Lista de obras - Helen Fletcher - Dominio Público Uruguay

A New Vaccine for Tuberculosis: The Challenges of Development and Deployment

artículo científico publicado en 2009

A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults

artículo científico publicado en 2011

A comparison of IFNgamma detection methods used in tuberculosis vaccine trials

artículo científico publicado en 2008

A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB pathogenesis

artículo científico publicado en 2013

A molecular assay for sensitive detection of pathogen-specific T-cells

artículo científico publicado en 2011

A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis

artículo científico publicado en 2016

Adaption of the ex vivo mycobacterial growth inhibition assay for use with murine lung cells

artículo científico publicado en 2020

Association of Human Antibodies to Arabinomannan With Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction

artículo científico publicado en 2016

Big Data in Vaccinology: Introduction and section summaries

artículo científico publicado en 2015

Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1.

artículo científico publicado en 2008

Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials

artículo científico publicado en 2005

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials

artículo científico publicado en 2007

Cholera toxin enhances vaccine-induced protection against Mycobacterium tuberculosis challenge in mice

artículo científico publicado en 2013

Comparing human T cell and NK cell responses in viral-based malaria vaccine trials

artículo científico publicado en 2009

Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery

artículo científico publicado en 2012

Correlates of immune protection from tuberculosis

artículo científico publicado en 2007

Corrigendum to “MIG (CXCL9) is a more sensitive measure than IFN-γ of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines” [J. Immunol. Methods 340 (2009) 33–41].

artículo científico publicado en 2011

Corrigendum: T-cell activation is an immune correlate of risk in BCG vaccinated infants

artículo científico publicado en 2016

Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques

artículo científico publicado en 2019

Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes

artículo científico publicado en 2015

Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design

artículo científico publicado en 2006

Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults

artículo científico publicado en 2012

Evaluation of a human BCG challenge model to assess antimycobacterial immunity induced by BCG and a candidate tuberculosis vaccine, MVA85A, alone and in combination

artículo científico publicado en 2013

Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal

artículo científico publicado en 2010

Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model

artículo científico publicado en 2014

High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis

scientific article published on 08 March 2018

Historical BCG vaccination combined with drug treatment enhances inhibition of mycobacterial growth ex vivo in human peripheral blood cells

artículo científico publicado en 2019

Human biomarkers: can they help us to develop a new tuberculosis vaccine?

artículo científico publicado en 2016

Identification of Pneumocystis carinii DNA by polymerase chain reaction in necropsy lung samples from children dying of respiratory tract illnesses

artículo científico publicado en 2002

Identification of Pneumocystis carinii DNA in oropharyngeal mouth washes from AIDS children dying of respiratory illnesses

artículo científico publicado en 2002

Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations

artículo científico publicado en 2008

Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation.

artículo científico publicado en 2004

Individual-level factors associated with variation in mycobacterial-specific immune response: Gender and previous BCG vaccination status

artículo científico publicado en 2015

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response

artículo científico publicado en 2014

Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG.

artículo científico publicado en 2013

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines

artículo científico publicado en 2015

Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A

artículo científico publicado en 2010

Investments in tuberculosis research - what are the gaps?

artículo científico publicado en 2016

MIG (CXCL9) is a more sensitive measure than IFN-gamma of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines

artículo científico publicado en 2008

MIG and the regulatory cytokines IL-10 and TGF-β1 correlate with malaria vaccine immunogenicity and efficacy

artículo científico publicado en 2010

Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians

artículo científico publicado en 2003

Mycobacterial growth inhibition in murine splenocytes as a surrogate for protection against Mycobacterium tuberculosis (M. tb).

artículo científico publicado en 2013

Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data

artículo científico publicado en 2013

Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines

artículo científico publicado en 2015

Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants

artículo científico publicado en 2016

Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1.

artículo científico publicado en 2011

Process of assay selection and optimization for the study of case and control samples from a phase IIb efficacy trial of a candidate tuberculosis vaccine, MVA85A

artículo científico publicado en 2014

Profiling the host immune response to tuberculosis vaccines

artículo científico publicado en 2015

Profiling the host response to malaria vaccination and malaria challenge

artículo científico publicado en 2015

Progress and challenges in TB vaccine development

artículo científico publicado en 2018

Quantitative PCR evaluation of cellular immune responses in Kenyan children vaccinated with a candidate malaria vaccine

artículo científico publicado en 2009

Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy

scientific article published on 16 September 2013

Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis

artículo científico publicado en 2006

Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans

artículo científico publicado en 2004

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

artículo científico publicado en 2018

Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A.

artículo científico publicado en 2013

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa

artículo científico publicado en 2008

Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A

artículo científico publicado en 2009

Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa

artículo científico publicado en 2008

Sensitivity of IFN-gamma release assay to detect latent tuberculosis infection is retained in HIV-infected patients but dependent on HIV/AIDS progression

artículo científico publicado en 2008

Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A

artículo científico publicado en 2014

Single nucleotide polymorphisms in the Toll-like receptor 3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccine

artículo científico publicado en 2011

Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine

artículo científico publicado en 2016

Social determinants and BCG efficacy: a call for a socio-biological approach to TB prevention.

artículo científico publicado en 2018

Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points

artículo científico publicado en 2016

T-Cell Responses Are Associated with Survival in Acute Melioidosis Patients

artículo científico publicado en 2015

T-cell activation is an immune correlate of risk in BCG vaccinated infants

artículo científico publicado en 2016

TB vaccine development and the End TB Strategy: importance and current status.

artículo científico publicado en 2016

TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'.

artículo científico publicado en 2014

Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A

artículo científico publicado en 2011

The <i>in vitro</i> direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human primate cells

publication published on 30 March 2021

The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV-infected postpartum women

artículo científico publicado en 2014

The convergent epidemiology of tuberculosis and human cytomegalovirus infection.

artículo científico publicado en 2018

The prospective evaluation of a nested polymerase chain reaction assay for the early detection of Aspergillus infection in patients with leukaemia or undergoing allograft treatment

artículo científico publicado en 2002

The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children

artículo científico publicado en 2013

Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model

artículo científico publicado en 2015

Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth

artículo científico publicado en 2009

Tuberculosis vaccines: current status and future prospects

artículo científico publicado en 2006

Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection

artículo científico publicado en 2005

VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy.

artículo científico publicado en 2018

Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians

artículo científico publicado en 2003

World TB Day 2018: The Challenge of Drug Resistant Tuberculosis

artículo científico publicado en 2018

Lista de obras de Helen Fletcher

A New Vaccine for Tuberculosis: The Challenges of Development and Deployment

A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults

A comparison of IFNgamma detection methods used in tuberculosis vaccine trials

A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB pathogenesis

A molecular assay for sensitive detection of pathogen-specific T-cells

A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis

Adaption of the ex vivo mycobacterial growth inhibition assay for use with murine lung cells

Association of Human Antibodies to Arabinomannan With Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction

Big Data in Vaccinology: Introduction and section summaries

Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1.

Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials

Cholera toxin enhances vaccine-induced protection against Mycobacterium tuberculosis challenge in mice

Comparing human T cell and NK cell responses in viral-based malaria vaccine trials

Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery

Correlates of immune protection from tuberculosis

Corrigendum to “MIG (CXCL9) is a more sensitive measure than IFN-γ of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines” [J. Immunol. Methods 340 (2009) 33–41].

Corrigendum: T-cell activation is an immune correlate of risk in BCG vaccinated infants

Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques

Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes

Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design

Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults

Evaluation of a human BCG challenge model to assess antimycobacterial immunity induced by BCG and a candidate tuberculosis vaccine, MVA85A, alone and in combination

Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal

Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model

High monocyte to lymphocyte ratio is associated with impaired protection after subcutaneous administration of BCG in a mouse model of tuberculosis

Historical BCG vaccination combined with drug treatment enhances inhibition of mycobacterial growth ex vivo in human peripheral blood cells

Human biomarkers: can they help us to develop a new tuberculosis vaccine?

Identification of Pneumocystis carinii DNA by polymerase chain reaction in necropsy lung samples from children dying of respiratory tract illnesses

Identification of Pneumocystis carinii DNA in oropharyngeal mouth washes from AIDS children dying of respiratory illnesses

Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations

Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation.

Individual-level factors associated with variation in mycobacterial-specific immune response: Gender and previous BCG vaccination status

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response

Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG.

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines

Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A

Investments in tuberculosis research - what are the gaps?

MIG (CXCL9) is a more sensitive measure than IFN-gamma of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines

MIG and the regulatory cytokines IL-10 and TGF-β1 correlate with malaria vaccine immunogenicity and efficacy

Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians

Mycobacterial growth inhibition in murine splenocytes as a surrogate for protection against Mycobacterium tuberculosis (M. tb).

Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data

Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines

Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants

Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1.

Process of assay selection and optimization for the study of case and control samples from a phase IIb efficacy trial of a candidate tuberculosis vaccine, MVA85A

Profiling the host immune response to tuberculosis vaccines

Profiling the host response to malaria vaccination and malaria challenge

Progress and challenges in TB vaccine development

Quantitative PCR evaluation of cellular immune responses in Kenyan children vaccinated with a candidate malaria vaccine

Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy

Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis

Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A.

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa

Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A

Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa

Sensitivity of IFN-gamma release assay to detect latent tuberculosis infection is retained in HIV-infected patients but dependent on HIV/AIDS progression

Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A

Single nucleotide polymorphisms in the Toll-like receptor 3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccine

Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine

Social determinants and BCG efficacy: a call for a socio-biological approach to TB prevention.

Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points

T-Cell Responses Are Associated with Survival in Acute Melioidosis Patients

T-cell activation is an immune correlate of risk in BCG vaccinated infants

TB vaccine development and the End TB Strategy: importance and current status.

TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'.

Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A

The <i>in vitro</i> direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human primate cells

The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV-infected postpartum women

The convergent epidemiology of tuberculosis and human cytomegalovirus infection.

The prospective evaluation of a nested polymerase chain reaction assay for the early detection of Aspergillus infection in patients with leukaemia or undergoing allograft treatment

The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children

Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model

Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth

Tuberculosis vaccines: current status and future prospects

Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection