Lista de obras - Jogeshwar Mukherjee - Dominio Público Uruguay

(18)F-Fluorodeoxyglucamines: Reductive amination of hydrophilic (18)F-fluoro-2-deoxyglucose with lipophilic amines for the development of potential PET imaging agents

artículo científico publicado en 2015

11C-Fallypride: radiosynthesis and preliminary evaluation of a novel dopamine D2/D3 receptor PET radiotracer in non-human primate brain

artículo científico publicado en 2004

11C-L-methionine positron emission tomography in the clinical management of cerebral gliomas.

artículo científico publicado en 2007

18F-Fallypride PET of pancreatic islets: in vitro and in vivo rodent studies

artículo científico publicado en 2011

18F-Fluorodeoxyglycosylamines: Maillard reaction of 18F-fluorodeoxyglucose with biological amines.

artículo científico publicado en 2013

18F-desmethoxyfallypride: a fluorine-18 labeled radiotracer with properties similar to carbon-11 raclopride for PET imaging studies of dopamine D2 receptors.

artículo científico publicado en 1996

2-deoxy-2-[18F]fluoro-d-mannose positron emission tomography imaging in atherosclerosis

artículo científico publicado en 2014

5-HT1A sex based differences in Bmax, in vivo KD, and BPND in the nonhuman primate

artículo científico publicado en 2013

A comparative study on the uptake and incorporation of radiolabeled methionine, choline and fluorodeoxyglucose in human astrocytoma.

artículo científico publicado en 2002

A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse

artículo científico publicado en 2012

Adrenergic pathway activation enhances brown adipose tissue metabolism: a [¹⁸F]FDG PET/CT study in mice

artículo científico publicado en 2013

An in vivo comparison of cis- and trans-[18F]mefway in the nonhuman primate

artículo científico publicado en 2011

Binding characteristics of high-affinity dopamine D2/D3 receptor agonists, 11C-PPHT and 11C-ZYY-339 in rodents and imaging in non-human primates by PET.

artículo científico publicado en 2004

Brain and Brown Adipose Tissue Metabolism in Transgenic Tg2576 Mice Models of Alzheimer Disease Assessed Using 18F-FDG PET Imaging.

artículo científico publicado en 2017

Classification of Therapeutic and Experimental Drugs for Brown Adipose Tissue Activation: Potential Treatment Strategies for Diabetes and Obesity

artículo científico publicado en 2016

Comparative assessment of (18) F-Mefway as a serotonin 5-HT1A receptor PET imaging agent across species: Rodents, nonhuman primates, and humans

artículo científico publicado en 2015

D2 receptor occupancy following lurasidone treatment in patients with schizophrenia or schizoaffective disorder.

artículo científico publicado en 2013

D2/D3 dopamine receptor binding with [F-18]fallypride correlates of executive function in medication-naïve patients with schizophrenia

artículo científico publicado en 2017

Development and Evaluation of [125 I]IPPI for Tau Imaging in Post-Mortem Human Alzheimer's Disease Brain

artículo científico publicado en 2020

Development of N-[3-(2',4'-dichlorophenoxy)-2-18F-fluoropropyl]-N-methylpropargylamine (18F-fluoroclorgyline) as a potential PET radiotracer for monoamine oxidase-A

scientific article published on 01 August 1999

Development of fluorescence imaging probes for nicotinic acetylcholine α4β2∗ receptors

artículo científico publicado en 2017

Dopamine D-2 receptors imaged by PET in Cebus apella using [18F]benzamide neuroleptic

artículo científico publicado en 1990

Dopamine D3 receptor binding of (18)F-fallypride: Evaluation using in vitro and in vivo PET imaging studies.

artículo científico publicado en 2015

Dual targeting agents for Aβ plaque/P-glycoprotein and Aβ plaque/nicotinic acetylcholine α4β2* receptors-potential approaches to facilitate Aβ plaque removal in Alzheimer's disease brain

artículo científico publicado en 2018

Effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor PET radiotracer, (18)F-nifene: A measure of acetylcholine competition.

