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Lista de obras de Hiroyuki Kagechika

13-cis-retinoic acid alters the cellular morphology of slice-cultured serotonergic neurons in the rat.

artículo científico publicado en 2008

6-Arylcoumarin as a Scaffold of Photofunctional Molecules with OFF-ON-OFF Type Regulation

artículo científico publicado en 2020

6-arylcoumarins as novel nonsteroidal type progesterone antagonists: an example with receptor-binding-dependent fluorescence

artículo científico publicado en 2011

9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models.

artículo científico publicado en 2017

A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs on Early Embryogenesis

artículo científico publicado en 2015

A Polarity-Sensitive Fluorescent Amino Acid and its Incorporation into Peptides for the Ratiometric Detection of Biomolecular Interactions

scientific article published on 13 October 2019

A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells

artículo científico publicado en 2015

A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers ⬇️

artículo científico publicado el 15 de septiembre de 1997

A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model

artículo científico publicado en 2006

A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells.

artículo científico publicado en 2015

A novel melatonin derivative modulates sleep-wake cycle in rats.

artículo científico publicado en 2004

A synthetic retinoid Am80 (tamibarotene) rescues the memory deficit caused by scopolamine in a passive avoidance paradigm.

artículo científico publicado en 2004

ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes

artículo científico publicado en 2021

Absolute Helical Arrangement of Sulfonamide in the Crystal

artículo científico publicado en 2003

Acidic heterocycles as novel hydrophilic pharmacophore of androgen receptor ligands with a carborane core structure

artículo científico publicado en 2008

Action mechanism of retinoid-synergistic dibenzodiazepines

artículo científico publicado en 1997

Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-κBp50

artículo científico publicado en 2013

Affinity gels for purification of retinoid-specific binding protein (RSBP)

scientific article published on 01 August 1988

All trans-retinoic acid analogs promote cancer cell apoptosis through non-genomic Crabp1 mediating ERK1/2 phosphorylation

artículo científico publicado en 2016

All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-delta

artículo científico publicado en 2011

All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: possible involvement of paracrine effects of endogenous vascular endothelial growth factor signaling

artículo científico publicado en 2006

Alpha-glucosidase inhibitors with a 4,5,6,7-tetrachlorophthalimide skeleton pendanted with a cycloalkyl or dicarba-closo-dodecaborane group.

artículo científico publicado en 2001

Alteration in the cellular response to retinoic acid of a human acute promyelocytic leukemia cell line, UF-1, carrying a patient-derived mutant PML-RARalpha chimeric gene

artículo científico publicado en 2004

Amide Conformational Switching Induced by Protonation of Aromatic Substituent

scientific article published on 01 April 2003

ApoC-III gene expression is sharply increased during adipogenesis and is augmented by retinoid X receptor (RXR) agonists

artículo científico publicado en 2008

Boron cluster-based development of potent nonsecosteroidal vitamin D receptor ligands: direct observation of hydrophobic interaction between protein surface and carborane

artículo científico publicado en 2011

Carboxylic Derivatives of Vitamin K2 Inhibit Hepatocellular Carcinoma Cell Growth through Caspase/Transglutaminase-Related Signaling Pathways

artículo científico publicado en 2015

Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid

artículo científico publicado en 2012

Chemical biology research on nuclear receptors

artículo científico publicado en 2008

Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.

artículo científico publicado en 2013

Chiral spherical molecule constructed from aromatic amides: facile synthesis and highly ordered network structure in the crystal

artículo científico publicado en 2008

Conformational Properties of Aromatic Oligoamides Bearing Pyrrole Rings

artículo científico publicado en 2018

Conformational and Chiral Properties of Cyclic-tri(N-methyl-meta-benzamide) Bearing Amidino Groups

scientific article published on 24 June 2015

Contribution of AP-1 interference induced by TAC-101 to tumor growth suppression in a hepatocellular carcinoma model.

artículo científico publicado en 2009

Copper-mediated C-C cross-coupling reaction of monocarba-closo-dodecaborate anion for the synthesis of functional molecules

artículo científico publicado en 2013

Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4.

artículo científico publicado en 1995

Design and Synthesis of 4-(4-Benzoylaminophenoxy)phenol Derivatives As Androgen Receptor Antagonists.

artículo científico publicado en 2013

Design and synthesis of 4-benzyl-1-(2H)-phthalazinone derivatives as novel androgen receptor antagonists.

artículo científico publicado en 2015

Design and synthesis of cyclic urea compounds: a pharmacological study for retinoidal activity

artículo científico publicado en 2004

Design and synthesis of nonsteroidal progesterone receptor antagonists based on C,C'-diphenylcarborane scaffold as a hydrophobic pharmacophore

artículo científico publicado en 2014

Design and synthesis of tetraol derivatives of 1,12-dicarba- closo -dodecaborane as non-secosteroidal vitamin D analogs

artículo científico publicado en 2014

Determination of endogenous levels of retinoic acid isomers in type II diabetes mellitus patients. Possible correlation with HbA1c values

artículo científico publicado en 2002

Development of 1,3-diphenyladamantane derivatives as nonsteroidal progesterone receptor antagonists.

artículo científico publicado en 2014

Development of 6-arylcoumarins as nonsteroidal progesterone antagonists. Structure-activity relationships and fluorescence properties.

artículo científico publicado en 2016

Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore

scientific article published on 04 August 2020

Development of Helical Aromatic Amide Foldamers with a Diphenylacetylene Backbone

scientific article published on 17 January 2020

Development of N-(4-Phenoxyphenyl)benzenesulfonamide Derivatives as Novel Nonsteroidal Progesterone Receptor Antagonists

artículo científico publicado en 2016

Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine

artículo científico publicado en 2018

Development of WNK signaling inhibitors as a new class of antihypertensive drugs.

artículo científico publicado en 2017

Development of a library of 6-arylcoumarins as candidate fluorescent sensors

artículo científico publicado en 2007

Development of nonsteroidal glucocorticoid receptor modulators based on N-benzyl-N-(4-phenoxyphenyl)benzenesulfonamide scaffold.

artículo científico publicado en 2017

Development of novel bisubstrate-type inhibitors of histone methyltransferase SET7/9.

artículo científico publicado en 2010

Development of p-carborane-based nonsteroidal progesterone receptor antagonists

artículo científico publicado en 2014

Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis.

artículo científico publicado en 2004

Differentiation inducers of human promyelocytic leukemia cells HL-60. Phenylcarbamoylbenzoic acids and polyene amides

artículo científico publicado en 1986

Differentiation-inducing activity of retinoic acid isomers and their oxidized analogs on human promyelocytic leukemia HL-60 cells

scientific article published on 01 December 1992

Diphenylamine-based retinoid antagonists: regulation of RAR and RXR function depending on the N-substituent

artículo científico publicado en 2011

Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.

artículo científico publicado en 2014

Docking simulations suggest that all-trans retinoic acid could bind to retinoid X receptors.

artículo científico publicado en 2015

Docosahexaenoic acid reduces haloperidol-induced dyskinesias in mice: involvement of Nur77 and retinoid receptors.

artículo científico publicado en 2004

Down-regulation of histone deacetylase 4, -5 and -6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin.

artículo científico publicado en 2017

Effect of synthetic retinoid, TAC-101, on experimental autoimmune disease.

artículo científico publicado en 2003

Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression.

artículo científico publicado en 2015

Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons

artículo científico publicado en 2008

Efficient induction of CCR9 on T cells requires coactivation of retinoic acid receptors and retinoid X receptors (RXRs): exaggerated T Cell homing to the intestine by RXR activation with organotins

artículo científico publicado en 2010

Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' release control

artículo científico publicado en 2009

Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway

artículo científico publicado en 2010

Expression of the ligand-binding domain-containing region of retinoic acid receptors alpha, beta and gamma in Escherichia coli and evaluation of ligand-binding selectivity

artículo científico publicado en 1993

Fluorescent and photoaffinity labeling probes for retinoic acid receptors

artículo científico publicado en 1991

Fluorescent probes for retinoic acid receptors: molecular measures for the ligand binding pocket

scientific article published on 01 October 1991

Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes

artículo científico publicado en 2006

Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning.

artículo científico publicado en 2011

Hypoxia-inducible factor-3alpha functions as an accelerator of 3T3-L1 adipose differentiation

artículo científico publicado en 2009

Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription

artículo científico publicado en 2016

Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells.

artículo científico publicado en 1999

Identification of absolute helical structures of aromatic multilayered oligo(m-phenylurea)s in solution.

