Lista de obras - Nicholas J. Mantis - Dominio Público Uruguay

A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking

artículo científico publicado en 2016

A Collection of Single-Domain Antibodies that Crowd Ricin Toxin's Active Site

artículo científico publicado en 2018

A Humanized Monoclonal Antibody Cocktail to Prevent Pulmonary Ricin Intoxication

artículo científico publicado en 2020

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

artículo científico publicado en 2016

A Supercluster of Neutralizing Epitopes at the Interface of Ricin's Enzymatic (RTA) and Binding (RTB) Subunits.

artículo científico publicado en 2017

A monoclonal antibody that targets the conserved core/lipid A region of lipopolysaccharide affects motility and reduces intestinal colonization of both classical and El Tor Vibrio cholerae biotypes.

artículo científico publicado en 2016

A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin

artículo científico publicado en 2009

A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles.

artículo científico publicado en 2014

A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin

artículo científico publicado en 2014

Alpha-galactosylceramide (αGalCer) Enhances Vaccine-induced Protection in a Model of Ricin Intoxication.

artículo científico publicado en 2018

An intranasally administered monoclonal antibody cocktail abrogates ricin toxin-induced pulmonary tissue damage and inflammation

artículo científico publicado en 2019

Analysis of adhesion molecules involved in leukocyte homing into the basolateral pockets of mouse Peyer's patch M cells

artículo científico publicado en 2004

Applications in Stimulated Emission Depletion Microscopy: Localization of a Protein Toxin in the Endoplasmic Reticulum Following Retrograde Transport

artículo científico publicado en 2016

Association of a protective monoclonal IgA with the O antigen of Salmonella enterica serovar Typhimurium impacts type 3 secretion and outer membrane integrity.

artículo científico publicado en 2012

Biomedical Applications of Lumazine Synthase

artículo científico publicado en 2018

Biophysical characterization and immunization studies of dominant negative inhibitor (DNI), a candidate anthrax toxin subunit vaccine.

artículo científico publicado en 2013

Characterization of a novel high-affinity monoclonal immunoglobulin G antibody against the ricin B subunit

artículo científico publicado en 2006

Chimeric plantibody passively protects mice against aerosolized ricin challenge

artículo científico publicado en 2014

Collaboration of epithelial cells with organized mucosal lymphoid tissues.

artículo científico publicado en 2001

Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice

artículo científico publicado en 2014

Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens.

artículo científico publicado en 2015

Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity

scientific article published on 01 July 2018

Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies

artículo científico publicado en 2014

Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB).

artículo científico publicado en 2014

Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen

artículo científico publicado en 2013

Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils.

artículo científico publicado en 2016

Evaluation of lumazine synthase from Bacillus anthracis as a presentation platform for polyvalent antigen display.

artículo científico publicado en 2017

Evidence for widespread epithelial damage and coincident production of monocyte chemotactic protein 1 in a murine model of intestinal ricin intoxication

artículo científico publicado en 2007

FRUIT, a scar-free system for targeted chromosomal mutagenesis, epitope tagging, and promoter replacement in Escherichia coli and Salmonella enterica.

artículo científico publicado en 2012

Fine-Specificity Epitope Analysis Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies

artículo científico publicado en 2018

Folding domains within the ricin toxin A subunit as targets of protective antibodies

artículo científico publicado en 2010

Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants

artículo científico publicado en 2015

High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine

artículo científico publicado en 2017

High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin

artículo científico publicado en 2017

High-throughput, cell-based screens to identify small-molecule inhibitors of ricin toxin and related category b ribosome inactivating proteins (RIPs).

artículo científico publicado en 2013

Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge.

scientific article published on 27 July 2016

Identification of new classes of ricin toxin inhibitors by virtual screening

artículo científico publicado en 2010

Identification of small molecules that suppress ricin-induced stress-activated signaling pathways

artículo científico publicado en 2012

Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen

artículo científico publicado en 2010

Immunity to Ricin: Fundamental Insights into Toxin–Antibody Interactions ⬇️

artículo científico publicado el 1 de enero de 2012

Immunization of mice with peptomers covalently coupled to aluminum oxide nanoparticles

artículo científico publicado en 1999

Immunization of mice with recombinant gp41 in a systemic prime/mucosal boost protocol induces HIV-1-specific serum IgG and secretory IgA antibodies

artículo científico publicado en 2001

Immunoglobulin A antibodies against ricin A and B subunits protect epithelial cells from ricin intoxication

artículo científico publicado en 2006

Inhibition of Salmonella enterica serovar typhimurium motility and entry into epithelial cells by a protective antilipopolysaccharide monoclonal immunoglobulin A antibody.

artículo científico publicado en 2008

Inhibition of invasive salmonella by orally administered IgA and IgG monoclonal antibodies

artículo científico publicado en 2020

Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site

scientific article published on 10 January 2020

LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity

artículo científico publicado en 2013

Localization of non-linear neutralizing B cell epitopes on ricin toxin's enzymatic subunit (RTA)

artículo científico publicado en 2013

Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies

artículo científico publicado en 2015

Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor binding and nuclease subunits

artículo científico publicado en 2021

Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage.

artículo científico publicado en 2014

Mucosal vaccines for biodefense.

scientific article published on January 2012

Neutralizing activity and protective immunity to ricin toxin conferred by B subunit (RTB)-specific Fab fragments

artículo científico publicado en 2013

Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro

artículo científico publicado en 2013

Neutralizing monoclonal antibodies directed against defined linear epitopes on domain 4 of anthrax protective antigen

artículo científico publicado en 2009

Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice.

artículo científico publicado en 2016

Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells

artículo científico publicado en 2014

Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin

artículo científico publicado en 2020

Phenotypic Analysis of a Population of IgA+ Cells in the Follicle-Associated Epithelium of Mouse Peyer's Patches

artículo científico publicado en 2015

Plant-based expression of a partially humanized neutralizing monoclonal IgG directed against an immunodominant epitope on the ricin toxin A subunit.

artículo científico publicado en 2011

Plant-based production of two chimeric monoclonal IgG antibodies directed against immunodominant epitopes of Vibrio cholerae lipopolysaccharide.

artículo científico publicado en 2015

Progress and challenges associated with the development of ricin toxin subunit vaccines

artículo científico publicado en 2016

Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB).

artículo científico publicado en 2011

Rapid effects of a protective O-polysaccharide-specific monoclonal IgA on Vibrio cholerae agglutination, motility, and surface morphology

artículo científico publicado en 2015

Recent advances in the development of vaccines against ricin

artículo científico publicado en 2016

Rediscovering IgA

artículo científico publicado en 2011

Rescue of rhesus macaques from the lethality of aerosolized ricin toxin

artículo científico publicado en 2019

Ricin induces IL-8 secretion from human monocyte/macrophages by activating the p38 MAP kinase pathway.

artículo científico publicado en 2006

Role of Maternal Dietary Peanut Exposure in Development of Food Allergy and Oral Tolerance

artículo científico publicado en 2015

Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin ⬇️

artículo científico publicado el 9 de septiembre de 2011

Sampling of Candida albicans and Candida tropicalis by Langerin-positive dendritic cells in mouse Peyer's patches.

artículo científico publicado en 2015

Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut

artículo científico publicado en 2011

Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin-Ab complexes

scientific article published on 16 July 2019

Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins

artículo científico publicado en 2022

Sites of vulnerability on ricin B chain revealed through epitope mapping of toxin-neutralizing monoclonal antibodies

artículo científico publicado en 2020

Small-molecule inhibitors of ricin and Shiga toxins.

artículo científico publicado en 2012

Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin's binding subunit

artículo científico publicado en 2017

Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization.

scientific article published on 10 April 2013

Stepwise engineering of heterodimeric single domain camelid VHH antibodies that passively protect mice from ricin toxin.

artículo científico publicado en 2013

Structural Analysis of Single Domain Antibodies Bound to a Second Neutralizing Hot Spot on Ricin Toxin's Enzymatic Subunit

artículo científico publicado en 2016

Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.

artículo científico publicado en 2016

Sub-domains of ricin's B subunit as targets of toxin neutralizing and non-neutralizing monoclonal antibodies

artículo científico publicado en 2012

TNF Family Cytokines Induce Distinct Cell Death Modalities in the A549 Human Lung Epithelial Cell Line when Administered in Combination with Ricin Toxin

artículo científico publicado en 2019

TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell Death

artículo científico publicado en 2018

The Factor H-binding site of CspZ as a protective target against multi-strain, tick-transmitted Lyme disease

artículo científico publicado en 2020

The nadB gene of Salmonella typhimurium complements the nicotinic acid auxotrophy of Shigella flexneri

artículo científico publicado en 1996

Thermal stability and epitope integrity of a lyophilized ricin toxin subunit vaccine

artículo científico publicado en 2018

Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection

artículo científico publicado en 2015

Three-dimensional reconstruction of murine Peyer's patches from immunostained cryosections

artículo científico publicado en 2013

Transcytosis of IgA Attenuates Salmonella Invasion in Human Enteroids and Intestinal Organoids

artículo científico publicado en 2022

Transient suppression of Shigella flexneri type 3 secretion by a protective O-antigen-specific monoclonal IgA ⬇️

artículo científico publicado en 2011

Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies

artículo científico publicado en 2017

Vaccines against the category B toxins: Staphylococcal enterotoxin B, epsilon toxin and ricin.

artículo científico publicado en 2005

Vibrio cholerae O1 secretes an extracellular matrix in response to antibody-mediated agglutination

artículo científico publicado en 2018

Lista de obras de Nicholas J. Mantis

A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking

A Collection of Single-Domain Antibodies that Crowd Ricin Toxin's Active Site

A Humanized Monoclonal Antibody Cocktail to Prevent Pulmonary Ricin Intoxication

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

A Supercluster of Neutralizing Epitopes at the Interface of Ricin's Enzymatic (RTA) and Binding (RTB) Subunits.

A monoclonal antibody that targets the conserved core/lipid A region of lipopolysaccharide affects motility and reduces intestinal colonization of both classical and El Tor Vibrio cholerae biotypes.

A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin

A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles.

A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin

Alpha-galactosylceramide (αGalCer) Enhances Vaccine-induced Protection in a Model of Ricin Intoxication.

An intranasally administered monoclonal antibody cocktail abrogates ricin toxin-induced pulmonary tissue damage and inflammation

Analysis of adhesion molecules involved in leukocyte homing into the basolateral pockets of mouse Peyer's patch M cells

Applications in Stimulated Emission Depletion Microscopy: Localization of a Protein Toxin in the Endoplasmic Reticulum Following Retrograde Transport

Association of a protective monoclonal IgA with the O antigen of Salmonella enterica serovar Typhimurium impacts type 3 secretion and outer membrane integrity.

Biomedical Applications of Lumazine Synthase

Biophysical characterization and immunization studies of dominant negative inhibitor (DNI), a candidate anthrax toxin subunit vaccine.

Characterization of a novel high-affinity monoclonal immunoglobulin G antibody against the ricin B subunit

Chimeric plantibody passively protects mice against aerosolized ricin challenge

Collaboration of epithelial cells with organized mucosal lymphoid tissues.

Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice

Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens.

Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity

Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies

Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB).

Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen

Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils.

Evaluation of lumazine synthase from Bacillus anthracis as a presentation platform for polyvalent antigen display.

Evidence for widespread epithelial damage and coincident production of monocyte chemotactic protein 1 in a murine model of intestinal ricin intoxication

FRUIT, a scar-free system for targeted chromosomal mutagenesis, epitope tagging, and promoter replacement in Escherichia coli and Salmonella enterica.

Fine-Specificity Epitope Analysis Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies

Folding domains within the ricin toxin A subunit as targets of protective antibodies

Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants

High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine

High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin

High-throughput, cell-based screens to identify small-molecule inhibitors of ricin toxin and related category b ribosome inactivating proteins (RIPs).

Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge.

Identification of new classes of ricin toxin inhibitors by virtual screening

Identification of small molecules that suppress ricin-induced stress-activated signaling pathways

Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen

Immunity to Ricin: Fundamental Insights into Toxin–Antibody Interactions ⬇️

Immunization of mice with peptomers covalently coupled to aluminum oxide nanoparticles

Immunization of mice with recombinant gp41 in a systemic prime/mucosal boost protocol induces HIV-1-specific serum IgG and secretory IgA antibodies

Immunoglobulin A antibodies against ricin A and B subunits protect epithelial cells from ricin intoxication

Inhibition of Salmonella enterica serovar typhimurium motility and entry into epithelial cells by a protective antilipopolysaccharide monoclonal immunoglobulin A antibody.

Inhibition of invasive salmonella by orally administered IgA and IgG monoclonal antibodies

Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site

LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity

Localization of non-linear neutralizing B cell epitopes on ricin toxin's enzymatic subunit (RTA)

Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies

Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor binding and nuclease subunits

Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage.

Mucosal vaccines for biodefense.

Neutralizing activity and protective immunity to ricin toxin conferred by B subunit (RTB)-specific Fab fragments

Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro

Neutralizing monoclonal antibodies directed against defined linear epitopes on domain 4 of anthrax protective antigen

Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice.

Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells

Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin

Phenotypic Analysis of a Population of IgA+ Cells in the Follicle-Associated Epithelium of Mouse Peyer's Patches

Plant-based expression of a partially humanized neutralizing monoclonal IgG directed against an immunodominant epitope on the ricin toxin A subunit.

Plant-based production of two chimeric monoclonal IgG antibodies directed against immunodominant epitopes of Vibrio cholerae lipopolysaccharide.

Progress and challenges associated with the development of ricin toxin subunit vaccines

Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB).

Rapid effects of a protective O-polysaccharide-specific monoclonal IgA on Vibrio cholerae agglutination, motility, and surface morphology

Recent advances in the development of vaccines against ricin

Rediscovering IgA

Rescue of rhesus macaques from the lethality of aerosolized ricin toxin

Ricin induces IL-8 secretion from human monocyte/macrophages by activating the p38 MAP kinase pathway.

Role of Maternal Dietary Peanut Exposure in Development of Food Allergy and Oral Tolerance

Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin ⬇️

Sampling of Candida albicans and Candida tropicalis by Langerin-positive dendritic cells in mouse Peyer's patches.

Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut

Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin-Ab complexes

Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins

Sites of vulnerability on ricin B chain revealed through epitope mapping of toxin-neutralizing monoclonal antibodies

Small-molecule inhibitors of ricin and Shiga toxins.

Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin's binding subunit

Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization.

Stepwise engineering of heterodimeric single domain camelid VHH antibodies that passively protect mice from ricin toxin.