Filtros de búsqueda

Lista de obras de William Denny

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

artículo científico publicado en 2019

3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3

artículo científico publicado en 2012

4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione Inhibitors of the Checkpoint Kinase Wee1. Structure−Activity Relationships for Chromophore Modification and Phenyl Ring Substitution

article

4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death.

artículo científico publicado en 2010

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase

artículo científico publicado en 2007

6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

artículo científico publicado en 2017

6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.

artículo científico publicado en 2017

7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis.

artículo científico publicado en 2017

A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells

artículo científico publicado en 2016

A diacridine derivative that binds by bisintercalation at two contiguous sites on DNA

artículo científico publicado en 1985

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types ⬇️

artículo científico publicado el 15 de agosto de 2011

A mitochondria-selective near-infrared-emitting fluorescent dye for cellular imaging studies

scientific article published on 03 May 2018

A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy

artículo científico publicado en 2008

A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation

artículo científico publicado en 2009

A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions

artículo científico publicado en 2020

A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors.

artículo científico publicado en 2009

A roadmap for drug discovery and its translation to small molecule agents in clinical development for tuberculosis treatment

artículo científico publicado en 2008

Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction

artículo científico publicado en 2003

Amsacrine as a Topoisomerase II Poison: Importance of Drug–DNA Interactions ⬇️

artículo científico publicado el 10 de febrero de 2012

An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca 2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay

artículo científico publicado en 2018

An improved synthesis of 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

artículo científico publicado en 2002

Anionic carbonato and oxalato cobalt(III) nitrogen mustard complexes.

artículo científico publicado en 2004

Antimalarial 9-anilinoacridine compounds directed at hematin

artículo científico publicado en 2003

Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid

artículo científico publicado en 2017

Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides

artículo científico publicado en 2017

Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.

artículo científico publicado en 2004

Benzenesulphonamide inhibitors of the cytolytic protein perforin.

artículo científico publicado en 2016

Beta-Testing of PI3-Kinase Inhibitors: Is Beta Better? ⬇️

artículo científico publicado el 1 de mayo de 2012

Biarylmethoxy 2-nitroimidazooxazine antituberculosis agents: Effects of proximal ring substitution and linker reversal on metabolism and efficacy.

artículo científico publicado en 2015

Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors

artículo científico publicado en 2017

COMMENTARY. Pre-emptive Nutrition: Refining the Targets of Drugs Targeted to Colorectal Cancer

artículo científico publicado en 2015

Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221.

artículo científico publicado en 2007

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.

artículo científico publicado en 2014

Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).

artículo científico publicado en 2010

Combined neutron and X-ray diffraction studies of DNA in crystals and solutions

article

Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.

artículo científico publicado en 2017

Comparison of hematin-targeting properties of pynacrine, an acridine analog of the benzonaphthyridine antimalarial pyronaridine

artículo científico publicado en 2014

Corrigendum: Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis

artículo científico publicado en 2015

Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.

artículo científico publicado en 2013

Cross-bridged cyclen or cyclam Co(III) complexes containing cytotoxic ligands as hypoxia-activated prodrugs.

artículo científico publicado en 2013

Crystal structure of 9-amino-N-[2-(4-morpholinyl)ethyl]-4-acridinecarboxamide bound to d(CGTACG)2: implications for structure-activity relationships of acridinecarboxamide topoisomerase poisons

artículo científico publicado en 2002

Cyclic Tetrapeptides from Nature and Design: A Review of Synthetic Methodologies, Structure, and Function

artículo científico publicado en 2019

DNA and the chromosome - varied targets for chemotherapy

artículo científico publicado en 2004

DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine

artículo científico publicado en 2004

Demonstration by real-time polymerase chain reaction that cellular DNA alkylation by novel aminoindoline compounds affects expression of the protooncogene c-myc

artículo científico publicado en 2005

Determination of the Hypnotic Potency in Rats of the Novel Ketamine Ester Analogue SN 35210.

artículo científico publicado en 2015

Development and evaluation of PIK75 nanosuspension, a phosphatidylinositol-3-kinase inhibitor.

artículo científico publicado en 2012

Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.

artículo científico publicado en 2018

Development of PIK-75 nanosuspension formulation with enhanced delivery efficiency and cytotoxicity for targeted anti-cancer therapy.

artículo científico publicado en 2013

Development of Rapidly Metabolized and Ultra-Short-Acting Ketamine Analogs

artículo científico publicado en 2015

Diarylthiophenes as inhibitors of the pore-forming protein perforin

artículo científico publicado en 2015

Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin

artículo científico publicado en 2008

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors.

artículo científico publicado en 2011

Effect of common and experimental anti-tuberculosis treatments on Mycobacterium tuberculosis growing as biofilms

artículo científico publicado en 2016

Effect of common and experimental anti-tuberculosis treatments on Mycobacterium tuberculosis growing as biofilms

artículo científico publicado en 2016

Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.

artículo científico publicado en 2003

Effect of wet milling process on the solid state of indomethacin and simvastatin.

artículo científico publicado en 2009

Effects of anticancer drugs on transcription factor-DNA interactions.

artículo científico publicado en 2005

Enhanced conversion of DNA radical damage to double strand breaks by 1,2,4-benzotriazine 1,4-dioxides linked to a DNA binder compared to tirapazamine

artículo científico publicado en 2003

Epigenetic regulation of gene expression as an anticancer drug target

artículo científico publicado en 2011

Evaluation of a crystalline nanosuspension: polymorphism, process induced transformation and in vivo studies

artículo científico publicado en 2011

Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay.

artículo científico publicado en 2016

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

artículo científico publicado en 2007

Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative

artículo científico publicado en 2016

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin

artículo científico publicado en 2013

Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling

artículo científico publicado en 2015

Formulation and pharmacokinetics of lipid nanoparticles of a chemically sensitive nitrogen mustard derivative: Chlorambucil

artículo científico publicado en 2008

Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction

artículo científico publicado en 2014

Frameshift mutations induced by four isomeric nitroacridines and their des-nitro counterpart in the lacZ reversion assay in Escherichia coli

artículo científico publicado en 2006

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

artículo científico publicado en 2009

Genotoxicity of non-covalent interactions: DNA intercalators

artículo científico publicado en 2007

Giving Anemia a Boost with Inhibitors of Prolyl Hydroxylase ⬇️

artículo científico publicado el 12 de marzo de 2012

Heptamethine cyanine dye mediated drug delivery: Hype or Hope

artículo científico publicado en 2020

Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal

scientific article published on 10 October 2020

Homobivalent Conjugation Increases the Allosteric Effect of 9-aminoacridine at the α1-Adrenergic Receptors

artículo científico publicado en 2016

Human α1-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines

artículo científico publicado en 2014

Hypoxia-activated prodrugs in cancer therapy: progress to the clinic

artículo científico publicado en 2010

Hypoxia-activated prodrugs: substituent effects on the properties of nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) prodrugs of DNA minor groove alkylating agents.

artículo científico publicado en 2009

Hypoxia-selective 3-alkyl 1,2,4-benzotriazine 1,4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity

artículo científico publicado en 2007

Hypoxic selectivity and solubility--investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy.

artículo científico publicado en 2010

Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting

artículo científico publicado en 2003

In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II.

artículo científico publicado en 2002

In vitro susceptibility of Trichomonas vaginalis to AT-specific minor groove binding drugs

artículo científico publicado en 2003

Inhibition of strigolactone receptors by N-phenylanthranilic acid derivatives: Structural and functional insights.

artículo científico publicado en 2018

Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo

scientific article published on 26 September 2019

Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles.

artículo científico publicado en 2011

Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones ⬇️

artículo científico publicado el 22 de diciembre de 2011

Intermediates in the reduction of the antituberculosis drug PA-824, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, in aqueous solution

artículo científico publicado en 2008

Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents.

