Lista de obras - Ian L Megson - Dominio Público Uruguay

2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors

artículo científico publicado en 2010

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

artículo científico publicado en 2013

A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium

artículo científico publicado en 2000

A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

artículo científico publicado en 2003

A novel electron paramagnetic resonance-based assay for prostaglandin H synthase-1 activity

artículo científico publicado en 2006

A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

artículo científico publicado en 2008

A potential role for extracellular nitric oxide generation in cGMP-independent inhibition of human platelet aggregation: biochemical and pharmacological considerations

artículo científico publicado en 2005

A randomized crossover study to assess the effect of an oat‐rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes ⬇️

artículo científico publicado el 22 de junio de 2013

Acoustic speed and attenuation coefficient in sheep aorta measured at 5-9 MHz.

artículo científico publicado en 2006

Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure.

artículo científico publicado en 2010

Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man

artículo científico publicado en 2013

Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin

artículo científico publicado en 2003

Apoptosis and Atherosclerosis: The Role of Nitric Oxide

scholarly article by Catherine Shaw et al published 1 February 2006 in Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry

Association between exposure to environmental tobacco smoke and biomarkers of oxidative stress among patients hospitalised with acute myocardial infarction

artículo científico publicado en 2013

B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure

artículo científico publicado en 2005

Bioavailable Concentrations of Delphinidin and Its Metabolite, Gallic Acid, Induce Antioxidant Protection Associated with Increased Intracellular Glutathione in Cultured Endothelial Cells

artículo científico publicado en 2017

Clearance of dying cells and autoimmunity

artículo científico publicado en 2007

Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume

artículo científico publicado en 2010

Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity.

artículo científico publicado en 2005

Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2

artículo científico publicado en 2008

Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

artículo científico publicado en 2009

Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice

artículo científico publicado en 2005

Development and characterization of glutamyl-protected N-hydroxyguanidines as reno-active nitric oxide donor drugs with therapeutic potential in acute renal failure.

artículo científico publicado en 2013

Diabetic fatty liver disease is associated with specific changes in blood-borne markers

scientific article published on 01 May 2012

Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs

artículo científico publicado en 2011

Differential susceptibility to nitric oxide-evoked apoptosis in human inflammatory cells

artículo científico publicado en 2010

Diffusion of nitric oxide and scavenging by blood in the vasculature

scientific article published on 01 September 1998

Direct Vascular Effects of Protease-Activated Receptor Type 1 Agonism In Vivo in Humans

scientific article published on 02 October 2006

Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals

artículo científico publicado en 2009

Dissociation of DNA fragmentation from other hallmarks of apoptosis in nitric oxide-treated neutrophils: differences between individual nitric oxide donor drugs

artículo científico publicado en 2001

Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis

artículo científico

Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?

artículo científico publicado en 2014

Endothelial dysfunction: from molecular mechanisms to measurement, clinical implications, and therapeutic opportunities

artículo científico publicado en 2008

Exceptional Behavior over the Whole Adsorption−Storage−Delivery Cycle for NO in Porous Metal Organic Frameworks

article

Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits

artículo científico publicado en 2013

Extracellular nitric oxide release mediates soluble guanylate cyclase-independent vasodilator action of spermine NONOate: comparison with other nitric oxide donors in isolated rat femoral arteries

artículo científico publicado en 2004

Food intake and dietary glycaemic index in free-living adults with and without type 2 diabetes mellitus

artículo científico publicado en 2011

GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism

artículo científico publicado en 2004

Genetic association of the AKT1 gene with schizophrenia in a British population

artículo científico publicado en 2010

High-capacity hydrogen and nitric oxide adsorption and storage in a metal-organic framework

artículo científico publicado en 2007

In vivo speciation studies and antioxidant properties of bromine in Laminaria digitata reinforce the significance of iodine accumulation for kelps

artículo científico publicado en 2013

Inducible nitric oxide synthase activity does not contribute to the maintenance of peripheral vascular tone in patients with heart failure

artículo científico publicado en 2006

Inhibition of Human Platelet Aggregation by Nitric Oxide Donor Drugs: Relative Contribution of cGMP-Independent Mechanisms

scientific article published on 01 December 2000

Investigation of the Interaction Between the Ser447Term Polymorphism of Lipoprotein Lipase and the Stroke-Related Risk Factors in Ischemic Stroke

artículo científico publicado en 2010

Iron-sulphur cluster nitrosyls, a novel class of nitric oxide generator: mechanism of vasodilator action on rat isolated tail artery ⬇️

artículo científico publicado el 1 de noviembre de 1992

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-α

scientific article published on 29 October 2008

Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets

artículo científico publicado en 2006

Mechanisms for an effect of acetylcysteine on renal function after exposure to radio-graphic contrast material: study protocol

artículo científico publicado en 2012

Mechanisms of resolution of inflammation: a focus on cardiovascular disease

artículo científico publicado en 2011

Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing

artículo científico publicado en 2010

Metal–organic frameworks for the storage and delivery of biologically active hydrogen sulfide

article

N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial.

artículo científico publicado en 2012

N-Substituted analogues of S-nitroso-N-acetyl-D,L-penicillamine: chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries

artículo científico publicado en 1999

NO-Releasing Zeolites and Their Antithrombotic Properties

artículo científico publicado en 2006

NO-loaded Zn(2+)-exchanged zeolite materials: a potential bifunctional anti-bacterial strategy

artículo científico publicado en 2009

Neocuproine, a selective Cu(I) chelator, and the relaxation of rat vascular smooth muscle by S-nitrosothiols

artículo científico publicado en 1997

NiO and Co3O4 nanoparticles induce lung DTH-like responses and alveolar lipoproteinosis

artículo científico publicado en 2011

Nitric oxide and the mechanism of rat vascular smooth muscle photorelaxation

artículo científico publicado en 2003

Nitric oxide photogeneration from trans-Cr(cyclam)(ONO)(2)(+) in a reducing environment. activation of soluble guanylyl cyclase and arterial vasorelaxation

artículo científico publicado en 2010

No association between the PPARG gene and schizophrenia in a British population.

artículo científico publicado en 2009

Non-heme iron nitrosyls in biology

artículo científico publicado en 2002

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.

artículo científico publicado en 2013

Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryl trinitrate-tolerant rat femoral arteries.

artículo científico publicado en 2000

Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryltrinitrate-tolerant rat femoral arteries

artículo científico publicado en 2000

Novel role for low molecular weight plasma thiols in nitric oxide-mediated control of platelet function

artículo científico publicado en 2002

Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes

artículo científico publicado en 2014

Oral vitamin C reduces arterial stiffness and platelet aggregation in humans.

artículo científico publicado en 1999

Persistent endothelial dysfunction in humans after diesel exhaust inhalation

artículo científico publicado en 2007

Photochemistry of trans-Cr(cyclam)(ONO)2+, a nitric oxide precursor

artículo científico publicado en 2011

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

artículo científico publicado en 2014

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

artículo científico publicado en 2013

Preserved endothelial vasomotion and fibrinolytic function in patients with acute stent thrombosis or in-stent restenosis

artículo científico publicado en 2003

Principal component and causal analysis of structural and acute in vitro toxicity data for nanoparticles ⬇️

artículo científico publicado en 2014

Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes.

artículo científico publicado en 2011

Prolonged effect of a novel S-nitrosated glyco-amino acid in endothelium-denuded rat femoral arteries: potential as a slow release nitric oxide donor drug

artículo científico publicado en 1997

Recent developments in nitric oxide donor drugs.

artículo científico publicado en 2007

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

artículo científico publicado en 2007

Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose.

artículo científico publicado en 2008

Ruthenium complexes as nitric oxide scavengers: a potential therapeutic approach to nitric oxide-mediated diseases.

artículo científico publicado en 1997

S-nitrosothiols for nitrate tolerance

artículo científico publicado en 1999

Search for schizophrenia susceptibility variants at the HLA-DRB1 locus among a British population

artículo científico publicado en 2012

Selective modifiers of glutathione biosynthesis and 'repriming' of vascular smooth muscle photorelaxation

artículo científico publicado en 2000

Sildenafil offers protection against NSAID-induced gastric injury

artículo científico publicado en 2005

Sildenafil potentiates nitric oxide mediated inhibition of human platelet aggregation

artículo científico publicado en 2005

Simultaneous and cooperative gas storage and gas production using bifunctional zeolites

article

Surface derivatization state of polystyrene latex nanoparticles determines both their potency and their mechanism of causing human platelet aggregation in vitro

artículo científico publicado en 2010

Surface functionalization affects the zeta potential, coronal stability and membranolytic activity of polymeric nanoparticles

artículo científico publicado en 2013

Synthesis, Decomposition, and Vasodilator Action of Some New S-Nitrosated Dipeptides

scientific article published on 01 January 1998

The 2011 survey on hypertensive disorders of pregnancy (HDP) in China: prevalence, risk factors, complications, pregnancy and perinatal outcomes

artículo científico publicado en 2014

The TGM2 gene is associated with schizophrenia in a British population.

artículo científico publicado en 2009

The effect of oxidative stress on endothelium-dependent and nitric oxide donor-induced relaxation: implications for nitrate tolerance

artículo científico publicado en 2002

The functional significance of the TGM2 gene in schizophrenia: A correlation of SNPs and circulating IL-2 levels

article

Therapeutic effects of nitric oxide-aspirin hybrid drugs

artículo científico publicado en 2006

Therapeutic potential of N-acetylcysteine as an antiplatelet agent in patients with type-2 diabetes ⬇️

artículo científico publicado en 2011

Topical application of acidified nitrite to the nail renders it antifungal and causes nitrosation of cysteine groups in the nail plate

artículo científico publicado en 2007

Vascular effects of apelin in vivo in man.

artículo científico publicado en 2008

Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles

artículo científico publicado en 2012

Lista de obras de Ian L Megson

2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium

A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury

A novel electron paramagnetic resonance-based assay for prostaglandin H synthase-1 activity

A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

A potential role for extracellular nitric oxide generation in cGMP-independent inhibition of human platelet aggregation: biochemical and pharmacological considerations

A randomized crossover study to assess the effect of an oat‐rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes ⬇️

Acoustic speed and attenuation coefficient in sheep aorta measured at 5-9 MHz.

Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure.

Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man

Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin

Apoptosis and Atherosclerosis: The Role of Nitric Oxide

Association between exposure to environmental tobacco smoke and biomarkers of oxidative stress among patients hospitalised with acute myocardial infarction

B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure

Bioavailable Concentrations of Delphinidin and Its Metabolite, Gallic Acid, Induce Antioxidant Protection Associated with Increased Intracellular Glutathione in Cultured Endothelial Cells

Clearance of dying cells and autoimmunity

Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume

Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity.

Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2

Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice

Development and characterization of glutamyl-protected N-hydroxyguanidines as reno-active nitric oxide donor drugs with therapeutic potential in acute renal failure.

Diabetic fatty liver disease is associated with specific changes in blood-borne markers

Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs

Differential susceptibility to nitric oxide-evoked apoptosis in human inflammatory cells

Diffusion of nitric oxide and scavenging by blood in the vasculature

Direct Vascular Effects of Protease-Activated Receptor Type 1 Agonism In Vivo in Humans

Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals

Dissociation of DNA fragmentation from other hallmarks of apoptosis in nitric oxide-treated neutrophils: differences between individual nitric oxide donor drugs

Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis

Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?

Endothelial dysfunction: from molecular mechanisms to measurement, clinical implications, and therapeutic opportunities

Exceptional Behavior over the Whole Adsorption−Storage−Delivery Cycle for NO in Porous Metal Organic Frameworks

Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits

Extracellular nitric oxide release mediates soluble guanylate cyclase-independent vasodilator action of spermine NONOate: comparison with other nitric oxide donors in isolated rat femoral arteries

Food intake and dietary glycaemic index in free-living adults with and without type 2 diabetes mellitus

GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism

Genetic association of the AKT1 gene with schizophrenia in a British population

High-capacity hydrogen and nitric oxide adsorption and storage in a metal-organic framework

In vivo speciation studies and antioxidant properties of bromine in Laminaria digitata reinforce the significance of iodine accumulation for kelps

Inducible nitric oxide synthase activity does not contribute to the maintenance of peripheral vascular tone in patients with heart failure

Inhibition of Human Platelet Aggregation by Nitric Oxide Donor Drugs: Relative Contribution of cGMP-Independent Mechanisms

Investigation of the Interaction Between the Ser447Term Polymorphism of Lipoprotein Lipase and the Stroke-Related Risk Factors in Ischemic Stroke

Iron-sulphur cluster nitrosyls, a novel class of nitric oxide generator: mechanism of vasodilator action on rat isolated tail artery ⬇️

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-α

Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets

Mechanisms for an effect of acetylcysteine on renal function after exposure to radio-graphic contrast material: study protocol

Mechanisms of resolution of inflammation: a focus on cardiovascular disease

Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing

Metal–organic frameworks for the storage and delivery of biologically active hydrogen sulfide

N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial.

N-Substituted analogues of S-nitroso-N-acetyl-D,L-penicillamine: chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries

NO-Releasing Zeolites and Their Antithrombotic Properties

NO-loaded Zn(2+)-exchanged zeolite materials: a potential bifunctional anti-bacterial strategy

Neocuproine, a selective Cu(I) chelator, and the relaxation of rat vascular smooth muscle by S-nitrosothiols

NiO and Co3O4 nanoparticles induce lung DTH-like responses and alveolar lipoproteinosis

Nitric oxide and the mechanism of rat vascular smooth muscle photorelaxation

Nitric oxide photogeneration from trans-Cr(cyclam)(ONO)(2)(+) in a reducing environment. activation of soluble guanylyl cyclase and arterial vasorelaxation

No association between the PPARG gene and schizophrenia in a British population.

Non-heme iron nitrosyls in biology

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.

Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryl trinitrate-tolerant rat femoral arteries.

Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryltrinitrate-tolerant rat femoral arteries

Novel role for low molecular weight plasma thiols in nitric oxide-mediated control of platelet function

Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes

Oral vitamin C reduces arterial stiffness and platelet aggregation in humans.

Persistent endothelial dysfunction in humans after diesel exhaust inhalation

Photochemistry of trans-Cr(cyclam)(ONO)2+, a nitric oxide precursor

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

Preserved endothelial vasomotion and fibrinolytic function in patients with acute stent thrombosis or in-stent restenosis

Principal component and causal analysis of structural and acute in vitro toxicity data for nanoparticles ⬇️

Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes.

Prolonged effect of a novel S-nitrosated glyco-amino acid in endothelium-denuded rat femoral arteries: potential as a slow release nitric oxide donor drug

Recent developments in nitric oxide donor drugs.

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose.

Ruthenium complexes as nitric oxide scavengers: a potential therapeutic approach to nitric oxide-mediated diseases.