 2015

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

artículo científico publicado en 2000

Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor

artículo científico publicado en 2014

LRP and PDGF signaling: a pathway to atherosclerosis

artículo científico publicado en 2004

LRP: role in vascular wall integrity and protection from atherosclerosis

artículo científico publicado en 2003

Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy

artículo científico publicado en 2012

M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere

scientific journal article

Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle

artículo científico publicado en 2011

Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor

artículo científico publicado en 2014

Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.

artículo científico publicado en 2018

Muscle atrophy in Titin M-line deficient mice

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

artículo científico publicado en 2005

Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor

scientific journal article

Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae

scientific journal article

Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response

artículo científico publicado en 2015

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing

artículo científico publicado en 2012

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

artículo científico publicado en 2014

Recessive TTN truncating mutations define novel forms of core myopathy with heart disease

scientific article published on 08 October 2013

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy

artículo científico publicado en 2016

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

artículo científico publicado en 1999

Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis

artículo científico publicado en 2008

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury

artículo científico publicado en 2007

SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy

artículo científico publicado en 2022

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

artículo científico publicado en 2002

Sustained somatic gene inactivation by viral transfer of Cre recombinase.

artículo científico publicado en 1996

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy

scientific journal article

The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development

artículo científico publicado en 2014

The cell adhesion protein CAR is a negative regulator of synaptic transmission

article

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

artículo científico publicado en 2001

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2

scientific journal article

The tight junction protein CAR regulates cardiac conduction and cell-cell communication

artículo científico publicado en 2008

Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions

artículo científico publicado en 2011

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres

artículo científico publicado en 2011

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction

artículo científico publicado en 2009

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.

artículo científico publicado en 2002

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes

artículo científico publicado en 2021

Lista de obras de Michael Gotthardt

A proteome map of murine heart and skeletal muscle

Adaptations in titin's spring elements in normal and cardiomyopathic hearts.

Altered contractility of skeletal muscle in mice deficient in titin's M-band region

Axial tubule junctions control rapid calcium signaling in atria

CAR-diology--a virus receptor in the healthy and diseased heart

Calcium sensitivity and myofilament lattice structure in titin N2B KO mice

Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice

Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo

Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region

Cellular signalling by lipoprotein receptors

Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure

Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1.

Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes

Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure

Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness

Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP.

Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

Interspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor

LRP and PDGF signaling: a pathway to atherosclerosis

LRP: role in vascular wall integrity and protection from atherosclerosis

Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy

M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere

Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle

Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor

Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4.

Muscle atrophy in Titin M-line deficient mice

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor

Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae

Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing

RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

Recessive TTN truncating mutations define novel forms of core myopathy with heart disease

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury

SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

Sustained somatic gene inactivation by viral transfer of Cre recombinase.

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy

The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development

The cell adhesion protein CAR is a negative regulator of synaptic transmission

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2

The tight junction protein CAR regulates cardiac conduction and cell-cell communication

Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions

Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres

Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes