Lista de obras - Timothy E. Hardingham - Dominio Público Uruguay

Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage

artículo científico publicado en 1996

Alternative splicing in the aggrecan G3 domain influences binding interactions with tenascin-C and other extracellular matrix proteins

artículo científico publicado en 2004

Arterial mesenchyme and arteriosclerosis. Some aspects of the organization and interaction of connective tissue proteoglycans

artículo científico publicado en 1974

Articular cartilage cultured with interleukin 1. Increased release of link protein, hyaluronate-binding region and other proteoglycan fragments

artículo científico publicado en 1986

Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin

artículo científico publicado en 2014

Binding of oligosaccharides of hyaluronic acid to proteoglycans

artículo científico publicado en 1973

Biosynthesis of proteoglycans in cartilage.

artículo científico publicado en 1975

Bone marrow-derived mesenchymal stem cells express the pericyte marker 3G5 in culture and show enhanced chondrogenesis in hypoxic conditions

article

Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus

artículo científico publicado en 2003

Cartilage proteoglycan depletion in acute and chronic antigen-induced arthritis

artículo científico publicado en 1989

Cartilage proteoglycans. Structure and heterogeneity of the protein core and the effects of specific protein modifications on the binding to hyaluronate ⬇️

artículo científico publicado el 1 de julio de 1976

Cartilage proteoglycans: structure, interactions and organization

artículo científico publicado en 1977

Cartilage repair using human embryonic stem cell-derived chondroprogenitors

artículo científico publicado en 2014

Cartilage tissue engineering approaches applicable in orthopaedic surgery: the past, the present, and the future

artículo científico publicado en 2012

Cartilage, SOX9 and Notch signals in chondrogenesis

artículo científico publicado en 2006

Cell- and Tissue-Based Approaches for Cartilage Repair ⬇️

artículo científico publicado el 1 de diciembre de 2010

Cellular methods in cartilage research: primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells

artículo científico publicado en 2008

Changes in chondroitin sulphate structure induced by joint disease

Changes in chondroitin sulphate structure induced by joint disease.

artículo científico publicado en 1995

Changes in glycosaminoglycan epitope levels in knee joint fluid following injury

artículo científico publicado en 1995

Changes in proteoglycan turnover in experimental canine osteoarthritic cartilage

artículo científico publicado en 1992

Chondrocyte phenotype and cell survival are regulated by culture conditions and by specific cytokines through the expression of Sox-9 transcription factor.

artículo científico publicado en 2001

Chondrocyte responses in cartilage and in experimental osteoarthritis

artículo científico publicado en 1991

Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly.

artículo científico publicado en 2016

Chondrogenic differentiation of human bone marrow stem cells in transwell cultures: generation of scaffold-free cartilage

artículo científico publicado en 2007

Chondroitin sulfate and joint disease ⬇️

artículo científico publicado el 1 de mayo de 1998

Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva

artículo científico publicado en 2002

Confocal-FRAP analysis of ECM molecular interactions.

artículo científico publicado en 2000

Dermatan sulphate proteoglycan from human articular cartilage. Variation in its content with age and its structural comparison with a small chondroitin sulphate proteoglycan from pig laryngeal cartilage

artículo científico publicado en 1988

Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes.

artículo científico publicado en 2006

Directed differentiation of human embryonic stem cells toward chondrocytes

artículo científico publicado en 2010

Effect of Alpinia galanga extract on cartilage degradation and on gene expression in human chondrocyte and synovial fibroblast metabolism

article

Electric birefringence studies of cartilage proteoglycan aggregation

artículo científico publicado en 1977

Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis

artículo científico publicado en 1993

Equilibrium-binding studies of pig laryngeal cartilage proteoglycans with hyaluronate oligosaccharide fractions

artículo científico publicado en 1980

Extending the Paradigm of Osteoarthritis: Comment on the Editorial by McAlindon

artículo científico publicado en 2016

Extracellular matrix and pathogenic mechanisms in osteoarthritis

artículo científico publicado en 2008

Fat pad-derived mesenchymal stem cells as a potential source for cell-based adipose tissue repair strategies.

artículo científico publicado en 2012

Fell-Muir lecture: cartilage 2010 - the known unknowns

artículo científico publicado en 2010

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

artículo científico publicado en 1993

Gene expression changes in damaged osteoarthritic cartilage identify a signature of non-chondrogenic and mechanical responses

scientific article published on 10 March 2016

Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy.

artículo científico publicado en 2010

Generating cartilage repair from pluripotent stem cells

artículo científico publicado en 2013

Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants.

artículo científico publicado en 2000

Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2.

artículo científico publicado en 2008

Human link protein gene: structure and transcription pattern in chondrocytes

artículo científico publicado en 1994

Human meniscus cells express hypoxia inducible factor-1alpha and increased SOX9 in response to low oxygen tension in cell aggregate culture

artículo científico publicado en 2007

Hyaluronan binding to link module of TSG-6 and to G1 domain of aggrecan is differently regulated by pH.

artículo científico publicado en 2008

Hyaluronic acid in cartilage and proteoglycan aggregation

artículo científico publicado en 1974

Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes

artículo científico publicado en 2009

Hypoxic conditions increase hypoxia-inducible transcription factor 2alpha and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients

artículo científico publicado en 2007

Immunoglobulin fold and tandem repeat structures in proteoglycan N-terminal domains and link protein

artículo científico publicado en 1989

Increased proteoglycan synthesis in cartilage in experimental canine osteoarthritis does not reflect a permanent change in chondrocyte phenotype

scientific article published on 01 April 1995

Increased release of matrix components from articular cartilage in experimental canine osteoarthritis

artículo científico publicado en 1992

Inhibition of interleukin-1-induced synovitis and articular cartilage proteoglycan loss in the rabbit knee by recombinant human interleukin-1 receptor antagonist.

artículo científico publicado en 1991

Isabella Helen Mary Muir CBE. 20 August 1920—28 November 2005

Biographical article

Isolation and sequence of cDNA clones for pig and human cartilage link protein

Macromolecular diffusion of biological polymers measured by confocal fluorescence recovery after photobleaching

artículo científico publicado en 1998

Mesenchymal stem cells, sources of cells and differentiation potential

artículo científico

Modulation of native chondroitin sulphate structure in tissue development and in disease

artículo científico publicado en 1990

Molecular conformations in proteoglycan aggregation

artículo científico publicado en 1983

Neutron and X-ray solution-scattering studies of the ternary complex between proteoglycan-binding region, link protein and hyaluronan ⬇️

artículo científico publicado el 1 de julio de 1992

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

artículo científico publicado en 1994

New approaches to the investigation of hyaluronan networks

artículo científico publicado en 1999

Notch signaling during chondrogenesis of human bone marrow stem cells

artículo científico publicado en 2009

Notch signaling through Jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis

artículo científico publicado en 2008

Novel confocal-FRAP analysis of carbohydrate-protein interactions within the extracellular matrix

artículo científico publicado en 2001

Order within disorder: aggrecan chondroitin sulphate-attachment region provides new structural insights into protein sequences classified as disordered

artículo científico publicado en 2010

PhenomeExpress: a refined network analysis of expression datasets by inclusion of known disease phenotypes

artículo científico publicado en 2015

PhenomeScape: a cytoscape app to identify differentially regulated sub-networks using known disease associations.

artículo científico publicado en 2016

Physical properties of the hyaluronate binding region of proteoglycan from pig laryngeal cartilage

artículo científico publicado en 1981

Proteoglycan biosynthesis in chondrocytes: protein A-gold localization of proteoglycan protein core and chondroitin sulfate within Golgi subcompartments.

artículo científico publicado en 1985

Proteoglycans of cartilage: An assessment of their structure

artículo científico publicado en 1971

Proteoglycans: many forms and many functions

artículo científico publicado en 1992

Raised chondroitin sulfate epitopes and hyaluronan in serum from rheumatoid arthritis and osteoarthritis patients

artículo científico publicado en 2005

Raised serum chondroitin sulfate epitope level in ovarian epithelial cancer

artículo científico publicado en 2006

Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization

artículo científico publicado en 2006

Replacement of proteoglycans in embryonic chick cartilage in organ culture after treatment with testicular hyaluronidase

artículo científico publicado en 1972

Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes

artículo científico publicado en 2005

SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription

artículo científico publicado en 2008

SOX9 transduction of a human chondrocytic cell line identifies novel genes regulated in primary human chondrocytes and in osteoarthritis

artículo científico publicado en 2007

Separate effects of exogenous hyaluronic acid on proteoglycan synthesis and deposition in pericellular matrix by cultured chick embryo limb chondrocytes

artículo científico publicado en 1980

Solution structure and dynamics of cartilage aggrecan

artículo científico publicado en 2006

Stem cell applications and tissue engineering approaches in surgical practice

artículo científico publicado en 2009

Stratification of knee osteoarthritis: two major patient subgroups identified by genome-wide expression analysis of articular cartilage.

artículo científico publicado en 2017

Structural and immunological studies of keratan sulphates from mature bovine articular cartilage

artículo científico publicado en 1989

Structure and stability of proteoglycan aggregates.

artículo científico publicado en 1975

Studies on the G3 Domain of Aggrecan from Human Cartilagea

artículo científico publicado en 1996

The Folded Protein Modules of the C-terminal G3 Domain of Aggrecan Can Each Facilitate the Translocation and Secretion of the Extended Chondroitin Sulfate Attachment Sequence

artículo científico publicado en 1999

The characterisation of mesenchymal stem cells: a stem cell is not a stem cell is not a stem cell

artículo científico

The detection of substructures within proteoglycan molecules. Electron-microscopic immuno-localization with the use of Protein A-gold

artículo científico publicado en 1987

The development of a mature collagen network in cartilage from human bone marrow stem cells in Transwell culture.

artículo científico publicado en 2015

The effect of temperature on the biosynthesis of chondroitin 4-sulphate in cartilage slices in vitro

artículo científico publicado en 1970

The epitope characterisation and the osteogenic differentiation potential of human fat pad-derived stem cells is maintained with ageing in later life

artículo científico publicado en 2008

The formation of proteoglycan aggregates in vitro

The influence of donor and hypoxic conditions on the assembly of cartilage matrix by osteoarthritic human articular chondrocytes on Hyalograft matrices

artículo científico publicado en 2008

The influence of link protein stabilization on the viscometric properties of proteoglycan aggregate solutions

artículo científico publicado en 1989

The intracellular localisation of proteoglycans and their accumulation in chondrocytes treated with monensin

artículo científico publicado en 1985

The matrix-forming phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia

artículo científico publicado en 2006

The molecular basis of the solution properties of hyaluronan investigated by confocal fluorescence recovery after photobleaching

artículo científico publicado en 1999

The potential of stem cells in the treatment of knee cartilage defects

artículo científico publicado en 2010

The primary structure of human cartilage link protein

artículo científico publicado en 1990

The primary structure of human cartilage link protein

scientific article (published 1990-03-11)

The recovery of articular cartilage in explant culture from interleukin-1α: Effects on proteoglycan synthesis and degradation

article

The structure of aggrecan and its turnover in cartilage

artículo científico publicado en 1995

The sulphation pattern in chondroitin sulphate chains investigated by chondroitinase ABC and ACII digestion and reactivity with monoclonal antibodies

artículo científico publicado en 1994

The viscoelasticity of self-assembled proteoglycan combs.

artículo científico publicado en 2008

Tissue engineering: chondrocytes and cartilage

artículo científico publicado en 2002

Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9.

artículo científico publicado en 2004

Tumour necrosis factor alpha stimulates nitric oxide production more potently than interleukin-1beta in porcine articular chondrocytes.

artículo científico publicado en 2002

Two related but distinct chondroitin sulfate mimetope octasaccharide sequences recognized by monoclonal antibody WF6.

artículo científico publicado en 2007

View from a small island

artículo científico publicado en 2003

Viscoelastic properties of proteoglycan solutions with varying proportions present as aggregates

artículo científico publicado en 1987

X-ray fibre diffraction of cartilage proteoglycan aggregates containing hyaluronic acid

artículo científico publicado en 1974

[Repair of the articular cartilage after exposure to interleukin-1]

artículo científico publicado en 1996

Lista de obras de Timothy E. Hardingham

Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage

Alternative splicing in the aggrecan G3 domain influences binding interactions with tenascin-C and other extracellular matrix proteins

Arterial mesenchyme and arteriosclerosis. Some aspects of the organization and interaction of connective tissue proteoglycans

Articular cartilage cultured with interleukin 1. Increased release of link protein, hyaluronate-binding region and other proteoglycan fragments

Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin

Binding of oligosaccharides of hyaluronic acid to proteoglycans

Biosynthesis of proteoglycans in cartilage.

Bone marrow-derived mesenchymal stem cells express the pericyte marker 3G5 in culture and show enhanced chondrogenesis in hypoxic conditions

Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus

Cartilage proteoglycan depletion in acute and chronic antigen-induced arthritis

Cartilage proteoglycans. Structure and heterogeneity of the protein core and the effects of specific protein modifications on the binding to hyaluronate ⬇️

Cartilage proteoglycans: structure, interactions and organization

Cartilage repair using human embryonic stem cell-derived chondroprogenitors

Cartilage tissue engineering approaches applicable in orthopaedic surgery: the past, the present, and the future

Cartilage, SOX9 and Notch signals in chondrogenesis

Cell- and Tissue-Based Approaches for Cartilage Repair ⬇️

Cellular methods in cartilage research: primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells

Changes in chondroitin sulphate structure induced by joint disease

Changes in chondroitin sulphate structure induced by joint disease.

Changes in glycosaminoglycan epitope levels in knee joint fluid following injury

Changes in proteoglycan turnover in experimental canine osteoarthritic cartilage

Chondrocyte phenotype and cell survival are regulated by culture conditions and by specific cytokines through the expression of Sox-9 transcription factor.

Chondrocyte responses in cartilage and in experimental osteoarthritis

Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly.

Chondrogenic differentiation of human bone marrow stem cells in transwell cultures: generation of scaffold-free cartilage

Chondroitin sulfate and joint disease ⬇️

Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva

Confocal-FRAP analysis of ECM molecular interactions.

Dermatan sulphate proteoglycan from human articular cartilage. Variation in its content with age and its structural comparison with a small chondroitin sulphate proteoglycan from pig laryngeal cartilage

Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes.

Directed differentiation of human embryonic stem cells toward chondrocytes

Effect of Alpinia galanga extract on cartilage degradation and on gene expression in human chondrocyte and synovial fibroblast metabolism

Electric birefringence studies of cartilage proteoglycan aggregation

Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis

Equilibrium-binding studies of pig laryngeal cartilage proteoglycans with hyaluronate oligosaccharide fractions

Extending the Paradigm of Osteoarthritis: Comment on the Editorial by McAlindon

Extracellular matrix and pathogenic mechanisms in osteoarthritis

Fat pad-derived mesenchymal stem cells as a potential source for cell-based adipose tissue repair strategies.

Fell-Muir lecture: cartilage 2010 - the known unknowns

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

Gene expression changes in damaged osteoarthritic cartilage identify a signature of non-chondrogenic and mechanical responses

Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy.

Generating cartilage repair from pluripotent stem cells

Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants.

Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2.

Human link protein gene: structure and transcription pattern in chondrocytes

Human meniscus cells express hypoxia inducible factor-1alpha and increased SOX9 in response to low oxygen tension in cell aggregate culture

Hyaluronan binding to link module of TSG-6 and to G1 domain of aggrecan is differently regulated by pH.

Hyaluronic acid in cartilage and proteoglycan aggregation

Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes

Hypoxic conditions increase hypoxia-inducible transcription factor 2alpha and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients

Immunoglobulin fold and tandem repeat structures in proteoglycan N-terminal domains and link protein

Increased proteoglycan synthesis in cartilage in experimental canine osteoarthritis does not reflect a permanent change in chondrocyte phenotype

Increased release of matrix components from articular cartilage in experimental canine osteoarthritis

Inhibition of interleukin-1-induced synovitis and articular cartilage proteoglycan loss in the rabbit knee by recombinant human interleukin-1 receptor antagonist.

Isabella Helen Mary Muir CBE. 20 August 1920—28 November 2005

Isolation and sequence of cDNA clones for pig and human cartilage link protein

Macromolecular diffusion of biological polymers measured by confocal fluorescence recovery after photobleaching

Mesenchymal stem cells, sources of cells and differentiation potential

Modulation of native chondroitin sulphate structure in tissue development and in disease

Molecular conformations in proteoglycan aggregation

Neutron and X-ray solution-scattering studies of the ternary complex between proteoglycan-binding region, link protein and hyaluronan ⬇️

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

New approaches to the investigation of hyaluronan networks

Notch signaling during chondrogenesis of human bone marrow stem cells

Notch signaling through Jagged-1 is necessary to initiate chondrogenesis in human bone marrow stromal cells but must be switched off to complete chondrogenesis

Novel confocal-FRAP analysis of carbohydrate-protein interactions within the extracellular matrix

Order within disorder: aggrecan chondroitin sulphate-attachment region provides new structural insights into protein sequences classified as disordered

PhenomeExpress: a refined network analysis of expression datasets by inclusion of known disease phenotypes

PhenomeScape: a cytoscape app to identify differentially regulated sub-networks using known disease associations.

Physical properties of the hyaluronate binding region of proteoglycan from pig laryngeal cartilage

Proteoglycan biosynthesis in chondrocytes: protein A-gold localization of proteoglycan protein core and chondroitin sulfate within Golgi subcompartments.

Proteoglycans of cartilage: An assessment of their structure

Proteoglycans: many forms and many functions

Raised chondroitin sulfate epitopes and hyaluronan in serum from rheumatoid arthritis and osteoarthritis patients

Raised serum chondroitin sulfate epitope level in ovarian epithelial cancer

Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization

Replacement of proteoglycans in embryonic chick cartilage in organ culture after treatment with testicular hyaluronidase

Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes