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Lista de obras de Helen Blackwell

2‐Aminobenzimidazole Derivatives Strongly Inhibit and Disperse Pseudomonas aeruginosa Biofilms ⬇️

artículo científico publicado el 5 de abril de 2012

A Comparative Analysis of Synthetic Quorum Sensing Modulators in Pseudomonas aeruginosa: New Insights into Mechanism, Active Efflux Susceptibility, Phenotypic Response, and Next-Generation Ligand Design

artículo científico publicado en 2015

A comparative study of non-native N-acyl l-homoserine lactone analogs in two Pseudomonas aeruginosa quorum sensing receptors that share a common native ligand yet inversely regulate virulence

scientific article published on 14 May 2018

A peptoid ribbon secondary structure

artículo científico publicado en 2013

A stoma care nurse specialist

artículo científico publicado en 2015

Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa.

artículo científico publicado en 2014

Application of Ring-Closing Metathesis to the Synthesis of Rigidified Amino Acids and Peptides

article

Attenuation of quorum sensing in the pathogen Acinetobacter baumannii using non-native N-Acyl homoserine lactones

artículo científico publicado en 2012

Attenuation of virulence in pathogenic bacteria using synthetic quorum-sensing modulators under native conditions on plant hosts

artículo científico publicado en 2011

Bacterial Quorum Sensing Signals Self-Assemble in Aqueous Media to Form Micelles and Vesicles: An Integrated Experimental and Molecular Dynamics Study

scientific article published on 09 April 2020

Bacterial crowd control with iron

scientific article published on 01 July 2005

Characterization of structural elements in native autoinducing peptides and non-native analogues that permit the differential modulation of AgrC-type quorum sensing receptors in Staphylococcus aureus

artículo científico publicado en 2015

Chemical Control of Quorum Sensing in E. coli: Identification of Small Molecule Modulators of SdiA and Mechanistic Characterization of a Covalent Inhibitor

artículo científico publicado en 2020

Chemical Genetics Reveals Environment-Specific Roles for Quorum Sensing Circuits in Pseudomonas aeruginosa.

artículo científico publicado en 2016

Chemical Interrogation of LuxR-type Quorum Sensing Receptors Reveals New Insights into Receptor Selectivity and the Potential for Interspecies Bacterial Signaling

artículo científico publicado en 2017

Chemical genetic approaches to plant biology

artículo científico publicado en 2003

Chemical methods to interrogate bacterial quorum sensing pathways

artículo científico publicado en 2012

Chemical modification of reactive multilayered films fabricated from poly(2-alkenyl azlactone)s: design of surfaces that prevent or promote mammalian cell adhesion and bacterial biofilm growth

artículo científico publicado en 2009

Chemical probes of quorum sensing: from compound development to biological discovery

artículo científico publicado en 2016

Comparative analyses of N-acylated homoserine lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing

artículo científico publicado en 2008

Competition studies confirm two major barriers that can preclude the spread of resistance to quorum-sensing inhibitors in bacteria

artículo científico publicado en 2014

Conformational Switch to a β-Turn in a Staphylococcal Quorum Sensing Signal Peptide Causes a Dramatic Increase in Potency

scientific article published on 02 January 2020

Construction of Peptoids with AllTrans-Amide Backbones and Peptoid Reverse Turns via the Tactical Incorporation ofN-Aryl Side Chains Capable of Hydrogen Bonding ⬇️

artículo científico publicado el 17 de septiembre de 2010

Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump

artículo científico publicado en 2007

Correction to "N-Acyl l-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in Pseudomonas aeruginosa"

scientific article published on 12 May 2020

Corrigendum: Active Efflux Influences the Potency of Quorum Sensing Inhibitors inPseudomonas aeruginosa

scholarly article published in ChemBioChem

Deciphering a protolanguage for bacteria-host communication.

artículo científico publicado en 2008

Decoding Products of Diversity Pathways from Stock Solutions Derived from Single Polymeric Macrobeads H.E.B. and L.P. contributed equally to this work. We thank the National Institute of General Medical Sciences (GM-52067) for the support of this re

Design and conformational analysis of peptoids containing N‐hydroxy amides reveals a unique sheet‐like secondary structure ⬇️

artículo científico publicado el 1 de enero de 2011

Design and synthesis of macrocyclic peptomers as mimics of a quorum sensing signal from Staphylococcus aureus

artículo científico publicado en 2008

Design, Synthesis, and Biochemical Characterization of Non-Native Antagonists of the Pseudomonas aeruginosa Quorum Sensing Receptor LasR with Nanomolar IC50 Values

artículo científico publicado en 2020

Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing

artículo científico publicado en 2011

Discovery of fluorescent cyanopyridine and deazalumazine dyes using small molecule macroarrays

artículo científico publicado en 2006

Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform

artículo científico publicado en 2002

Efficient construction of diketopiperazine macroarrays through a cyclative-cleavage strategy and their evaluation as luminescence inhibitors in the bacterial symbiont Vibrio fischeri

artículo científico publicado en 2009

Efficient synthesis and evaluation of quorum-sensing modulators using small molecule macroarrays

artículo científico publicado en 2009

Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators

artículo científico publicado en 2008

Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

artículo científico publicado en 2008

Expedient construction of small molecule macroarrays via sequential palladium- and copper-mediated reactions and their ex situ biological testing

artículo científico publicado en 2012

Expedient synthesis and design strategies for new peptoid construction

artículo científico publicado en 2005

Extraordinarily robust polyproline type I peptoid helices generated via the incorporation of α-chiral aromatic N-1-naphthylethyl side chains

artículo científico publicado en 2011

Healing the wounds

artículo científico publicado en 2007

Helping people who self-harm

artículo científico publicado en 2008

Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis

artículo científico publicado en 1998

Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus

artículo científico publicado en 2016

Highly potent inhibitors of quorum sensing in Staphylococcus aureus revealed through a systematic synthetic study of the group-III autoinducing peptide

artículo científico publicado en 2013

Hitting the SPOT: small-molecule macroarrays advance combinatorial synthesis

artículo científico publicado en 2006

Identification of Synthetic Inducers and Inhibitors of the Quorum-Sensing Regulator LasR in Pseudomonas aeruginosa by High-Throughput Screening ⬇️

artículo científico publicado el 8 de octubre de 2010

Identification of Unanticipated and Novel N-Acyl L-Homoserine Lactones (AHLs) Using a Sensitive Non-Targeted LC-MS/MS Method

artículo científico publicado en 2016

Implant-Associated Bacterial Biofilm and Quorum Sensing in Periprosthetic Joint Infections

artículo científico publicado en 2018

Improved Small-Molecule Macroarray Platform for the Rapid Synthesis and Discovery of Antibacterial Chalcones ⬇️

artículo científico publicado el 6 de enero de 2011

Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics

artículo científico publicado en 2006

Interkingdom Responses to Bacterial Quorum Sensing Signals Regulate Frequency and Rate of Nodulation in Legume-Rhizobia Symbiosis

artículo científico publicado en 2016

Introduction to Bacterial Signals and Chemical Communication ⬇️

artículo científico publicado el 12 de enero de 2011

Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum

artículo científico publicado en 2011

Liquid Crystal Emulsions that Intercept and Report on Bacterial Quorum Sensing

artículo científico publicado en 2020

Local and tunable n-->pi* interactions regulate amide isomerism in the peptoid backbone

artículo científico publicado en 2007

Mechanism of agonism and antagonism of the Pseudomonas aeruginosa quorum sensing regulator QscR with non-native ligands.

artículo científico publicado en 2018

Microwave-Facilitated SPOT-Synthesis of Antibacterial Dipeptoids

artículo científico publicado en 2017

Microwave-accelerated SPOT-synthesis on cellulose supports

artículo científico publicado en 2004

Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action

artículo científico publicado en 2007

Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by nonlactone ligands

artículo científico publicado en 2014

N-Acyl Homoserine Lactone Analog Modulators of the Pseudomonas aeruginosa Rhll Quorum Sensing Signal Synthase

scientific article published on 09 October 2019

N-Acyl l-Homocysteine Thiolactones Are Potent and Stable Synthetic Modulators of the RhlR Quorum Sensing Receptor in Pseudomonas aeruginosa

artículo científico publicado en 2019

N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus.

artículo científico publicado en 2014

N-[1-(Pentafluorophenyl)ethyl]acetamide

artículo científico publicado en 2006

N-phenylacetanoyl-L-homoserine lactones can strongly antagonize or superagonize quorum sensing in Vibrio fischeri

artículo científico publicado en 2007

Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus

artículo científico publicado en 2015

New and unexpected insights into the modulation of LuxR-type quorum sensing by cyclic dipeptides

artículo científico publicado en 2009

New strategies for the design of folded peptoids revealed by a survey of noncovalent interactions in model systems

artículo científico publicado en 2009

Non-native N-aroyl L-homoserine lactones are potent modulators of the quorum sensing receptor RpaR in Rhodopseudomonas palustris

artículo científico publicado en 2013

Non-native acylated homoserine lactones reveal that LuxIR quorum sensing promotes symbiont stability.

artículo científico publicado en 2013

Non-native autoinducer analogs capable of modulating the SdiA quorum sensing receptor in serovar Typhimurium

artículo científico publicado en 2018

Nonwoven Polymer Nanofiber Coatings That Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Nonbactericidal Approaches to Infection Control.

artículo científico publicado en 2017

Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis

artículo científico publicado en 2019

Out of the oil bath and into the oven--microwave-assisted combinatorial chemistry heats up.

artículo científico publicado en 2003

Plant responses to bacterial N-acyl L-homoserine lactones are dependent on enzymatic degradation to L-homoserine

artículo científico publicado en 2014

Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non-native Ligands: An Emerging Target for Virulence Control in Pseudomonas aeruginosa

artículo científico publicado en 2015

Potent and Selective Synthetic Modulators of a Quorum Sensing Repressor in Pseudomonas aeruginosa Identified from Second‐Generation Libraries of N‐Acylated L‐Homoserine Lactones ⬇️

artículo científico publicado el 11 de abril de 2011

Potent modulation of the CepR quorum sensing receptor and virulence in a Burkholderia cepacia complex member using non-native lactone ligands

artículo científico publicado en 2019

Quorum sensing in bacterial species that use degenerate autoinducers can be tuned by using structurally identical non-native ligands.

artículo científico publicado en 2011

Quorum-sensing signals in the microbial community of the cabbage white butterfly larval midgut

artículo científico publicado en 2008

Rapid identification of antibacterial agents effective against Staphylococcus aureus using small-molecule macroarrays

scientific article published on 01 April 2007

Rapid synthesis of diketopiperazine macroarrays via Ugi four-component reactions on planar solid supports

artículo científico publicado en 2006

SIR1, an upstream component in auxin signaling identified by chemical genetics

artículo científico publicado en 2003

Selection of appropriate autoinducer analogs for the modulation of quorum sensing at the host-bacteria interface

artículo científico publicado en 2018

Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors.

artículo científico publicado en 2016

Simplified Autoinducing Peptide Mimetics with Single-Nanomolar Activity Against the Staphylococcus aureus AgrC Quorum Sensing Receptor

scientific article published on 13 March 2019

Slippery Liquid-Infused Porous Surfaces that Prevent Bacterial Surface Fouling and Inhibit Virulence Phenotypes in Surrounding Planktonic Cells.

artículo científico publicado en 2016

Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach

artículo científico publicado en 2016

Small Molecules That Modulate Quorum Sensing and Control Virulence in Pseudomonas aeruginosa ⬇️

artículo científico publicado el 15 de octubre de 2010

Small molecule disruption of quorum sensing cross-regulation in pseudomonas aeruginosa causes major and unexpected alterations to virulence phenotypes

artículo científico publicado en 2015

Small molecule inhibitors of bacterial quorum sensing and biofilm formation

artículo científico publicado en 2005

Small molecule macroarray construction via Ugi four-component reactions

scientific article published on 01 September 2005

Small molecule macroarray construction via palladium-mediated carbon-carbon bond-forming reactions: highly efficient synthesis and screening of stilbene arrays

artículo científico publicado en 2010

Solid-phase and microwave-assisted syntheses of 2,5-diketopiperazines: small molecules with great potential

artículo científico publicado en 2007

Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR

artículo científico publicado en 2018

Structural characterization of native autoinducing peptides and abiotic analogues reveals key features essential for activation and inhibition of an AgrC quorum sensing receptor in Staphylococcus aureus

artículo científico publicado en 2013

Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor

artículo científico publicado en 2015

Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation

artículo científico publicado en 2016

Structure-Function Analyses of the N-Butanoyl l-Homoserine Lactone Quorum-Sensing Signal Define Features Critical to Activity in RhlR

scientific article published on 31 August 2018

Structure-function relationships in peptoids: recent advances toward deciphering the structural requirements for biological function

scientific article published on 11 February 2009

Surface coatings that promote rapid release of peptide-based AgrC inhibitors for attenuation of quorum sensing in Staphylococcus aureus

artículo científico publicado en 2013

Surface-mediated release of a small-molecule modulator of bacterial biofilm formation: a non-bactericidal approach to inhibiting biofilm formation in Pseudomonas aeruginosa

artículo científico publicado en 2013

Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity ⬇️

artículo científico publicado el 9 de septiembre de 2010

Synthesis and application of an N-acylated l-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors ⬇️

artículo científico publicado el 22 de abril de 2011

Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators

artículo científico publicado en 2012

Synthesis and characterization of nitroaromatic peptoids: fine tuning peptoid secondary structure through monomer position and functionality

artículo científico publicado en 2009

Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa

artículo científico publicado en 2008

The State of the Union Is Strong: a Review of ASM's 6th Conference on Cell-Cell Communication in Bacteria

scientific article published on 25 June 2018

The role of the specialist nurse in pelvic floor dysfunction

artículo científico publicado en 2003

Thiolactone modulators of quorum sensing revealed through library design and screening ⬇️

artículo científico publicado el 15 de agosto de 2011

Tuning peptoid secondary structure with pentafluoroaromatic functionality: a new design paradigm for the construction of discretely folded peptoid structures

artículo científico publicado en 2006

Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR.

artículo científico publicado en 2015

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