Lista de obras - Filip Cuyckens - Dominio Público Uruguay

A comparison between HPLC-dynamic reaction cell-ICP-MS and HPLC-sector field-ICP-MS for the detection of glutathione-trapped reactive drug metabolites using clozapine as a model compound

article

A pilot study on the use of laser ablation-ICP-mass spectrometry for assessing/mapping the distribution of a drug and its metabolites across the body compartments of rats

A pre-column derivatization method allowing quantitative metabolite profiling of carboxyl and phenolic hydroxyl group containing pharmaceuticals in human plasma via liquid chromatography-inductively coupled plasma-tandem mass spectrometry (LC-ICP-MS/

A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation

artículo científico publicado en 2017

Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects

artículo científico publicado en 2009

Absorption, metabolism, and excretion of oral ¹⁴C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men.

artículo científico publicado en 2014

Adduct ion formation as a tool for the molecular structure assessment of ten isomers in traveling wave and trapped ion mobility spectrometry

scientific article published on 13 June 2019

An atmospheric pressure ionization source using a high voltage target compared to electrospray ionization for the LC/MS analysis of pharmaceutical compounds.

artículo científico publicado en 2017

Antiprotozoal and antiangiogenic saponins from Apodytes dimidiata

artículo científico publicado en 2011

Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes

artículo científico publicado en 2019

Atmospheric Pressure Ionization Using a High Voltage Target Compared to Electrospray Ionization.

artículo científico publicado en 2016

Characterization of organosulfates from the photooxidation of isoprene and unsaturated fatty acids in ambient aerosol using liquid chromatography/(-) electrospray ionization mass spectrometry

artículo científico publicado en 2008

Characterization of polar organosulfates in secondary organic aerosol from the green leaf volatile 3-Z-hexenal

artículo científico publicado en 2014

Combined Liquid Chromatography-Infrared Ion Spectroscopy for Identification of Regioisomeric Drug Metabolites

artículo científico publicado en 2017

Comparison of triple quadrupole and high-resolution TOF-MS for quantification of peptides

artículo científico publicado en 2012

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease

article

Determination of the glycosylation site in flavonoid mono-O-glycosides by collision-induced dissociation of electrospray-generated deprotonated and sodiated molecules

artículo científico publicado en 2005

Determination of the total drug-related chlorine and bromine contents in human blood plasma using high performance liquid chromatography-tandem ICP-mass spectrometry (HPLC-ICP-MS/MS).

artículo científico publicado en 2016

Development and validation of a novel quantification approach for gradient elution reversed phase high-performance liquid chromatography coupled to tandem ICP-mass spectrometry (RP-HPLC-ICP-MS/MS) and its application to diclofenac and its related co

artículo científico publicado en 2017

Direct stereochemical assignment of hexose and pentose residues in flavonoid O-glycosides by fast atom bombardment and electrospray ionization mass spectrometry

artículo científico publicado en 2002

Disposition, metabolism, and excretion of [14C]doripenem after a single 500-milligram intravenous infusion in healthy men.

artículo científico publicado en 2008

Enhanced performance for the analysis of prostaglandins and thromboxanes by liquid chromatography-tandem mass spectrometry using a new atmospheric pressure ionization source.

artículo científico publicado en 2016

Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration

artículo científico publicado en 2009

Fast high-performance liquid chromatography method for quality control of soy extracts

scientific article published on 01 June 2004

Flexible nano- and microliter injections on a single liquid chromatography-mass spectrometry system: Minimizing sample preparation and maximizing linear dynamic range

artículo científico publicado en 2017

HPLC/ICP-MS in combination with "reverse" online isotope dilution in drug metabolism studies

artículo científico publicado en 2012

Herbal remedy-associated acute renal failure secondary to Cape aloes

artículo científico publicado en 2002

High sensitivity and selectivity in quantitative analysis of drugs in biological samples using 4-column multidimensional micro-UHPLC-MS enabling enhanced sample loading capacity

artículo científico publicado en 2017

High volume injections of biological samples for sensitive metabolite profiling and quantitation

artículo científico publicado en 2014

High-Resolution Mass Spectrometry Quantification: Impact of Differences in Data Processing of Centroid and Continuum Data

artículo científico publicado en 2018

High-resolution MS: first choice for peptide quantification?

artículo científico publicado en 2013

High-resolution laser ablation-inductively coupled plasma-mass spectrometry imaging of cisplatin-induced nephrotoxic side effects

artículo científico publicado en 2016

Hyphenation of reverse-phase HPLC and ICP-MS for metabolite profiling--application to a novel antituberculosis compound as a case study

artículo científico publicado en 2007

Identifying metabolite ions of peptide drugs in the presence of an in vivo matrix background

artículo científico publicado en 2012

Improved liquid chromatography—Online radioactivity detection for metabolite profiling

artículo científico publicado en 2008

In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin

artículo científico publicado en 2016

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

artículo científico publicado en 2009

Infrared ion spectroscopy: New opportunities for small-molecule identification in mass spectrometry - A tutorial perspective

scientific article published on 24 October 2019

Ion mobility mass spectrometry: Small molecule applications

artículo científico publicado en 2019

Ionisation efficiencies can be predicted in complicated biological matrices: A proof of concept

scientific article published on 31 May 2018

IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers

artículo científico publicado en 2009

Mass Spectrometry Imaging of Drug Related Crystal-Like Structures in Formalin-Fixed Frozen and Paraffin-Embedded Rabbit Kidney Tissue Sections

artículo científico publicado en 2015

Mass spectrometric methods for the characterisation and differentiation of isomeric O-diglycosyl flavonoids

artículo científico publicado en 2001

Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry

artículo científico publicado en 2018

Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans.

artículo científico publicado en 2014

Montmorillonite and Laponite Clay Materials for the Solidification of Lipid-Based Formulations for the Basic Drug Blonanserin: In Vitro and in Vivo Investigations

artículo científico publicado en 2018

Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

artículo científico publicado en 2009

One drop chemical derivatization--DESI-MS analysis for metabolite structure identification

artículo científico publicado en 2015

Optimization of a liquid chromatography method based on simultaneous electrospray ionization mass spectrometric and ultraviolet photodiode array detection for analysis of flavonoid glycosides

artículo científico publicado en 2002

Optimization of flow splitting and make-up flow conditions in liquid chromatography/electrospray ionization mass spectrometry

scientific article published on 01 February 2019

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.

artículo científico publicado en 2015

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.

artículo científico publicado en 2014

Product ion mobility as a promising tool for assignment of positional isomers of drug metabolites

artículo científico publicado en 2011

Quantitative Metabolite Profiling of an Amino Group Containing Pharmaceutical in Human Plasma via Precolumn Derivatization and High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry

artículo científico publicado en 2017

Rapid quantification of 14 saponins of Maesa lanceolata by UPLC-MS/MS.

artículo científico publicado en 2010

Selective drug metabolite trace analysis by very high-volume injections and heartcut two-dimensional (2D)-ultrahigh performance liquid chromatography (UHPLC)

scientific article published on 24 April 2019

Speciation analysis of bromine-containing drug metabolites in feces samples from a human in vivo study by means of HPLC/ICP-MS combined with on-line isotope dilution

artículo científico publicado en 2011

Strategies and analytical workflows to extend the dynamic range in quantitative LC-MS/MS analysis

artículo científico publicado en 2019

Structural characterization of chromone C-glucosides in a toxic herbal remedy

artículo científico publicado en 2003

Structural characterization of flavonol di-O-glycosides from Farsetia aegyptia by electrospray ionization and collision-induced dissociation mass spectrometry

artículo científico publicado en 2005

Structure characterization of flavonoid O-diglycosides by positive and negative nano-electrospray ionization ion trap mass spectrometry

artículo científico publicado en 2001

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity

artículo científico publicado en 2014

The application of liquid chromatography-electrospray ionization mass spectrometry and collision-induced dissociation in the structural characterization of acylated flavonol O-glycosides from the seeds of Carrichtera annua.

artículo científico publicado en 2003

Translational safety biomarkers of colonic barrier integrity in the rat

artículo científico publicado en 2018

Use of relative 12C/14C isotope ratios to estimate metabolite concentrations in the absence of authentic standards

artículo científico publicado en 2012

Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development.

artículo científico publicado en 2008

Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

artículo científico publicado en 2009

Lista de obras de Filip Cuyckens

A comparison between HPLC-dynamic reaction cell-ICP-MS and HPLC-sector field-ICP-MS for the detection of glutathione-trapped reactive drug metabolites using clozapine as a model compound

A pilot study on the use of laser ablation-ICP-mass spectrometry for assessing/mapping the distribution of a drug and its metabolites across the body compartments of rats

A pre-column derivatization method allowing quantitative metabolite profiling of carboxyl and phenolic hydroxyl group containing pharmaceuticals in human plasma via liquid chromatography-inductively coupled plasma-tandem mass spectrometry (LC-ICP-MS/

A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation

Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects

Absorption, metabolism, and excretion of oral ¹⁴C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men.

Adduct ion formation as a tool for the molecular structure assessment of ten isomers in traveling wave and trapped ion mobility spectrometry

An atmospheric pressure ionization source using a high voltage target compared to electrospray ionization for the LC/MS analysis of pharmaceutical compounds.

Antiprotozoal and antiangiogenic saponins from Apodytes dimidiata

Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes

Atmospheric Pressure Ionization Using a High Voltage Target Compared to Electrospray Ionization.

Characterization of organosulfates from the photooxidation of isoprene and unsaturated fatty acids in ambient aerosol using liquid chromatography/(-) electrospray ionization mass spectrometry

Characterization of polar organosulfates in secondary organic aerosol from the green leaf volatile 3-Z-hexenal

Combined Liquid Chromatography-Infrared Ion Spectroscopy for Identification of Regioisomeric Drug Metabolites

Comparison of triple quadrupole and high-resolution TOF-MS for quantification of peptides

Cross-Species Molecular Imaging of Bile Salts and Lipids in Liver: Identification of Molecular Structural Markers in Health and Disease

Determination of the glycosylation site in flavonoid mono-O-glycosides by collision-induced dissociation of electrospray-generated deprotonated and sodiated molecules

Determination of the total drug-related chlorine and bromine contents in human blood plasma using high performance liquid chromatography-tandem ICP-mass spectrometry (HPLC-ICP-MS/MS).

Development and validation of a novel quantification approach for gradient elution reversed phase high-performance liquid chromatography coupled to tandem ICP-mass spectrometry (RP-HPLC-ICP-MS/MS) and its application to diclofenac and its related co

Direct stereochemical assignment of hexose and pentose residues in flavonoid O-glycosides by fast atom bombardment and electrospray ionization mass spectrometry

Disposition, metabolism, and excretion of [14C]doripenem after a single 500-milligram intravenous infusion in healthy men.

Enhanced performance for the analysis of prostaglandins and thromboxanes by liquid chromatography-tandem mass spectrometry using a new atmospheric pressure ionization source.

Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration

Fast high-performance liquid chromatography method for quality control of soy extracts

Flexible nano- and microliter injections on a single liquid chromatography-mass spectrometry system: Minimizing sample preparation and maximizing linear dynamic range

HPLC/ICP-MS in combination with "reverse" online isotope dilution in drug metabolism studies

Herbal remedy-associated acute renal failure secondary to Cape aloes

High sensitivity and selectivity in quantitative analysis of drugs in biological samples using 4-column multidimensional micro-UHPLC-MS enabling enhanced sample loading capacity

High volume injections of biological samples for sensitive metabolite profiling and quantitation

High-Resolution Mass Spectrometry Quantification: Impact of Differences in Data Processing of Centroid and Continuum Data

High-resolution MS: first choice for peptide quantification?

High-resolution laser ablation-inductively coupled plasma-mass spectrometry imaging of cisplatin-induced nephrotoxic side effects

Hyphenation of reverse-phase HPLC and ICP-MS for metabolite profiling--application to a novel antituberculosis compound as a case study

Identifying metabolite ions of peptide drugs in the presence of an in vivo matrix background

Improved liquid chromatography—Online radioactivity detection for metabolite profiling

In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

Infrared ion spectroscopy: New opportunities for small-molecule identification in mass spectrometry - A tutorial perspective

Ion mobility mass spectrometry: Small molecule applications

Ionisation efficiencies can be predicted in complicated biological matrices: A proof of concept

IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers

Mass Spectrometry Imaging of Drug Related Crystal-Like Structures in Formalin-Fixed Frozen and Paraffin-Embedded Rabbit Kidney Tissue Sections

Mass spectrometric methods for the characterisation and differentiation of isomeric O-diglycosyl flavonoids

Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry

Metabolism and excretion of canagliflozin in mice, rats, dogs, and humans.

Montmorillonite and Laponite Clay Materials for the Solidification of Lipid-Based Formulations for the Basic Drug Blonanserin: In Vitro and in Vivo Investigations

Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

One drop chemical derivatization--DESI-MS analysis for metabolite structure identification

Optimization of a liquid chromatography method based on simultaneous electrospray ionization mass spectrometric and ultraviolet photodiode array detection for analysis of flavonoid glycosides

Optimization of flow splitting and make-up flow conditions in liquid chromatography/electrospray ionization mass spectrometry

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.

Product ion mobility as a promising tool for assignment of positional isomers of drug metabolites

Quantitative Metabolite Profiling of an Amino Group Containing Pharmaceutical in Human Plasma via Precolumn Derivatization and High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry

Rapid quantification of 14 saponins of Maesa lanceolata by UPLC-MS/MS.

Selective drug metabolite trace analysis by very high-volume injections and heartcut two-dimensional (2D)-ultrahigh performance liquid chromatography (UHPLC)

Speciation analysis of bromine-containing drug metabolites in feces samples from a human in vivo study by means of HPLC/ICP-MS combined with on-line isotope dilution

Strategies and analytical workflows to extend the dynamic range in quantitative LC-MS/MS analysis

Structural characterization of chromone C-glucosides in a toxic herbal remedy

Structural characterization of flavonol di-O-glycosides from Farsetia aegyptia by electrospray ionization and collision-induced dissociation mass spectrometry

Structure characterization of flavonoid O-diglycosides by positive and negative nano-electrospray ionization ion trap mass spectrometry

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity

The application of liquid chromatography-electrospray ionization mass spectrometry and collision-induced dissociation in the structural characterization of acylated flavonol O-glycosides from the seeds of Carrichtera annua.

Translational safety biomarkers of colonic barrier integrity in the rat

Use of relative 12C/14C isotope ratios to estimate metabolite concentrations in the absence of authentic standards

Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development.

Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.