Lista de obras - John E Burke - Dominio Público Uruguay

(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase

artículo científico publicado en 2019

A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2.

artículo científico publicado en 2008

A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion

artículo científico publicado en 2019

Accurate prediction of protein structures and interactions using a three-track neural network

artículo científico publicado en 2021

Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation

artículo científico publicado en 2022

Allosteric activation of PI3Kα by oncogenic mutations.

artículo científico publicado en 2013

An intrinsic lipid-binding interface controls sphingosine kinase 1 function

artículo científico publicado en 2018

An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery

artículo científico publicado en 2017

Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry

artículo científico publicado en 2008

Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex

artículo científico publicado en 2016

Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication

scientific article published on 12 December 2019

Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease

scientific article published on 28 September 2019

Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.

artículo científico publicado en 2017

Conformational sampling of membranes by Akt controls its activation and inactivation

artículo científico publicado en 2018

Connecting with an old partner in a new way.

artículo científico publicado en 2013

Crystal structure of a lipin/Pah phosphatidic acid phosphatase

scientific article published on 11 March 2020

Crystal structure of an archaeal CorB magnesium transporter

artículo científico publicado en 2021

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

artículo científico publicado en 2017

Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases

scientific article published on 09 December 2019

Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ

artículo científico publicado en 2016

Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders

scientific article published on 14 November 2018

Dissecting the molecular assembly of the Toxoplasma gondii MyoA motility complex

artículo científico publicado en 2017

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

artículo científico publicado en 2016

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS) ⬇️

artículo científico publicado el 13 de septiembre de 2012

Dynamic structural biology at the protein membrane interface

artículo científico publicado en 2019

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α

artículo científico publicado en 2011

Endo-fucoidan hydrolases from glycoside hydrolase family 107 (GH107) display structural and mechanistic similarities to α-L-fucosidases from GH29

scientific article published in Journal of Biological Chemistry

Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes.

artículo científico publicado en 2017

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness

artículo científico publicado en 2012

Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets

artículo científico publicado en 2008

Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry

artículo científico publicado en 2008

In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate

artículo científico publicado en 2021

Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry

scientific article published on 25 June 2009

Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry

scientific article published on June 2009

Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry

artículo científico publicado en 2016

Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases.

artículo científico publicado en 2018

Molecular basis for recognition of the cancer glycobiomarker LacdiNAc (GalNAc(β1-4)GlcNAc) by Wisteria floribunda agglutinin

artículo científico publicado en 2016

Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11

artículo científico publicado en 2023

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

artículo científico publicado en 2016

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

artículo científico publicado en 2013

Molecular insight into the autoinhibition of a master regulator of lipid signalling in human disease

artículo científico publicado en 2020

Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas

artículo científico publicado en 2017

Neolymphostin A is a Covalent Phosphoinositide-3-kinase (PI3-K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor that Employs an Unusual Electrophilic Vinylogous Ester

artículo científico publicado en 2018

Novel K-Ras G12C Switch-II covalent binders destabilize Ras and accelerate nucleotide exchange

artículo científico publicado en 2018

Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans

artículo científico publicado en 2017

Novel roles of phosphoinositides in signaling, lipid transport, and disease

scientific article published on 20 January 2020

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

artículo científico publicado en 2012

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control

artículo científico publicado en 2013

Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane

artículo científico publicado en 2021

Phospholipase A2 biochemistry

artículo científico publicado en 2009

Phospholipase A2 structure/function, mechanism, and signaling

artículo científico publicado en 2008

Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

artículo científico publicado en 2010

Probing the Architecture, Dynamics, and Inhibition of the PI4KIIIα/TTC7/FAM126 Complex

artículo científico publicado en 2018

Probing the dynamic regulation of peripheral membrane proteins using hydrogen deuterium exchange-MS (HDX-MS).

artículo científico publicado en 2015

Publisher Correction: Crystal structure of a lipin/Pah phosphatidic acid phosphatase

scientific article published on 02 April 2020

Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States

artículo científico publicado en 2017

Recognition of protein-linked glycans as a determinant of peptidase activity

artículo científico publicado en 2017

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

scientific article published on 27 June 2019

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway

artículo científico publicado en 2016

Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module

artículo científico publicado en 2016

Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease

artículo científico publicado en 2018

Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases

artículo científico publicado en 2011

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

artículo científico publicado en 2018

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

artículo científico publicado en 2015

Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors

artículo científico publicado en 2014

Synergy in activating class I PI3Ks

artículo científico

The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3.

artículo científico publicado en 2016

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

scientific journal article

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

artículo científico publicado en 2016

The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme

artículo científico publicado en 2019

The middle lipin domain adopts a membrane-binding dimeric protein fold

artículo científico publicado en 2021

The substrate specificity of the human TRAPPII complex's Rab-guanine nucleotide exchange factor activity

artículo científico publicado en 2020

Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease

artículo científico publicado en 2016

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

artículo científico publicado en 2018

Using Hydrogen-Deuterium Exchange Mass Spectrometry to Examine Protein-Membrane Interactions

artículo científico publicado en 2016

Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11

artículo científico publicado en 2016

Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes

artículo científico publicado en 2012

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi

artículo científico publicado en 2013

pH Biosensing by PI4P Regulates Cargo Sorting at the TGN

artículo científico publicado en 2020

Lista de obras de John E Burke

(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase

A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2.

A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion

Accurate prediction of protein structures and interactions using a three-track neural network

Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation

Allosteric activation of PI3Kα by oncogenic mutations.

An intrinsic lipid-binding interface controls sphingosine kinase 1 function

An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery

Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry

Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex

Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication

Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease

Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1.

Conformational sampling of membranes by Akt controls its activation and inactivation

Connecting with an old partner in a new way.

Crystal structure of a lipin/Pah phosphatidic acid phosphatase

Crystal structure of an archaeal CorB magnesium transporter

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases

Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ

Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders

Dissecting the molecular assembly of the Toxoplasma gondii MyoA motility complex

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS) ⬇️

Dynamic structural biology at the protein membrane interface

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α

Endo-fucoidan hydrolases from glycoside hydrolase family 107 (GH107) display structural and mechanistic similarities to α-L-fucosidases from GH29

Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes.

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness

Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets

Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry

In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate

Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry

Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry

Methods in the Study of PTEN Structure: X-Ray Crystallography and Hydrogen Deuterium Exchange Mass Spectrometry

Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases.

Molecular basis for recognition of the cancer glycobiomarker LacdiNAc (GalNAc(β1-4)GlcNAc) by Wisteria floribunda agglutinin

Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

Molecular insight into the autoinhibition of a master regulator of lipid signalling in human disease

Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas

Neolymphostin A is a Covalent Phosphoinositide-3-kinase (PI3-K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor that Employs an Unusual Electrophilic Vinylogous Ester

Novel K-Ras G12C Switch-II covalent binders destabilize Ras and accelerate nucleotide exchange

Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans

Novel roles of phosphoinositides in signaling, lipid transport, and disease

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control

Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane

Phospholipase A2 biochemistry

Phospholipase A2 structure/function, mechanism, and signaling

Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

Probing the Architecture, Dynamics, and Inhibition of the PI4KIIIα/TTC7/FAM126 Complex

Probing the dynamic regulation of peripheral membrane proteins using hydrogen deuterium exchange-MS (HDX-MS).

Publisher Correction: Crystal structure of a lipin/Pah phosphatidic acid phosphatase

Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States

Recognition of protein-linked glycans as a determinant of peptidase activity

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway

Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module

Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease

Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors

Synergy in activating class I PI3Ks

The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3.

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme

The middle lipin domain adopts a membrane-binding dimeric protein fold

The substrate specificity of the human TRAPPII complex's Rab-guanine nucleotide exchange factor activity

Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

Using Hydrogen-Deuterium Exchange Mass Spectrometry to Examine Protein-Membrane Interactions

Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11

Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi