Lista de obras - Alessandro Contini - Dominio Público Uruguay

1H-Azepine-2-oxo-5-amino-5-carboxylic Acid: A 310 Helix Inducer and an Effective Tool for Functionalized Gold Nanoparticles

artículo científico publicado en 2015

1H-Azepine-4-amino-4-carboxylic acid: a new α,α-disubstituted ornithine analogue capable of inducing helix conformations in short Ala-Aib pentapeptides

artículo científico publicado en 2012

2-Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: an appealing scaffold for the design of Rac1-Tiam1 protein-protein interaction inhibitors

artículo científico publicado en 2014

A highly diastereoselective synthesis of α-hydroxy-β-amino acid derivatives via a Lewis acid catalyzed three-component condensation reaction.

artículo científico publicado en 2010

A tendril perversion in a helical oligomer: trapping and characterizing a mobile screw-sense reversal

artículo científico publicado en 2017

An Updated Test of AMBER Force Fields and Implicit Solvent Models in Predicting the Secondary Structure of Helical, β-Hairpin, and Intrinsically Disordered Peptides

artículo científico publicado en 2016

Asymmetric Modular Synthesis of a Semirigid Dipeptide Mimetic by Cascade Cycloaddition/Ring Rearrangement and Borohydride Reduction

artículo científico publicado en 2014

Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models

artículo científico publicado en 2013

Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts.

artículo científico publicado en 2016

Computational investigation of the nucleophilic reaction between methylthiolate and 4-bromo-3-methylamino-isothiazole 1,1-dioxide

Design, synthesis and pharmacophoric model building of novel substituted nicotinic acid hydrazones with potential antiproliferative activity.

artículo científico publicado en 2012

Expedient chemical synthesis of 75mer DNA binding domain of MafA: an insight on its binding to insulin enhancer

artículo científico publicado en 2012

Explicit Ligand Hydration Shells Improve the Correlation between MM-PB/GBSA Binding Energies and Experimental Activities.

artículo científico publicado en 2013

Identification of the first enantiopure Rac1-Tiam1 protein-protein interaction inhibitor and its optimized synthesis via phosphine free remote group directed hydroarylation

artículo científico publicado en 2018

Isothiazoles. Part XV. A mild and efficient synthesis of new antiproliferative 5-sulfanylsubstituted 3-alkylaminoisothiazole 1,1-dioxides

artículo científico publicado en 2006

Mechanism of Stabilization of Helix Secondary Structure by Constrained Cα-Tetrasubstituted α-Amino Acids

scientific article published on 12 January 2015

Model peptides containing the 3-sulfanyl-norbornene amino acid, a conformationally constrained cysteine analogue effective inducer of 310-helix secondary structures

article

Molecular dynamic simulation of mGluR5 amino terminal domain: essential dynamics analysis captures the agonist or antagonist behaviour of ligands

artículo científico publicado en 2013

Molecular dynamics and tubulin polymerization kinetics study on 1,14-heterofused taxanes: evidence of stabilization of the tubulin head-to-tail dimer-dimer interaction.

artículo científico publicado en 2012

Molecular insights into dimerization inhibition of c-Maf transcription factor

scholarly article by Sara Pellegrino published in December 2014

Non-natural 3-Arylmorpholino-β-amino Acid as a PPII Helix Inducer

artículo científico publicado en 2020

Origin of Helical Screw Sense Selectivity Induced by Chiral Constrained Cα-Tetrasubstituted α-Amino Acids in Aib-based Peptides

artículo científico publicado en 2015

Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases.

artículo científico publicado en 2017

Rescoring Virtual Screening Results with the MM-PBSA Methods: Beware of Internal Dielectric Constants

scientific article published on 15 May 2019

Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors.

artículo científico publicado en 2013

SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease

artículo científico publicado en 2008

Stereodivergent synthesis of 5-aminopipecolic acids and application in the preparation of a cyclic RGD peptidomimetic as a nanomolar αVβ3 integrin ligand

artículo científico publicado en 2018

Synthesis and "double-faced" antioxidant activity of polyhydroxylated 4-thiaflavans

artículo científico publicado en 2005

Synthesis and conformational analysis of peptides embodying 2,3-methanopipecolic acids.

artículo científico publicado en 2017

Synthesis, structural, and biological evaluation of bis-heteroarylmaleimides and bis-heterofused imides

artículo científico publicado en 2011

Tandem Tetrahydroisoquinoline-4-carboxylic Acid/β-Alanine as a New Construct Able To Induce a Flexible Turn

artículo científico publicado en 2017

Tautomeric equilibria of [1]benzopyrano[3,4-d]imidazol-4(3H)-ones, a theoretical and NMR study

scientific article published on 01 January 2006

Tetrahydro-4 H-(pyrrolo[3,4- d]isoxazol-3-yl)methanamine: A Bicyclic Diamino Scaffold Stabilizing Parallel Turn Conformations

scientific article published on 18 September 2018

Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical target

artículo científico publicado en 2009

VCD spectroscopy as an excellent probe of chiral metal complexes containing a carbon monoxide vibrational chromophore

artículo científico publicado en 2015

Virtual screening approach for the identification of new Rac1 inhibitors

artículo científico publicado en 2009

[2 + 4] and [4 + 2] cycloadditions of o-thioquinones with 1,3-dienes: a computational study

artículo científico publicado en 2006

β-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species.

artículo científico publicado en 2016

Lista de obras de Alessandro Contini

1H-Azepine-2-oxo-5-amino-5-carboxylic Acid: A 310 Helix Inducer and an Effective Tool for Functionalized Gold Nanoparticles

1H-Azepine-4-amino-4-carboxylic acid: a new α,α-disubstituted ornithine analogue capable of inducing helix conformations in short Ala-Aib pentapeptides

2-Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: an appealing scaffold for the design of Rac1-Tiam1 protein-protein interaction inhibitors

A highly diastereoselective synthesis of α-hydroxy-β-amino acid derivatives via a Lewis acid catalyzed three-component condensation reaction.

A tendril perversion in a helical oligomer: trapping and characterizing a mobile screw-sense reversal

An Updated Test of AMBER Force Fields and Implicit Solvent Models in Predicting the Secondary Structure of Helical, β-Hairpin, and Intrinsically Disordered Peptides

Asymmetric Modular Synthesis of a Semirigid Dipeptide Mimetic by Cascade Cycloaddition/Ring Rearrangement and Borohydride Reduction

Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models

Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts.

Computational investigation of the nucleophilic reaction between methylthiolate and 4-bromo-3-methylamino-isothiazole 1,1-dioxide

Design, synthesis and pharmacophoric model building of novel substituted nicotinic acid hydrazones with potential antiproliferative activity.

Expedient chemical synthesis of 75mer DNA binding domain of MafA: an insight on its binding to insulin enhancer

Explicit Ligand Hydration Shells Improve the Correlation between MM-PB/GBSA Binding Energies and Experimental Activities.

Identification of the first enantiopure Rac1-Tiam1 protein-protein interaction inhibitor and its optimized synthesis via phosphine free remote group directed hydroarylation

Isothiazoles. Part XV. A mild and efficient synthesis of new antiproliferative 5-sulfanylsubstituted 3-alkylaminoisothiazole 1,1-dioxides

Mechanism of Stabilization of Helix Secondary Structure by Constrained Cα-Tetrasubstituted α-Amino Acids

Model peptides containing the 3-sulfanyl-norbornene amino acid, a conformationally constrained cysteine analogue effective inducer of 310-helix secondary structures

Molecular dynamic simulation of mGluR5 amino terminal domain: essential dynamics analysis captures the agonist or antagonist behaviour of ligands

Molecular dynamics and tubulin polymerization kinetics study on 1,14-heterofused taxanes: evidence of stabilization of the tubulin head-to-tail dimer-dimer interaction.

Molecular insights into dimerization inhibition of c-Maf transcription factor

Non-natural 3-Arylmorpholino-β-amino Acid as a PPII Helix Inducer

Origin of Helical Screw Sense Selectivity Induced by Chiral Constrained Cα-Tetrasubstituted α-Amino Acids in Aib-based Peptides

Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases.

Rescoring Virtual Screening Results with the MM-PBSA Methods: Beware of Internal Dielectric Constants

Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors.

SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease

Stereodivergent synthesis of 5-aminopipecolic acids and application in the preparation of a cyclic RGD peptidomimetic as a nanomolar αVβ3 integrin ligand

Synthesis and "double-faced" antioxidant activity of polyhydroxylated 4-thiaflavans

Synthesis and conformational analysis of peptides embodying 2,3-methanopipecolic acids.

Synthesis, structural, and biological evaluation of bis-heteroarylmaleimides and bis-heterofused imides

Tandem Tetrahydroisoquinoline-4-carboxylic Acid/β-Alanine as a New Construct Able To Induce a Flexible Turn

Tautomeric equilibria of [1]benzopyrano[3,4-d]imidazol-4(3H)-ones, a theoretical and NMR study

Tetrahydro-4 H-(pyrrolo[3,4- d]isoxazol-3-yl)methanamine: A Bicyclic Diamino Scaffold Stabilizing Parallel Turn Conformations

Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical target

VCD spectroscopy as an excellent probe of chiral metal complexes containing a carbon monoxide vibrational chromophore

Virtual screening approach for the identification of new Rac1 inhibitors

[2 + 4] and [4 + 2] cycloadditions of o-thioquinones with 1,3-dienes: a computational study

β-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species.