Lista de obras - Bruno Sepodes - Dominio Público Uruguay

Advanced Therapy Medicinal Products for Rare Diseases: State of Play of Incentives Supporting Development in Europe

artículo científico publicado en 2017

Alginate films containing Lactobacillus plantarum as wound dressing for prevention of burn infection

scientific article published on 13 October 2011

Animal models for metabolic, neuromuscular and ophthalmological rare diseases.

artículo científico

Anti-Inflammatory Effect of Erythropoietin in the TNBS-induced Colitis.

artículo científico publicado en 2016

Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis

artículo científico publicado en 2019

Anti-inflammatory effect of lycopene on carrageenan-induced paw oedema and hepatic ischaemia-reperfusion in the rat.

artículo científico publicado en 2009

Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation

artículo científico publicado en 2014

Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats

artículo científico publicado en 2010

Are Novel, Nonrandomized Analytic Methods Fit for Decision Making? The Need for Prospective, Controlled, and Transparent Validation

artículo científico publicado en 2019

Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study.

artículo científico publicado en 2009

Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis.

artículo científico publicado en 2014

Clinical trials for Covid-19: can we better use the short window of opportunity?

artículo científico publicado en 2020

Comparative analysis of the scope of European Union paediatric investigation plans with corresponding orphan designations

artículo científico publicado en 2017

Defining orphan conditions in the context of the European orphan regulation: challenges and evolution

article

Demonstrating significant benefit of orphan medicines: analysis of 15 years of experience in Europe

artículo científico publicado en 2017

Development of Exon Skipping Therapies for Duchenne Muscular Dystrophy: A Critical Review and a Perspective on the Outstanding Issues.

artículo científico publicado en 2017

Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities.

artículo científico publicado en 2017

Effects of diethyldithiocarbamate (DETC) on liver injury induced by ischemia-reperfusion in rats

artículo científico publicado en 2007

Erratum to: Establishing medical plausibility in the context of orphan medicines designation in the European Union

artículo científico publicado en 2015

Erythropoietin preserves the integrity and quality of organs for transplantation after cardiac death

artículo científico publicado en 2011

Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat.

artículo científico publicado en 2015

Establishing medical plausibility in the context of orphan medicines designation in the European Union.

artículo científico publicado en 2014

Establishing rarity in the context of orphan medicinal product designation in the European Union

artículo científico publicado en 2017

European regulation on orphan medicinal products: 10 years of experience and future perspectives

artículo científico publicado en 2011

Evaluation of cardiovascular protective effect of different apple varieties – Correlation of response with composition

article

Evolving prevalence of haematological malignancies in orphan designation procedures in the European Union

artículo científico publicado en 2017

Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats

artículo científico publicado en 2008

Exercise training is associated with improved levels of C-reactive protein and adiponectin in ZDF (type 2) diabetic rats

artículo científico publicado en 2007

Hemin reduces inflammation associated with TNBS-induced colitis

artículo científico publicado en 2018

Hurdles in gene therapy regulatory approval: a retrospective analysis of European Marketing Authorization Applications

scientific article published on 21 December 2018

In vivo anti-inflammatory effect and toxicological screening of Maytenus heterophylla and Maytenus senegalensis extracts.

artículo científico publicado en 2010

Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat.

artículo científico publicado en 2015

Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion

artículo científico publicado en 2014

Nonclinical data supporting orphan medicinal product designations in the area of rare infectious diseases

scientific article published on 05 November 2019

Nonclinical data supporting orphan medicinal product designations: lessons from rare neurological conditions

artículo científico publicado en 2017

Optimising bench science to withstand regulatory scrutiny

artículo científico publicado en 2018

PO9-243 EXERCISE TRAINING AND THE INFLAMMATORY RESPONSE IN ZDF (TYPE 2) DIABETIC RATS

Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability

scientific article published on 22 June 2019

Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat.

artículo científico publicado en 2016

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis

article

Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock.

artículo científico publicado en 2010

Recombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat

artículo científico publicado en 2006

Red Raspberry Phenols Inhibit Angiogenesis: A Morphological and Subcellular Analysis Upon Human Endothelial Cells

artículo científico publicado en 2015

Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice

scientific article published on 06 June 2019

Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice

scientific article published on 22 August 2019

Regulation Of Orphan Medicinal Products In Europe: History Trends And Challenges.

artículo científico publicado en 2016

Regulatory and Scientific Advancements in Gene Therapy: State-of-the-Art of Clinical Applications and of the Supporting European Regulatory Framework.

artículo científico publicado en 2017

Regulatory watch: The orphan drug pipeline in Europe.