artículo científico publicado en 2018

KEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects

scientific article published on 19 December 2019

Ketamine esters and amides as short-acting anaesthetics: Structure-activity relationships for the side-chain

scientific article published on 05 February 2019

Kinetic studies of the binding of acridinecarboxamide topoisomerase poisons to DNA: implications for mode of binding of ligands with uncharged chromophores

artículo científico publicado en 2002

L-Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors

artículo científico publicado en 2015

Long-chain triazolyl acids as inhibitors of osteoclastogenesis

artículo científico publicado en 2013

Mass spectrometry studies of the binding of the minor groove-directed alkylating agent alkamin to AT-tract oligonucleotides.

artículo científico publicado en 2009

Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.

artículo científico publicado en 2007

Microtubule-stabilizing properties of the avocado-derived toxins (+)-(R)-persin and (+)-(R)-tetrahydropersin in cancer cells and activity of related synthetic analogs

artículo científico publicado en 2016

Mode of cell death induced in Chinese hamster cells by sequence-selective DNA minor groove binding nitrogen mustards: comparison with untargeted mustards and with Hoechst 33342.

artículo científico publicado en 2003

Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3)

artículo científico publicado en 2014

N-alkylated cyclen cobalt(III) complexes of 1-(chloromethyl)-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugs.

artículo científico publicado en 2011

Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy.

artículo científico publicado en 2012

Nitroacridines with selective toxicity towards hypoxic mammalian cells: Synthesis and stability of tritiated derivatives

artículo científico publicado en 1985

Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapy

artículo científico publicado en 2005

Non-covalent ligand/DNA interactions: minor groove binding agents

artículo científico publicado en 2007

Novel angular benzophenazines: dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents

artículo científico publicado en 2002

Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR ⬇️

artículo científico publicado el 25 de noviembre de 2011

Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors

artículo científico publicado en 2016

Optimization of the auxiliary ligand shell of Cobalt(III)(8-hydroxyquinoline) complexes as model hypoxia-selective radiation-activated prodrugs.

artículo científico publicado en 2004

Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides

artículo científico publicado en 2004

PARP inhibitor cyanine dye conjugate with enhanced cytotoxic and antiproliferative activity in patient derived glioblastoma cell lines

artículo científico publicado en 2020

Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport

artículo científico publicado en 2007

Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors

artículo científico publicado en 2010

Phenazine-1-carboxamides: structure-cytotoxicity relationships for 9-substituents and changes in the H-bonding pattern of the cationic side chain

artículo científico publicado en 2005

Phosphatidylinositol 3-kinase inhibitor (PIK75) containing surface functionalized nanoemulsion for enhanced drug delivery, cytotoxicity and pro-apoptotic activity in ovarian cancer cells

artículo científico publicado en 2012

Phosphoinositide 3-kinase α inhibitors: a patent review

artículo científico publicado en 2013

Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.

artículo científico publicado en 2009

Phosphoinositide-3-kinases (PI3Ks): combined comparative modeling and 3D-QSAR to rationalize the inhibition of p110alpha

artículo científico publicado en 2008

Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: the role of redox equilibria

artículo científico publicado en 2006

Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.

artículo científico publicado en 2002

Quinazolines as novel anti-inflammatory histone deacetylase inhibitors.

artículo científico publicado en 2010

Radical properties governing the hypoxia-selective cytotoxicity of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.

artículo científico publicado en 2005

Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy

artículo científico publicado en 2020

Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides.

artículo científico publicado en 2017

Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent

artículo científico publicado en 2009

Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis.

artículo científico publicado en 2016

Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis

artículo científico publicado en 2014

Selective Treatment of Hypoxic Tumor Cells In Vivo: Phosphate Pre‐Prodrugs of Nitro Analogues of the Duocarmycins ⬇️

artículo científico publicado el 17 de febrero de 2011

Small-molecule CSF1R kinase inhibitors; review of patents 2015-present

artículo científico publicado en 2020

Spin trapping of radicals other than the *OH radical upon reduction of the anticancer agent tirapazamine by cytochrome P450 reductase

artículo científico publicado en 2009

Structural characterisation of bisintercalation in higher-order DNA at a junction-like quadruplex

artículo científico publicado en 2002

Structure of 9-amino-[N-(2-dimethylamino)propyl]acridine-4-carboxamide bound to d(CGTACG)(2): a comparison of structures of d(CGTACG)(2) complexed with intercalatorsin the presence of cobalt

artículo científico publicado en 2004

Structure of the d(CGCGAATTCGCG)2 complex of the minor groove binding alkylating agent alkamin studied by mass spectrometry

artículo científico publicado en 2007

Structure-Activity Relationships for the Anaesthetic and Analgaesic Properties of Aromatic Ring-Substituted Ketamine Esters

artículo científico publicado en 2020

Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1.

artículo científico publicado en 2005

Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase

artículo científico publicado en 2003

Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

artículo científico publicado en 2011

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

artículo científico publicado en 2018

Structure-activity relationships for analogues of the phenazine-based dual topoisomerase I/II inhibitor XR11576.

artículo científico publicado en 2002

Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents

artículo científico publicado en 2002

Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

scientific article published on 15 February 2019

Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine

artículo científico publicado en 2003

Structures and dynamics of DNA complexes of the desmethyl analog of the cytotoxin MLN944: Insights into activity when a methyl isn't futile

scientific article published on 06 April 2020

Structures of two minor-groove-binding quinolinium quaternary salts complexed with d(CGCGAATTCGCG)(2) at 1.6 and 1.8 Angstrom resolution

artículo científico publicado en 2005

Structure–activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1 ⬇️

artículo científico publicado el 6 de abril de 2013

Structure–activity relationships for ketamine esters as short-acting anaesthetics ⬇️

artículo científico publicado el 27 de junio de 2013

Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

artículo científico publicado en 2020

Substituted 9-aminoacridine-4-carboxamides tethered to platinum(II)diamine complexes: chemistry, cytotoxicity and DNA sequence selectivity.

artículo científico publicado en 2010

Substituted arylsulphonamides as inhibitors of perforin-mediated lysis

artículo científico publicado en 2017

Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria

scientific article published on 22 May 2020

Syntheses of 8-quinolinolatocobalt(III) complexes containing cyclen based auxiliary ligands as models for hypoxia-activated prodrugs

artículo científico publicado en 2010

Syntheses, crystal structure and cytotoxicity of diamine platinum(II) complexes containing maltol

artículo científico publicado en 2005

Synthesis and Evaluation of Imidazo[1,2-a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3-Kinase Inhibitors

scientific article published on 12 March 2019

Synthesis and Microtubule Destabilizing Activity of N-Cyclopropyl-4-((3,4-dihydroquinolin-1(2H)-yl)sulfonyl)benzamide and its Analogs

artículo científico publicado en 2018

Synthesis and Structure−Activity Relationships of Aza- and Diazabiphenyl Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

article

Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis.

artículo científico publicado en 2008

Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).

artículo científico publicado en 2011

Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474) ⬇️

artículo científico publicado el 6 de abril de 2013

Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474

artículo científico publicado en 2019

Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.

artículo científico publicado en 2017

Synthesis and cytotoxic activity of N-(2-diethylamino)ethylcarboxamide and other derivatives of 10H-quindoline

artículo científico publicado en 2002

Synthesis and cytotoxic activity of N-[(alkylamino)alkyl]carboxamide derivatives of 7-oxo-7H-benz[de]anthracene, 7-oxo-7H-naphtho[1,2,3-de]quinoline, and 7-oxo-7H-benzo[e]perimidine.

artículo científico publicado en 2005

Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridin-(5H)ones.

artículo científico publicado en 2005

Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines

artículo científico publicado en 2003

Synthesis and cytotoxicity of thieno[2,3-b]quinoline-2-carboxamide and cycloalkyl[b]thieno[3,2-e]pyridine-2-carboxamide derivatives.

artículo científico publicado en 2016

Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units.

artículo científico publicado en 2017

Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy

artículo científico publicado en 2003

Synthesis and evaluation of stable bidentate transition metal complexes of 1-(chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as hypoxia selective cytotoxins.

artículo científico publicado en 2009

Synthesis and evaluation of unsymmetrical bis(arylcarboxamides) designed as topoisomerase-Targeted anticancer drugs ⬇️

artículo científico publicado el 1 de enero de 2002

Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells

artículo científico publicado en 2011

Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3

artículo científico publicado en 2013

Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy

artículo científico publicado en 2007

Synthesis and structure-activity relationships for extended side chain analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

artículo científico publicado en 2015

Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis

scientific article published on 24 September 2020

Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases

artículo científico publicado en 2008

Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains

artículo científico publicado en 2010

Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor

artículo científico publicado en 2005

Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases

artículo científico publicado en 2008

Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5h-imidazo[2,1-b][1,3]oxazine (PA-824).

artículo científico publicado en 2011

Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

artículo científico publicado en 2010

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.

artículo científico publicado en 2007

Synthesis, reduction potentials, and antitubercular activity of ring A/B analogues of the bioreductive drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

artículo científico publicado en 2009

Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogue of Bedaquiline

artículo científico publicado en 2020

Synthetic studies utilizing podocarpic acid ⬇️

1969 doctoral thesis by William Alexander Denny at University of Auckland

Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

artículo científico publicado en 2016

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality ⬇️

artículo científico publicado el 3 de agosto de 2011

Targeting of nanoparticles in cancer: drug delivery and diagnostics

artículo científico publicado en 2011

Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3).

artículo científico publicado en 2013

The Activity of SN33638, an Inhibitor of AKR1C3, on Testosterone and 17β-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast Cancer

artículo científico publicado en 2014

The DNA sequence selectivity of maltolato-containing cisplatin analogues in purified plasmid DNA and in intact human cells

scientific article published on 13 June 2009

The Nitroimidazooxazines (PA-824 and Analogs): Structure–Activity Relationship and Mechanistic Studies ⬇️

artículo científico publicado el 1 de agosto de 2010

The drug vehicle and solvent N-methylpyrrolidone is an immunomodulator and antimyeloma compound

artículo científico publicado en 2014

The effect of DNA-alkylating agents on gene expression from two integrated reporter genes in a mouse mammary tumor line

artículo científico publicado en 2002

The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy

scientific article published on 25 August 2011

The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycins

scientific article published on 29 June 2011

The post-lockdown period should be used to acquire effective therapies for future resurgence in SARS-Cov-2 infections

artículo científico publicado en 2020

The solution structure of bis(phenazine-1-carboxamide)-DNA complexes: MLN 944 binding corrected and extended

artículo científico publicado en 2014

The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents

artículo científico publicado en 2007

The synthesis of a novel Crizotinib heptamethine cyanine dye conjugate that potentiates the cytostatic and cytotoxic effects of Crizotinib in patient-derived glioblastoma cell lines

scientific article published on 29 July 2019

Therapeutic reactivation of mutant p53 protein by quinazoline derivatives ⬇️

artículo científico publicado el 13 de septiembre de 2011

Transcription factors as targets for DNA-interacting drugs.

artículo científico publicado en 2003

Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain

artículo científico publicado en 2019

Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins

artículo científico publicado en 2008

Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family

artículo científico publicado en 2016

Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors

artículo científico publicado en 2006

Unsymmetrical DNA cross-linking agents: combination of the CBI and PBD pharmacophores.

artículo científico publicado en 2003

Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs

artículo científico publicado en 2006

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

artículo científico publicado en 2021

Validation of inhibitors of an ABC transporter required to transport lipopolysaccharide to the cell surface in Escherichia coli ⬇️

artículo científico publicado el 18 de abril de 2013

Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology

artículo científico publicado en 2019

Weight loss effects of quaternary salts of 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles; structure–activity relationships ⬇️

artículo científico publicado el 10 de diciembre de 2011

α₁-Adrenoceptor and serotonin 5-HT(1A) receptor affinity of homobivalent 4-aminoquinoline compounds: an investigation of the effect of linker length

artículo científico publicado en 2013

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda