Lista de obras - Dimitrios Vlachakis - Dominio Público Uruguay

3D Molecular Modelling Study of the H7N9 RNA-Dependent RNA Polymerase as an Emerging Pharmacological Target

artículo científico publicado en 2013

3D Molecular Modelling of the Helicase Enzyme of the Endemic, Zoonotic Greek Goat Encephalitis Virus

3D molecular modeling and evolutionary study of the Trypanosoma brucei DNA Topoisomerase IB, as a new emerging pharmacological target

artículo científico publicado en 2013

3D structural analysis of proteins using electrostatic surfaces based on image segmentation

artículo científico publicado en 2014

A Bioinformatics Method for the Production of Antibody-Drug Conjugates Through Site-Specific Cysteine Conjugation

article

A Machine Learning Methodology for Enzyme Functional Classification Combining Structural and Protein Sequence Descriptors

scholarly article by Afshine Amidi et al published 2016 in Lecture Notes in Computer Science

A comprehensive phylogenetic analysis of deadenylases

artículo científico publicado en 2013

A holistic evolutionary and structural study of flaviviridae provides insights into the function and inhibition of HCV helicase

artículo científico publicado en 2013

A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.

artículo científico publicado en 2018

A novel mutation of the hGR gene causing Chrousos syndrome.

artículo científico publicado en 2015

A splice variant of the human phosphohistidine phosphatase 1 (PHPT1) is degraded by the proteasome.

artículo científico publicado en 2014

An integrated in silico approach to design specific inhibitors targeting human poly(a)-specific ribonuclease

artículo científico publicado en 2012

An updated evolutionary study of Flaviviridae NS3 helicase and NS5 RNA-dependent RNA polymerase reveals novel invariable motifs as potential pharmacological targets

artículo científico publicado en 2016

An updated evolutionary study of the Notch family reveals a new ancient origin and novel invariable motifs as potential pharmacological targets

scientific article published on 05 November 2020

Antibodies as stratagems against cancer

artículo científico publicado en 2016

Antibody Clustering Using a Machine Learning Pipeline that Fuses Genetic, Structural, and Physicochemical Properties

artículo científico publicado en 2020

Antibody Drug Conjugate bioinformatics: drug delivery through the letterbox

artículo científico publicado en 2013

Antiviral Stratagems Against HIV-1 Using RNA Interference (RNAi) Technology

artículo científico publicado en 2013

Applied bioinformatics in the structural, post-genomic era

Automatic single- and multi-label enzymatic function prediction by machine learning

artículo científico publicado en 2017

Carcinogenic Pesticide Control Hijacking Endosymbiosis; The Paradigm of DSB-A from for the Management of

artículo científico publicado en 2018

Competitive inhibition of human poly(A)-specific ribonuclease (PARN) by synthetic fluoro-pyranosyl nucleosides.

artículo científico publicado en 2009

Computational Construction of Antibody-Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker

artículo científico publicado en 2014

Computer-Aided Drug Design and Biological Evaluation of Novel Anti-Greek Goat Encephalitis Agents

Current state-of-the-art molecular dynamics methods and applications.

artículo científico publicado en 2014

Delineation of the functional and structural properties of the glutathione transferase family from the plant pathogen Erwinia carotovora

artículo científico publicado en 2018

Design, synthesis and application of benzyl-sulfonate biomimetic affinity adsorbents for monoclonal antibody purification from transgenic corn.

artículo científico publicado en 2014

Directed evolution of Tau class glutathione transferases reveals a site that regulates catalytic efficiency and masks co-operativity

artículo científico publicado en 2016

Discovery of a Novel HCV Helicase Inhibitor by a De Novo Drug Design Approach

artículo científico publicado en 2008

Discovery of a novel HCV helicase inhibitor by a de novo drug design approach

artículo científico publicado en 2009

DrugOn: a fully integrated pharmacophore modeling and structure optimization toolkit

artículo científico publicado en 2015

Drugena: A Fully Automated Immunoinformatics Platform for the Design of Antibody-Drug Conjugates Against Neurodegenerative Diseases

artículo científico publicado en 2020

EnzyNet: enzyme classification using 3D convolutional neural networks on spatial representation.

artículo científico publicado en 2018

Erratum to: Structuprint: a scalable and extensible tool for two-dimensional representation of protein surfaces

artículo científico publicado en 2016

Functional Toll-Like Receptor 9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis

artículo científico publicado en 2016

Functional characterization of the hGRαT556I causing Chrousos syndrome.

artículo científico publicado en 2015

Functional characterization of two novel germline mutations of the KCNJ5 gene in hypertensive patients without primary aldosteronism but with ACTH-dependent aldosterone hypersecretion

artículo científico publicado en 2016

Genetic and structural study of DNA-directed RNA polymerase II of Trypanosoma brucei, towards the designing of novel antiparasitic agents.

artículo científico publicado en 2017

Genomic big data hitting the storage bottleneck.

artículo científico publicado en 2018

Gromita: a fully integrated graphical user interface to gromacs 4

artículo científico publicado en 2009

Hepatopulmonary hydatidosis in a ten-year-old girl: a case report

artículo científico publicado en 2010

IMGT/Collier-de-Perles: a two-dimensional visualization tool for amino acid domain sequences

artículo científico publicado en 2013

Insights into the Influence of Specific Splicing Events on the Structural Organization of

scholarly article by Dimitrios Vlachakis published in September 2018

Insights into the molecular mechanisms of stress and inflammation in ageing and frailty of the elderly

artículo científico publicado en 2017

Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas

artículo científico publicado en 2022

Introducing Drugster: a comprehensive and fully integrated drug design, lead and structure optimization toolkit

artículo científico publicado en 2012

Investigating the structural stability of the Tup1-interaction domain of Ssn6: evidence for a conformational change on the complex.

artículo científico

Kinetic and in silico analysis of the slow-binding inhibition of human poly(A)-specific ribonuclease (PARN) by novel nucleoside analogues.

artículo científico publicado en 2011

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

scientific article published on 22 May 2020

Microbiome Hijacking Towards an Integrative Pest Management Pipeline

artículo científico publicado en 2020

Modelling and mutational evidence identify the substrate binding site and functional elements in APC amino acid transporters.

artículo científico publicado en 2009

Molecular dynamics simulations through GPU video games technologies

artículo científico publicado en 2014

Molecular modeling and pharmacophore elucidation study of the Classical Swine Fever virus helicase as a promising pharmacological target.

artículo científico publicado en 2013

Molecular modelling study of the 3D structure of the bovine viral diarrhea virus (BVDV) helicase.

artículo científico publicado en 2008

Notch signaling and ageing

artículo científico publicado en 2015

Olive Oil Polyphenols in Neurodegenerative Pathologies

artículo científico publicado en 2020

On integrating multi-experiment microarray data

artículo científico publicado en 2014

Pathogenic and Low-Frequency Variants in Children With Central Precocious Puberty

artículo científico publicado en 2021

Phosphorylation of the arginine/serine repeats of lamin B receptor by SRPK1-insights from molecular dynamics simulations

artículo científico publicado en 2011

Protein signatures using electrostatic molecular surfaces in harmonic space.

artículo científico publicado en 2013

Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis

scientific article published on 01 November 2019

SNP and Structural Study of the Notch Superfamily Provides Insights and Novel Pharmacological Targets against the CADASIL Syndrome and Neurodegenerative Diseases

artículo científico publicado en 2024

Silencing motifs in the Clr2 protein from fission yeast, Schizosaccharomyces pombe

artículo científico publicado en 2014

Space constrained homology modelling: the paradigm of the RNA-dependent RNA polymerase of dengue (type II) virus.

artículo científico publicado en 2013

Speeding up the drug discovery process: structural similarity searches using molecular surfaces

artículo científico publicado en 2012

State-of-the-art technology in modern computer-aided drug design.

artículo científico publicado en 2012

Structuprint: a scalable and extensible tool for two-dimensional representation of protein surfaces

artículo científico publicado en 2016

Structural Study of the DNA: Clock/Bmal1 Complex Provides Insights for the Role of Cortisol, hGR, and HPA Axis in Stress Management and Sleep Disorders

artículo científico publicado en 2020

Structural models for the design of novel antiviral agents against Greek Goat Encephalitis

artículo científico publicado en 2014

Structure-based design and application of a nucleotide coenzyme mimetic ligand: Application to the affinity purification of nucleotide dependent enzymes

artículo científico publicado en 2018

Structure-based design and application of an engineered glutathione transferase for the development of an optical biosensor for pesticides determination

scientific article published on 24 December 2018

The Interaction of the Microtubule Targeting Anticancer Drug Colchicine with Human Glutathione Transferases

artículo científico publicado en 2020

The interaction of Schistosoma japonicum glutathione transferase with Cibacron blue 3GA and its fragments

scientific article published on 02 April 2020

Theoretical study of the Usutu virus helicase 3D structure, by means of computer-aided homology modelling

artículo científico publicado en 2009

Towards the elucidation of the regulatory network guiding the insulin producing cells' differentiation

artículo científico publicado en 2012

Lista de obras de Dimitrios Vlachakis

3D Molecular Modelling Study of the H7N9 RNA-Dependent RNA Polymerase as an Emerging Pharmacological Target

3D Molecular Modelling of the Helicase Enzyme of the Endemic, Zoonotic Greek Goat Encephalitis Virus

3D molecular modeling and evolutionary study of the Trypanosoma brucei DNA Topoisomerase IB, as a new emerging pharmacological target

3D structural analysis of proteins using electrostatic surfaces based on image segmentation

A Bioinformatics Method for the Production of Antibody-Drug Conjugates Through Site-Specific Cysteine Conjugation

A Machine Learning Methodology for Enzyme Functional Classification Combining Structural and Protein Sequence Descriptors

A comprehensive phylogenetic analysis of deadenylases

A holistic evolutionary and structural study of flaviviridae provides insights into the function and inhibition of HCV helicase

A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.

A novel mutation of the hGR gene causing Chrousos syndrome.

A splice variant of the human phosphohistidine phosphatase 1 (PHPT1) is degraded by the proteasome.

An integrated in silico approach to design specific inhibitors targeting human poly(a)-specific ribonuclease

An updated evolutionary study of Flaviviridae NS3 helicase and NS5 RNA-dependent RNA polymerase reveals novel invariable motifs as potential pharmacological targets

An updated evolutionary study of the Notch family reveals a new ancient origin and novel invariable motifs as potential pharmacological targets

Antibodies as stratagems against cancer

Antibody Clustering Using a Machine Learning Pipeline that Fuses Genetic, Structural, and Physicochemical Properties

Antibody Drug Conjugate bioinformatics: drug delivery through the letterbox

Antiviral Stratagems Against HIV-1 Using RNA Interference (RNAi) Technology

Applied bioinformatics in the structural, post-genomic era

Automatic single- and multi-label enzymatic function prediction by machine learning

Carcinogenic Pesticide Control Hijacking Endosymbiosis; The Paradigm of DSB-A from for the Management of

Competitive inhibition of human poly(A)-specific ribonuclease (PARN) by synthetic fluoro-pyranosyl nucleosides.

Computational Construction of Antibody-Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker

Computer-Aided Drug Design and Biological Evaluation of Novel Anti-Greek Goat Encephalitis Agents

Current state-of-the-art molecular dynamics methods and applications.

Delineation of the functional and structural properties of the glutathione transferase family from the plant pathogen Erwinia carotovora

Design, synthesis and application of benzyl-sulfonate biomimetic affinity adsorbents for monoclonal antibody purification from transgenic corn.

Directed evolution of Tau class glutathione transferases reveals a site that regulates catalytic efficiency and masks co-operativity

Discovery of a Novel HCV Helicase Inhibitor by a De Novo Drug Design Approach

Discovery of a novel HCV helicase inhibitor by a de novo drug design approach

DrugOn: a fully integrated pharmacophore modeling and structure optimization toolkit

Drugena: A Fully Automated Immunoinformatics Platform for the Design of Antibody-Drug Conjugates Against Neurodegenerative Diseases

EnzyNet: enzyme classification using 3D convolutional neural networks on spatial representation.

Erratum to: Structuprint: a scalable and extensible tool for two-dimensional representation of protein surfaces

Functional Toll-Like Receptor 9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis

Functional characterization of the hGRαT556I causing Chrousos syndrome.

Functional characterization of two novel germline mutations of the KCNJ5 gene in hypertensive patients without primary aldosteronism but with ACTH-dependent aldosterone hypersecretion

Genetic and structural study of DNA-directed RNA polymerase II of Trypanosoma brucei, towards the designing of novel antiparasitic agents.

Genomic big data hitting the storage bottleneck.

Gromita: a fully integrated graphical user interface to gromacs 4

Hepatopulmonary hydatidosis in a ten-year-old girl: a case report

IMGT/Collier-de-Perles: a two-dimensional visualization tool for amino acid domain sequences

Insights into the Influence of Specific Splicing Events on the Structural Organization of

Insights into the molecular mechanisms of stress and inflammation in ageing and frailty of the elderly

Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas

Introducing Drugster: a comprehensive and fully integrated drug design, lead and structure optimization toolkit

Investigating the structural stability of the Tup1-interaction domain of Ssn6: evidence for a conformational change on the complex.

Kinetic and in silico analysis of the slow-binding inhibition of human poly(A)-specific ribonuclease (PARN) by novel nucleoside analogues.

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

Microbiome Hijacking Towards an Integrative Pest Management Pipeline

Modelling and mutational evidence identify the substrate binding site and functional elements in APC amino acid transporters.

Molecular dynamics simulations through GPU video games technologies

Molecular modeling and pharmacophore elucidation study of the Classical Swine Fever virus helicase as a promising pharmacological target.

Molecular modelling study of the 3D structure of the bovine viral diarrhea virus (BVDV) helicase.

Notch signaling and ageing

Olive Oil Polyphenols in Neurodegenerative Pathologies

On integrating multi-experiment microarray data

Pathogenic and Low-Frequency Variants in Children With Central Precocious Puberty

Phosphorylation of the arginine/serine repeats of lamin B receptor by SRPK1-insights from molecular dynamics simulations

Protein signatures using electrostatic molecular surfaces in harmonic space.

Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis

SNP and Structural Study of the Notch Superfamily Provides Insights and Novel Pharmacological Targets against the CADASIL Syndrome and Neurodegenerative Diseases

Silencing motifs in the Clr2 protein from fission yeast, Schizosaccharomyces pombe

Space constrained homology modelling: the paradigm of the RNA-dependent RNA polymerase of dengue (type II) virus.

Speeding up the drug discovery process: structural similarity searches using molecular surfaces

State-of-the-art technology in modern computer-aided drug design.

Structuprint: a scalable and extensible tool for two-dimensional representation of protein surfaces

Structural Study of the DNA: Clock/Bmal1 Complex Provides Insights for the Role of Cortisol, hGR, and HPA Axis in Stress Management and Sleep Disorders

Structural models for the design of novel antiviral agents against Greek Goat Encephalitis

Structure-based design and application of a nucleotide coenzyme mimetic ligand: Application to the affinity purification of nucleotide dependent enzymes

Structure-based design and application of an engineered glutathione transferase for the development of an optical biosensor for pesticides determination

The Interaction of the Microtubule Targeting Anticancer Drug Colchicine with Human Glutathione Transferases

The interaction of Schistosoma japonicum glutathione transferase with Cibacron blue 3GA and its fragments

Theoretical study of the Usutu virus helicase 3D structure, by means of computer-aided homology modelling

Towards the elucidation of the regulatory network guiding the insulin producing cells' differentiation