Lista de obras - Leonardo Pardo - Dominio Público Uruguay

3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT(4) receptor

artículo científico publicado en 2001

A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.

artículo científico publicado en 2012

A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist.

artículo científico publicado en 2002

A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor

artículo científico publicado en 2001

A molecular dissection of the glycoprotein hormone receptors.

artículo científico publicado en 2004

A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.

artículo científico publicado en 2017

A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors.

artículo científico publicado en 2015

A structural insight into the reorientation of transmembrane domains 3 and 5 during family A G protein-coupled receptor activation

artículo científico publicado en 2010

A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

artículo científico publicado en 2005

Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.

artículo científico publicado en 2002

Activation of the mu opioid receptor involves conformational rearrangements of multiple transmembrane domains

artículo científico publicado en 2008

An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor

artículo científico publicado en 2005

Analysis of the interactions of sulfur-containing amino acids in membrane proteins

artículo científico publicado en 2016

Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

artículo científico publicado en 2010

Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists

artículo científico publicado en 2002

Benzimidazole derivatives. 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists

artículo científico publicado en 2003

Binding of proteins to the minor groove of DNA: what are the structural and energetic determinants for kinking a basepair step?

artículo científico publicado en 2003

Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance

artículo científico publicado en 2007

Chemical probes for the recognition of cannabinoid receptors in native systems

artículo científico publicado en 2012

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors

artículo científico publicado en 2015

Comparison of sucralfate and ranitidine in the treatment of duodenal ulcers

artículo científico publicado en 1991

Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors

artículo científico publicado en 2009

Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors

artículo científico publicado en 2007

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

artículo científico publicado en 2012

Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.

artículo científico publicado en 2003

Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor.

artículo científico publicado en 2002

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

artículo científico publicado en 2016

Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy

artículo científico publicado en 2011

Dihydro-beta-agarofuran sesquiterpenes: a new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania.

artículo científico publicado en 2005

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

artículo científico publicado en 2018

Experimental and theoretical characterization of the high-affinity cation-binding site of the purple membrane.

artículo científico publicado en 1998

Functional elements of the gastric inhibitory polypeptide receptor: Comparison between secretin- and rhodopsin-like G protein-coupled receptors

artículo científico publicado en 2015

GPCRtm: An amino acid substitution matrix for the transmembrane region of class A G Protein-Coupled Receptors

artículo científico publicado en 2015

Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity

artículo científico publicado en 2003

Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding

artículo científico publicado en 2006

Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.

artículo científico publicado en 2011

Identification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of calcineurin binding partners.

artículo científico publicado en 2015

Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome

scientific article published on 01 January 2008

Impact of helix irregularities on sequence alignment and homology modeling of G protein-coupled receptors

artículo científico

Influence of the g- conformation of Ser and Thr on the structure of transmembrane helices

artículo científico publicado en 2009

Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers

artículo científico publicado en 2010

Ligand binding determinants for angiotensin II type 1 receptor from computer simulations

artículo científico publicado en 2013

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

artículo científico publicado en 2010

Linking agonist binding to histamine H1 receptor activation

artículo científico publicado en 2005

Lysine 183 and glutamic acid 157 of the TSH receptor: two interacting residues with a key role in determining specificity toward TSH and human CG.

artículo científico publicado en 2002

Membrane Protein Simulations Using AMBER Force Field and Berger Lipid Parameters

Modeling of G protein-coupled receptors using crystal structures: from monomers to signaling complexes

artículo científico publicado en 2014

Modulation of ligand selectivity associated with activation of the transmembrane region of the human follitropin receptor.

artículo científico publicado en 2004

Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen Atoms

artículo científico publicado en 2015

Molecular Determinants of MAO Selectivity in a Series of Indolylmethylamine Derivatives: Biological Activities, 3D-QSAR/CoMFA Analysis, and Computational Simulation of Ligand Recognition

artículo científico publicado en 2000

Molecular basis of ligand dissociation in β-adrenergic receptors

artículo científico publicado en 2011

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

artículo científico publicado en 2011

On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2

artículo científico publicado en 2006

On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors ⬇️

artículo científico publicado el 1 de mayo de 1992

Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives

artículo científico publicado en 2003

Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity.

artículo científico publicado en 2007

Progressive DNA bending is made possible by gradual changes in the torsion angle of the glycosyl bond.

artículo científico publicado en 1998

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.

artículo científico publicado en 2016

Relation between sequence and structure in membrane proteins.

artículo científico publicado en 2013

SAR studies of dihydro-beta-agarofuran sesquiterpenes as inhibitors of the multidrug-resistance phenotype in a Leishmania tropica line overexpressing a P-glycoprotein-like transporter.

artículo científico publicado en 2004

Selective binding of the TATA box-binding protein to the TATA box-containing promoter: analysis of structural and energetic factors

artículo científico publicado en 1998

Ser and Thr residues modulate the conformation of pro-kinked transmembrane alpha-helices

artículo científico publicado en 2004

Serine and threonine residues bend alpha-helices in the chi(1) = g(-) conformation.

artículo científico publicado en 2000

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease

artículo científico publicado en 2014

Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands

scientific article published in Journal of Biological Chemistry

Structural models of class a G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity

artículo científico publicado en 2007

Structural-functional analysis of the third transmembrane domain of the corticotropin-releasing factor type 1 receptor: role in activation and allosteric antagonism

artículo científico publicado en 2014

Structure and activity of membrane receptors: Modeling and computational simulation of ligand recognition in a three-dimensional model of the 5-hydroxytryptamine1A receptor

scientific article published on 01 April 1996

Sucralfate versus ranitidine in the treatment of gastric ulcer

scientific article published on 01 June 1989

Synthesis and pharmacophore modeling of naphthoquinone derivatives with cytotoxic activity in human promyelocytic leukemia HL-60 cell line

artículo científico publicado en 2007

Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors

artículo científico publicado en 2005

Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity

artículo científico publicado en 2009

TMalphaDB and TMbetaDB: web servers to study the structural role of sequence motifs in α-helix and β-barrel domains of membrane proteins

artículo científico publicado en 2015

The Cloned Equine Thyrotropin Receptor Is Hypersensitive to Human Chorionic Gonadotropin; Identification of Three Residues in the Extracellular Domain Involved in Ligand Specificity

artículo científico publicado en 2008

The G-protein coupled receptor family: actors with many faces

artículo científico publicado en 2012

The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain.

artículo científico publicado en 2013

The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation

artículo científico publicado en 2001

The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin

artículo científico publicado en 2007

The coexistence of a novel inactivating mutant thyrotropin receptor allele with two thyroid peroxidase mutations: a genotype-phenotype correlation

artículo científico publicado en 2011

The effect of the molecular mechanism of G protein-coupled receptor activation on the process of signal transduction ⬇️

artículo científico publicado el 17 de septiembre de 1997

The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.

artículo científico publicado en 2014

The mutational landscape of human olfactory G protein-coupled receptors

artículo científico publicado en 2021

The pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor

artículo científico publicado en 2016

The role of hydrophobic amino acids in the structure and function of the rhodopsin family of G protein-coupled receptors

artículo científico publicado en 2013

The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptors

artículo científico publicado en 2007

The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions

artículo científico publicado en 2005

The specificity of binding of glycoprotein hormones to their receptors

artículo científico publicado en 2008

Theoretical studies on the histamine H2 receptor: construction of a receptor model based on the structural properties of dimaprit and N alpha-guanylhistamine

scientific article published on 01 December 1991

Theoretical studies on the histamine H2 receptor: molecular mechanism of action of antagonists ⬇️

artículo científico publicado el 1 de agosto de 1992

[The nature of drug consumption in Spain in the last 10 years]

artículo científico publicado en 1983

Lista de obras de Leonardo Pardo

3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT(4) receptor

A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.

A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist.

A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor

A molecular dissection of the glycoprotein hormone receptors.

A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.

A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors.