artículo científico publicado en 2016

Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice

artículo científico publicado en 2009

Stakeholder cooperation to overcome challenges in orphan medicine development: the example of Duchenne muscular dystrophy.

artículo científico publicado en 2016

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

artículo científico publicado en 2015

TDZD-8 pre-treatment in transient middle cerebral artery occlusion

scholarly article published October 2014

Tempol, an intracelullar free radical scavenger, reduces liver injury in hepatic ischemia-reperfusion in the rat.

artículo científico publicado en 2004

The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat.

artículo científico publicado en 2002

Thiadiazolidinone-8 Ameliorates Inflammation Associated with Experimental Colitis in Mice

artículo científico publicado en 2017

Use of biomarkers in the context of orphan medicines designation in the European Union

artículo científico publicado en 2014

Worldwide collaboration for orphan drug designation

artículo científico publicado en 2016

Lista de obras de Bruno Sepodes

Advanced Therapy Medicinal Products for Rare Diseases: State of Play of Incentives Supporting Development in Europe

Alginate films containing Lactobacillus plantarum as wound dressing for prevention of burn infection

Animal models for metabolic, neuromuscular and ophthalmological rare diseases.

Anti-Inflammatory Effect of Erythropoietin in the TNBS-induced Colitis.

Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis

Anti-inflammatory effect of lycopene on carrageenan-induced paw oedema and hepatic ischaemia-reperfusion in the rat.

Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation

Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats

Are Novel, Nonrandomized Analytic Methods Fit for Decision Making? The Need for Prospective, Controlled, and Transparent Validation

Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study.

Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis.

Clinical trials for Covid-19: can we better use the short window of opportunity?

Comparative analysis of the scope of European Union paediatric investigation plans with corresponding orphan designations

Defining orphan conditions in the context of the European orphan regulation: challenges and evolution

Demonstrating significant benefit of orphan medicines: analysis of 15 years of experience in Europe

Development of Exon Skipping Therapies for Duchenne Muscular Dystrophy: A Critical Review and a Perspective on the Outstanding Issues.

Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities.

Effects of diethyldithiocarbamate (DETC) on liver injury induced by ischemia-reperfusion in rats

Erratum to: Establishing medical plausibility in the context of orphan medicines designation in the European Union

Erythropoietin preserves the integrity and quality of organs for transplantation after cardiac death

Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat.

Establishing medical plausibility in the context of orphan medicines designation in the European Union.

Establishing rarity in the context of orphan medicinal product designation in the European Union

European regulation on orphan medicinal products: 10 years of experience and future perspectives

Evaluation of cardiovascular protective effect of different apple varieties – Correlation of response with composition

Evolving prevalence of haematological malignancies in orphan designation procedures in the European Union

Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats

Exercise training is associated with improved levels of C-reactive protein and adiponectin in ZDF (type 2) diabetic rats

Hemin reduces inflammation associated with TNBS-induced colitis

Hurdles in gene therapy regulatory approval: a retrospective analysis of European Marketing Authorization Applications

In vivo anti-inflammatory effect and toxicological screening of Maytenus heterophylla and Maytenus senegalensis extracts.

Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat.

Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion

Nonclinical data supporting orphan medicinal product designations in the area of rare infectious diseases

Nonclinical data supporting orphan medicinal product designations: lessons from rare neurological conditions

Optimising bench science to withstand regulatory scrutiny

PO9-243 EXERCISE TRAINING AND THE INFLAMMATORY RESPONSE IN ZDF (TYPE 2) DIABETIC RATS

Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability

Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat.

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis

Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock.

Recombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat

Red Raspberry Phenols Inhibit Angiogenesis: A Morphological and Subcellular Analysis Upon Human Endothelial Cells

Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice

Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice

Regulation Of Orphan Medicinal Products In Europe: History Trends And Challenges.

Regulatory and Scientific Advancements in Gene Therapy: State-of-the-Art of Clinical Applications and of the Supporting European Regulatory Framework.

Regulatory watch: The orphan drug pipeline in Europe.

Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice

Stakeholder cooperation to overcome challenges in orphan medicine development: the example of Duchenne muscular dystrophy.

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

TDZD-8 pre-treatment in transient middle cerebral artery occlusion

Tempol, an intracelullar free radical scavenger, reduces liver injury in hepatic ischemia-reperfusion in the rat.

The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat.

Thiadiazolidinone-8 Ameliorates Inflammation Associated with Experimental Colitis in Mice

Use of biomarkers in the context of orphan medicines designation in the European Union

Worldwide collaboration for orphan drug designation