Lista de obras - Nick R. Leslie - Dominio Público Uruguay

3D Printing in Suspension Baths: Keeping the Promises of Bioprinting Afloat

scientific article published on 16 January 2020

A screen for novel phosphoinositide 3-kinase effector proteins.

artículo científico publicado en 2011

A simple and robust real-time qPCR method for the detection of PIK3CA mutations

artículo científico publicado en 2018

A unified nomenclature and amino acid numbering for human PTEN.

artículo científico publicado en 2014

Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.

artículo científico publicado en 2001

Assaying PTEN catalysis in vitro

artículo científico publicado en 2014

Beta1-integrin and PTEN control the phosphorylation of protein kinase C.

artículo científico publicado en 2000

C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy

artículo científico publicado en 2013

Cell biology. Where is PTEN?

artículo científico publicado en 2013

Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase

artículo científico publicado en 2007

Class I PI 3-kinases: Function and evolution

artículo científico

Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.

artículo científico publicado en 2016

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling

scientific article published on 26 August 2013

Differential redox regulation within the PTP superfamily

artículo científico publicado en 2007

Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1 ⬇️

artículo científico publicado el 22 de octubre de 2012

Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases.

artículo científico

Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

artículo científico publicado en 2014

GSK3 and its interactions with the PI3K/AKT/mTOR signalling network

artículo científico publicado en 2017

Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

artículo científico publicado en 2005

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold

artículo científico publicado en 2012

Importin-11 keeps PTEN safe from harm

artículo científico publicado en 2017

In Cell and In Vitro Assays to Measure PTEN Ubiquitination

artículo científico publicado en 2016

Indirect mechanisms of carcinogenesis via downregulation of PTEN function.

artículo científico publicado en 2009

Inherited PTEN mutations and the prediction of phenotype

artículo científico publicado en 2016

Leptin regulates AMPA receptor trafficking via PTEN inhibition

scientific journal article

Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

artículo científico publicado en 2006

Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.

artículo científico publicado en 2007

Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A.

artículo científico publicado en 2010

Mechanisms of PTEN loss in cancer: It's all about diversity

artículo científico publicado en 2019

Metabolic switching of PI3K-dependent lipid signals

artículo científico publicado en 2007

Migration Stimulating Factor (MSF) promotes fibroblast migration by inhibiting AKT.

artículo científico publicado en 2010

Mutant PTEN in Cancer: Worse Than Nothing

artículo científico publicado en 2014

MyosinV controls PTEN function and neuronal cell size.

artículo científico publicado en 2009

Non-genomic loss of PTEN function in cancer: not in my genes.

artículo científico publicado en 2011

P-REX2a driving tumorigenesis by PTEN inhibition

artículo científico publicado en 2009

PDK1 controls upstream PI3K expression and PIP3 generation.

artículo científico publicado en 2013

PTEN function: how normal cells control it and tumour cells lose it

artículo científico publicado en 2004

PTEN inhibitors: an evaluation of current compounds.

artículo científico publicado en 2014

PTEN is destabilized by phosphorylation on Thr366.

artículo científico publicado en 2007

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

artículo científico publicado en 2008

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

artículo científico publicado en 2012

PTEN regulates IGF-1R-mediated therapy resistance in melanoma.

artículo científico publicado en 2015

PTEN: The down side of PI 3-kinase signalling.

artículo científico publicado en 2002

PTEN: an intercellular peacekeeper?

artículo científico publicado en 2012

Phosphoinositide-regulated kinases and phosphoinositide phosphatases.

artículo científico publicado en 2001

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

artículo científico publicado en 2014

Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN

artículo científico publicado en 2013

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

artículo científico publicado en 2009

PtdIns5P protects Akt from dephosphorylation through PP2A inhibition.

artículo científico publicado en 2009

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

artículo científico publicado en 2003

Redox regulation of phosphatase function.

artículo científico publicado en 2004

Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

artículo científico publicado en 2004

Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN.

artículo científico publicado en 2006

Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN.

artículo científico publicado en 2007

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

artículo científico publicado en 2008

TPIP: a novel phosphoinositide 3-phosphatase ⬇️

artículo científico publicado el 1 de diciembre de 2001

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

artículo científico publicado en 2001

The PTEN protein: cellular localization and post-translational regulation

artículo científico publicado en 2016

The regulation of cell migration by PTEN.

artículo científico publicado en 2005

Three-dimensional bioprinting of complex cell laden alginate hydrogel structures

artículo científico publicado en 2015

Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.

artículo científico publicado en 2010

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

artículo científico publicado en 2008

Yeast-based methods to assess PTEN phosphoinositide phosphatase activity in vivo.

artículo científico publicado en 2014

Lista de obras de Nick R. Leslie

3D Printing in Suspension Baths: Keeping the Promises of Bioprinting Afloat

A screen for novel phosphoinositide 3-kinase effector proteins.

A simple and robust real-time qPCR method for the detection of PIK3CA mutations

A unified nomenclature and amino acid numbering for human PTEN.

Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.

Assaying PTEN catalysis in vitro

Beta1-integrin and PTEN control the phosphorylation of protein kinase C.

C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy

Cell biology. Where is PTEN?

Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase

Class I PI 3-kinases: Function and evolution

Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling

Differential redox regulation within the PTP superfamily

Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1 ⬇️

Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases.

Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

GSK3 and its interactions with the PI3K/AKT/mTOR signalling network

Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold

Importin-11 keeps PTEN safe from harm

In Cell and In Vitro Assays to Measure PTEN Ubiquitination

Indirect mechanisms of carcinogenesis via downregulation of PTEN function.

Inherited PTEN mutations and the prediction of phenotype

Leptin regulates AMPA receptor trafficking via PTEN inhibition

Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.

Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A.

Mechanisms of PTEN loss in cancer: It's all about diversity

Metabolic switching of PI3K-dependent lipid signals

Migration Stimulating Factor (MSF) promotes fibroblast migration by inhibiting AKT.

Mutant PTEN in Cancer: Worse Than Nothing

MyosinV controls PTEN function and neuronal cell size.

Non-genomic loss of PTEN function in cancer: not in my genes.

P-REX2a driving tumorigenesis by PTEN inhibition

PDK1 controls upstream PI3K expression and PIP3 generation.

PTEN function: how normal cells control it and tumour cells lose it

PTEN inhibitors: an evaluation of current compounds.

PTEN is destabilized by phosphorylation on Thr366.

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

PTEN regulates IGF-1R-mediated therapy resistance in melanoma.

PTEN: The down side of PI 3-kinase signalling.

PTEN: an intercellular peacekeeper?

Phosphoinositide-regulated kinases and phosphoinositide phosphatases.

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells.

Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

PtdIns5P protects Akt from dephosphorylation through PP2A inhibition.

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

Redox regulation of phosphatase function.

Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

Stimulation of PI 3-kinase signaling via inhibition of the tumor suppressor phosphatase, PTEN.

Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN.

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

TPIP: a novel phosphoinositide 3-phosphatase ⬇️

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

The PTEN protein: cellular localization and post-translational regulation

The regulation of cell migration by PTEN.

Three-dimensional bioprinting of complex cell laden alginate hydrogel structures

Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

Yeast-based methods to assess PTEN phosphoinositide phosphatase activity in vivo.