Lista de obras - Petra Heffeter - Dominio Público Uruguay

A Dogma in Doubt: Hydrolysis of Equatorial Ligands of PtIV Complexes under Physiological Conditions

artículo científico publicado en 2019

A novel class of bis- and tris-chelate diam(m)inebis(dicarboxylato)platinum(IV) complexes as potential anticancer prodrugs.

artículo científico publicado en 2014

Abstract 1671: Fibroblast growth factor receptor 3 enhances progression of hepatocellular carcinoma

Abstract 2573: Investigation of factors involved in the hypersensitivity to KP1339-treatment

Abstract 2637: Terminal dimethyl substitution of Triapine leads to activation of CHOP and induction of apoptosis via ER stress in human colon cancer cells

Abstract 3541: Combination of the ruthenium compound KP1339 with the tyrosine kinase inhibitor sorafenib: A promising approach for the treatment of human hepatoma

Abstract 4397: Preclinical development of a novel hypoxia-activated EGFR inhibitor using a cobalt(III)-based prodrug design

scholarly article by Petra Heffeter et al published 1 August 2015 in Cancer Research

Abstract 5461: Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance

Active vitamin D potentiates the anti-neoplastic effects of calcium in the colon: A cross talk through the calcium-sensing receptor

artículo científico publicado en 2015

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation

artículo científico publicado en 2012

An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin.

artículo científico publicado en 2017

Anticancer Activity of Metal Complexes: Involvement of Redox Processes ⬇️

artículo científico publicado el 11 de mayo de 2011

Anticancer activity of methyl-substituted oxaliplatin analogs

artículo científico publicado en 2012

Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24).

artículo científico publicado en 2005

Anticancer effects of zoledronic acid against human osteosarcoma cells.

artículo científico publicado en 2006

Application of C60 Fullerene-Doxorubicin Complex for Tumor Cell Treatment In Vitro and In Vivo.

artículo científico publicado en 2015

Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation

artículo científico publicado en 2016

Bioimaging of isosteric osmium and ruthenium anticancer agents by LA-ICP-MS.

artículo científico publicado en 2018

Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46.

artículo científico publicado en 2014

ChemInform Abstract: NKP-1339, the First Ruthenium-Based Anticancer Drug on the Edge to Clinical Application

Chronic arsenic trioxide exposure leads to enhanced aggressiveness via Met oncogene addiction in cancer cells

artículo científico publicado en 2016

Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application.

artículo científico publicado en 2014

Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation

artículo científico publicado en 2020

Destruxins: fungal-derived cyclohexadepsipeptides with multifaceted anticancer and antiangiogenic activities

artículo científico publicado en 2013

Development of an experimental protocol for uptake studies of metal compounds in adherent tumor cells

artículo científico publicado en 2009

Differences in protein binding and excretion of Triapine and its Fe(III) complex

artículo científico publicado en 2015

EGCG-meditated cyto- and genotoxicity in HaCat keratinocytes is impaired by cell-mediated clearance of auto-oxidation-derived H2O2: an algorithm for experimental setting correction

artículo científico publicado en 2011

EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells

artículo científico publicado en 2013

EVI1 promotes tumor growth via transcriptional repression of MS4A3.

artículo científico

Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells.

artículo científico publicado en 2015

Enhanced anticancer activity and circumvention of resistance mechanisms by novel polymeric/ phospholipidic nanocarriers of doxorubicin

artículo científico publicado en 2014

Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells.

artículo científico publicado en 2007

Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy.

artículo científico publicado en 2014

Fibroblast growth factor receptors as therapeutic targets in human melanoma: synergism with BRAF inhibition

artículo científico publicado en 2011

Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells.

artículo científico publicado en 2004

Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention

artículo científico publicado en 2016

Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation.

artículo científico publicado en 2009

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones

artículo científico publicado en 2012

In vitro studies on cisplatin focusing on kinetic aspects of intracellular chemistry by LC-ICP-MS.

artículo científico publicado en 2013

Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019.

artículo científico publicado en 2011

Interactions between ABC-transport proteins and the secondary Fusarium metabolites enniatin and beauvericin

artículo científico publicado en 2009

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339.

artículo científico publicado en 2010

Intrinsic and Acquired Forms of Resistance against the Anticancer Ruthenium Compound KP1019 [Indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A)

scientific article published on 26 August 2004

Long-term exposure of immortalized keratinocytes to arsenic induces EMT, impairs differentiation in organotypic skin models and mimics aspects of human skin derangements.

artículo científico publicado en 2017

Macromolecular Pt(IV) Prodrugs from Poly(organo)phosphazenes.

artículo científico publicado en 2016

Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.

artículo científico publicado en 2013

Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

artículo científico publicado en 2011

Mechanisms underlying the anticancer activities of the angucycline landomycin E.

artículo científico publicado en 2007

Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation

artículo científico publicado en 2013

Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy

artículo científico publicado en 2007

Mouse tissue distribution and persistence of the food-born fusariotoxins Enniatin B and Beauvericin

artículo científico publicado en 2016

Multi-scale imaging of anticancer platinum(iv) compounds in murine tumor and kidney

scientific article published on 03 February 2016

Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).

artículo científico publicado en 2007

NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer.

artículo científico publicado en 2012

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

article by Robert Trondl et al published 4 April 2014 in Chemical Science

Nanoformulation improves activity of the (pre)clinical anticancer ruthenium complex KP1019.

artículo científico publicado en 2014

Nanoformulations of anticancer thiosemicarbazones to reduce methemoglobin formation and improve anticancer activity

scholarly article in RSC Advances, vol. 6 no. 61, 2016

Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity.

artículo científico publicado en 2013

Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy

artículo científico publicado en 2010

Osmium(IV) complexes with 1H- and 2H-indazoles: tautomer identity versus spectroscopic properties and antiproliferative activity

artículo científico publicado en 2012

Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction

artículo científico publicado en 2009

Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation

artículo científico publicado en 2013

Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A

artículo científico publicado en 2019

Post-digestion stabilization of osmium enables quantification by ICP-MS in cell culture and tissue

artículo científico publicado en 2017

Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice.

artículo científico publicado en 2014

Quantitative determination of intact free cisplatin in cell models by LC-ICP-MS

Resistance against novel anticancer metal compounds: differences and similarities

artículo científico publicado en 2008

Ribonucleotide reductase as one important target of [Tris(1,10-phenanthroline)lanthanum(III)] trithiocyanate (KP772).

artículo científico publicado en 2009

Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways.

artículo científico publicado en 2014

Specific antioxidant compounds differentially modulate cytotoxic activity of doxorubicin and cisplatin: in vitro and in vivo study

artículo científico publicado en 2014

Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents

artículo científico publicado en 2011

Structure-Related Mode-of-Action Differences of Anticancer Organoruthenium Complexes with β-Diketonates

artículo científico publicado en 2015

Synergistic anticancer activity of arsenic trioxide with erlotinib is based on inhibition of EGFR-mediated DNA double-strand break repair

artículo científico publicado en 2013

Synthesis and Preclinical Evaluation of Radiolabeled [103Ru]BOLD-100

artículo científico publicado en 2023

The First Anticancer Tris(pyrazolyl)borate Molybdenum(IV) Complexes: Tested in Vitro and in Vivo-A Comparison of O,O-, S,O-, and N,N-Chelate Effects

artículo científico publicado en 2019

The Na+/K+-ATPase is the Achilles heel of multi-drug-resistant cancer cells

artículo científico publicado en 2009

The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines

artículo científico publicado en 2009

The naturally born fusariotoxin enniatin B and sorafenib exert synergistic activity against cervical cancer in vitro and in vivo.

artículo científico publicado en 2014

The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo

artículo científico publicado en 2013

The study of reduced versus oxidized glutathione in cancer cell models employing isotopically labelled standards

Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance

artículo científico publicado en 2022

Trabectedin Is Active against Malignant Pleural Mesothelioma Cell and Xenograft Models and Synergizes with Chemotherapy and Bcl-2 Inhibition In Vitro

artículo científico publicado en 2016

Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells.

artículo científico publicado en 2013

Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance.

artículo científico publicado en 2015

Trivanillic polyphenols with anticancer cytostatic effects through the targeting of multiple kinases and intracellular Ca2+ release

artículo científico publicado en 2012

Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(IV)-based anticancer agents.

artículo científico publicado en 2015

Tumor-targeting of EGFR inhibitors by hypoxia-mediated activation

artículo científico publicado en 2014

Tumorspezifische, Hypoxie-basierte Aktivierung von EGFR-Inhibitoren

Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity

artículo científico publicado en 2012

Water-Soluble, Biocompatible Polyphosphazenes with Controllable and pH-Promoted Degradation Behavior

artículo científico publicado en 2014

X-ray absorption near edge structure spectroscopy to resolve the in vivo chemistry of the redox-active indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019).

artículo científico publicado en 2013

Lista de obras de Petra Heffeter

A Dogma in Doubt: Hydrolysis of Equatorial Ligands of PtIV Complexes under Physiological Conditions

A novel class of bis- and tris-chelate diam(m)inebis(dicarboxylato)platinum(IV) complexes as potential anticancer prodrugs.

Abstract 1671: Fibroblast growth factor receptor 3 enhances progression of hepatocellular carcinoma

Abstract 2573: Investigation of factors involved in the hypersensitivity to KP1339-treatment

Abstract 2637: Terminal dimethyl substitution of Triapine leads to activation of CHOP and induction of apoptosis via ER stress in human colon cancer cells

Abstract 3541: Combination of the ruthenium compound KP1339 with the tyrosine kinase inhibitor sorafenib: A promising approach for the treatment of human hepatoma

Abstract 4397: Preclinical development of a novel hypoxia-activated EGFR inhibitor using a cobalt(III)-based prodrug design

Abstract 5461: Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance

Active vitamin D potentiates the anti-neoplastic effects of calcium in the colon: A cross talk through the calcium-sensing receptor

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation

An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin.

Anticancer Activity of Metal Complexes: Involvement of Redox Processes ⬇️

Anticancer activity of methyl-substituted oxaliplatin analogs

Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24).

Anticancer effects of zoledronic acid against human osteosarcoma cells.

Application of C60 Fullerene-Doxorubicin Complex for Tumor Cell Treatment In Vitro and In Vivo.

Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation

Bioimaging of isosteric osmium and ruthenium anticancer agents by LA-ICP-MS.

Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46.

ChemInform Abstract: NKP-1339, the First Ruthenium-Based Anticancer Drug on the Edge to Clinical Application

Chronic arsenic trioxide exposure leads to enhanced aggressiveness via Met oncogene addiction in cancer cells

Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application.

Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation

Destruxins: fungal-derived cyclohexadepsipeptides with multifaceted anticancer and antiangiogenic activities

Development of an experimental protocol for uptake studies of metal compounds in adherent tumor cells

Differences in protein binding and excretion of Triapine and its Fe(III) complex

EGCG-meditated cyto- and genotoxicity in HaCat keratinocytes is impaired by cell-mediated clearance of auto-oxidation-derived H2O2: an algorithm for experimental setting correction

EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells

EVI1 promotes tumor growth via transcriptional repression of MS4A3.

Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells.

Enhanced anticancer activity and circumvention of resistance mechanisms by novel polymeric/ phospholipidic nanocarriers of doxorubicin

Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells.

Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy.

Fibroblast growth factor receptors as therapeutic targets in human melanoma: synergism with BRAF inhibition

Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells.

Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention

Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation.

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones

In vitro studies on cisplatin focusing on kinetic aspects of intracellular chemistry by LC-ICP-MS.

Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019.

Interactions between ABC-transport proteins and the secondary Fusarium metabolites enniatin and beauvericin

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339.

Intrinsic and Acquired Forms of Resistance against the Anticancer Ruthenium Compound KP1019 [Indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A)

Long-term exposure of immortalized keratinocytes to arsenic induces EMT, impairs differentiation in organotypic skin models and mimics aspects of human skin derangements.

Macromolecular Pt(IV) Prodrugs from Poly(organo)phosphazenes.

Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.

Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

Mechanisms underlying the anticancer activities of the angucycline landomycin E.

Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation

Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy

Mouse tissue distribution and persistence of the food-born fusariotoxins Enniatin B and Beauvericin

Multi-scale imaging of anticancer platinum(iv) compounds in murine tumor and kidney

Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).

NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer.

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

Nanoformulation improves activity of the (pre)clinical anticancer ruthenium complex KP1019.

Nanoformulations of anticancer thiosemicarbazones to reduce methemoglobin formation and improve anticancer activity

Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity.

Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy

Osmium(IV) complexes with 1H- and 2H-indazoles: tautomer identity versus spectroscopic properties and antiproliferative activity

Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction

Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation

Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A

Post-digestion stabilization of osmium enables quantification by ICP-MS in cell culture and tissue

Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice.

Quantitative determination of intact free cisplatin in cell models by LC-ICP-MS

Resistance against novel anticancer metal compounds: differences and similarities

Ribonucleotide reductase as one important target of [Tris(1,10-phenanthroline)lanthanum(III)] trithiocyanate (KP772).

Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways.

Specific antioxidant compounds differentially modulate cytotoxic activity of doxorubicin and cisplatin: in vitro and in vivo study

Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents

Structure-Related Mode-of-Action Differences of Anticancer Organoruthenium Complexes with β-Diketonates

Synergistic anticancer activity of arsenic trioxide with erlotinib is based on inhibition of EGFR-mediated DNA double-strand break repair

Synthesis and Preclinical Evaluation of Radiolabeled [103Ru]BOLD-100

The First Anticancer Tris(pyrazolyl)borate Molybdenum(IV) Complexes: Tested in Vitro and in Vivo-A Comparison of O,O-, S,O-, and N,N-Chelate Effects

The Na+/K+-ATPase is the Achilles heel of multi-drug-resistant cancer cells

The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines

The naturally born fusariotoxin enniatin B and sorafenib exert synergistic activity against cervical cancer in vitro and in vivo.

The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo