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Lista de obras de Robert S. Phillips

19F-NMR reveals metal and operator-induced allostery in MerR.

artículo científico publicado en 2007

6-Nitro-L-tryptophan: a novel spectroscopic probe of trp aporepressor and human serum albumin

artículo científico publicado en 1988

A Mannose Family Phosphotransferase System Permease and Associated Enzymes Are Required for Utilization of Fructoselysine and Glucoselysine in Salmonella enterica Serovar Typhimurium.

artículo científico publicado en 2015

A Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase mutant derivative highly active and stereoselective on phenylacetone and benzylacetone.

artículo científico publicado en 2007

A matrix-assisted laser desorption/ionization compatible reagent for tagging tryptophan residues

artículo científico publicado en 2006

A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population

artículo científico publicado en 2011

A redox-active FKBP-type immunophilin functions in accumulation of the photosystem II supercomplex in Arabidopsis thaliana.

artículo científico publicado en 2006

A resonance Raman study of substrate and inhibitor binding to protocatechuate-3,4-dioxygenase

artículo científico publicado en 1978

A straightforward kinetic evidence for coexistence of "induced fit" and "selected fit" in the reaction mechanism of a mutant tryptophan indole lyase Y72F from Proteus vulgaris

artículo científico publicado en 2014

Activity and selectivity of W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus in organic solvents and ionic liquids: mono- and biphasic media

artículo científico publicado en 2008

Aminoacrylate intermediates in the reaction of Citrobacter freundii tyrosine phenol-lyase

artículo científico publicado en 2006

Aspartic acid 214 in Citrobacter freundii tyrosine phenol-lyase ensures sufficient C--H-acidity of the external aldimine intermediate and proper orientation of the cofactor at the active site

artículo científico publicado en 2006

Asymmetric kinetics of protein structural changes.

artículo científico publicado en 2009

Asymmetric reduction and oxidation of aromatic ketones and alcohols using W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus

artículo científico publicado en 2007

Benzimidazole analogs of (L)-tryptophan are substrates and inhibitors of tryptophan indole lyase from Escherichia coli

artículo científico publicado en 2013

Benzoate decreases the binding of cis,cis-muconate to the BenM regulator despite the synergistic effect of both compounds on transcriptional activation.

artículo científico publicado en 2004

Binding of phenol and analogues to alanine complexes of tyrosine phenol-lyase from Citrobacter freundii: implications for the mechanisms of alpha,beta-elimination and alanine racemization

artículo científico publicado en 1993

Bioactivation of Catha edulis alkaloids: enzymatic ketonization of norpseudoephedrine

artículo científico publicado en 1982

Cellobiose oxidase from Phanerochaete chrysosporium. Stopped-flow spectrophotometric analysis of pH-dependent reduction

scientific article published on 01 July 1992

Chemistry and diversity of pyridoxal-5'-phosphate dependent enzymes.

artículo científico publicado en 2015

Cold inactivation and dissociation into dimers of Escherichia coli tryptophanase and its W330F mutant form

artículo científico publicado en 1998

Cold-induced enzyme inactivation: how does cooling lead to pyridoxal phosphate-aldimine bond cleavage in tryptophanase?

artículo científico publicado en 2002

Conformational changes and loose packing promote E. coli Tryptophanase cold lability

artículo científico publicado en 2009

Crystal Structure of d-Ornithine/d-Lysine Decarboxylase, a Stereoinverting Decarboxylase: Implications for Substrate Specificity and Stereospecificity of Fold III Decarboxylases

artículo científico publicado en 2019

Crystal Structures of Wild-Type and F448A Mutant Citrobacter freundii Tyrosine Phenol-Lyase Complexed with a Substrate and Inhibitors: Implications for the Reaction Mechanism

artículo científico publicado en 2018

Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity

artículo científico publicado en 2009

Crystallographic Snapshots of Tyrosine Phenol-lyase Show That Substrate Strain Plays a Role in C–C Bond Cleavage

artículo científico publicado en 2011

Crystals of tryptophan indole-lyase and tyrosine phenol-lyase form stable quinonoid complexes

artículo científico publicado en 2002

Detection of open and closed conformations of tryptophan synthase by 15N-heteronuclear single-quantum coherence nuclear magnetic resonance of bound 1-15N-L-tryptophan

artículo científico publicado en 2003

Differential effects of bromination on substrates and inhibitors of kynureninase from Pseudomonas fluorescens

artículo científico publicado en 2003

Differential effects of temperature and hydrostatic pressure on the formation of quinonoid intermediates from L-Trp and L-Met by H463F mutant Escherichia coli tryptophan indole-lyase

artículo científico publicado en 2005

Dopamine-B-hydroxylase: suicide inhibition by the novel olefinic substrate, 1-phenyl-1-aminomethylethene

artículo científico publicado en 1983

Effects of alpha-deuteration and of aza and thia analogs of L-tryptophan on formation of intermediates in the reaction of Escherichia coli tryptophan indole-lyase.

artículo científico publicado en 1996

Effects of hydrostatic pressure on the conformational equilibrium of tryptophan synthase from Salmonella typhimurium.

artículo científico publicado en 2010

Effects of pressure and osmolytes on the allosteric equilibria of Salmonella typhimurium tryptophan synthase

artículo científico publicado en 2012

Enzymatic syntheses of 6-(4H-selenolo[3,2-b]pyrrolyl)-L-alanine, 4-(6H-selenolo[2,3-b]pyrrolyl)-L-alanine, and 6-(4H-furo[3,2-b]pyrrolyl-L-alanine

artículo científico publicado en 1999

Enzymatic synthesis of aza-l-tyrosines

artículo científico publicado en 2001

Evidence of preorganization in quinonoid intermediate formation from L-Trp in H463F mutant Escherichia coli tryptophan indole-lyase from effects of pressure and pH.

artículo científico publicado en 2012

Excited state tautomerization of azaindole

artículo científico publicado en 2005

Formation in vitro of hybrid dimers of H463F and Y74F mutant Escherichia coli tryptophan indole-lyase rescues activity with L-tryptophan

artículo científico publicado en 2002

High-efficiency incorporation in vivo of tyrosine analogues with altered hydroxyl acidity in place of the catalytic tyrosine-14 of Delta 5-3-ketosteroid isomerase of Comamonas (Pseudomonas) testosteroni: effects of the modifications on isomerase kin

artículo científico publicado en 1998

Histidine ligand protonation and redox potential in the rieske dioxygenases: role of a conserved aspartate in anthranilate 1,2-dioxygenase

artículo científico publicado en 2003

Hydrostatic pressure affects the conformational equilibrium of Salmonella typhimurium tryptophan synthase

artículo científico publicado en 2005

Hysteresis and negative cooperativity in human UDP-glucose dehydrogenase.

artículo científico publicado en 2013

I86A/C295A mutant secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus has broadened substrate specificity for aryl ketones

artículo científico publicado en 2016

Indole can act as an extracellular signal to regulate biofilm formation of Escherichia coli and other indole-producing bacteria

artículo científico publicado en 2003

Indole protects tryptophan indole-lyase, but not tryptophan synthase, from inactivation by trifluoroalanine

artículo científico publicado en 1992

Influence of steric bulk and electrostatics on the hydroxylation regiospecificity of tryptophan hydroxylase: characterization of methyltryptophans and azatryptophans as substrates

scientific article published on 01 December 1999

Inhibition of Escherichia coli tryptophan indole-lyase by tryptophan homologues

artículo científico publicado en 2014

Inhibition of tyrosine phenol-lyase by tyrosine homologues.

artículo científico publicado en 2016

Inhibition of tyrosine phenol-lyase from Citrobacter freundii by 2-azatyrosine and 3-azatyrosine

artículo científico publicado en 2001

Insights into the mechanism of Pseudomonas dacunhae aspartate beta-decarboxylase from rapid-scanning stopped-flow kinetics

artículo científico publicado en 2010

Interactions of Escherichia coli tryptophanase with quasisubstrates and monovalent cations studied by the circular dichroism and fluorescence methods.

artículo científico publicado en 1996

Investigation of the role of 3-hydroxyanthranilic acid in the degradation of lignin by white-rot fungus Pycnoporus cinnabarinus

artículo científico publicado en 2001

Ionization state of pyridoxal 5'-phosphate in D-serine dehydratase, dialkylglycine decarboxylase and tyrosine phenol-lyase and the influence of monovalent cations as inferred by 31P NMR spectroscopy

artículo científico publicado en 2005

Kinetics and mechanism of superoxide reduction by two-iron superoxide reductase from Desulfovibrio vulgaris

artículo científico publicado en 2002

Kinetics of the superoxide reductase catalytic cycle

artículo científico publicado en 2003

Ligand effects on the limited proteolysis of phenylalanine hydroxylase: evidence for multiple conformational states

scientific article published on 01 February 1983

Mass defect labeling of cysteine for improving peptide assignment in shotgun proteomic analyses

artículo científico publicado en 2006

Methionine gamma-lyase: mechanistic deductions from the kinetic pH-effects. The role of the ionic state of a substrate in the enzymatic activity.

artículo científico publicado en 2009

Mutation of Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase at Trp-110 affects stereoselectivity of aromatic ketone reduction.

artículo científico publicado en 2014

Oxygenation of fluorinated tyrosines by mushroom tyrosinase releases fluoride ion

artículo científico publicado en 1990

Preparation and photophysical properties of a caged kynurenine

artículo científico publicado en 2012

Preparation of 3-bromo-L-tyrosine and 3,5-dibromo-L-tyrosine

artículo científico publicado en 2012

Pressure and temperature jump relaxation kinetics of the conformational change in Salmonella typhimurium tryptophan synthase L-serine complex: large activation compressibility and heat capacity changes demonstrate the contribution of solvation

artículo científico publicado en 2008

Properties of tryptophan indole-lyase from a piezophilic bacterium, Photobacterium profundum SS9

artículo científico publicado en 2010

Protein expression in Escherichia coli S17-1 biofilms: impact of indole.

artículo científico publicado en 2006

Quantitative effects of allosteric ligands and mutations on conformational equilibria in Salmonella typhimurium tryptophan synthase

artículo científico publicado en 2007

Racemization of enantiopure secondary alcohols by Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase.

artículo científico publicado en 2013

Reaction of Pseudomonas fluorescens kynureninase with beta-benzoyl-L-alanine: detection of a new reaction intermediate and a change in rate-determining step

artículo científico publicado en 2004

Reactions of O-acyl-L-serines with tryptophanase, tyrosine phenol-lyase, and tryptophan synthase

artículo científico publicado en 1987

Regioselective nitration of N(alpha),N(1)-bis(trifluoroacetyl)-L-tryptophan methyl ester: efficient synthesis of 2-nitro and 6-nitro-N-trifluoroacetyl-L-tryptophan methyl ester

artículo científico publicado en 2008

Role of aspartate-133 and histidine-458 in the mechanism of tryptophan indole-lyase from Proteus vulgaris

artículo científico publicado en 2003

Role of lysine-256 in Citrobacter freundii tyrosine phenol-lyase in monovalent cation activation

artículo científico publicado en 2004

Salmonella utilizes D-glucosaminate via a mannose family phosphotransferase system permease and associated enzymes.

artículo científico publicado en 2013

Site-directed mutagenesis of tyrosine-71 to phenylalanine in Citrobacter freundii tyrosine phenol-lyase: evidence for dual roles of tyrosine-71 as a general acid catalyst in the reaction mechanism and in cofactor binding

scientific article published on 01 September 1995

Stereospecificity of Pseudomonas fluorescens kynureninase for diastereomers of beta-methylkynurenine

artículo científico publicado en 1999

Stopped-flow studies of the reaction of D-tartronate semialdehyde-2-phosphate with human neuronal enolase and yeast enolase 1.

artículo científico publicado en 2010

Structure and Mechanism of d-Glucosaminate-6-phosphate Ammonia-lyase: A Novel Octameric Assembly for a Pyridoxal 5'-Phosphate-Dependent Enzyme, and Unprecedented Stereochemical Inversion in the Elimination Reaction of a d-Amino Acid

artículo científico publicado en 2021

Structure and mechanism of kynureninase.

artículo científico publicado en 2013

Substituent effects on the reaction of beta-benzoylalanines with Pseudomonas fluorescens kynureninase

artículo científico publicado en 2010

Substituents effects on activity of kynureninase from Homo sapiens and Pseudomonas fluorescens

artículo científico publicado en 2013

Substrate and inhibitor specificity of kynurenine monooxygenase from Cytophaga hutchinsonii

artículo científico publicado en 2017

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.

artículo científico publicado en 2014

The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway Is Related to the Heme-Dependent Dioxygenase Superfamily †

artículo científico publicado en 2007

The Second Enzyme in Pyrrolnitrin Biosynthetic Pathway Is Related to the Heme-Dependent Dioxygenase Superfamily,

article published in 2007

The catalytic mechanism of kynureninase from Pseudomonas fluorescens: evidence for transient quinonoid and ketimine intermediates from rapid-scanning stopped-flow spectrophotometry

artículo científico publicado en 1998

The catalytic mechanism of kynureninase from Pseudomonas fluorescens: insights from the effects of pH and isotopic substitution on steady-state and pre-steady-state kinetics

artículo científico publicado en 1998

The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4'-hydroxyphenyl)propionic acid, together with site-directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity

artículo científico publicado en 1997

The crystal structure of the Pseudomonas dacunhae aspartate-beta-decarboxylase dodecamer reveals an unknown oligomeric assembly for a pyridoxal-5'-phosphate-dependent enzyme

artículo científico publicado en 2009

The design and synthesis of a selective inhibitor of fucosyltransferase VI.

artículo científico publicado en 2004

The environments of Trp-248 and Trp-330 in tryptophan indole-lyase from Escherichia coli

artículo científico publicado en 1990

The mechanism of Escherichia coli tryptophan indole-lyase: substituent effects on steady-state and pre-steady-state kinetic parameters for aryl-substituted tryptophan derivatives.

artículo científico publicado en 1995

The mechanism of alpha-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase. What is the role of quinonoid intermediates?

artículo científico publicado en 2004

The phosphate of pyridoxal-5'-phosphate is an acid/base catalyst in the mechanism of Pseudomonas fluorescens kynureninase.

artículo científico publicado en 2014

The reaction of indole with the aminoacrylate intermediate of Salmonella typhimurium tryptophan synthase: observation of a primary kinetic isotope effect with 3-[(2)H]indole

artículo científico publicado en 2004

The role of acidic dissociation of substrate's phenol group in the mechanism of tyrosine phenol-lyase

artículo científico publicado en 2003

The role of glutamic acid-69 in the activation of Citrobacter freundii tyrosine phenol-lyase by monovalent cations.

artículo científico

The role of substrate strain in the mechanism of the carbon-carbon lyases

artículo científico publicado en 2014

The role of the catalytic base in the protein tyrosine kinase Csk

artículo científico publicado en 1995

The stereospecificity of secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus is partially determined by active site water.

artículo científico publicado en 2001

Three-dimensional structure of kynureninase from Pseudomonas fluorescens

artículo científico publicado en 2004

Threonine-124 and phenylalanine-448 in Citrobacter freundii tyrosine phenol-lyase are necessary for activity with L-tyrosine

artículo científico publicado en 2002

Tryptophanase from Proteus vulgaris: the conformational rearrangement in the active site, induced by the mutation of Tyrosine 72 to phenylalanine, and its mechanistic consequences.

artículo científico publicado en 2006

Tyrosine phenol-lyase and tryptophan indole-lyase encapsulated in wet nanoporous silica gels: Selective stabilization of tertiary conformations

artículo científico publicado en 2004

Xerogel-encapsulated W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus performs asymmetric reduction of hydrophobic ketones in organic solvents

artículo científico publicado en 2007