Lista de obras - Manuel Merlos - Dominio Público Uruguay

(Pyridylcyanomethyl)piperazines as orally active PAF antagonists

scientific article published on 01 October 1992

4-substituted 2-alkoxytetrahydrofurans as potent and long-lasting PAF antagonists

scientific article published on 01 February 1992

A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats.

artículo científico publicado en 2006

Alternative binding assay of GP IIb/IIIa antagonists with a nonradioactive labeling method of platelets

artículo científico publicado en 2001

Antihistaminic effects of rupatadine and PKPD modelling

artículo científico publicado en 2008

Antinociception by Sigma-1 Receptor Antagonists: Central and Peripheral Effects.

artículo científico publicado en 2016

Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic stimuli.

artículo científico publicado en 2007

Atorvastatin prevents carbohydrate response element binding protein activation in the fructose-fed rat by activating protein kinase A

scientific journal article

Blockade of sigma 1 receptors alleviates sensory signs of diabetic neuropathy in rats

artículo científico publicado en 2016

Changes in saccharin preference behavior as a primary outcome to evaluate pain and analgesia in acetic acid-induced visceral pain in mice

artículo científico publicado en 2015

Characterization of [3H]apafant binding to PAF receptor on rabbit platelet membranes: a comparison of a microplate filtration system and a standard method

scientific article published on 01 September 1996

Cold ischemia in the absence of alloreactivity induces chronic transplant nephropathy through a process mediated by the platelet-activating factor

scientific article published on 01 December 2000

Comparative study of the effect of CV-6209, a specific PAF-antagonist, on rat paw edema caused by different phlogogen agents

artículo científico publicado en 1990

Cytosolic lipogenic enzymes: Effect of fibric acid derivatives in vitro

scientific article published on 01 January 1993

Decreased susceptibility to copper-induced oxidation of rat-lipoproteins after fibrate treatment: influence of fatty acid composition.

artículo científico publicado en 1996

Design of potent linear PAF antagonists

artículo científico publicado en 1991

Design, synthesis, and structure-activity relationship studies of novel 1-[(1-acyl-4-piperidyl)methyl]-1H-2- methylimidazo[4,5-c]pyridine derivatives as potent, orally active platelet-activating factor antagonists

artículo científico publicado en 1996

Different effects of fibrates on the microsomal fatty acid chain elongation and the acyl composition of phospholipids in guinea-pigs

artículo científico publicado en 1995

Differential inhibition of long-chain acyl-CoA hydrolases by hypolipidemic drugs in vitro.

artículo científico publicado en 1992

Discovery and pharmacological evaluation of new platelet glycoprotein gpIIb/IIIa antagonists.

artículo científico publicado en 1998

Disubstituted tetrahydrofurans and dioxolanes and PAF antagonists

artículo científico publicado en 1991

Down-regulation of acyl-CoA oxidase gene expression and increased NF-kappaB activity in etomoxir-induced cardiac hypertrophy.

artículo científico publicado en 2002

Down-regulation of acyl-CoA oxidase gene expression in heart of troglitazone-treated mice through a mechanism involving chicken ovalbumin upstream promoter transcription factor II.

artículo científico publicado en 2003

Effect of endotoxin and platelet-activating factor on rat vascular permeability: role of vasoactive mediators

artículo científico publicado en 1997

Effects of PAF-antagonists in mouse ear oedema induced by several inflammatory agents

artículo científico publicado en 1991

Effects of UR-12633, a new antagonist of platelet-activating factor, in rodent models of endotoxic shock

artículo científico publicado en 1996

Effects of a new platelet-activating factor antagonist, UR-12670, on several endotoxic shock markers in rats.

artículo científico publicado en 1997

Effects of centrally acting analgesics on spinal segmental reflexes and wind-up

artículo científico publicado en 2014

Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats

artículo científico publicado en 2014

Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction

artículo científico publicado en 2016

Evaluation of formalin-induced pain behavior and glutamate release in the spinal dorsal horn using in vivo microdialysis in conscious rats

artículo científico publicado en 2012

Evaluation of responsive gene expression as a sensitive and specific biomarker in patients with ulcerative colitis

artículo científico publicado en 2013

Fibrates modify rat hepatic fatty acid chain elongation and desaturation in vitro

artículo científico publicado en 1993

Flavonoids as inhibitors of rat liver cytosolic glutathione S-transferase

scientific article published on 01 June 1991

Gemfibrozil modifies acyl composition of liver microsomal phospholipids from guinea-pigs without promoting peroxisomal proliferation

article

In vitro and in vivo studies with flutrimazole, a new imidazole derivative with antifungal activity

artículo científico publicado en 1992

In vitro effect of clofibric acid derivatives on rat hepatic microsomal electron transport chains

scientific article published on 01 October 1991

In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1.

artículo científico publicado en 2000

In vitro study of caffeic acid-bovine serum albumin interaction

artículo científico publicado en 1988

Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: a single-dose, randomized, open-label, two-way crossover study.

artículo científico publicado en 2007

Influence of lipid profile and fatty acid composition on the oxidation behavior of rat and guinea pig low density lipoprotein.

artículo científico publicado en 1998

Inhibition of rat liver microsomal fatty acid chain elongation by gemfibrozil in vitro

artículo científico publicado en 1992

Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat

artículo científico publicado en 2000

Investigational sigma-1 receptor antagonists for the treatment of pain.

artículo científico

Lipoprotein composition and oxidative modification during therapy with gemfibrozil and lovastatin in patients with combined hyperlipidaemia.

artículo científico publicado en 1998

Liquid fructose down-regulates liver insulin receptor substrate 2 and gluconeogenic enzymes by modifying nutrient sensing factors in rats

artículo científico publicado en 2013

Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells

artículo científico publicado en 2014

Long-term protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats

article

Metabolic alterations and increased liver mTOR expression precede the development of autoimmune disease in a murine model of lupus erythematosus

artículo científico publicado en 2012

Modulation of peripheral μ-opioid analgesia by σ1 receptors

artículo científico publicado en 2013

New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol

artículo científico publicado en 1998

New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones

artículo científico publicado en 1998

New water-soluble sulfonylphosphoramidic acid derivatives of the COX-2 selective inhibitor cimicoxib. A novel approach to sulfonamide prodrugs

artículo científico publicado en 2004

Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity

artículo científico publicado en 2001

Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells

artículo científico publicado en 2008

PGC-1beta down-regulation is associated with reduced ERRalpha activity and MCAD expression in skeletal muscle of senescence-accelerated mice.

artículo científico publicado en 2006

PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.

artículo científico publicado en 2010

Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation

artículo científico publicado en 2006

Peroxisome proliferator-activated receptor alpha down-regulation is associated with enhanced ceramide levels in age-associated cardiac hypertrophy

artículo científico publicado en 2007

Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study.

artículo científico publicado en 2008

Pharmacological properties of S1RA, a new sigma‐1 receptor antagonist that inhibits neuropathic pain and activity‐induced spinal sensitization ⬇️

artículo científico publicado el 1 de agosto de 2012

Protective effect of UR-12670 on chronic nephropathy induced by warm ischaemia in ageing uninephrectomized rats

artículo científico publicado en 2001

Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment

artículo científico publicado en 2010

Relationship between plasma lipids and palmitoyl-CoA hydrolase and synthetase activities with peroxisomal proliferation in rats treated with fibrates.

artículo científico publicado en 1994

S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice

artículo científico publicado en 2014

Selective modification of rat hepatic microsomal fatty acid chain elongation and desaturation by fibrates: relationship with peroxisome proliferation

artículo científico publicado en 1995

Sigma 1 receptor: a new therapeutic target for pain.

artículo científico

Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects.

artículo científico publicado en 2013

Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial.

artículo científico publicado en 2000

Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862) ⬇️

artículo científico publicado el 27 de julio de 2012

Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines.

artículo científico publicado en 2001

Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selective σ1 receptor ligands.

artículo científico publicado en 2013

Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles

artículo científico publicado en 2003

Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists

artículo científico publicado en 1993

The Role of Peroxisome Proliferator-Activated Receptor beta/delta on the Inflammatory Basis of Metabolic Disease.

artículo científico publicado en 2010

The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production.

artículo científico publicado en 2003

The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis

artículo científico publicado en 2012

The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition

article

The new salicylate derivative UR-1505 modulates the Th2/humoral response in a dextran sodium sulphate model of colitis that resembles ulcerative colitis

artículo científico publicado en 2009

The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats

artículo científico publicado en 2016

The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control

artículo científico publicado en 2015

Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages

artículo científico publicado en 2011

Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent

artículo científico publicado en 1996

UR-1505, a new salicylate, blocks T cell activation through nuclear factor of activated T cells

artículo científico publicado en 2007

UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis

artículo científico publicado en 2008

UR-60427, a novel H4 receptor-inverse agonist that shows good efficacy in a rat asthma model

artículo científico publicado en 2010

Walnut-enriched diet increases the association of LDL from hypercholesterolemic men with human HepG2 cells.

artículo científico publicado en 2001

[(3-Pyridylalkyl)piperidylidene]benzocycloheptapyridine derivatives as dual antagonists of PAF and histamine

scientific article published on 01 August 1994

Lista de obras de Manuel Merlos

(Pyridylcyanomethyl)piperazines as orally active PAF antagonists

4-substituted 2-alkoxytetrahydrofurans as potent and long-lasting PAF antagonists

A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats.

Alternative binding assay of GP IIb/IIIa antagonists with a nonradioactive labeling method of platelets

Antihistaminic effects of rupatadine and PKPD modelling

Antinociception by Sigma-1 Receptor Antagonists: Central and Peripheral Effects.

Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic stimuli.

Atorvastatin prevents carbohydrate response element binding protein activation in the fructose-fed rat by activating protein kinase A

Blockade of sigma 1 receptors alleviates sensory signs of diabetic neuropathy in rats

Changes in saccharin preference behavior as a primary outcome to evaluate pain and analgesia in acetic acid-induced visceral pain in mice

Characterization of [3H]apafant binding to PAF receptor on rabbit platelet membranes: a comparison of a microplate filtration system and a standard method

Cold ischemia in the absence of alloreactivity induces chronic transplant nephropathy through a process mediated by the platelet-activating factor

Comparative study of the effect of CV-6209, a specific PAF-antagonist, on rat paw edema caused by different phlogogen agents

Cytosolic lipogenic enzymes: Effect of fibric acid derivatives in vitro

Decreased susceptibility to copper-induced oxidation of rat-lipoproteins after fibrate treatment: influence of fatty acid composition.

Design of potent linear PAF antagonists

Design, synthesis, and structure-activity relationship studies of novel 1-[(1-acyl-4-piperidyl)methyl]-1H-2- methylimidazo[4,5-c]pyridine derivatives as potent, orally active platelet-activating factor antagonists

Different effects of fibrates on the microsomal fatty acid chain elongation and the acyl composition of phospholipids in guinea-pigs

Differential inhibition of long-chain acyl-CoA hydrolases by hypolipidemic drugs in vitro.

Discovery and pharmacological evaluation of new platelet glycoprotein gpIIb/IIIa antagonists.

Disubstituted tetrahydrofurans and dioxolanes and PAF antagonists

Down-regulation of acyl-CoA oxidase gene expression and increased NF-kappaB activity in etomoxir-induced cardiac hypertrophy.

Down-regulation of acyl-CoA oxidase gene expression in heart of troglitazone-treated mice through a mechanism involving chicken ovalbumin upstream promoter transcription factor II.

Effect of endotoxin and platelet-activating factor on rat vascular permeability: role of vasoactive mediators

Effects of PAF-antagonists in mouse ear oedema induced by several inflammatory agents

Effects of UR-12633, a new antagonist of platelet-activating factor, in rodent models of endotoxic shock

Effects of a new platelet-activating factor antagonist, UR-12670, on several endotoxic shock markers in rats.

Effects of centrally acting analgesics on spinal segmental reflexes and wind-up

Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats

Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction

Evaluation of formalin-induced pain behavior and glutamate release in the spinal dorsal horn using in vivo microdialysis in conscious rats

Evaluation of responsive gene expression as a sensitive and specific biomarker in patients with ulcerative colitis

Fibrates modify rat hepatic fatty acid chain elongation and desaturation in vitro

Flavonoids as inhibitors of rat liver cytosolic glutathione S-transferase

Gemfibrozil modifies acyl composition of liver microsomal phospholipids from guinea-pigs without promoting peroxisomal proliferation

In vitro and in vivo studies with flutrimazole, a new imidazole derivative with antifungal activity

In vitro effect of clofibric acid derivatives on rat hepatic microsomal electron transport chains

In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1.

In vitro study of caffeic acid-bovine serum albumin interaction

Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: a single-dose, randomized, open-label, two-way crossover study.

Influence of lipid profile and fatty acid composition on the oxidation behavior of rat and guinea pig low density lipoprotein.

Inhibition of rat liver microsomal fatty acid chain elongation by gemfibrozil in vitro

Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat

Investigational sigma-1 receptor antagonists for the treatment of pain.

Lipoprotein composition and oxidative modification during therapy with gemfibrozil and lovastatin in patients with combined hyperlipidaemia.

Liquid fructose down-regulates liver insulin receptor substrate 2 and gluconeogenic enzymes by modifying nutrient sensing factors in rats

Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells

Long-term protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats

Metabolic alterations and increased liver mTOR expression precede the development of autoimmune disease in a murine model of lupus erythematosus

Modulation of peripheral μ-opioid analgesia by σ1 receptors

New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol

New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones

New water-soluble sulfonylphosphoramidic acid derivatives of the COX-2 selective inhibitor cimicoxib. A novel approach to sulfonamide prodrugs

Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity

Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells

PGC-1beta down-regulation is associated with reduced ERRalpha activity and MCAD expression in skeletal muscle of senescence-accelerated mice.

PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.

Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation

Peroxisome proliferator-activated receptor alpha down-regulation is associated with enhanced ceramide levels in age-associated cardiac hypertrophy

Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study.

Pharmacological properties of S1RA, a new sigma‐1 receptor antagonist that inhibits neuropathic pain and activity‐induced spinal sensitization ⬇️

Protective effect of UR-12670 on chronic nephropathy induced by warm ischaemia in ageing uninephrectomized rats

Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment

Relationship between plasma lipids and palmitoyl-CoA hydrolase and synthetase activities with peroxisomal proliferation in rats treated with fibrates.

S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice

Selective modification of rat hepatic microsomal fatty acid chain elongation and desaturation by fibrates: relationship with peroxisome proliferation

Sigma 1 receptor: a new therapeutic target for pain.

Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects.

Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial.

Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862) ⬇️

Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines.

Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selective σ1 receptor ligands.

Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles

Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists

The Role of Peroxisome Proliferator-Activated Receptor beta/delta on the Inflammatory Basis of Metabolic Disease.

The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production.

The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis

The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition

The new salicylate derivative UR-1505 modulates the Th2/humoral response in a dextran sodium sulphate model of colitis that resembles ulcerative colitis