artículo científico publicado en 2009

Identification of an intermediate in the deboronation of ortho-carborane: an adduct of ortho-carborane with two nucleophiles on one boron atom

artículo científico publicado en 2008

Identifying the receptor subtype selectivity of retinoid X and retinoic acid receptors via quantum mechanics.

artículo científico publicado en 2017

In vitro murine spermatogenesis in an organ culture system

artículo científico publicado en 2010

Increased hydrophobicity and estrogenic activity of simple phenols with silicon and germanium-containing substituents.

artículo científico publicado en 2012

Inhibition of IL-1-induced IL-6 production by synthetic retinoids

artículo científico publicado en 1997

Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch.

artículo científico publicado en 2010

Inhibition of ornithine decarboxylase induction by retinobenzoic acids in relation to their binding affinities to cellular retinoid-binding proteins

scientific article published on 01 January 1988

Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists

artículo científico publicado en 2020

Modulation of intramolecular heterodimer-induced fluorescence quenching of tricarbocyanine dye for the development of fluorescent sensor

artículo científico publicado en 2010

Molecular chirality and chiral capsule-type dimer formation of cyclic triamidesvia hydrogen-bonding interactions

artículo científico publicado en 2012

Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells

artículo científico publicado en 2015

Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells

artículo científico publicado en 2013

MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells

artículo científico publicado en 2011

NR4A nuclear receptors mediate carnitine palmitoyltransferase 1A gene expression by the rexinoid HX600.

artículo científico publicado en 2012

Neuritogenic activity of a genipin derivative in retinal ganglion cells is mediated by retinoic acid receptor β expression through nitric oxide/S-nitrosylation signaling ⬇️

artículo científico publicado el 9 de noviembre de 2011

New type inducers of differentiation of human HL-60 promyelocytic leukemia cells. Terephthalic anilides

scientific article published on 01 October 1984

Novel Nonsteroidal Progesterone Receptor (PR) Antagonists with a Phenanthridinone Skeleton

artículo científico publicado en 2018

Novel retinoid X receptor (RXR) antagonists having a dicarba-closo-dodecaborane as a hydrophobic moiety

artículo científico publicado en 2004

Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions

artículo científico publicado en 2002

Novel retinoidal tropolone derivatives. Bioisosteric relationship of tropolone ring with benzoic acid moiety in retinoid structure

artículo científico publicado en 2001

Novel thyroid hormone receptor antagonists with an N-alkylated diphenylamine skeleton.

artículo científico publicado en 2007

Novel vitamin D receptor ligands bearing a spherical hydrophobic core structure—Comparison of bicyclic hydrocarbon derivatives with boron cluster derivatives

artículo científico publicado en 2012

Peroxisome proliferator-activated receptor gamma ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells.

artículo científico publicado en 2006

Polymethylcarborane as a novel bioactive moiety: derivatives with potent retinoid antagonistic activity

scientific article published on 01 August 2000

Possible involvement of retinoid-like cofactor in serum in hemin/protoporphyrin-IX-induced differentiation of human leukemia K562 cells.

artículo científico publicado en 1995

RXR agonist enhances the differentiation of cardiomyocytes derived from embryonic stem cells in serum-free conditions.

artículo científico publicado en 2005

RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21$^{\rm{Cip1}}$ pathway in adipocytes

scientific article published on 09 February 2012

Redox-Induced Conformational Alteration ofN,N-Diarylamides

artículo científico publicado en 2007

Regulation of Retinoidal Actions by Diazepinylbenzoic Acids.1Retinoid Synergists Which Activate the RXR−RAR Heterodimers

artículo científico publicado en 1997

Retinoic acid imprints gut-homing specificity on T cells

artículo científico publicado en 2004

Retinoic acid induces expression of the thyroid hormone transporter, monocarboxylate transporter 8 (Mct8).

artículo científico publicado en 2010

Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages.

artículo científico publicado en 2012

Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass

artículo científico publicado en 2014

Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells

artículo científico publicado en 2014

Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells

artículo científico publicado en 2005

Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors

artículo científico publicado en 2003

Retinoid X receptor agonists modulate Foxp3⁺ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation

artículo científico publicado en 2013

Retinoid X receptor gamma signaling accelerates CNS remyelination

artículo científico publicado en 2010

Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression.

artículo científico publicado en 2016

Retinoids induce growth inhibition and apoptosis in mast cell tumor cell lines

artículo científico publicado en 2006

STAT5a/PPARgamma pathway regulates involucrin expression in keratinocyte differentiation

artículo científico publicado en 2007

Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model

artículo científico publicado en 2014

Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway

artículo científico publicado en 2009

Specific uptake of retinoids into human promyelocytic leukemia cells HL-60 by retinoid-specific binding protein: possibly the true retinoid receptor

artículo científico publicado en 1988

Spontaneous Resolution of Aromatic Sulfonamides:  Effective Screening Method and Discrimination of Absolute Structure

artículo científico publicado en 2006

Steric structure-activity relationship of cyproheptadine derivatives as inhibitors of histone methyltransferase Set7/9.

artículo científico publicado en 2016

Structural development of p-carborane-based potent non-secosteroidal vitamin D analogs

artículo científico publicado en 2014

Structure-Activity study of retinoid agonists bearing substituted dicarba-closo-dodecaborane. Relation between retinoidal activity and conformation of two aromatic nuclei

artículo científico publicado en 2001

Structure-activity relationship of novel (benzoylaminophenoxy)phenol derivatives as anti-prostate cancer agents

artículo científico publicado en 2018

Structure-activity relationship study on benzoic acid part of diphenylamine-based retinoids

artículo científico publicado en 2012

Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives

artículo científico publicado en 2013

Synergistic potentiation of thiazolidinedione-induced ST 13 preadipocyte differentiation by RAR synergists.

artículo científico publicado en 2001

Synthesis and Biological Activity of Carboxyphenylquinolines and Related Compounds as New Potent Retinoids. Retinobenzoic Acids. VII ⬇️

artículo científico publicado el 1 de diciembre de 1994

Synthesis and Conformational Analysis of Alternately N-Alkylated Aromatic Amide Oligomers

artículo científico publicado en 2018

Synthesis and structure–activity relationship of p-carborane-based non-secosteroidal vitamin D analogs

scientific article published on 21 January 2014

Synthesis of porphyrinylamide and observation of N-methylation-induced trans–cis amide conformational alteration

Synthesis of soluble aromatic multilayered tetra(m-phenylurea) and analysis of its helical conformation in various solvents.

artículo científico publicado en 2011

Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5.

artículo científico publicado en 2005

Synthetic retinoids, retinobenzoic acids, Am80, Am580 and Ch55 regulate morphogenesis in chick limb bud.

artículo científico publicado en 1990

Synthetic retinoids: recent developments concerning structure and clinical utility.

artículo científico publicado en 2005

Systematic synthesis and anti-inflammatory activity of ω-carboxylated menaquinone derivatives--Investigations on identified and putative vitamin K₂ metabolites

artículo científico publicado en 2015

The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction.

artículo científico publicado en 2009

The endocrine disruptors nonylphenol and octylphenol exert direct effects on T cells to suppress Th1 development and enhance Th2 development

artículo científico publicado en 2004

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

scientific journal article

The mevalonate pathway regulates primitive streak formation via protein farnesylation

artículo científico publicado en 2016

The retinoic acid receptor agonist Am80 increases mucosal inflammation in an IL-6 dependent manner during Trichuris muris infection

artículo científico publicado en 2013

The retinoic acid receptors alpha and beta are expressed in the human promyelocytic leukemia cell line HL-60

scientific article published on 01 July 1989

The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities.

artículo científico publicado en 2008

Thyromimetics: a review of recent reports and patents (2004 - 2009).

artículo científico publicado en 2010

Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRα/RXR.

artículo científico publicado en 2011

Unusual conformational preference of an aromatic secondary urea: solvent-dependent open-closed conformational switching of N,N'-bis(porphyrinyl)urea

artículo científico publicado en 2013

Upregulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase/Akt pathway.

artículo científico publicado en 2005

Utility of boron clusters for drug design. Relation between estrogen receptor binding affinity and hydrophobicity of phenols bearing various types of carboranyl groups

artículo científico publicado en 2003

Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif

artículo científico publicado en 2016

[Retinoid therapy for autoimmune diseases]

artículo científico publicado en 2006

beta-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages

scientific article published on 22 April 2007

c-Jun N-terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor α protein in hepatic cells

artículo científico publicado en 2011

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