Lista de obras - W David Wilson - Dominio Público Uruguay

A New Generation of Minor-Groove-Binding-Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context

scientific article published on 07 March 2019

A modular design for minor groove binding and recognition of mixed base pair sequences of DNA.

artículo científico publicado en 2017

A novel approach using electrospray ionization mass spectrometry to study competitive binding of small molecules with mixed DNA sequences.

artículo científico publicado en 2014

A short DNA sequence confers strong bleomycin binding to hairpin DNAs

artículo científico publicado en 2014

AzaHx, a novel fluorescent, DNA minor groove and G·C recognition element: Synthesis and DNA binding properties of a p-anisyl-4-aza-benzimidazole-pyrrole-imidazole (azaHx-PI) polyamide.

artículo científico publicado en 2015

Binding to the DNA Minor Groove by Heterocyclic Dications: From AT‐Specific Monomers to GC Recognition with Dimers ⬇️

artículo científico publicado el 1 de diciembre de 2012

Bound Compound, Interfacial Water, and Phenyl Ring Rotation Dynamics of a Compound in the DNA Minor Groove

scientific article published on 09 August 2018

Compound Shape Effects in Minor Groove Binding Affinity and Specificity for Mixed Sequence DNA

article

Correlation of local effects of DNA sequence and position of β-alanine inserts with polyamide-DNA complex binding affinities and kinetics.

artículo científico publicado en 2012

DNA Binding Polyamides and the Importance of DNA Recognition in their use as Gene-Specific and Antiviral Agents

artículo científico publicado en 2014

DNA-Binding Properties of New Fluorescent AzaHx Amides: Methoxypyridylazabenzimidazolepyrroleimidazole/pyrrole

artículo científico publicado en 2018

Design and synthesis of heterocyclic cations for specific DNA recognition: from AT-rich to mixed-base-pair DNA sequences

artículo científico publicado en 2014

Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides

artículo científico publicado en 2013

Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature

artículo científico publicado en 2013

Discovery of new G-quadruplex binding chemotypes

artículo científico publicado en 2014

Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide

artículo científico publicado en 2018

Extending the σ-Hole Motif for Sequence-Specific Recognition of the DNA Minor Groove

scientific article published on 15 April 2020

First Structure of a Designed Minor Groove Binding Heterocyclic Cation that Specifically Recognizes Mixed DNA Base Pair Sequences.

artículo científico publicado en 2017

Green fluorescent diamidines as diagnostic probes for trypanosomes

artículo científico publicado en 2013

Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model

artículo científico publicado en 2019

Hx-amides: DNA sequence recognition by the fluorescent Hx (p-anisylbenzimidazole)•pyrrole and Hx•imidazole pairings.

artículo científico publicado en 2013

Imino proton NMR guides the reprogramming of A•T specific minor groove binders for mixed base pair recognition.

artículo científico publicado en 2016

Lithium Hexamethyldisilazane Transformation of Transiently Protected 4-Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation

artículo científico publicado en 2016

May the Best Molecule Win: Competition ESI Mass Spectrometry

artículo científico publicado en 2015

Mechanistic heterogeneity in site recognition by the structurally homologous DNA-binding domains of the ETS family transcription factors Ets-1 and PU.1.

artículo científico publicado en 2014

Mixed up minor groove binders: Convincing A·T specific compounds to recognize a G·C base pair

artículo científico publicado en 2015

Modulation of DNA-polyamide interaction by β-alanine substitutions: a study of positional effects on binding affinity, kinetics and thermodynamics.

artículo científico publicado en 2014

Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide

artículo científico publicado en 2016

Molecular Basis for Sequence-Dependent Induced DNA Bending

artículo científico publicado en 2013

Novel amidines and analogues as promising agents against intracellular parasites: a systematic review

artículo científico publicado en 2013

Probing the electrostatics and pharmacological modulation of sequence-specific binding by the DNA-binding domain of the ETS family transcription factor PU.1: a binding affinity and kinetics investigation

artículo científico publicado en 2013

Quantitative Investigation of Protein-Nucleic Acid Interactions by Biosensor Surface Plasmon Resonance.

artículo científico publicado en 2015

Resolution of mixed site DNA complexes with dimer-forming minor-groove binders by using electrospray ionization mass spectrometry: compound structure and DNA sequence effects

artículo científico publicado en 2015

Second Generation G-Quadruplex Stabilizing Trimethine Cyanines

scientific article published on 26 September 2019

Selective G-quadruplex DNA recognition by a new class of designed cyanines

artículo científico publicado en 2013

Small-molecule Binding to the DNA Minor Groove Is Mediated by a Conserved Water Cluster ⬇️

artículo científico publicado el 16 de enero de 2013

Strand invasion of DNA quadruplexes by PNA: comparison of homologous and complementary hybridization.

artículo científico publicado en 2013

Structure-based design of flavone derivatives as c-myc oncogene down-regulators

artículo científico publicado en 2012

Structure-dependent binding of arylimidamides to the DNA minor groove

artículo científico publicado en 2013

Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines

scientific article published on 23 October 2013

Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues

artículo científico publicado en 2013

Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI.

artículo científico publicado en 2016

Systematic synthetic and biophysical development of mixed sequence DNA binding agents.

artículo científico publicado en 2016

The Thiophene "Sigma-Hole" as a Concept for Preorganized, Specific Recognition of G⋅C Base Pairs in the DNA Minor Groove

artículo científico publicado en 2016

The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine

artículo científico publicado en 2014

Understanding mixed sequence DNA recognition by novel designed compounds: the kinetic and thermodynamic behavior of azabenzimidazole diamidines

artículo científico publicado en 2014

Unexpected DNA Affinity and Sequence Selectivity through Core Rigidity in Guanidinium-Based Minor Groove Binders

artículo científico publicado en 2014

YM155 inhibits topoisomerase function

artículo científico publicado en 2016

Lista de obras de W David Wilson

A New Generation of Minor-Groove-Binding-Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context

A modular design for minor groove binding and recognition of mixed base pair sequences of DNA.

A novel approach using electrospray ionization mass spectrometry to study competitive binding of small molecules with mixed DNA sequences.

A short DNA sequence confers strong bleomycin binding to hairpin DNAs

AzaHx, a novel fluorescent, DNA minor groove and G·C recognition element: Synthesis and DNA binding properties of a p-anisyl-4-aza-benzimidazole-pyrrole-imidazole (azaHx-PI) polyamide.

Binding to the DNA Minor Groove by Heterocyclic Dications: From AT‐Specific Monomers to GC Recognition with Dimers ⬇️

Bound Compound, Interfacial Water, and Phenyl Ring Rotation Dynamics of a Compound in the DNA Minor Groove

Compound Shape Effects in Minor Groove Binding Affinity and Specificity for Mixed Sequence DNA

Correlation of local effects of DNA sequence and position of β-alanine inserts with polyamide-DNA complex binding affinities and kinetics.

DNA Binding Polyamides and the Importance of DNA Recognition in their use as Gene-Specific and Antiviral Agents

DNA-Binding Properties of New Fluorescent AzaHx Amides: Methoxypyridylazabenzimidazolepyrroleimidazole/pyrrole

Design and synthesis of heterocyclic cations for specific DNA recognition: from AT-rich to mixed-base-pair DNA sequences

Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides

Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature

Discovery of new G-quadruplex binding chemotypes

Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide

Extending the σ-Hole Motif for Sequence-Specific Recognition of the DNA Minor Groove

First Structure of a Designed Minor Groove Binding Heterocyclic Cation that Specifically Recognizes Mixed DNA Base Pair Sequences.

Green fluorescent diamidines as diagnostic probes for trypanosomes

Heterocyclic Diamidine DNA Ligands as HOXA9 Transcription Factor Inhibitors: Design, Molecular Evaluation, and Cellular Consequences in a HOXA9-Dependant Leukemia Cell Model

Hx-amides: DNA sequence recognition by the fluorescent Hx (p-anisylbenzimidazole)•pyrrole and Hx•imidazole pairings.

Imino proton NMR guides the reprogramming of A•T specific minor groove binders for mixed base pair recognition.

Lithium Hexamethyldisilazane Transformation of Transiently Protected 4-Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation

May the Best Molecule Win: Competition ESI Mass Spectrometry

Mechanistic heterogeneity in site recognition by the structurally homologous DNA-binding domains of the ETS family transcription factors Ets-1 and PU.1.

Mixed up minor groove binders: Convincing A·T specific compounds to recognize a G·C base pair

Modulation of DNA-polyamide interaction by β-alanine substitutions: a study of positional effects on binding affinity, kinetics and thermodynamics.

Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide

Molecular Basis for Sequence-Dependent Induced DNA Bending

Novel amidines and analogues as promising agents against intracellular parasites: a systematic review

Probing the electrostatics and pharmacological modulation of sequence-specific binding by the DNA-binding domain of the ETS family transcription factor PU.1: a binding affinity and kinetics investigation

Quantitative Investigation of Protein-Nucleic Acid Interactions by Biosensor Surface Plasmon Resonance.

Resolution of mixed site DNA complexes with dimer-forming minor-groove binders by using electrospray ionization mass spectrometry: compound structure and DNA sequence effects

Second Generation G-Quadruplex Stabilizing Trimethine Cyanines

Selective G-quadruplex DNA recognition by a new class of designed cyanines

Small-molecule Binding to the DNA Minor Groove Is Mediated by a Conserved Water Cluster ⬇️

Strand invasion of DNA quadruplexes by PNA: comparison of homologous and complementary hybridization.

Structure-based design of flavone derivatives as c-myc oncogene down-regulators

Structure-dependent binding of arylimidamides to the DNA minor groove

Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines

Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues

Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI.

Systematic synthetic and biophysical development of mixed sequence DNA binding agents.

The Thiophene "Sigma-Hole" as a Concept for Preorganized, Specific Recognition of G⋅C Base Pairs in the DNA Minor Groove

The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine

Understanding mixed sequence DNA recognition by novel designed compounds: the kinetic and thermodynamic behavior of azabenzimidazole diamidines

Unexpected DNA Affinity and Sequence Selectivity through Core Rigidity in Guanidinium-Based Minor Groove Binders

YM155 inhibits topoisomerase function