Lista de obras - Martin C Taylor - Dominio Público Uruguay

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

artículo científico publicado en 2008

A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging

artículo científico publicado en 2015

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies

scientific article published on 12 March 2020

Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease

scholarly article by Amanda Fortes Francisco et al published October 2018 in Antimicrobial Agents and Chemotherapy

Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population

artículo científico publicado en 2012

Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert

artículo científico publicado en 2014

Biological factors that impinge on Chagas disease drug development

artículo científico publicado en 2017

Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei

artículo científico publicado en 2011

Challenges in Chagas Disease Drug Development

scientific article published on 17 June 2020

Control of VSG gene expression sites in Trypanosoma brucei ⬇️

artículo científico publicado el 1 de marzo de 1998

Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue.

artículo científico publicado en 2013

Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.

artículo científico publicado en 2018

Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions

artículo científico publicado en 2019

Frequent loss of the active site during variant surface glycoprotein expression site switching in vitro in Trypanosoma brucei.

artículo científico publicado en 1998

Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.

artículo científico publicado en 2005

Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature

artículo científico publicado en 2005

Genetic techniques in Trypanosoma cruzi.

artículo científico publicado en 2011

Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole

artículo científico publicado en 2017

Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase

artículo científico publicado en 2013

Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy

artículo científico publicado en 2016

Huprines as a new family of dual acting trypanocidal-antiplasmodial agents

artículo científico publicado en 2011

Imaging the development of chronic Chagas disease after oral transmission

artículo científico publicado en 2018

In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis

artículo científico publicado en 2013

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.

artículo científico publicado en 2012

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection

scientific article published on 20 March 2020

Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor

artículo científico publicado en 2022

Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging

artículo científico publicado en 2015

Lipophilic Guanylhydrazone Analogues As Promising Trypanocidal Agents: An Extended SAR Study

scientific article published on 10 February 2020

Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: an extended SAR study

artículo científico publicado en 2017

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale

artículo científico publicado en 2021

Mechanism of genetic exchange in American trypanosomes

artículo científico publicado en 2003

Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression

artículo científico publicado en 2007

Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity

artículo científico publicado en 2015

Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity

artículo científico publicado en 2011

Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity

artículo científico publicado en 2019

Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation

artículo científico publicado en 2018

Pathogen imaging applications

artículo científico publicado en 2017

Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs".

artículo científico publicado en 2015

Synthesis and Evaluation of Nifurtimox-Adamantane Adducts with Trypanocidal Activity

scientific article published on 27 May 2019

Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.

artículo científico publicado en 2016

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.

artículo científico publicado en 2011

Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA

scholarly article by Andrea Bistrović et al published December 2018 in Journal of Enzyme Inhibition and Medicinal Chemistry

TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum

artículo científico publicado en 2002

Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.

artículo científico publicado en 2018

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.

artículo científico publicado en 2002

The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements

artículo científico publicado en 2006

The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence

scientific article (publication date: April 2015)

The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase

artículo científico publicado en 2007

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

artículo científico publicado en 2014

Trypanocidal activity of aziridinyl nitrobenzamide prodrugs

artículo científico publicado en 2010

Validation of spermidine synthase as a drug target in African trypanosomes.

artículo científico publicado en 2008

Vitamin C biosynthesis in trypanosomes: a role for the glycosome

artículo científico publicado en 2005

pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi

artículo científico publicado en 2006

β- d -Glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres ⬇️

artículo científico publicado el 3 de marzo de 1998

Lista de obras de Martin C Taylor

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging

A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies

Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease

Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population

Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert

Biological factors that impinge on Chagas disease drug development

Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei

Challenges in Chagas Disease Drug Development

Control of VSG gene expression sites in Trypanosoma brucei ⬇️

Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue.

Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.

Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions

Frequent loss of the active site during variant surface glycoprotein expression site switching in vitro in Trypanosoma brucei.

Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.

Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature

Genetic techniques in Trypanosoma cruzi.

Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole

Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase

Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy

Huprines as a new family of dual acting trypanocidal-antiplasmodial agents

Imaging the development of chronic Chagas disease after oral transmission

In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection

Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor

Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging

Lipophilic Guanylhydrazone Analogues As Promising Trypanocidal Agents: An Extended SAR Study

Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: an extended SAR study

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale

Mechanism of genetic exchange in American trypanosomes

Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression

Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity

Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity

Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity

Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation

Pathogen imaging applications

Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs".

Synthesis and Evaluation of Nifurtimox-Adamantane Adducts with Trypanocidal Activity

Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.

Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA

TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum

Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.

The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements

The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence

The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

Trypanocidal activity of aziridinyl nitrobenzamide prodrugs

Validation of spermidine synthase as a drug target in African trypanosomes.

Vitamin C biosynthesis in trypanosomes: a role for the glycosome

pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi

β- d -Glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres ⬇️