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Lista de obras de Roberto Cappai

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

artículo científico publicado en 2011

6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation

artículo científico publicado en 2006

A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(II) complex that binds to amyloid-beta plaques.

artículo científico publicado en 2010

A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease

artículo científico

A serial analysis of gene expression profile of the Alzheimer's disease Tg2576 mouse model.

artículo científico publicado en 2009

APP involvement in retinogenesis of mice

artículo científico publicado en 2010

Accumulation of Insoluble α-Synuclein in Dementia with Lewy Bodies

artículo científico publicado en 2000

Alleviating transcriptional inhibition of the norepinephrine slc6a2 transporter gene in depolarized neurons

artículo científico publicado en 2010

Alois Alzheimer and Alzheimer's disease: a centennial perspective.

artículo científico publicado en 2006

Alpha-synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: implications in Parkinson's disease

artículo científico publicado en 2010

Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study

article

Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF).

artículo científico publicado en 2002

Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment

artículo científico publicado en 1997

Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.

artículo científico publicado en 1999

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth.

artículo científico publicado en 2018

Amyloid beta.

artículo científico publicado en 1999

Amyloid imaging in Alzheimer's disease and other dementias

artículo científico publicado en 2009

Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate

artículo científico publicado en 2014

Amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina

artículo científico publicado en 2012

Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity

artículo científico publicado en 2008

Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions

artículo científico publicado en 2005

Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope

artículo científico publicado en 2008

Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex

artículo científico publicado en 2018

Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease

artículo científico publicado en 2010

Characterisation of the effect of knockout of the amyloid precursor protein on outcome following mild traumatic brain injury

artículo científico publicado en 2012

Characterization of PiB binding to white matter in Alzheimer disease and other dementias

artículo científico publicado en 2009

Characterization of a polymorphic family of integral membrane proteins in promastigotes of different Leishmania species

article

Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

artículo científico publicado en 2019

Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice

artículo científico publicado en 2009

Clioquinol Treatment in Familiar Early Onset of Alzheimer’s Disease

artículo científico publicado en 2006

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease

artículo científico publicado en 2004

Cloning and analysis of the RESA-2 gene: a DNA homologue of the ring-infected erythrocyte surface antigen gene of Plasmodium falciparum

artículo científico publicado en 1992

Cloning and sequence of a Leishmania major homologue to the fibrillarin gene

artículo científico publicado en 1994

Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis

artículo científico publicado en 2014

Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide

artículo científico publicado en 2007

Conformational behavior and aggregation of ataxin-3 in SDS.

artículo científico publicado en 2013

Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence

artículo científico publicado en 2009

Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivity

artículo científico publicado en 2010

Copper Coordination by Familial Mutants of Parkinson’s Disease-Associated α-Synuclein

scholarly article by Simon C. Drew et al published 20 October 2009 in Applied Magnetic Resonance

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.

artículo científico publicado en 2001

Copper binding to the Alzheimer's disease amyloid precursor protein

artículo científico publicado en 2007

Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

artículo científico publicado en 1999

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

scientific journal article

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

artículo científico publicado en 2013

Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments

artículo científico publicado en 2003

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

artículo científico publicado en 2005

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge

artículo científico publicado en 2006

Correlative studies support lipid peroxidation is linked to PrPres propagation as an early primary pathogenic event in prion disease

artículo científico publicado en 2005

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

artículo científico publicado en 1999

Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease.

artículo científico publicado en 2008

Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease

artículo científico publicado en 2004

Cu2+Binding Modes of Recombinant α-Synuclein − Insights from EPR Spectroscopy

artículo científico publicado en 2008

Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576 mouse model of Alzheimer's disease.

artículo científico publicado en 2005

Detection of prion epitopes on PrP and PrP of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP.

artículo científico publicado en 2005

Development of a Platinum Complex as an anti‐Amyloid Agent for the Therapy of Alzheimer’s Disease ⬇️

artículo científico publicado el 10 de febrero de 2013

Dimeric structures of alpha-synuclein bind preferentially to lipid membranes

artículo científico publicado en 2008

Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation

artículo científico publicado en 2003

Dopamine and the dopamine oxidation product 5,6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of alpha-synuclein in a pH-dependent manner

artículo científico publicado en 2009

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

artículo científico publicado en 2005

Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor-related protein on neurite outgrowth from sympathetic neurons in culture

artículo científico publicado en 1998

Engineered antibody intervention strategies for Alzheimer's disease and related dementias by targeting amyloid and toxic oligomers.

artículo científico publicado en 2008

Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution

artículo científico publicado en 2004

Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid

artículo científico publicado en 2008

Evaluation of the effects of treatment with sAPPα on functional and histological outcome following controlled cortical impact injury in mice

artículo científico publicado en 2012

Evidence for prion protein expression in enteroglial cells of the myenteric plexus of mouse intestine

article

Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione

artículo científico publicado en 1999

Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease

artículo científico publicado en 1997

Expression of human amyloid precursor protein ectodomains in Pichia pastoris: analysis of culture conditions, purification, and characterization

artículo científico publicado en 1997

Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex.

artículo científico publicado en 2004

Familial prion disease mutation alters the secondary structure of recombinant mouse prion protein: implications for the mechanism of prion formation

artículo científico publicado en 1999

Formation of a High Affinity Lipid-Binding Intermediate during the Early Aggregation Phase of α-Synuclein†

artículo científico publicado en 2008

Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation

artículo científico publicado en 2009

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology

artículo científico publicado en 2006

Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts

scientific journal article

Gene knockout of tau expression does not contribute to the pathogenesis of prion disease

artículo científico publicado en 2011

Generation of a recombinant Fab antibody reactive with the Alzheimer's disease-related Abeta peptide

artículo científico publicado en 2002

Guanidine hydrochloride denaturation of dopamine-induced α-synuclein oligomers: a small-angle X-ray scattering study

artículo científico publicado en 2013

Histidine 14 modulates membrane binding and neurotoxicity of the Alzheimer's disease amyloid-beta peptide

artículo científico publicado en 2010

Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways

artículo científico publicado en 2001

Identification of a novel amyloid precursor protein processing pathway that generates secreted N‐terminal fragments ⬇️

artículo científico publicado el 6 de abril de 2012

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

artículo científico publicado en 2008

In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.

artículo científico publicado en 2009

In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.

artículo científico publicado en 2007

In vitro characterization of [18F]-florbetaben, an Aβ imaging radiotracer

artículo científico publicado en 2012

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

scholarly article

Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein

artículo científico publicado en 1998

Interaction of linear homologous DNA duplexes via Holliday junction formation.

artículo científico publicado en 2001

Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity

artículo científico publicado en 2004

Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.

artículo científico publicado en 1999

Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126.

artículo científico publicado en 2001

Iron inhibits neurotoxicity induced by trace copper and biological reductants

artículo científico publicado en 2004

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

artículo científico publicado en 2010

Making sense of the amyloid precursor protein: its tail tells an interesting tale

artículo científico publicado en 2014

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

artículo científico publicado en 2011

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

artículo científico publicado en 2002

Metals and amyloid-beta in Alzheimer's disease

artículo científico publicado en 2005

Methionine oxidation: Implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease

article

Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity

artículo científico publicado en 2005

Modulation of alpha-synuclein aggregation by dopamine: a review.

artículo científico publicado en 2009

Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.

artículo científico publicado en 2006

Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the aggregating species

artículo científico publicado en 2007

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

artículo científico publicado en 2005

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

artículo científico publicado en 2014

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

artículo científico publicado en 2003

Neurotoxicity from glutathione depletion is dependent on extracellular trace copper

artículo científico publicado en 2003

Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation

artículo científico publicado en 2007

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

artículo científico publicado en 2002

PAMAM Dendrimers as Potential Agents against Fibrillation ofα-Synuclein, a Parkinson's Disease-Related Protein

artículo científico publicado en 2009

Packaging of prions into exosomes is associated with a novel pathway of PrP processing.

artículo científico publicado en 2007

Plasma alpha-synuclein is decreased in subjects with Parkinson's disease

artículo científico publicado en 2006

Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease

artículo científico publicado en 2008

Possible mechanisms of APP-mediated oxidative stress in Alzheimer's disease

artículo científico publicado en 2002

Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: immunodetection of alpha-, beta-, and gamma-secretase products

artículo científico publicado en 1998

Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function

artículo científico publicado en 2014

Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue

artículo científico publicado en 2014

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

artículo científico publicado en 2008

Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth

artículo científico publicado en 1999

Residues surrounding the glycosylphosphatidylinositol anchor attachment site of PrP modulate prion infection: insight from the resistance of rabbits to prion disease.

artículo científico publicado en 2010

SERF protein is a direct modifier of amyloid fiber assembly.

artículo científico publicado en 2012

Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth

artículo científico publicado en 1996

Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage

artículo científico publicado en 2003

Solution Conformation and Heparin-induced Dimerization of the Full-length Extracellular Domain of the Human Amyloid Precursor Protein

article

Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity

artículo científico publicado en 2009

Stimulus pattern dependence of the Alzheimer's disease amyloid-beta 42 peptide's inhibition of long term potentiation in mouse hippocampal slices

artículo científico publicado en 2009

Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions

artículo científico publicado en 2007

Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution

artículo científico publicado en 2007

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

artículo científico publicado en 2003

Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons.

artículo científico publicado en 2001

Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation

artículo científico publicado en 2011

Synthetic dityrosine-linked β-amyloid dimers form stable, soluble, neurotoxic oligomers

article

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

artículo científico publicado en 2012

The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase

artículo científico publicado en 2001

The Leishmania promastigote surface antigen 2 complex is differentially expressed during the parasite life cycle

artículo científico publicado en 1995

The N-terminal residues 43 to 60 form the interface for dopamine mediated α-synuclein dimerisation.

artículo científico publicado en 2015

The Plasmodium falciparum hypoxanthine-guanine phosphoribosyl transferase gene has a 5' upstream intron

artículo científico publicado en 1992

The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons

artículo científico publicado en 1999

The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism.

artículo científico publicado en 2012

The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.

artículo científico publicado en 1999

The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126.

artículo científico publicado en 1999

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

artículo científico publicado en 2012

The interplay between lipids and dopamine on α-synuclein oligomerization and membrane binding.

artículo científico publicado en 2013

The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein.

artículo científico publicado en 2009

The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96-110.

artículo científico publicado en 2013

The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains

artículo científico publicado en 2011

The neurotransmitter serotonin interrupts α-synuclein amyloid maturation

artículo científico publicado en 2011

The redox chemistry of the Alzheimer's disease amyloid beta peptide.

artículo científico publicado en 2007

The structure of dopamine induced alpha-synuclein oligomers.

artículo científico publicado en 2010

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

artículo científico publicado en 2004

Variable phenotype of Alzheimer's disease with spastic paraparesis

artículo científico publicado en 2001

sAPPα rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury

artículo científico publicado en 2012

α-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease

artículo científico publicado en 2014

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