Lista de obras - Steven Molinski - Dominio Público Uruguay

Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface

artículo científico publicado en 2016

Biophysical Approaches Facilitate Computational Drug Discovery for ATP-Binding Cassette Proteins.

artículo científico publicado en 2017

Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site.

artículo científico publicado en 2018

Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474.

artículo científico publicado en 2016

Conformational defects underlie proteasomal degradation of Dent's disease-causing mutants of ClC-5

artículo científico publicado en 2013

Correctors of the major Cystic Fibrosis mutant interact through membrane spanning domains.

artículo científico publicado en 2018

Facilitating Structure-Function Studies of CFTR Modulator Sites with Efficiencies in Mutagenesis and Functional Screening.

artículo científico publicado en 2015

Functional Rescue of F508del-CFTR Using Small Molecule Correctors

artículo científico publicado en 2012

Genetic, cell biological, and clinical interrogation of the CFTR mutation c.3700 A>G (p.Ile1234Val) informs strategies for future medical intervention.

artículo científico publicado en 2014

Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics

artículo científico publicado en 2017

Identification and validation of hits from high throughput screens for CFTR modulators

artículo científico publicado en 2012

Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial

artículo científico publicado en 2006

Mammalian multidrug-resistance proteins (MRPs).

artículo científico

Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue.

artículo científico publicado en 2017

Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia

artículo científico publicado en 2017

Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells

artículo científico publicado en 2007

Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity

artículo científico publicado en 2015

The Antiretroviral Agent Nelfinavir Mesylate: A Potential Therapy for Systemic Sclerosis.

artículo científico publicado en 2017

The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain.

artículo científico publicado en 2016

The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.

artículo científico publicado en 2014

VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface.

artículo científico publicado en 2014

Lista de obras de Steven Molinski

Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface

Biophysical Approaches Facilitate Computational Drug Discovery for ATP-Binding Cassette Proteins.

Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site.

Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474.

Conformational defects underlie proteasomal degradation of Dent's disease-causing mutants of ClC-5

Correctors of the major Cystic Fibrosis mutant interact through membrane spanning domains.

Facilitating Structure-Function Studies of CFTR Modulator Sites with Efficiencies in Mutagenesis and Functional Screening.

Functional Rescue of F508del-CFTR Using Small Molecule Correctors

Genetic, cell biological, and clinical interrogation of the CFTR mutation c.3700 A>G (p.Ile1234Val) informs strategies for future medical intervention.

Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics

Identification and validation of hits from high throughput screens for CFTR modulators

Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial

Mammalian multidrug-resistance proteins (MRPs).

Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue.

Phenotypic profiling of CFTR modulators in patient-derived respiratory epithelia

Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells

Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity

The Antiretroviral Agent Nelfinavir Mesylate: A Potential Therapy for Systemic Sclerosis.

The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain.

The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.

VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface.