Lista de obras - Russell J Cox - Dominio Público Uruguay

13CLabeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibioticzeamine from Dickeya zeae

artículo científico publicado en 2009

O-Methylation steps during strobilurin and bolineol biosynthesis

artículo científico publicado en 2019

A Natural Plasmid Uniquely Encodes Two Biosynthetic Pathways Creating a Potent Anti-MRSA Antibiotic ⬇️

artículo científico publicado el 31 de marzo de 2011

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis

artículo científico publicado en 2013

A new synthesis of phosphoramidates: inhibitors of the key bacterial enzyme aspartate semi-aldehyde dehydrogenase

artículo científico publicado en 2002

Acyl palladium species in synthesis: single-step synthesis of alpha,beta-unsaturated ketones from acid chlorides

artículo científico publicado en 2006

Acylation of Streptomyces type II polyketide synthase acyl carrier proteins

article

Antroxazole A, an oxazole-containing chamigrane dimer from the fungus Antrodiella albocinnamomea with immunosuppressive activity

Authentic heterologous expression of the tenellin iterative polyketide synthase nonribosomal peptide synthetase requires coexpression with an enoyl reductase.

artículo científico publicado en 2008

Bacterial diaminopimelate metabolism as a target for antibiotic design.

artículo científico publicado en 2000

Biosynthesis of Mupirocin by Pseudomonas fluorescens NCIMB 10586 Involves Parallel Pathways

artículo científico publicado en 2014

Biosynthesis of oxygenated brasilane terpene glycosides involves a promiscuous N-acetylglucosamine transferase ⬇️

scientific article published on 16 September 2020

Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana.

artículo científico publicado en 2007

Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase

artículo científico publicado en 2010

Catalytic self-acylation of type II polyketide synthase acyl carrier proteins

scientific article published on 01 January 1998

Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis

scientific article published on 25 July 2007

Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi ⬇️

scientific article published on 26 November 2018

Chemical mechanisms involved during the biosynthesis of tropolones.

artículo científico

Classic fungal natural products in the genomic age: the molecular legacy of Harold Raistrick

artículo científico publicado en 2018

Design, synthesis and analysis of inhibitors of bacterial aspartate semialdehyde dehydrogenase.

artículo científico publicado en 2005

Diastereoselective synthesis of cyclopropane amino acids using diazo compounds generated in situ.

artículo científico publicado en 2003

Dissecting the component reactions catalyzed by the actinorhodin minimal polyketide synthase.

artículo científico publicado en 2007

Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390 ⬇️

scientific article published on 04 March 2011

Evidence for enzyme catalysed intramolecular [4+2] Diels-Alder cyclization during the biosynthesis of pyrichalasin H

scientific article published on 01 March 2020

Expression, purification and preliminary X-ray diffraction analysis of a ketoreductase from a type II polyketide synthase.

artículo científico publicado en 2004

First heterologous reconstruction of a complete functional fungal biosynthetic multigene cluster.

artículo científico publicado en 2010

First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determination.

artículo científico publicado en 2003

Function of pathway specific regulators in the ACE1 and pyrichalasin H biosynthetic gene clusters

artículo científico publicado en 2019

Functional analysis of the conserved transcriptional regulator CfWor1 in Cladosporium fulvum reveals diverse roles in the virulence of plant pathogenic fungi

artículo científico publicado en 2014

Fungal type I polyketide synthases.

artículo científico publicado en 2009

Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum. ⬇️

artículo científico publicado en 2004

Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari ⬇️

artículo científico publicado en 2020

Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

scientific article published on 01 July 2017

Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis.

artículo científico publicado en 2012

Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis.

artículo científico publicado en 2016

Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae

artículo científico publicado en 2015

High quality genome sequences of thirteen Hypoxylaceae (Ascomycota) strengthen the phylogenetic family backbone and enable the discovery of new taxa ⬇️

artículo científico

Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production

artículo científico publicado en 2016

Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues ⬇️

artículo científico publicado en 2016

In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase.

artículo científico publicado en 2017

In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: the "leaky hosepipe" mechanism.

artículo científico publicado en 2008

Indium mediated allylation of glyoxylate oxime ethers, esters and cyanoformates.

artículo científico publicado en 2004

Investigating the Function of Cryptic Cytochalasan Cytochrome P450 Monooxygenases Using Combinatorial Biosynthesis

artículo científico publicado en 2019

Investigating the biosynthesis of Sch-642305 in the fungus Phomopsis sp. CMU-LMA

artículo científico publicado en 2020

Investigations into the biosynthesis of the antifungal strobilurins.

artículo científico publicado en 2018

Isolation and characterisation of a ferrirhodin synthetase gene from the sugarcane pathogen Fusarium sacchari.

artículo científico publicado en 2013

Kinetic and mechanistic analysis of the malonyl CoA:ACP transacylase from Streptomyces coelicolor indicates a single catalytically competent serine nucleophile at the active site.

artículo científico publicado en 2002

Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the entomopathogenic fungus Beauveria bassiana.

artículo científico publicado en 2008

MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor

artículo científico publicado en 1998

Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production

artículo científico publicado en 2011

Minimum Information about a Biosynthetic Gene cluster.

artículo científico publicado en 2015

Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase

scientific article published on 30 July 2019

Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens

article

Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase

artículo científico publicado en 2010

Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by pseudomonas fluorescens: pseudomonic acid B biosynthesis precedes pseudomonic acid A

scientific article published on 23 March 2007

Nongenetic Reprogramming of a Fungal Highly Reducing Polyketide Synthase

scientific article published on 15 June 2011

Novel nonadride, heptadride and maleic acid metabolites from the byssochlamic acid producer Byssochlamys fulva IMI 40021 - an insight into the biosynthesis of maleidrides. ⬇️

artículo científico

Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungi.

artículo científico publicado en 2017

Oxidative dearomatisation: the key step of sorbicillinoid biosynthesis†Electronic supplementary information (ESI) available: Containing all experimental details. See DOI: 10.1039/c3sc52911hClick here for additional data file

artículo científico publicado en 2013

Oxidative rearrangements during fungal biosynthesis.

artículo científico publicado en 2014

Oxidative steps during the biosynthesis of squalestatin S1

scientific article published on 15 November 2018

Peptide inhibitors of N-succinyl diaminopimelic acid aminotransferase (DAP-AT): a novel class of antimicrobial compounds.

artículo científico publicado en 1998

Post-translational modification of heterologously expressed Streptomyces type II polyketide synthase acyl carrier proteins.

artículo científico publicado en 1997

Probing the Interactions of early polyketide intermediates with the Actinorhodin ACP from S. coelicolor A3(2)

artículo científico publicado en 2009

Rapid and flexible synthesis of 1-deoxy-d-xylulose-5-phosphate, the substrate for 1-deoxy-d-xylulose-5-phosphate reductoisomerase ⬇️

artículo científico publicado el 21 de septiembre de 2003

Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis

scientific article published on 24 September 2004

Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite.

artículo científico publicado en 2011

Recent advances in reconstructing microbial secondary metabolites biosynthesis in Aspergillus spp.

artículo científico publicado en 2018

Reengineering the programming of a functional domain of an iterative highly reducing polyketide synthase

artículo científico publicado en 2020

Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes.

artículo científico publicado en 2005

Secondary metabolism and biotrophic lifestyle in the tomato pathogen Cladosporium fulvum

artículo científico publicado en 2014

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics. ⬇️

artículo científico publicado en 2017

Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.

artículo científico publicado en 2005

Strobilurin biosynthesis in Basidiomycete fungi

artículo científico publicado en 2018

Structural Revision and Biosynthesis of the Fungal Phytotoxins Phyllostictines A and B.

artículo científico publicado en 2017

Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi ⬇️

artículo científico publicado en 2019

Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming

artículo científico publicado en 2016

Subtle temperature-induced changes in small molecule conformer dynamics - observed and quantified by NOE spectroscopy

scientific article published on 01 February 2016

Synthesis and evaluation of conformationally restricted inhibitors of aspartate semialdehyde dehydrogenase.

artículo científico publicado en 2011

Synthesis of [1,2-13C2, 15N]-L-homoserine and its incorporation by the PKS-NRPS system of Fusarium moniliforme into the mycotoxin fusarin C

artículo científico publicado en 2007

Targeted Gene Inactivations Expose Silent Cytochalasans in Magnaporthe grisea NI980

scientific article published on 17 May 2019

The Malonyl Transferase Activity of Type II Polyketide Synthase Acyl Carrier Proteins

article

The biosynthesis and catabolism of the maleic anhydride moiety of stipitatonic acid.

artículo científico publicado en 2014

The chemical mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase from Escherichia coli.

artículo científico publicado en 2007

The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis.

artículo científico publicado en 2018

The molecular steps of citrinin biosynthesis in fungi. ⬇️

artículo científico publicado en 2015

The same but different: multiple functions of the fungal flavin dependent monooxygenase SorD from Penicillium chrysogenum

artículo científico publicado en 2020

Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD

artículo científico publicado en 2013

Uncovering biosynthetic relationships between antifungal nonadrides and octadrides ⬇️

artículo científico publicado en 2020

β-chain extension: a new mode of carbon-carbon bond formation and chain extension by polyketide synthases

artículo científico publicado en 2013

Lista de obras de Russell J Cox

13CLabeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibioticzeamine from Dickeya zeae

<i>O</i>-Methylation steps during strobilurin and bolineol biosynthesis

A Natural Plasmid Uniquely Encodes Two Biosynthetic Pathways Creating a Potent Anti-MRSA Antibiotic ⬇️

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis

A new synthesis of phosphoramidates: inhibitors of the key bacterial enzyme aspartate semi-aldehyde dehydrogenase

Acyl palladium species in synthesis: single-step synthesis of alpha,beta-unsaturated ketones from acid chlorides

Acylation of Streptomyces type II polyketide synthase acyl carrier proteins

Antroxazole A, an oxazole-containing chamigrane dimer from the fungus Antrodiella albocinnamomea with immunosuppressive activity

Authentic heterologous expression of the tenellin iterative polyketide synthase nonribosomal peptide synthetase requires coexpression with an enoyl reductase.

Bacterial diaminopimelate metabolism as a target for antibiotic design.

Biosynthesis of Mupirocin by Pseudomonas fluorescens NCIMB 10586 Involves Parallel Pathways

Biosynthesis of oxygenated brasilane terpene glycosides involves a promiscuous N-acetylglucosamine transferase ⬇️

Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana.

Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase

Catalytic self-acylation of type II polyketide synthase acyl carrier proteins

Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis

Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi ⬇️

Chemical mechanisms involved during the biosynthesis of tropolones.

Classic fungal natural products in the genomic age: the molecular legacy of Harold Raistrick

Design, synthesis and analysis of inhibitors of bacterial aspartate semialdehyde dehydrogenase.

Diastereoselective synthesis of cyclopropane amino acids using diazo compounds generated in situ.

Dissecting the component reactions catalyzed by the actinorhodin minimal polyketide synthase.

Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390 ⬇️

Evidence for enzyme catalysed intramolecular [4+2] Diels-Alder cyclization during the biosynthesis of pyrichalasin H

Expression, purification and preliminary X-ray diffraction analysis of a ketoreductase from a type II polyketide synthase.

First heterologous reconstruction of a complete functional fungal biosynthetic multigene cluster.

First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determination.

Function of pathway specific regulators in the <i>ACE1</i> and pyrichalasin H biosynthetic gene clusters

Functional analysis of the conserved transcriptional regulator CfWor1 in Cladosporium fulvum reveals diverse roles in the virulence of plant pathogenic fungi

Fungal type I polyketide synthases.

Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum. ⬇️

Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari ⬇️

Genetic and chemical characterisation of the cornexistin pathway provides further insight into maleidride biosynthesis

Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis.

Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis.

Heterologous expression of the avirulence gene ACE1 from the fungal rice pathogen Magnaporthe oryzae

High quality genome sequences of thirteen Hypoxylaceae (Ascomycota) strengthen the phylogenetic family backbone and enable the discovery of new taxa ⬇️

Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production

Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues ⬇️

In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase.

In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: the "leaky hosepipe" mechanism.

Indium mediated allylation of glyoxylate oxime ethers, esters and cyanoformates.

Investigating the Function of Cryptic Cytochalasan Cytochrome P450 Monooxygenases Using Combinatorial Biosynthesis

Investigating the biosynthesis of Sch-642305 in the fungus <i>Phomopsis</i> sp. CMU-LMA

Investigations into the biosynthesis of the antifungal strobilurins.

Isolation and characterisation of a ferrirhodin synthetase gene from the sugarcane pathogen Fusarium sacchari.

Kinetic and mechanistic analysis of the malonyl CoA:ACP transacylase from Streptomyces coelicolor indicates a single catalytically competent serine nucleophile at the active site.

Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the entomopathogenic fungus Beauveria bassiana.

MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor

Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production

Minimum Information about a Biosynthetic Gene cluster.

Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase

Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens

Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase

Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by pseudomonas fluorescens: pseudomonic acid B biosynthesis precedes pseudomonic acid A

Nongenetic Reprogramming of a Fungal Highly Reducing Polyketide Synthase

Novel nonadride, heptadride and maleic acid metabolites from the byssochlamic acid producer Byssochlamys fulva IMI 40021 - an insight into the biosynthesis of maleidrides. ⬇️

Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungi.

Oxidative dearomatisation: the key step of sorbicillinoid biosynthesis†Electronic supplementary information (ESI) available: Containing all experimental details. See DOI: 10.1039/c3sc52911hClick here for additional data file

Oxidative rearrangements during fungal biosynthesis.

Oxidative steps during the biosynthesis of squalestatin S1

Peptide inhibitors of N-succinyl diaminopimelic acid aminotransferase (DAP-AT): a novel class of antimicrobial compounds.

Post-translational modification of heterologously expressed Streptomyces type II polyketide synthase acyl carrier proteins.

Probing the Interactions of early polyketide intermediates with the Actinorhodin ACP from S. coelicolor A3(2)

Rapid and flexible synthesis of 1-deoxy-d-xylulose-5-phosphate, the substrate for 1-deoxy-d-xylulose-5-phosphate reductoisomerase ⬇️

Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis

Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite.

Recent advances in reconstructing microbial secondary metabolites biosynthesis in Aspergillus spp.

Reengineering the programming of a functional domain of an iterative highly reducing polyketide synthase

Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes.

Secondary metabolism and biotrophic lifestyle in the tomato pathogen Cladosporium fulvum

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics. ⬇️

Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.

Strobilurin biosynthesis in Basidiomycete fungi

Structural Revision and Biosynthesis of the Fungal Phytotoxins Phyllostictines A and B.

Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi ⬇️

Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming

Subtle temperature-induced changes in small molecule conformer dynamics - observed and quantified by NOE spectroscopy

Synthesis and evaluation of conformationally restricted inhibitors of aspartate semialdehyde dehydrogenase.