Lista de obras - Michael A Farrar - Dominio Público Uruguay

A developmentally controlled competitive STAT5-PU.1 DNA binding mechanism regulates activity of the Ig κ E3' enhancer.

artículo científico publicado en 2012

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

artículo científico publicado en 1996

Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells

artículo científico publicado en 2015

Attenuation of IL-7 receptor signaling is not required for allelic exclusion

artículo científico publicado en 2006

B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements

artículo científico publicado en 2008

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

artículo científico publicado en 2019

BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.

artículo científico publicado en 2008

Combination therapeutics of Nilotinib and radiation in acute lymphoblastic leukemia as an effective method against drug-resistance

artículo científico publicado en 2017

Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis

artículo científico publicado en 2006

Constitutively active STAT5 constructs

artículo científico publicado en 2013

Control of B cell development by Ras-mediated activation of Raf.

artículo científico publicado en 1997

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.

artículo científico publicado en 2014

Coumermycin-induced dimerization of GyrB-containing fusion proteins.

artículo científico publicado en 2000

Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development.

artículo científico publicado en 2010

Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo

artículo científico publicado en 2012

Design and Use of Constitutively Active STAT5 Constructs

artículo científico publicado el 1 de enero de 2010

Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells.

artículo científico publicado en 2003

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia

artículo científico publicado en 2011

Evidence for heterogeneity of the DPA and DPB alleles derived from a DRw11,DQw7,DPw4 cell line

artículo científico publicado en 1989

Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens

artículo científico publicado en 2011

Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity.

artículo científico publicado en 2016

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

artículo científico publicado en 2007

IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development

artículo científico publicado en 2008

IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle

artículo científico publicado en 2012

IL-7/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naive CD4 T cell survival in peripheral lymphoid organs

artículo científico publicado en 2007

Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis

artículo científico publicado en 2018

Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor.

artículo científico publicado en 1992

Identification of two regions within the cytoplasmic domain of the human interferon-gamma receptor required for function.

artículo científico publicado en 1991

Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells

artículo científico publicado en 2015

In vivo survival and homeostatic proliferation of natural killer cells.

artículo científico publicado en 2003

Inhibition of cellular responsiveness to interferon-gamma (IFN gamma) induced by overexpression of inactive forms of the IFN gamma receptor.

artículo científico publicado en 1993

Interleukin-2 and STAT5 in regulatory T cell development and function

artículo científico publicado en 2013

Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation.

artículo científico publicado en 2015

JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors

artículo científico publicado en 2019

Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.

artículo científico publicado en 2008

Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection

artículo científico publicado en 2008

Membrane localization of Raf assists engagement of downstream effectors

artículo científico publicado en 2000

Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation

artículo científico publicado en 2003

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

artículo científico publicado en 2014

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

scientific journal article

Regulation of lymphocyte development by cell-type-specific interpretation of Notch signals.

artículo científico publicado en 2008

Regulatory T Cell Development in the Thymus

artículo científico publicado en 2019

Restricted STAT5 activation dictates appropriate thymic B versus T cell lineage commitment

artículo científico publicado en 2005

STAT5 activation underlies IL7 receptor-dependent B cell development

artículo científico publicado en 2004

Signal transduction pathways regulating the development of alpha beta T cells

artículo científico publicado en 1998

Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma

artículo científico publicado en 2018

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia

artículo científico publicado en 2015

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

scientific article published in Nature Communications

The role of STAT5 in the development, function, and transformation of B and T lymphocytes.

artículo científico publicado en 2011

Thymic regulatory T cells arise via two distinct developmental programs

scientific article published on 14 January 2019

Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways

artículo científico publicado en 2010

Turning transcription on or off with STAT5: when more is less

artículo científico publicado en 2011

Lista de obras de Michael A Farrar

A developmentally controlled competitive STAT5-PU.1 DNA binding mechanism regulates activity of the Ig κ E3' enhancer.

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells

Attenuation of IL-7 receptor signaling is not required for allelic exclusion

B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.

Combination therapeutics of Nilotinib and radiation in acute lymphoblastic leukemia as an effective method against drug-resistance

Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis

Constitutively active STAT5 constructs

Control of B cell development by Ras-mediated activation of Raf.

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.

Coumermycin-induced dimerization of GyrB-containing fusion proteins.

Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development.

Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo

Design and Use of Constitutively Active STAT5 Constructs

Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells.

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia

Evidence for heterogeneity of the DPA and DPB alleles derived from a DRw11,DQw7,DPw4 cell line

Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens

Heterologous Vaccination and Checkpoint Blockade Synergize To Induce Antileukemia Immunity.

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development

IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle

IL-7/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naive CD4 T cell survival in peripheral lymphoid organs

Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis

Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor.

Identification of two regions within the cytoplasmic domain of the human interferon-gamma receptor required for function.

Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells

In vivo survival and homeostatic proliferation of natural killer cells.

Inhibition of cellular responsiveness to interferon-gamma (IFN gamma) induced by overexpression of inactive forms of the IFN gamma receptor.

Interleukin-2 and STAT5 in regulatory T cell development and function

Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation.

JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors

Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.

Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection

Membrane localization of Raf assists engagement of downstream effectors

Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

Regulation of lymphocyte development by cell-type-specific interpretation of Notch signals.

Regulatory T Cell Development in the Thymus

Restricted STAT5 activation dictates appropriate thymic B versus T cell lineage commitment

STAT5 activation underlies IL7 receptor-dependent B cell development

Signal transduction pathways regulating the development of alpha beta T cells

Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

The role of STAT5 in the development, function, and transformation of B and T lymphocytes.

Thymic regulatory T cells arise via two distinct developmental programs

Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways

Turning transcription on or off with STAT5: when more is less