Lista de obras - Jörg Rademann - Dominio Público Uruguay

2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease

artículo científico publicado en 2021

A phosphorane as supported acylanion equivalent: linker reagents for smooth and versatile C-C coupling reactions

scientific article published on 01 June 2003

Acylated cholesteryl galactosides are ubiquitous glycolipid antigens among Borrelia burgdorferi sensu lato

artículo científico publicado en 2011

Advanced polymer reagents based on activated reactants and reactive intermediates: powerful novel tools in diversity-oriented synthesis

artículo científico publicado en 2003

Alkylating Polymers: Resin-Released Carbenium Ions as Versatile Reactive Intermediates in Polymer-Assisted Solution-Phase Synthesis

article published in 2001

Alkylating Polymers: Resin-Released Carbenium Ions as Versatile Reactive Intermediates in Polymer-Assisted Solution-Phase Synthesis J.R. gratefully acknowledges support from Prof. M. E. Maier, Tübingen, the Strukturfonds of the University of Tübinge

artículo científico publicado en 2001

Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).

artículo científico publicado en 2013

An Intrinsic Hydrophobicity Scale for Amino Acids and Its Application to Fluorinated Compounds

scientific article published on 10 May 2019

An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors

artículo científico publicado en 2006

Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains

artículo científico publicado en 2012

Benzyl Mono-P-Fluorophosphonate and Benzyl Penta-P-Fluorophosphate Anions Are Physiologically Stable Phosphotyrosine Mimetics and Inhibitors of Protein Tyrosine Phosphatases

artículo científico publicado en 2017

Biological characterization, mechanistic investigation and structure-activity relationship of chemically stable TLR2 antagonists

scientific article published on 25 April 2020

Biophysical characterization of synthetic rhamnolipids

artículo científico publicado en 2006

Biotransformation of 2,4-toluenediamine in human skin and reconstructed tissues

artículo científico publicado en 2017

C-acylations of polymeric phosphoranylidene acetates for C-terminal variation of peptide carboxylic acids

artículo científico publicado en 2007

C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells

artículo científico publicado en 2017

Catalytic activation of pre-substrates via dynamic fragment assembly on protein templates

artículo científico publicado en 2014

Catching a Moving Target: Comparative Modeling of Flaviviral NS2B-NS3 Reveals Small Molecule Zika Protease Inhibitors

scientific article published on 03 March 2020

Characterization of defined sulfated heparin-like oligosaccharides by electrospray ionization ion trap mass spectrometry

artículo científico publicado en 2021

Chemical synthesis of a glycolipid library by a solid-phase strategy allows elucidation of the structural specificity of immunostimulation by rhamnolipids

artículo científico publicado en 2006

Chemoenzymatic Synthesis of Nonasulfated Tetrahyaluronan with a Paramagnetic Tag for Studying Its Complex with Interleukin-10.

artículo científico publicado en 2016

Chemoenzymatic synthesis of a glycolipid library and elucidation of the antigenic epitope for construction of a vaccine against Lyme disease

artículo científico publicado en 2010

Chemoselective Wittig and Michael ligations of unprotected peptidyl phosphoranes in water furnish potent inhibitors of caspase-3

artículo científico publicado en 2014

Chemoselective and Bioorthogonal Ligation Reactions. Concepts and Applications. 2 Bände Herausgegeben von W. Russ Algar, Philip Dawson und Igor L. Medintz.

artículo científico publicado en 2017

Chemoselective and Bioorthogonal Ligation Reactions. Concepts and Applications. 2 Volumes Edited by W. Russ Algar, Philip Dawson, and Igor L. Medintz.

artículo científico publicado en 2017

Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.

artículo científico publicado en 2016

Combinatorial Chemistry in the Commercial Jungle

scientific article published on 01 July 2001

Corrigendum to: Off-target inhibition by active site-targeting SHP2 inhibitors

artículo científico publicado en 2019

Coupling to polymeric scaffolds stabilizes biofunctional peptides for intracellular applications

artículo científico publicado en 2011

Cyclative cleavage through dipolar cycloaddition: polymer-bound azidopeptidylphosphoranes deliver locked cis-triazolylcyclopeptides as privileged protein binders

artículo científico publicado en 2010

Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept

artículo científico publicado en 2009

Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach

artículo científico publicado en 2005

Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain

artículo científico publicado en 2011

Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A

scientific article published on 02 December 2019

Dynamic substrate enhancement for the identification of specific, second-site-binding fragments targeting a set of protein tyrosine phosphatases

artículo científico publicado en 2011

Dynamic template-assisted strategies in fragment-based drug discovery.