A structural insight into the reorientation of transmembrane domains 3 and 5 during family A G protein-coupled receptor activation

A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.

Activation of the mu opioid receptor involves conformational rearrangements of multiple transmembrane domains

An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor

Analysis of the interactions of sulfur-containing amino acids in membrane proteins

Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists

Benzimidazole derivatives. 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists

Binding of proteins to the minor groove of DNA: what are the structural and energetic determinants for kinking a basepair step?

Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance

Chemical probes for the recognition of cannabinoid receptors in native systems

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors

Comparison of sucralfate and ranitidine in the treatment of duodenal ulcers

Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors

Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.

Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor.

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

Development of non-peptide ligands of growth factor receptor-bound protein 2-SRC homology 2 domain using molecular modeling and NMR spectroscopy

Dihydro-beta-agarofuran sesquiterpenes: a new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania.

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

Experimental and theoretical characterization of the high-affinity cation-binding site of the purple membrane.

Functional elements of the gastric inhibitory polypeptide receptor: Comparison between secretin- and rhodopsin-like G protein-coupled receptors

GPCRtm: An amino acid substitution matrix for the transmembrane region of class A G Protein-Coupled Receptors

Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity

Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding

Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.

Identification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of calcineurin binding partners.

Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome

Impact of helix irregularities on sequence alignment and homology modeling of G protein-coupled receptors

Influence of the g- conformation of Ser and Thr on the structure of transmembrane helices

Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers

Ligand binding determinants for angiotensin II type 1 receptor from computer simulations

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

Linking agonist binding to histamine H1 receptor activation

Lysine 183 and glutamic acid 157 of the TSH receptor: two interacting residues with a key role in determining specificity toward TSH and human CG.

Membrane Protein Simulations Using AMBER Force Field and Berger Lipid Parameters

Modeling of G protein-coupled receptors using crystal structures: from monomers to signaling complexes

Modulation of ligand selectivity associated with activation of the transmembrane region of the human follitropin receptor.

Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen Atoms

Molecular Determinants of MAO Selectivity in a Series of Indolylmethylamine Derivatives: Biological Activities, 3D-QSAR/CoMFA Analysis, and Computational Simulation of Ligand Recognition

Molecular basis of ligand dissociation in β-adrenergic receptors

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2

On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors ⬇️

Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives

Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity.

Progressive DNA bending is made possible by gradual changes in the torsion angle of the glycosyl bond.

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.

Relation between sequence and structure in membrane proteins.

SAR studies of dihydro-beta-agarofuran sesquiterpenes as inhibitors of the multidrug-resistance phenotype in a Leishmania tropica line overexpressing a P-glycoprotein-like transporter.

Selective binding of the TATA box-binding protein to the TATA box-containing promoter: analysis of structural and energetic factors

Ser and Thr residues modulate the conformation of pro-kinked transmembrane alpha-helices

Serine and threonine residues bend alpha-helices in the chi(1) = g(-) conformation.

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease

Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands

Structural models of class a G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity

Structural-functional analysis of the third transmembrane domain of the corticotropin-releasing factor type 1 receptor: role in activation and allosteric antagonism

Structure and activity of membrane receptors: Modeling and computational simulation of ligand recognition in a three-dimensional model of the 5-hydroxytryptamine1A receptor

Sucralfate versus ranitidine in the treatment of gastric ulcer

Synthesis and pharmacophore modeling of naphthoquinone derivatives with cytotoxic activity in human promyelocytic leukemia HL-60 cell line

Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors

Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity

TMalphaDB and TMbetaDB: web servers to study the structural role of sequence motifs in α-helix and β-barrel domains of membrane proteins

The Cloned Equine Thyrotropin Receptor Is Hypersensitive to Human Chorionic Gonadotropin; Identification of Three Residues in the Extracellular Domain Involved in Ligand Specificity

The G-protein coupled receptor family: actors with many faces

The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain.

The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation

The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin

The coexistence of a novel inactivating mutant thyrotropin receptor allele with two thyroid peroxidase mutations: a genotype-phenotype correlation