Lista de obras - Christian R Kowol - Dominio Público Uruguay

A Dogma in Doubt: Hydrolysis of Equatorial Ligands of PtIV Complexes under Physiological Conditions

artículo científico publicado en 2019

A quantitative structure-activity approach for lipophilicity estimation of antitumor complexes of different metals using microemulsion electrokinetic chromatography

artículo científico publicado en 2011

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo.

artículo científico publicado en 2016

An electrochemical study of antineoplastic gallium, iron and ruthenium complexes with redox noninnocent alpha-N-heterocyclic chalcogensemicarbazones

artículo científico publicado en 2008

Another step toward DNA selective targeting: Ni(II) and Cu(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes

artículo científico publicado en 2016

Anticancer Activity of Metal Complexes: Involvement of Redox Processes ⬇️

artículo científico publicado el 11 de mayo de 2011

Anticancer thiosemicarbazones: chemical properties, interaction with iron metabolism, and resistance development.

artículo científico publicado en 2018

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis

artículo científico publicado en 2018

Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46.

artículo científico publicado en 2014

Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux

artículo científico publicado en 2020

Comparative studies on the human serum albumin binding of the clinically approved EGFR inhibitors gefitinib, erlotinib, afatinib, osimertinib and the investigational inhibitor KP2187.

artículo científico publicado en 2018

Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones.

artículo científico publicado en 2018

Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation

artículo científico publicado en 2020

Critical assessment of different methods for quantitative measurement of metallodrug-protein associations

scientific article published on 29 August 2018

Differences in protein binding and excretion of Triapine and its Fe(III) complex

artículo científico publicado en 2015

EGFR-targeting peptide-coupled platinum(IV) complexes.

artículo científico publicado en 2017

Effect of metal ion complexation and chalcogen donor identity on the antiproliferative activity of 2-acetylpyridine N,N-dimethyl(chalcogen)semicarbazones.

artículo científico publicado en 2007

Enhanced anticancer activity and circumvention of resistance mechanisms by novel polymeric/ phospholipidic nanocarriers of doxorubicin

artículo científico publicado en 2014

Front Cover: Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity (Chem. Biodiversity 10/2022)

artículo científico publicado en 2022

Gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones: synthesis, characterization, cytotoxicity, and interaction with ribonucleotide reductase.

artículo científico publicado en 2007

Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention

artículo científico publicado en 2016

Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation.

artículo científico publicado en 2009

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones

artículo científico publicado en 2012

Improving the Stability of EGFR Inhibitor Cobalt(III) Prodrugs

artículo científico publicado en 2020

Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study.

artículo científico publicado en 2011

Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer.

artículo científico publicado en 2017

Investigation of amino acid containing [FeFe] hydrogenase models concerning pendant base effects

artículo científico publicado en 2009

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.

artículo científico publicado en 2016

Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074

Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.

artículo científico publicado en 2013

Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

artículo científico publicado en 2011

Metal Drugs and the Anticancer Immune Response

artículo científico publicado en 2018

Multi-scale imaging of anticancer platinum(iv) compounds in murine tumor and kidney

scientific article published on 03 February 2016

Multifunctional αvβ6 Integrin-Specific Peptide-Pt(IV) Conjugates for Cancer Cell Targeting

artículo científico publicado en 2017

Nanoformulation improves activity of the (pre)clinical anticancer ruthenium complex KP1019.

artículo científico publicado en 2014

Nanoformulations of anticancer FGFR inhibitors with improved therapeutic index

scientific article published on 16 August 2018

Novel tetracarboxylatoplatinum(IV) complexes as carboplatin prodrugs.

artículo científico publicado en 2012

Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation

artículo científico publicado en 2013

Preclinical characterization of anticancer gallium(III) complexes: solubility, stability, lipophilicity and binding to serum proteins

scientific article published on 25 July 2006

Reactive Oxygen Species (ROS)-Sensitive Prodrugs of the Tyrosine Kinase Inhibitor Crizotinib

scientific article published on 04 March 2020

Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study

artículo científico publicado en 2011

Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS).

artículo científico publicado en 2018

Synergistic anticancer activity of arsenic trioxide with erlotinib is based on inhibition of EGFR-mediated DNA double-strand break repair

artículo científico publicado en 2013

Synthesis and Cytotoxicity of Water-Soluble Dual- and Triple-Action Satraplatin Derivatives: Replacement of Equatorial Chlorides of Satraplatin by Acetates

artículo científico publicado en 2019

Synthesis and reactivity of the aquation product of the antitumor complex trans-[Ru(III)Cl4(indazole)2]-.

artículo científico publicado en 2008

Synthesis, Characterization and in vitro Studies of a Cathepsin B-Cleavable Prodrug of the VEGFR Inhibitor Sunitinib

artículo científico publicado en 2018

Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs.

artículo científico publicado en 2016

The first metal-based paullone derivative with high antiproliferative activity in vitro.

artículo científico publicado en 2006

Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance

artículo científico publicado en 2022

Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells.

artículo científico publicado en 2013

Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance.

artículo científico publicado en 2015

Tumor-targeting of EGFR inhibitors by hypoxia-mediated activation

artículo científico publicado en 2014

Tuning of lipophilicity and cytotoxic potency by structural variation of anticancer platinum(IV) complexes

artículo científico publicado en 2010

Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMS.

artículo científico publicado en 2017

Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity

artículo científico publicado en 2012

Vanadium(IV/V) complexes of Triapine and related thiosemicarbazones: Synthesis, solution equilibrium and bioactivity

artículo científico publicado en 2015

Lista de obras de Christian R Kowol

A Dogma in Doubt: Hydrolysis of Equatorial Ligands of PtIV Complexes under Physiological Conditions

A quantitative structure-activity approach for lipophilicity estimation of antitumor complexes of different metals using microemulsion electrokinetic chromatography

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo.

An electrochemical study of antineoplastic gallium, iron and ruthenium complexes with redox noninnocent alpha-N-heterocyclic chalcogensemicarbazones

Another step toward DNA selective targeting: Ni(II) and Cu(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes

Anticancer Activity of Metal Complexes: Involvement of Redox Processes ⬇️

Anticancer thiosemicarbazones: chemical properties, interaction with iron metabolism, and resistance development.

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis

Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46.

Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux

Comparative studies on the human serum albumin binding of the clinically approved EGFR inhibitors gefitinib, erlotinib, afatinib, osimertinib and the investigational inhibitor KP2187.

Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones.

Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation

Critical assessment of different methods for quantitative measurement of metallodrug-protein associations

Differences in protein binding and excretion of Triapine and its Fe(III) complex

EGFR-targeting peptide-coupled platinum(IV) complexes.

Effect of metal ion complexation and chalcogen donor identity on the antiproliferative activity of 2-acetylpyridine N,N-dimethyl(chalcogen)semicarbazones.

Enhanced anticancer activity and circumvention of resistance mechanisms by novel polymeric/ phospholipidic nanocarriers of doxorubicin

Front Cover: Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity (Chem. Biodiversity 10/2022)

Gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones: synthesis, characterization, cytotoxicity, and interaction with ribonucleotide reductase.

Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention

Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation.

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones

Improving the Stability of EGFR Inhibitor Cobalt(III) Prodrugs

Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study.

Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer.

Investigation of amino acid containing [FeFe] hydrogenase models concerning pendant base effects

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.

Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074

Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery.

Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

Metal Drugs and the Anticancer Immune Response

Multi-scale imaging of anticancer platinum(iv) compounds in murine tumor and kidney

Multifunctional αvβ6 Integrin-Specific Peptide-Pt(IV) Conjugates for Cancer Cell Targeting

Nanoformulation improves activity of the (pre)clinical anticancer ruthenium complex KP1019.

Nanoformulations of anticancer FGFR inhibitors with improved therapeutic index

Novel tetracarboxylatoplatinum(IV) complexes as carboplatin prodrugs.

Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation

Preclinical characterization of anticancer gallium(III) complexes: solubility, stability, lipophilicity and binding to serum proteins

Reactive Oxygen Species (ROS)-Sensitive Prodrugs of the Tyrosine Kinase Inhibitor Crizotinib

Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study

Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS).

Synergistic anticancer activity of arsenic trioxide with erlotinib is based on inhibition of EGFR-mediated DNA double-strand break repair

Synthesis and Cytotoxicity of Water-Soluble Dual- and Triple-Action Satraplatin Derivatives: Replacement of Equatorial Chlorides of Satraplatin by Acetates

Synthesis and reactivity of the aquation product of the antitumor complex trans-[Ru(III)Cl4(indazole)2]-.

Synthesis, Characterization and in vitro Studies of a Cathepsin B-Cleavable Prodrug of the VEGFR Inhibitor Sunitinib

Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs.

The first metal-based paullone derivative with high antiproliferative activity in vitro.

Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance

Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells.

Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance.

Tumor-targeting of EGFR inhibitors by hypoxia-mediated activation

Tuning of lipophilicity and cytotoxic potency by structural variation of anticancer platinum(IV) complexes

Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMS.

Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity

Vanadium(IV/V) complexes of Triapine and related thiosemicarbazones: Synthesis, solution equilibrium and bioactivity