artículo científico publicado en 2007

Enhancement of 18F-fluorodeoxyglucose metabolism in rat brain frontal cortex using a β3 adrenoceptor agonist

artículo científico publicado en 2014

Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging

artículo científico publicado en 2011

Evaluation of [11C]TAZA for amyloid β plaque imaging in postmortem human Alzheimer's disease brain region and whole body distribution in rodent PET/CT.

artículo científico publicado en 2016

Evaluation of [18F]Mefway Biodistribution and Dosimetry Based on Whole-Body PET Imaging of Mice ⬇️

artículo científico publicado el 1 de abril de 2013

Evaluation of [18F]Nifene biodistribution and dosimetry based on whole-body PET imaging of mice.

artículo científico publicado en 2012

Evaluation of d-amphetamine effects on the binding of dopamine D-2 receptor radioligand, 18F-fallypride in nonhuman primates using positron emission tomography

artículo científico publicado en 1997

Evaluation of dopamine D-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using 18F-fallypride

artículo científico publicado en 2001

Evaluation of monoamine oxidase B inhibition by fluoxetine (Prozac): an in vitro and in vivo study

scientific article published on 01 October 1997

Evaluation of serotonin 5-HT(1A) receptors in rodent models using [¹⁸F]mefway PET.

artículo científico publicado en 2013

Evaluation of the binding of the radiolabeled antidepressant drug, 18F-fluoxetine in the rodent brain: an in vitro and in vivo study

artículo científico publicado en 1998

First-in-human evaluation of 18F-mefway, a PET radioligand specific to serotonin-1A receptors.

artículo científico publicado en 2014

Fluorinated benzamide neuroleptics—2. Synthesis and radiosynthesis of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-3-substituted-2-methoxybenzamides ⬇️

artículo científico publicado el 1 de enero de 1991

Fluorinated benzazepines: 1. Synthesis, radiosynthesis and biological evaluation of a series of substituted benzazepines as potential radiotracers for positron emission tomographic studies of dopamine D-1 receptors

artículo científico publicado en 1996

Functional imaging of a large demyelinating lesion

artículo científico publicado en 2005

Human biodistribution and dosimetry of [18F]nifene, an α4β2* nicotinic acetylcholine receptor PET tracer.

artículo científico publicado en 2017

Human brain imaging of nicotinic acetylcholine α4β2* receptors using [18 F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways.

artículo científico publicado en 2017

Imaging pancreas in healthy and diabetic rodent model using [18F]fallypride positron emission tomography/computed tomography.

artículo científico publicado en 2014

In vivo kinetics of [F-18]MEFWAY: a comparison with [C-11]WAY100635 and [F-18]MPPF in the nonhuman primate.

artículo científico publicado en 2010

Initial Assessment of β3-Adrenoceptor-Activated Brown Adipose Tissue in Streptozotocin-Induced Type 1 Diabetes Rodent Model Using [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography

artículo científico publicado en 2015

Measurement of 5-HT(1A) receptor density and in-vivo binding parameters of [(18)F]mefway in the nonhuman primate.

artículo científico publicado en 2012

Measurement of d-amphetamine-induced effects on the binding of dopamine D-2/D-3 receptor radioligand, 18F-fallypride in extrastriatal brain regions in non-human primates using PET.

artículo científico publicado en 2005

Measuring α4β2* nicotinic acetylcholine receptor density in vivo with [(18)F]nifene PET in the nonhuman primate

artículo científico publicado en 2013

Moderate-level prenatal alcohol exposure alters striatal dopamine system function in rhesus monkeys

artículo científico publicado en 2005

Monoamine oxidase A inhibition by fluoxetine: an in vitro and in vivo study

artículo científico publicado en 1999

N-(6-18F-fluorohexyl)-N-methylpropargylamine: a fluorine-18-labeled monoamine oxidase B inhibitor for potential use in PET studies

artículo científico publicado en 1999

Nicotinic acetylcholine receptors in rat forebrain that bind ¹⁸F-nifene: relating PET imaging, autoradiography, and behavior.

artículo científico publicado en 2012

Nicotinic alpha4beta2 receptor imaging agents: part II. Synthesis and biological evaluation of 2-[18F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine (18F-nifene) in rodents and imaging by PET in nonhuman primate.

artículo científico publicado en 2006

Nicotinic α4β2 receptor imaging agents. Part III. Synthesis and biological evaluation of 3-(2-(S)-azetidinylmethoxy)-5-(3'-18F-fluoropropyl)pyridine (18F-nifzetidine).

artículo científico publicado en 2011

Nicotinic α4β2 receptor imaging agents. Part IV. Synthesis and biological evaluation of 3-(2-(S)-3,4-dehydropyrrolinyl methoxy)-5-(3'-¹⁸F-fluoropropyl)pyridine (¹⁸F-Nifrolene) using PET.

artículo científico publicado en 2012

PET imaging of α4β2* nicotinic acetylcholine receptors: quantitative analysis of 18F-nifene kinetics in the nonhuman primate.

artículo científico publicado en 2012

PET radiotracer development for imaging high-affinity state of dopamine D2 and D3 receptors: Binding studies of fluorine-18 labeled aminotetralins in rodents. ⬇️

artículo científico publicado en 2016

Performance evaluation of an Inveon PET preclinical scanner.

artículo científico publicado en 2009

Positron autoradiography for intravascular imaging: feasibility evaluation

artículo científico publicado en 2006

Preliminary evaluation of β3-adrenoceptor agonist-induced 18F-FDG metabolic activity of brown adipose tissue in obese Zucker rat.

artículo científico publicado en 2015

Prenatal stress, moderate fetal alcohol, and dopamine system function in rhesus monkeys.

artículo científico publicado en 2004

Quantitation of striatal and extrastriatal D-2 dopamine receptors using PET imaging of [(18)F]fallypride in nonhuman primates

artículo científico publicado en 2000

Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation ⬇️

artículo científico publicado el 1 de diciembre de 2011

Radiobrominated m-tyrosine analog as potential CNS L-dopa pet tracer

artículo científico publicado en 1988

Radionuclide probes for tissue damage

scientific article published on 01 May 1994

Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1'-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors

scientific article published on 01 October 1999

Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance ⬇️

artículo científico publicado el 31 de mayo de 2013

Specific α4β2 nicotinic acetylcholine receptor binding of [F-18]nifene in the rhesus monkey

artículo científico publicado en 2011

Spinal cord dopamine D2/D3 receptors: in vivo and ex vivo imaging in the rat using (18)F/(11)C-fallypride

artículo científico publicado en 2014

Striatal and extrastriatal microPET imaging of D2/D3 dopamine receptors in rat brain with [¹⁸F]fallypride and [¹⁸F]desmethoxyfallypride

artículo científico publicado en 2011

Synthesis and Evaluation of Mefway Analogs as Ligands for Serotonin 5HT1A Receptors

artículo científico publicado en 2015

Synthesis and biological evaluation of 18F-Norfallypride in the rodent brain using PET imaging.

artículo científico publicado en 2013

Synthesis and biological evaluation of the binding of dopamine D2/D3 receptor agonist, (R,S)-5-hydroxy-2-(N-propyl-N-(5'-(18)F-fluoropentyl)aminotetralin ((18)F-5-OH-FPPAT) in rodents and nonhuman primates

artículo científico publicado en 2004

Synthesis and evaluation of (S)-[(18)F]fesetron in the rat brain as a potential PET imaging agent for serotonin 5-HT3 receptors

artículo científico publicado en 2016

Synthesis and evaluation of 3-123I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic α4β2 receptor imaging agent ⬇️

artículo científico publicado el 10 de octubre de 2012

Synthesis of radiofluorinated analogs of m-tyrosine as potential L-dopa tracers via direct reaction with acetylhypofluorite

scientific article published on 01 January 1990

Synthesis, radiosynthesis, and biological evaluation of fluorinated thienylcyclohexyl piperidine derivatives as potential radiotracers for the NMDA receptor-linked calcium ionophore

artículo científico publicado en 1996

Targeting presynaptic norepinephrine transporter in brown adipose tissue: a novel imaging approach and potential treatment for diabetes and obesity.

artículo científico publicado en 2012

The Homozygote VCPR155H/R155H Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology ⬇️

artículo científico publicado el 28 de septiembre de 2012

The effects of lobeline on α4β2* nicotinic acetylcholine receptor binding and uptake of [18F]nifene in rats ⬇️

artículo científico publicado el 28 de enero de 2013

The multiple faces of valosin-containing protein-associated diseases: inclusion body myopathy with Paget's disease of bone, frontotemporal dementia, and amyotrophic lateral sclerosis.

artículo científico publicado en 2011

VCP Associated Inclusion Body Myopathy and Paget Disease of Bone Knock-In Mouse Model Exhibits Tissue Pathology Typical of Human Disease ⬇️

artículo científico publicado el 5 de octubre de 2010

[11C]cyclopropyl-FLB 457: a PET radioligand for low densities of dopamine D2 receptors

artículo científico publicado en 2008

¹²⁴I-Epidepride: a PET radiotracer for extended imaging of dopamine D2/D3 receptors.

artículo científico publicado en 2014

Lista de obras de Jogeshwar Mukherjee

(18)F-Fluorodeoxyglucamines: Reductive amination of hydrophilic (18)F-fluoro-2-deoxyglucose with lipophilic amines for the development of potential PET imaging agents

11C-Fallypride: radiosynthesis and preliminary evaluation of a novel dopamine D2/D3 receptor PET radiotracer in non-human primate brain

11C-L-methionine positron emission tomography in the clinical management of cerebral gliomas.

18F-Fallypride PET of pancreatic islets: in vitro and in vivo rodent studies

18F-Fluorodeoxyglycosylamines: Maillard reaction of 18F-fluorodeoxyglucose with biological amines.

18F-desmethoxyfallypride: a fluorine-18 labeled radiotracer with properties similar to carbon-11 raclopride for PET imaging studies of dopamine D2 receptors.

2-deoxy-2-[18F]fluoro-d-mannose positron emission tomography imaging in atherosclerosis

5-HT1A sex based differences in Bmax, in vivo KD, and BPND in the nonhuman primate

A comparative study on the uptake and incorporation of radiolabeled methionine, choline and fluorodeoxyglucose in human astrocytoma.

A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse

Adrenergic pathway activation enhances brown adipose tissue metabolism: a [¹⁸F]FDG PET/CT study in mice

An in vivo comparison of cis- and trans-[18F]mefway in the nonhuman primate

Binding characteristics of high-affinity dopamine D2/D3 receptor agonists, 11C-PPHT and 11C-ZYY-339 in rodents and imaging in non-human primates by PET.

Brain and Brown Adipose Tissue Metabolism in Transgenic Tg2576 Mice Models of Alzheimer Disease Assessed Using 18F-FDG PET Imaging.

Classification of Therapeutic and Experimental Drugs for Brown Adipose Tissue Activation: Potential Treatment Strategies for Diabetes and Obesity

Comparative assessment of (18) F-Mefway as a serotonin 5-HT1A receptor PET imaging agent across species: Rodents, nonhuman primates, and humans

D2 receptor occupancy following lurasidone treatment in patients with schizophrenia or schizoaffective disorder.

D2/D3 dopamine receptor binding with [F-18]fallypride correlates of executive function in medication-naïve patients with schizophrenia

Development and Evaluation of [125 I]IPPI for Tau Imaging in Post-Mortem Human Alzheimer's Disease Brain

Development of N-[3-(2',4'-dichlorophenoxy)-2-18F-fluoropropyl]-N-methylpropargylamine (18F-fluoroclorgyline) as a potential PET radiotracer for monoamine oxidase-A

Development of fluorescence imaging probes for nicotinic acetylcholine α4β2∗ receptors

Dopamine D-2 receptors imaged by PET in Cebus apella using [18F]benzamide neuroleptic

Dopamine D3 receptor binding of (18)F-fallypride: Evaluation using in vitro and in vivo PET imaging studies.

Dual targeting agents for Aβ plaque/P-glycoprotein and Aβ plaque/nicotinic acetylcholine α4β2* receptors-potential approaches to facilitate Aβ plaque removal in Alzheimer's disease brain

Effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor PET radiotracer, (18)F-nifene: A measure of acetylcholine competition.

Enhancement of 18F-fluorodeoxyglucose metabolism in rat brain frontal cortex using a β3 adrenoceptor agonist

Evaluation of 18F-nifene binding to α4β2 nicotinic receptors in the rat brain using microPET imaging

Evaluation of [11C]TAZA for amyloid β plaque imaging in postmortem human Alzheimer's disease brain region and whole body distribution in rodent PET/CT.

Evaluation of [18F]Mefway Biodistribution and Dosimetry Based on Whole-Body PET Imaging of Mice ⬇️

Evaluation of [18F]Nifene biodistribution and dosimetry based on whole-body PET imaging of mice.

Evaluation of d-amphetamine effects on the binding of dopamine D-2 receptor radioligand, 18F-fallypride in nonhuman primates using positron emission tomography

Evaluation of dopamine D-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using 18F-fallypride

Evaluation of monoamine oxidase B inhibition by fluoxetine (Prozac): an in vitro and in vivo study

Evaluation of serotonin 5-HT(1A) receptors in rodent models using [¹⁸F]mefway PET.

Evaluation of the binding of the radiolabeled antidepressant drug, 18F-fluoxetine in the rodent brain: an in vitro and in vivo study

First-in-human evaluation of 18F-mefway, a PET radioligand specific to serotonin-1A receptors.

Fluorinated benzamide neuroleptics—2. Synthesis and radiosynthesis of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-3-substituted-2-methoxybenzamides ⬇️

Fluorinated benzazepines: 1. Synthesis, radiosynthesis and biological evaluation of a series of substituted benzazepines as potential radiotracers for positron emission tomographic studies of dopamine D-1 receptors

Functional imaging of a large demyelinating lesion

Human biodistribution and dosimetry of [18F]nifene, an α4β2* nicotinic acetylcholine receptor PET tracer.

Human brain imaging of nicotinic acetylcholine α4β2* receptors using [18 F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways.

Imaging pancreas in healthy and diabetic rodent model using [18F]fallypride positron emission tomography/computed tomography.

In vivo kinetics of [F-18]MEFWAY: a comparison with [C-11]WAY100635 and [F-18]MPPF in the nonhuman primate.

Initial Assessment of β3-Adrenoceptor-Activated Brown Adipose Tissue in Streptozotocin-Induced Type 1 Diabetes Rodent Model Using [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography

Measurement of 5-HT(1A) receptor density and in-vivo binding parameters of [(18)F]mefway in the nonhuman primate.

Measurement of d-amphetamine-induced effects on the binding of dopamine D-2/D-3 receptor radioligand, 18F-fallypride in extrastriatal brain regions in non-human primates using PET.

Measuring α4β2* nicotinic acetylcholine receptor density in vivo with [(18)F]nifene PET in the nonhuman primate

Moderate-level prenatal alcohol exposure alters striatal dopamine system function in rhesus monkeys

Monoamine oxidase A inhibition by fluoxetine: an in vitro and in vivo study

N-(6-18F-fluorohexyl)-N-methylpropargylamine: a fluorine-18-labeled monoamine oxidase B inhibitor for potential use in PET studies

Nicotinic acetylcholine receptors in rat forebrain that bind ¹⁸F-nifene: relating PET imaging, autoradiography, and behavior.

Nicotinic alpha4beta2 receptor imaging agents: part II. Synthesis and biological evaluation of 2-[18F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine (18F-nifene) in rodents and imaging by PET in nonhuman primate.

Nicotinic α4β2 receptor imaging agents. Part III. Synthesis and biological evaluation of 3-(2-(S)-azetidinylmethoxy)-5-(3'-18F-fluoropropyl)pyridine (18F-nifzetidine).

Nicotinic α4β2 receptor imaging agents. Part IV. Synthesis and biological evaluation of 3-(2-(S)-3,4-dehydropyrrolinyl methoxy)-5-(3'-¹⁸F-fluoropropyl)pyridine (¹⁸F-Nifrolene) using PET.

PET imaging of α4β2* nicotinic acetylcholine receptors: quantitative analysis of 18F-nifene kinetics in the nonhuman primate.

PET radiotracer development for imaging high-affinity state of dopamine D2 and D3 receptors: Binding studies of fluorine-18 labeled aminotetralins in rodents. ⬇️

Performance evaluation of an Inveon PET preclinical scanner.

Positron autoradiography for intravascular imaging: feasibility evaluation

Preliminary evaluation of β3-adrenoceptor agonist-induced 18F-FDG metabolic activity of brown adipose tissue in obese Zucker rat.

Prenatal stress, moderate fetal alcohol, and dopamine system function in rhesus monkeys.

Quantitation of striatal and extrastriatal D-2 dopamine receptors using PET imaging of [(18)F]fallypride in nonhuman primates

Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation ⬇️

Radiobrominated m-tyrosine analog as potential CNS L-dopa pet tracer

Radionuclide probes for tissue damage

Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1'-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors

Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance ⬇️

Specific α4β2 nicotinic acetylcholine receptor binding of [F-18]nifene in the rhesus monkey

Spinal cord dopamine D2/D3 receptors: in vivo and ex vivo imaging in the rat using (18)F/(11)C-fallypride

Striatal and extrastriatal microPET imaging of D2/D3 dopamine receptors in rat brain with [¹⁸F]fallypride and [¹⁸F]desmethoxyfallypride

Synthesis and Evaluation of Mefway Analogs as Ligands for Serotonin 5HT1A Receptors

Synthesis and biological evaluation of 18F-Norfallypride in the rodent brain using PET imaging.

Synthesis and biological evaluation of the binding of dopamine D2/D3 receptor agonist, (R,S)-5-hydroxy-2-(N-propyl-N-(5'-(18)F-fluoropentyl)aminotetralin ((18)F-5-OH-FPPAT) in rodents and nonhuman primates

Synthesis and evaluation of (S)-[(18)F]fesetron in the rat brain as a potential PET imaging agent for serotonin 5-HT3 receptors

Synthesis and evaluation of 3-123I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic α4β2 receptor imaging agent ⬇️

Synthesis of radiofluorinated analogs of m-tyrosine as potential L-dopa tracers via direct reaction with acetylhypofluorite

Synthesis, radiosynthesis, and biological evaluation of fluorinated thienylcyclohexyl piperidine derivatives as potential radiotracers for the NMDA receptor-linked calcium ionophore

Targeting presynaptic norepinephrine transporter in brown adipose tissue: a novel imaging approach and potential treatment for diabetes and obesity.

The Homozygote VCPR155H/R155H Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology ⬇️

The effects of lobeline on α4β2* nicotinic acetylcholine receptor binding and uptake of [18F]nifene in rats ⬇️