Lista de obras - Rudi Fasan - Dominio Público Uruguay

Aldehyde and Ketone Synthesis by P450-Catalyzed Oxidative Deamination of Alkyl Azides

artículo científico publicado en 2016

Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.

artículo científico

Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3-Dihydrobenzofuran-Based Tricyclic Scaffolds

scientific article published on 24 June 2019

Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction.

artículo científico publicado en 2016

Bioinspired strategy for the ribosomal synthesis of thioether-bridged macrocyclic peptides in bacteria

artículo científico publicado en 2014

C-H Amination via Nitrene Transfer Catalyzed by Mononuclear Non-Heme Iron-Dependent Enzymes

scientific article published on 18 March 2020

Chemo-enzymatic fluorination of unactivated organic compounds

artículo científico publicado en 2008

Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs.

artículo científico publicado en 2016

Chemoselective Cyclopropanation over Carbene Y-H Insertion Catalyzed by an Engineered Carbene Transferase

artículo científico publicado en 2018

Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization

artículo científico publicado en 2021

Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity

artículo científico publicado en 2012

Correction: Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates

artículo científico publicado en 2015

Cyclopropanations via Heme Carbenes: Basic Mechanism and Effects of Carbene Substituent, Protein Axial Ligand, and Porphyrin Substitution.

artículo científico publicado en 2017

Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction

artículo científico publicado en 2017

Design, synthesis, and diversification of ribosomally derived peptide macrocycles

artículo científico

Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix

artículo científico publicado en 2014

Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization

artículo científico publicado en 2013

Diverse organo-peptide macrocycles via a fast and catalyst-free oxime/intein-mediated dual ligation

scientific article published on 07 September 2011

Effect of proximal ligand substitutions on the carbene and nitrene transferase activity of myoglobin

scientific article published on 11 March 2019

Efficient conversion of primary azides to aldehydes catalyzed by active site variants of myoglobin

artículo científico publicado en 2015

Emerging strategies to access peptide macrocycles from genetically encoded polypeptides

scientific article published on 29 March 2013

Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties

artículo científico publicado en 2007

Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.

artículo científico publicado en 2014

Enzymatic C(sp(3))-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones

artículo científico publicado en 2015

Enzymatic catalysis: New functional twists for P450s

artículo científico publicado en 2017

Enzyme stabilization via computationally guided protein stapling

artículo científico publicado en 2017

Evolutionary history of a specialized p450 propane monooxygenase

artículo científico publicado en 2008

Expanded toolbox for directing the biosynthesis of macrocyclic peptides in bacterial cells

scientific article published on 27 May 2020

Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions

artículo científico publicado en 2017

Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity.

artículo científico publicado en 2016

Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene

artículo científico publicado en 2017

Highly Stereoselective Synthesis of Fused Cyclopropane-γ-Lactams via Biocatalytic Iron-Catalyzed Intramolecular Cyclopropanation

scientific article published on 14 January 2020

Highly diastereo- and enantioselective synthesis of nitrile-substituted cyclopropanes via myoglobin-mediated carbene transfer catalysis

artículo científico publicado en 2018

Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts

artículo científico publicado en 2014

Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli

artículo científico publicado en 2010

Intermolecular carbene S-H insertion catalysed by engineered myoglobin-based catalysts†.

artículo científico publicado en 2015

Intramolecular C(sp(3))H amination of arylsulfonyl azides with engineered and artificial myoglobin-based catalysts.

artículo científico publicado en 2014

Macrocyclization of organo-peptide hybrids through a dual bio-orthogonal ligation: insights from structure-reactivity studies.

artículo científico publicado en 2012

Mechanistic Investigation of Biocatalytic Heme Carbenoid Si-H Insertions

scientific article published on 08 May 2019

Metal Substitution Modulates the Reactivity and Extends the Reaction Scope of Myoglobin Carbene Transfer Catalysts

artículo científico publicado en 2017

Modular assembly of macrocyclic organo-peptide hybrids using synthetic and genetically encoded precursors.

artículo científico publicado en 2011

Myoglobin-Catalyzed C-H Functionalization of Unprotected Indoles

scientific article published on 06 July 2018

Myoglobin-Catalyzed Olefination of Aldehydes

artículo científico publicado en 2016

Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates

artículo científico publicado en 2015

Natural, engineered, and artificial biocatalysts for organic synthesis

artículo científico publicado en 2014

Organic solvent stability and long-term storage of myoglobin-based carbene transfer biocatalysts

artículo científico publicado en 2020

Origin of high stereocontrol in olefin cyclopropanation catalyzed by an engineered carbene transferase

scientific article published on 28 December 2018

P450 fingerprinting method for rapid discovery of terpene hydroxylating P450 catalysts with diversified regioselectivity

artículo científico publicado en 2011

P450-catalyzed intramolecular sp(3) C-H amination with arylsulfonyl azide substrates.

artículo científico publicado en 2014

Protein ligand design: from phage display to synthetic protein epitope mimetics in human antibody Fc-binding peptidomimetics

artículo científico publicado en 2006

Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids

artículo científico publicado en 2015

Ribosomal Synthesis of Natural-Product-Like Bicyclic Peptides in Escherichia coli

artículo científico publicado en 2015

Ribosomal Synthesis of Thioether-Bridged Bicyclic Peptides.

artículo científico publicado en 2017

Selective Functionalization of Aliphatic Amines via Myoglobin-catalyzed Carbene N-H Insertion

scientific article published on 11 July 2019

Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acids

artículo científico publicado en 2016

Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 via Consensus-Guided Mutagenesis.

artículo científico publicado en 2017

Stereodivergent Intramolecular Cyclopropanation Enabled by Engineered Carbene Transferases

scientific article published on 29 May 2019

Stereoselective Cyclopropanation of Electron-Deficient Olefins with a Cofactor Redesigned Carbene Transferase Featuring Radical Reactivity

scientific article published on 05 September 2019

Stereoselective olefin cyclopropanation under aerobic conditions with an artificial enzyme incorporating an iron-chlorin e6 cofactor

artículo científico publicado en 2017

Structure of Sonic Hedgehog protein in complex with zinc(II) and magnesium(II) reveals ion-coordination plasticity relevant to peptide drug design

scientific article published on 30 October 2019

Structure-activity studies in a family of beta-hairpin protein epitope mimetic inhibitors of the p53-HDM2 protein-protein interaction

scientific article published on 01 March 2006

Synthesis of bicyclic organo-peptide hybrids via oxime/intein-mediated macrocyclization followed by disulfide bond formation

artículo científico publicado en 2014

Synthesis of macrocyclic organo-peptide hybrids from ribosomal polypeptide precursors via CuAAC-/hydrazide-mediated cyclization

artículo científico publicado en 2015

Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression.

artículo científico publicado en 2018

Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization

scientific article published on 25 May 2022

Tuning P450 Enzymes as Oxidation Catalysts

article

Two-Tier Screening Platform for Directed Evolution of Aminoacyl-tRNA Synthetases with Enhanced Stop Codon Suppression Efficiency

artículo científico publicado en 2017

Using a beta-hairpin to mimic an alpha-helix: cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction

artículo científico publicado en 2004

Lista de obras de Rudi Fasan

Aldehyde and Ketone Synthesis by P450-Catalyzed Oxidative Deamination of Alkyl Azides

Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis.

Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3-Dihydrobenzofuran-Based Tricyclic Scaffolds

Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction.

Bioinspired strategy for the ribosomal synthesis of thioether-bridged macrocyclic peptides in bacteria

C-H Amination via Nitrene Transfer Catalyzed by Mononuclear Non-Heme Iron-Dependent Enzymes

Chemo-enzymatic fluorination of unactivated organic compounds

Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs.

Chemoselective Cyclopropanation over Carbene Y-H Insertion Catalyzed by an Engineered Carbene Transferase

Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization

Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity

Correction: Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates

Cyclopropanations via Heme Carbenes: Basic Mechanism and Effects of Carbene Substituent, Protein Axial Ligand, and Porphyrin Substitution.

Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction

Design, synthesis, and diversification of ribosomally derived peptide macrocycles

Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix

Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization

Diverse organo-peptide macrocycles via a fast and catalyst-free oxime/intein-mediated dual ligation

Effect of proximal ligand substitutions on the carbene and nitrene transferase activity of myoglobin

Efficient conversion of primary azides to aldehydes catalyzed by active site variants of myoglobin

Emerging strategies to access peptide macrocycles from genetically encoded polypeptides

Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties

Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.

Enzymatic C(sp(3))-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones

Enzymatic catalysis: New functional twists for P450s

Enzyme stabilization via computationally guided protein stapling

Evolutionary history of a specialized p450 propane monooxygenase

Expanded toolbox for directing the biosynthesis of macrocyclic peptides in bacterial cells

Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions

Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity.

Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene

Highly Stereoselective Synthesis of Fused Cyclopropane-γ-Lactams via Biocatalytic Iron-Catalyzed Intramolecular Cyclopropanation

Highly diastereo- and enantioselective synthesis of nitrile-substituted cyclopropanes via myoglobin-mediated carbene transfer catalysis

Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts

Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli

Intermolecular carbene S-H insertion catalysed by engineered myoglobin-based catalysts†.

Intramolecular C(sp(3))H amination of arylsulfonyl azides with engineered and artificial myoglobin-based catalysts.

Macrocyclization of organo-peptide hybrids through a dual bio-orthogonal ligation: insights from structure-reactivity studies.

Mechanistic Investigation of Biocatalytic Heme Carbenoid Si-H Insertions

Metal Substitution Modulates the Reactivity and Extends the Reaction Scope of Myoglobin Carbene Transfer Catalysts

Modular assembly of macrocyclic organo-peptide hybrids using synthetic and genetically encoded precursors.

Myoglobin-Catalyzed C-H Functionalization of Unprotected Indoles

Myoglobin-Catalyzed Olefination of Aldehydes

Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates

Natural, engineered, and artificial biocatalysts for organic synthesis

Organic solvent stability and long-term storage of myoglobin-based carbene transfer biocatalysts

Origin of high stereocontrol in olefin cyclopropanation catalyzed by an engineered carbene transferase

P450 fingerprinting method for rapid discovery of terpene hydroxylating P450 catalysts with diversified regioselectivity

P450-catalyzed intramolecular sp(3) C-H amination with arylsulfonyl azide substrates.

Protein ligand design: from phage display to synthetic protein epitope mimetics in human antibody Fc-binding peptidomimetics

Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids

Ribosomal Synthesis of Natural-Product-Like Bicyclic Peptides in Escherichia coli

Ribosomal Synthesis of Thioether-Bridged Bicyclic Peptides.

Selective Functionalization of Aliphatic Amines via Myoglobin-catalyzed Carbene N-H Insertion

Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acids

Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 via Consensus-Guided Mutagenesis.

Stereodivergent Intramolecular Cyclopropanation Enabled by Engineered Carbene Transferases

Stereoselective Cyclopropanation of Electron-Deficient Olefins with a Cofactor Redesigned Carbene Transferase Featuring Radical Reactivity

Stereoselective olefin cyclopropanation under aerobic conditions with an artificial enzyme incorporating an iron-chlorin e6 cofactor

Structure of Sonic Hedgehog protein in complex with zinc(II) and magnesium(II) reveals ion-coordination plasticity relevant to peptide drug design

Structure-activity studies in a family of beta-hairpin protein epitope mimetic inhibitors of the p53-HDM2 protein-protein interaction

Synthesis of bicyclic organo-peptide hybrids via oxime/intein-mediated macrocyclization followed by disulfide bond formation

Synthesis of macrocyclic organo-peptide hybrids from ribosomal polypeptide precursors via CuAAC-/hydrazide-mediated cyclization

Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression.

Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization

Tuning P450 Enzymes as Oxidation Catalysts

Two-Tier Screening Platform for Directed Evolution of Aminoacyl-tRNA Synthetases with Enhanced Stop Codon Suppression Efficiency

Using a beta-hairpin to mimic an alpha-helix: cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction