Lista de obras - Francisco Corzana - Dominio Público Uruguay

A Double Diastereoselective Michael-Type Addition as an Entry to Conformationally Restricted Tn Antigen Mimics

artículo científico publicado en 2013

A dynamic combinatorial approach for the analysis of weak carbohydrate/aromatic complexes: dissecting facial selectivity in CH/π stacking interactions.

artículo científico publicado en 2013

A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2.

artículo científico publicado en 2016

A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer.

artículo científico

A simple structural-based approach to prevent aminoglycoside inactivation by bacterial defense proteins. Conformational restriction provides effective protection against neomycin-B nucleotidylation by ANT4.

artículo científico publicado en 2005

A thorough experimental study of CH/π interactions in water: quantitative structure-stability relationships for carbohydrate/aromatic complexes

artículo científico

Accurate Calculation of Chemical Shifts in Highly Dynamic H2@C60through an Integrated Quantum Mechanics/Molecular Dynamics Scheme

article

Antimicrobial peptides and their superior fluorinated analogues: structure-activity relationships as revealed by NMR spectroscopy and MD calculations.

artículo científico publicado en 2010

Asymmetric hetero Diels-Alder as an access to carbacephams.

artículo científico publicado en 2002

Bifunctional Chiral Dehydroalanines for Peptide Coupling and Stereoselective S-Michael Addition.

artículo científico publicado en 2016

Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation

artículo científico publicado en 2021

Cell-Penetrating Peptides Containing Fluorescent d -Cysteines

artículo científico publicado en 2018

Chemical Interrogation of Drug/RNA Complexes: From Chemical Reactivity to Drug Design

artículo científico publicado en 2013

Chemo- and Regioselective Lysine Modification on Native Proteins.

artículo científico publicado en 2018

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation

artículo científico publicado en 2017

Chondroitin Sulfate Tetrasaccharides: Synthesis, Three-Dimensional Structure and Interaction with Midkine

artículo científico

Conformational Behavior of d-Lyxose in Gas and Solution Phases by Rotational and NMR Spectroscopies

scientific article published on 04 June 2019

Conformational analysis of 2-substituted cyclobutane-alpha-amino acid derivatives. A synergistic experimental and computational study

artículo científico publicado en 2006

Conformational analysis of N-Boc-N,O-isopropylidene-α-serinals. A combined DFT and NMR study

Conformational effects of the non-natural alpha-methylserine on small peptides and glycopeptides.

artículo científico publicado en 2009

Conformational preferences of chiral acyclic homooligomeric β(2,2)-peptides

artículo científico publicado en 2014

Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts

artículo científico publicado en 2016

Conformations of the iduronate ring in short heparin fragments described by time-averaged distance restrained molecular dynamics.

artículo científico publicado en 2013

Cyclobutane amino acid analogues of furanomycin obtained by a formal [2 + 2] cycloaddition strategy promoted by methylaluminoxane

artículo científico publicado en 2010

Cyclohexane ring as a tool to select the presentation of the carbohydrate moiety in glycosyl amino acids

scientific article published on 01 March 2012

Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody

artículo científico publicado en 2015

Design of α-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety

artículo científico publicado en 2016

Detection of tumor-associated glycopeptides by lectins: the peptide context modulates carbohydrate recognition

artículo científico publicado en 2015

Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation.

artículo científico publicado en 2015

Effect of beta-O-glucosylation on L-Ser and L-Thr diamides: a bias toward alpha-helical conformations.

artículo científico publicado en 2006

Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents

artículo científico publicado en 2019

Engineering O-Glycosylation Points in Non-extended Peptides: Implications for the Molecular Recognition of Short Tumor-Associated Glycopeptides

artículo científico publicado en 2011

Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides.

artículo científico publicado en 2017

Exploiting structure-activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

artículo científico publicado en 2020

Exploring the use of conformationally locked aminoglycosides as a new strategy to overcome bacterial resistance

artículo científico publicado en 2006

Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders.

artículo científico publicado en 2016

Frontispiece: Site-Selective Modification of Proteins with Oxetanes

Fucosyltransferase-specific inhibition via next generation of fucose mimetics

artículo científico publicado en 2021

Identification of a secondary binding site in human macrophage galactose-type lectin by microarray studies: Implications for the molecular recognition of its ligands

artículo científico publicado en 2018

Impact of Aromatic Stacking on Glycoside Reactivity: Balancing CH/π and Cation/π Interactions for the Stabilization of Glycosyl-Oxocarbenium Ions

artículo científico publicado en 2019

Insights into the geometrical features underlying beta-O-GlcNAc glycosylation: water pockets drastically modulate the interactions between the carbohydrate and the peptide backbone

artículo científico publicado en 2009

Limited flexibility of lactose detected from residual dipolar couplings using molecular dynamics simulations and steric alignment methods

artículo científico publicado en 2005

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

scientific article published on 17 July 2018

Modulating weak interactions for molecular recognition: a dynamic combinatorial analysis for assessing the contribution of electrostatics to the stability of CH-π bonds in water

artículo científico publicado en 2015

Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3

scientific article published on 13 January 2020

Molecular recognition of aminoglycoside antibiotics by bacterial defence proteins: NMR study of the structural and conformational features of streptomycin inactivation by Bacillus subtilis aminoglycoside-6-adenyl transferase

artículo científico publicado en 2005

Molecular recognition of β-O-GlcNAc glycopeptides by a lectin-like receptor: binding modulation by the underlying Ser or Thr amino acids.

artículo científico publicado en 2011

Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment.

artículo científico publicado en 2015

Multiple keys for a single lock: the unusual structural plasticity of the nucleotidyltransferase (4')/kanamycin complex

artículo científico publicado en 2012

NMR-based analysis of aminoglycoside recognition by the resistance enzyme ANT(4'): the pattern of OH/NH3(+) substitution determines the preferred antibiotic binding mode and is critical for drug inactivation.

artículo científico publicado en 2008

New insights into alpha-GalNAc-Ser motif: influence of hydrogen bonding versus solvent interactions on the preferred conformation.

artículo científico publicado en 2006

New syntheses of enantiopure 2-methyl isoserines

article published in 2004

Non-natural amino acids as modulating agents of the conformational space of model glycopeptides

artículo científico publicado en 2008

Observation of the Unbiased Conformers of Putative DNA-Scaffold Ribosugars

artículo científico publicado en 2020

Preparation and Synthetic Applications of (S)- and (R)-N-Boc-N,O-isopropylidene-alpha-methylserinals: Asymmetric Synthesis of (S)- and (R)-2-Amino-2-methylbutanoic Acids (Iva)

artículo científico publicado en 1999

Principles of mucin structure: implications for the rational design of cancer vaccines derived from MUC1-glycopeptides.

artículo científico publicado en 2017

Quaternary chiral β(2,2)-amino acids with pyridinium and imidazolium substituents

artículo científico publicado en 2012

Quillaja Saponin Variants with Central Glycosidic Linkage Modifications Exhibit Distinct Conformations and Adjuvant Activities

artículo científico publicado en 2016

Rational design of a Tn antigen mimic

artículo científico publicado en 2011

Role of aromatic rings in the molecular recognition of aminoglycoside antibiotics: implications for drug design.

artículo científico publicado en 2010

Role of conserved salt bridges in homeodomain stability and DNA binding

artículo científico publicado en 2009

S-Michael additions to chiral dehydroalanines as an entry to glycosylated cysteines and a sulfa-Tn antigen mimic

artículo científico publicado en 2014

SN2 vs E2 on Quaternary Centers: An Easy Approach to Chiral β2,2-Amino Acids from Cyclic Sulfamidates

article by alberto avenoza et al published 2 March 2005 in Phosphorus, Sulfur, and Silicon and the Related Elements

Serine versus threonine glycosylation with α-O-GalNAc: unexpected selectivity in their molecular recognition with lectins.

artículo científico publicado en 2014

Serine versus threonine glycosylation: the methyl group causes a drastic alteration on the carbohydrate orientation and on the surrounding water shell

artículo científico publicado en 2007

Site-Selective Modification of Proteins with Oxetanes

artículo científico publicado en 2017

Solution structures of chemoenzymatically synthesized heparin and its precursors.

artículo científico publicado en 2008

Stabilizing unusual conformations in small peptides and glucopeptides using a hydroxylated cyclobutane amino acid.

artículo científico publicado en 2009

Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation

artículo científico publicado en 2020

Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

scientific article published on 26 October 2016

Structural analysis of a GalNAc-T2 mutant reveals an induced-fit catalytic mechanism for GalNAc-Ts.

artículo científico publicado en 2018

Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4

artículo científico publicado en 2018

Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase

artículo científico publicado en 2020

Structural basis for the synthesis of the core 1 structure by C1GalT1

artículo científico publicado en 2022

Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

artículo científico publicado en 2020

Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage

scientific article published on 20 February 2019

Structure-based design of highly crowded ribostamycin/kanamycin hybrids as a new family of antibiotics.

artículo científico publicado en 2010

Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2

artículo científico publicado en 2014

Synthesis and conformational analysis of hybrid α/β-dipeptides incorporating S-glycosyl-β(2,2)-amino acids

artículo científico publicado en 2014

Synthesis and conformational analysis of neoglycoconjugates derived from O- and S-glucose.

artículo científico publicado en 2013

Synthesis of Mixed α/β2,2-Peptides by Site-Selective Ring-Opening of Cyclic Quaternary Sulfamidates

artículo científico publicado en 2015

Synthesis of Nβ-Substituted α,β-Diamino Acids via Stereoselective N-Michael Additions to a Chiral Bicyclic Dehydroalanine

artículo científico publicado en 2020

Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment

artículo científico publicado en 2020

The Plasticity of the Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin

scientific article published on 01 October 2019

The Unusual Nucleotide Recognition Properties of the Resistance Enzyme ANT(4′): Inorganic Tri/Polyphosphate as a Substrate for Aminoglycoside Inactivation

artículo científico publicado en 2010

The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer.

artículo científico publicado en 2017

The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences

artículo científico publicado en 2017

The nature and sequence of the amino acid aglycone strongly modulates the conformation and dynamics effects of Tn antigen's clusters

artículo científico publicado en 2009

The pattern of distribution of amino groups modulates the structure and dynamics of natural aminoglycosides: implications for RNA recognition.

artículo científico

The use of time-averaged 3JHH restrained molecular dynamics (tar-MD) simulations for the conformational analysis of five-membered ring systems: methodology and applications.

artículo científico publicado en 2010

Tn Antigen Mimics Based on sp(2)-Iminosugars with Affinity for an anti-MUC1 Antibody

artículo científico publicado en 2016

Tn Antigen Mimics by Ring-Opening of Chiral Cyclic Sulfamidates with Carbohydrate C1-S- and C1-O-Nucleophiles

artículo científico publicado en 2018

Toward Enantiomerically Pure β-Seleno-α-amino Acids via Stereoselective Se-Michael Additions to Chiral Dehydroalanines

artículo científico publicado en 2020

Understanding the unusual regioselectivity in the nucleophilic ring-opening reactions of gem-disubstituted cyclic sulfates. Experimental and theoretical studies

scientific article published on 01 May 2003

Unraveling the Conformational Landscape of Ligand Binding to Glucose/Galactose-Binding Protein by Paramagnetic NMR and MD Simulations

artículo científico publicado en 2016

Unveiling the activation dynamics of a fold-switch bacterial glycosyltransferase by 19F NMR

scientific article published on 20 May 2020

Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition

scientific article published on 30 July 2018

Lista de obras de Francisco Corzana

A Double Diastereoselective Michael-Type Addition as an Entry to Conformationally Restricted Tn Antigen Mimics

A dynamic combinatorial approach for the analysis of weak carbohydrate/aromatic complexes: dissecting facial selectivity in CH/π stacking interactions.

A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2.

A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer.

A simple structural-based approach to prevent aminoglycoside inactivation by bacterial defense proteins. Conformational restriction provides effective protection against neomycin-B nucleotidylation by ANT4.

A thorough experimental study of CH/π interactions in water: quantitative structure-stability relationships for carbohydrate/aromatic complexes

Accurate Calculation of Chemical Shifts in Highly Dynamic H2@C60through an Integrated Quantum Mechanics/Molecular Dynamics Scheme

Antimicrobial peptides and their superior fluorinated analogues: structure-activity relationships as revealed by NMR spectroscopy and MD calculations.

Asymmetric hetero Diels-Alder as an access to carbacephams.

Bifunctional Chiral Dehydroalanines for Peptide Coupling and Stereoselective S-Michael Addition.

Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation

Cell-Penetrating Peptides Containing Fluorescent d -Cysteines

Chemical Interrogation of Drug/RNA Complexes: From Chemical Reactivity to Drug Design

Chemo- and Regioselective Lysine Modification on Native Proteins.

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation

Chondroitin Sulfate Tetrasaccharides: Synthesis, Three-Dimensional Structure and Interaction with Midkine

Conformational Behavior of d-Lyxose in Gas and Solution Phases by Rotational and NMR Spectroscopies

Conformational analysis of 2-substituted cyclobutane-alpha-amino acid derivatives. A synergistic experimental and computational study

Conformational analysis of N-Boc-N,O-isopropylidene-α-serinals. A combined DFT and NMR study

Conformational effects of the non-natural alpha-methylserine on small peptides and glycopeptides.

Conformational preferences of chiral acyclic homooligomeric β(2,2)-peptides

Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts

Conformations of the iduronate ring in short heparin fragments described by time-averaged distance restrained molecular dynamics.

Cyclobutane amino acid analogues of furanomycin obtained by a formal [2 + 2] cycloaddition strategy promoted by methylaluminoxane

Cyclohexane ring as a tool to select the presentation of the carbohydrate moiety in glycosyl amino acids

Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody

Design of α-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety

Detection of tumor-associated glycopeptides by lectins: the peptide context modulates carbohydrate recognition

Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation.

Effect of beta-O-glucosylation on L-Ser and L-Thr diamides: a bias toward alpha-helical conformations.

Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents

Engineering O-Glycosylation Points in Non-extended Peptides: Implications for the Molecular Recognition of Short Tumor-Associated Glycopeptides

Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides.

Exploiting structure-activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

Exploring the use of conformationally locked aminoglycosides as a new strategy to overcome bacterial resistance

Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders.

Frontispiece: Site-Selective Modification of Proteins with Oxetanes

Fucosyltransferase-specific inhibition <i>via</i> next generation of fucose mimetics

Identification of a secondary binding site in human macrophage galactose-type lectin by microarray studies: Implications for the molecular recognition of its ligands

Impact of Aromatic Stacking on Glycoside Reactivity: Balancing CH/π and Cation/π Interactions for the Stabilization of Glycosyl-Oxocarbenium Ions

Insights into the geometrical features underlying beta-O-GlcNAc glycosylation: water pockets drastically modulate the interactions between the carbohydrate and the peptide backbone

Limited flexibility of lactose detected from residual dipolar couplings using molecular dynamics simulations and steric alignment methods

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

Modulating weak interactions for molecular recognition: a dynamic combinatorial analysis for assessing the contribution of electrostatics to the stability of CH-π bonds in water

Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3

Molecular recognition of aminoglycoside antibiotics by bacterial defence proteins: NMR study of the structural and conformational features of streptomycin inactivation by Bacillus subtilis aminoglycoside-6-adenyl transferase

Molecular recognition of β-O-GlcNAc glycopeptides by a lectin-like receptor: binding modulation by the underlying Ser or Thr amino acids.

Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment.

Multiple keys for a single lock: the unusual structural plasticity of the nucleotidyltransferase (4')/kanamycin complex

NMR-based analysis of aminoglycoside recognition by the resistance enzyme ANT(4'): the pattern of OH/NH3(+) substitution determines the preferred antibiotic binding mode and is critical for drug inactivation.

New insights into alpha-GalNAc-Ser motif: influence of hydrogen bonding versus solvent interactions on the preferred conformation.

New syntheses of enantiopure 2-methyl isoserines

Non-natural amino acids as modulating agents of the conformational space of model glycopeptides

Observation of the Unbiased Conformers of Putative DNA-Scaffold Ribosugars

Preparation and Synthetic Applications of (S)- and (R)-N-Boc-N,O-isopropylidene-alpha-methylserinals: Asymmetric Synthesis of (S)- and (R)-2-Amino-2-methylbutanoic Acids (Iva)

Principles of mucin structure: implications for the rational design of cancer vaccines derived from MUC1-glycopeptides.

Quaternary chiral β(2,2)-amino acids with pyridinium and imidazolium substituents

Quillaja Saponin Variants with Central Glycosidic Linkage Modifications Exhibit Distinct Conformations and Adjuvant Activities

Rational design of a Tn antigen mimic

Role of aromatic rings in the molecular recognition of aminoglycoside antibiotics: implications for drug design.

Role of conserved salt bridges in homeodomain stability and DNA binding

S-Michael additions to chiral dehydroalanines as an entry to glycosylated cysteines and a sulfa-Tn antigen mimic

SN2 vs E2 on Quaternary Centers: An Easy Approach to Chiral β2,2-Amino Acids from Cyclic Sulfamidates

Serine versus threonine glycosylation with α-O-GalNAc: unexpected selectivity in their molecular recognition with lectins.

Serine versus threonine glycosylation: the methyl group causes a drastic alteration on the carbohydrate orientation and on the surrounding water shell

Site-Selective Modification of Proteins with Oxetanes

Solution structures of chemoenzymatically synthesized heparin and its precursors.

Stabilizing unusual conformations in small peptides and glucopeptides using a hydroxylated cyclobutane amino acid.

Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation

Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

Structural analysis of a GalNAc-T2 mutant reveals an induced-fit catalytic mechanism for GalNAc-Ts.

Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4

Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase

Structural basis for the synthesis of the core 1 structure by C1GalT1

Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage

Structure-based design of highly crowded ribostamycin/kanamycin hybrids as a new family of antibiotics.

Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2

Synthesis and conformational analysis of hybrid α/β-dipeptides incorporating S-glycosyl-β(2,2)-amino acids