artículo científico publicado en 2009

Effects of charge and charge distribution on the cellular uptake of multivalent arginine-containing peptide-polymer conjugates

artículo científico publicado en 2013

Efficient access to peptidyl ketones and peptidyl diketones via C-alkylations and C-acylations of polymer-supported phosphorus ylides followed by hydrolytic and/or oxidative cleavage

artículo científico publicado en 2010

Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization

artículo científico publicado en 2006

Epitope-mapping of transglutaminase with parallel label-free optical detection

artículo científico publicado en 2002

Extra- and intracellular imaging of human matrix metalloprotease 11 (hMMP-11) with a cell-penetrating FRET substrate.

artículo científico publicado en 2012

Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity.

artículo científico publicado en 2014

Fluorescent mimetics of CMP-Neu5Ac are highly potent, cell-permeable polarization probes of eukaryotic and bacterial sialyltransferases and inhibit cellular sialylation

artículo científico publicado en 2014

Fmoc-based synthesis of peptide thioacids for azide ligations via 2-cyanoethyl thioesters

artículo científico publicado en 2012

Fmoc-based synthesis of peptide thioesters for native chemical ligation employing a tert-butyl thiol linker

artículo científico publicado en 2011

HPMA as a scaffold for the modular assembly of functional peptide polymers by native chemical ligation

artículo científico publicado en 2008

High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.

artículo científico publicado en 2012

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions

artículo científico publicado en 2013

Hydrophobically assisted switching phase synthesis: the flexible combination of solid-phase and solution-phase reactions employed for oligosaccharide preparation.

artículo científico publicado en 2005

IR action spectroscopy of glycosaminoglycan oligosaccharides

artículo científico publicado en 2019

Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor.

artículo científico publicado en 2015

Identification and validation of a novel dual small-molecule TLR2/8 antagonist

scientific article published on 05 April 2020

Identification of a pyrrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening.

artículo científico publicado en 2018

Identification of the Glycosaminoglycan Binding Site of Interleukin-10 by NMR Spectroscopy

artículo científico publicado en 2015

Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins.

artículo científico publicado en 2016

Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

artículo científico publicado en 2016

Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic

artículo científico publicado en 2015

Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation

artículo científico publicado en 2010

Mapping Protein-Protein Interactions of the Resistance-Related Bacterial Zeta Toxin-Epsilon Antitoxin Complex (ε₂ζ₂) with High Affinity Peptide Ligands Using Fluorescence Polarization

artículo científico publicado en 2016

Metal-free, regioselective triazole ligations that deliver locked cis peptide mimetics.

artículo científico publicado en 2009

Modulation of Human CXCL12 Binding Properties to Glycosaminoglycans To Enhance Chemotactic Gradients

artículo científico publicado en 2019

Multivalent design of apoptosis-inducing bid-BH3 peptide-oligosaccharides boosts the intracellular activity at identical overall peptide concentrations

artículo científico publicado en 2012

Multivalent presentation of the cell-penetrating peptide nona-arginine on a linear scaffold strongly increases its membrane-perturbing capacity

artículo científico publicado en 2014

Nanoparticular Inhibitors of Flavivirus Proteases from Zika, West Nile and Dengue Virus Are Cell-Permeable Antivirals

artículo científico publicado en 2021

New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties

artículo científico publicado en 2012

One-Pot Synthesis of Unprotected Anomeric Glycosyl Thiols in Water for Glycan Ligation Reactions with Highly Functionalized Sugars

artículo científico publicado en 2016

Organic protein chemistry: drug discovery through the chemical modification of proteins

artículo científico publicado en 2004

Oxidizing Polymers: A Polymer-Supported, Recyclable Hypervalent Iodine(V) Reagent for the Efficient Conversion of Alcohols, Carbonyl Compounds, and Unsaturated Carbamates in Solution J.R. gratefully acknowledges generous support from Prof. M. E. Mai

artículo científico publicado en 2001

Oxoammonium Resins as Metal-Free, Highly Reactive, Versatile Polymeric Oxidation Reagents

artículo científico publicado en 2001

Oxoammonium Resins as Metal-Free, Highly Reactive, Versatile Polymeric Oxidation Reagents J.R. gratefully acknowledges generous support from Prof. M. E. Maier, Tübingen, the Strukturfonds of the Universität Tübingen, and Merck KGaA, Darmstadt, Germa

scientific article published on 01 April 2001

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

artículo científico publicado en 2011

Peptide-mediated surface coatings for the release of wound-healing cytokines

artículo científico publicado en 2020

Peptide-polymer ligands for a tandem WW-domain, an adaptive multivalent protein-protein interaction: lessons on the thermodynamic fitness of flexible ligands

artículo científico publicado en 2015

Pharmacological inhibition of FSGS-related TRPC6 gain of function mutants by semisynthetic larixol-derived compounds.

artículo científico publicado en 2017

Phenylthiomethyl Ketone-Based Fragments Show Selective and Irreversible Inhibition of Enteroviral 3C Proteases

artículo científico publicado en 2018

Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis

artículo científico publicado en 2009

Physical properties of poly(ethylene glycol) (PEG)-based resins for combinatorial solid phase organic chemistry: a comparison of PEG-cross-linked and PEG-grafted resins

artículo científico publicado en 2000

Polymer-bound alkyltriazenes for mild racemization-free esterification of amino acid and peptide derivatives

artículo científico publicado en 2004

Progress in the preparation of peptide aldehydes via polymer supported IBX oxidation and scavenging by threonyl resin

artículo científico publicado en 2005

Propargyl amides as irreversible inhibitors of cysteine proteases--a lesson on the biological reactivity of alkynes

artículo científico publicado en 2013

Protein-Templated Formation of an Inhibitor of the Blood Coagulation Factor Xa through a Background-Free Amidation Reaction

artículo científico publicado en 2017

Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery.

artículo científico publicado en 2017

Proteintemplat-gesteuerte Fragmentligationen - von der molekularen Erkennung zur Wirkstofffindung

scientific article published on 31 May 2017

Resin-bound aminofluorescein for C-terminal labeling of peptides: high-affinity polarization probes binding to polyproline-specific GYF domains

artículo científico publicado en 2008

Reversible cross-linking of hyperbranched polymers: a strategy for the combinatorial decoration of multivalent scaffolds

scientific article published on 01 February 2005

Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery.

artículo científico publicado en 2016

SPOCC-194, a new high functional group density PEG-based resin for solid-phase organic synthesis

artículo científico publicado en 2002

Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor.

artículo científico publicado en 2009

Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo

artículo científico publicado en 2015

Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening

scientific article published on 01 January 2008

Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.

artículo científico publicado en 2015

Side-Chain Modification of Peptides Using a Phosphoranylidene Amino Acid

scientific article published on 30 March 2020

Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography

artículo científico publicado en 2007

Solid-Phase Supported Synthesis of the Branched Pentasaccharide Moiety That Occurs in Most Complex Type N-Glycan Chains.

artículo científico publicado en 1998

Solid-phase synthesis of a glycosylated hexapeptide of human sialophorin, using the trichloroacetimidate method

scientific article published on 01 April 1995

Soluble peptidyl phosphoranes for metal-free, stereoselective ligations in organic and aqueous solution.

artículo científico publicado en 2011

Spatially resolved single bead analysis: homogeneity, diffusion, and adsorption in cross-linked polystyrene

scientific article published on 01 September 2001

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.

artículo científico publicado en 2008

Stereospecific synthesis of chiral 2,3-dihydro-1,4-benzodithiine and methyl-2,3-dihydro-1,4-benzodithiine derivatives and their toxic effects on Trypanosoma brucei

artículo científico publicado en 2005

Structural Basis for Binding of Fluorescent CMP-Neu5Ac Mimetics to Enzymes of the Human ST8Sia Family

artículo científico publicado en 2018

Structural and functional insights into the interaction of sulfated glycosaminoglycans with tissue inhibitor of metalloproteinase-3 - A possible regulatory role on extracellular matrix homeostasis

artículo científico publicado en 2016

Sulfated Hyaluronan Alters Endothelial Cell Activation in Vitro by Controlling the Biological Activity of the Angiogenic Factors Vascular Endothelial Growth Factor-A and Tissue Inhibitor of Metalloproteinase-3.

artículo científico publicado en 2017

Sulfated Hyaluronan Alters the Interaction Profile of TIMP-3 with the Endocytic Receptor LRP-1 Clusters II and IV and Increases the Extracellular TIMP-3 Level of Human Bone Marrow Stromal Cells

artículo científico publicado en 2016

Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF-β1 Signaling

artículo científico publicado en 2017

Sulfation Patterns of Saccharides and Heavy Metal Ion Binding

scientific article published on 28 July 2019

Syntheses of defined sulfated oligohyaluronans reveal structural effects, diversity and thermodynamics of GAG-protein binding

scientific article published on 01 November 2018

Tailoring ultraresins based on the cross-linking of polyethylene imines. Comparative investigation of the chemical composition, the swelling, the mobility, the chemical accessibility, and the performance in solid-phase synthesis of very high loaded

artículo científico publicado en 2004

The potential of P1 site alterations in peptidomimetic protease inhibitors as suggested by virtual screening and explored by the use of C-C-coupling reagents

artículo científico publicado en 2006

The structural investigation of glycosaminoglycan binding to CXCL12 displays distinct interaction sites

artículo científico publicado en 2016

The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation

artículo científico publicado en 2019

ULTRA loaded resins based on the cross-linking of linear poly(ethylene imine). Improving the atom economy of polymer-supported chemistry

artículo científico publicado en 2002

Understanding supported reactions in spherical compartments: a general algorithm to model and determine rate constants, diffusion coefficients, and spatial product distributions

artículo científico publicado en 2005

alpha-Ketocarbonyl peptides: a general approach to reactive resin-bound intermediates in the synthesis of peptide isosteres for protease inhibitor screening on solid support

artículo científico publicado en 2001

Lista de obras de Jörg Rademann

2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease

A phosphorane as supported acylanion equivalent: linker reagents for smooth and versatile C-C coupling reactions

Acylated cholesteryl galactosides are ubiquitous glycolipid antigens among Borrelia burgdorferi sensu lato

Advanced polymer reagents based on activated reactants and reactive intermediates: powerful novel tools in diversity-oriented synthesis

Alkylating Polymers: Resin-Released Carbenium Ions as Versatile Reactive Intermediates in Polymer-Assisted Solution-Phase Synthesis

Alkylating Polymers: Resin-Released Carbenium Ions as Versatile Reactive Intermediates in Polymer-Assisted Solution-Phase Synthesis J.R. gratefully acknowledges support from Prof. M. E. Maier, Tübingen, the Strukturfonds of the University of Tübinge

Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).

An Intrinsic Hydrophobicity Scale for Amino Acids and Its Application to Fluorinated Compounds

An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors

Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains

Benzyl Mono-P-Fluorophosphonate and Benzyl Penta-P-Fluorophosphate Anions Are Physiologically Stable Phosphotyrosine Mimetics and Inhibitors of Protein Tyrosine Phosphatases

Biological characterization, mechanistic investigation and structure-activity relationship of chemically stable TLR2 antagonists

Biophysical characterization of synthetic rhamnolipids

Biotransformation of 2,4-toluenediamine in human skin and reconstructed tissues

C-acylations of polymeric phosphoranylidene acetates for C-terminal variation of peptide carboxylic acids

C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells

Catalytic activation of pre-substrates via dynamic fragment assembly on protein templates

Catching a Moving Target: Comparative Modeling of Flaviviral NS2B-NS3 Reveals Small Molecule Zika Protease Inhibitors

Characterization of defined sulfated heparin-like oligosaccharides by electrospray ionization ion trap mass spectrometry

Chemical synthesis of a glycolipid library by a solid-phase strategy allows elucidation of the structural specificity of immunostimulation by rhamnolipids

Chemoenzymatic Synthesis of Nonasulfated Tetrahyaluronan with a Paramagnetic Tag for Studying Its Complex with Interleukin-10.

Chemoenzymatic synthesis of a glycolipid library and elucidation of the antigenic epitope for construction of a vaccine against Lyme disease

Chemoselective Wittig and Michael ligations of unprotected peptidyl phosphoranes in water furnish potent inhibitors of caspase-3

Chemoselective and Bioorthogonal Ligation Reactions. Concepts and Applications. 2 Bände Herausgegeben von W. Russ Algar, Philip Dawson und Igor L. Medintz.

Chemoselective and Bioorthogonal Ligation Reactions. Concepts and Applications. 2 Volumes Edited by W. Russ Algar, Philip Dawson, and Igor L. Medintz.

Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.

Combinatorial Chemistry in the Commercial Jungle

Corrigendum to: Off-target inhibition by active site-targeting SHP2 inhibitors

Coupling to polymeric scaffolds stabilizes biofunctional peptides for intracellular applications

Cyclative cleavage through dipolar cycloaddition: polymer-bound azidopeptidylphosphoranes deliver locked cis-triazolylcyclopeptides as privileged protein binders

Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept

Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach

Discovery, structure-activity relationship studies, and crystal structure of nonpeptide inhibitors bound to the Shank3 PDZ domain

Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A

Dynamic substrate enhancement for the identification of specific, second-site-binding fragments targeting a set of protein tyrosine phosphatases

Dynamic template-assisted strategies in fragment-based drug discovery.

Effects of charge and charge distribution on the cellular uptake of multivalent arginine-containing peptide-polymer conjugates

Efficient access to peptidyl ketones and peptidyl diketones via C-alkylations and C-acylations of polymer-supported phosphorus ylides followed by hydrolytic and/or oxidative cleavage

Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization

Epitope-mapping of transglutaminase with parallel label-free optical detection

Extra- and intracellular imaging of human matrix metalloprotease 11 (hMMP-11) with a cell-penetrating FRET substrate.

Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity.

Fluorescent mimetics of CMP-Neu5Ac are highly potent, cell-permeable polarization probes of eukaryotic and bacterial sialyltransferases and inhibit cellular sialylation

Fmoc-based synthesis of peptide thioacids for azide ligations via 2-cyanoethyl thioesters

Fmoc-based synthesis of peptide thioesters for native chemical ligation employing a tert-butyl thiol linker

HPMA as a scaffold for the modular assembly of functional peptide polymers by native chemical ligation

High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions

Hydrophobically assisted switching phase synthesis: the flexible combination of solid-phase and solution-phase reactions employed for oligosaccharide preparation.

IR action spectroscopy of glycosaminoglycan oligosaccharides

Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor.

Identification and validation of a novel dual small-molecule TLR2/8 antagonist

Identification of a pyrrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening.

Identification of the Glycosaminoglycan Binding Site of Interleukin-10 by NMR Spectroscopy

Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins.

Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic

Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation

Mapping Protein-Protein Interactions of the Resistance-Related Bacterial Zeta Toxin-Epsilon Antitoxin Complex (ε₂ζ₂) with High Affinity Peptide Ligands Using Fluorescence Polarization

Metal-free, regioselective triazole ligations that deliver locked cis peptide mimetics.

Modulation of Human CXCL12 Binding Properties to Glycosaminoglycans To Enhance Chemotactic Gradients

Multivalent design of apoptosis-inducing bid-BH3 peptide-oligosaccharides boosts the intracellular activity at identical overall peptide concentrations

Multivalent presentation of the cell-penetrating peptide nona-arginine on a linear scaffold strongly increases its membrane-perturbing capacity

Nanoparticular Inhibitors of Flavivirus Proteases from Zika, West Nile and Dengue Virus Are Cell-Permeable Antivirals

New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties

One-Pot Synthesis of Unprotected Anomeric Glycosyl Thiols in Water for Glycan Ligation Reactions with Highly Functionalized Sugars

Organic protein chemistry: drug discovery through the chemical modification of proteins

Oxidizing Polymers: A Polymer-Supported, Recyclable Hypervalent Iodine(V) Reagent for the Efficient Conversion of Alcohols, Carbonyl Compounds, and Unsaturated Carbamates in Solution J.R. gratefully acknowledges generous support from Prof. M. E. Mai

Oxoammonium Resins as Metal-Free, Highly Reactive, Versatile Polymeric Oxidation Reagents

Oxoammonium Resins as Metal-Free, Highly Reactive, Versatile Polymeric Oxidation Reagents J.R. gratefully acknowledges generous support from Prof. M. E. Maier, Tübingen, the Strukturfonds of the Universität Tübingen, and Merck KGaA, Darmstadt, Germa

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

Peptide-mediated surface coatings for the release of wound-healing cytokines

Peptide-polymer ligands for a tandem WW-domain, an adaptive multivalent protein-protein interaction: lessons on the thermodynamic fitness of flexible ligands

Pharmacological inhibition of FSGS-related TRPC6 gain of function mutants by semisynthetic larixol-derived compounds.

Phenylthiomethyl Ketone-Based Fragments Show Selective and Irreversible Inhibition of Enteroviral 3C Proteases

Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis

Physical properties of poly(ethylene glycol) (PEG)-based resins for combinatorial solid phase organic chemistry: a comparison of PEG-cross-linked and PEG-grafted resins

Polymer-bound alkyltriazenes for mild racemization-free esterification of amino acid and peptide derivatives

Progress in the preparation of peptide aldehydes via polymer supported IBX oxidation and scavenging by threonyl resin