Lista de obras - Tsuneya Ikezu - Dominio Público Uruguay

AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice ⬇️

artículo científico publicado el 15 de septiembre de 2011

Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity

artículo científico publicado en 2011

Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing

artículo científico publicado en 2019

Activation of NR1a/NR2B receptors by soluble factors from APP-stimulated monocyte-derived macrophages: implications for the pathogenesis of Alzheimer's disease

artículo científico publicado en 2004

Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types

artículo científico publicado en 1998

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy

artículo científico publicado en 2017

Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells

artículo científico publicado en 2022

Amino acids 356-372 constitute a Gi-activator sequence of the alpha 2-adrenergic receptor and have a Phe substitute in the G protein-activator sequence motif

artículo científico publicado en 1992

Amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sAPP- and Abeta-mediated neurotoxicity.

artículo científico publicado en 2003

Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms

artículo científico publicado en 1997

Betagamma subunits mediate the NPY enhancement of ATP-stimulated inositol phosphate formation

artículo científico publicado en 2004

Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product.

artículo científico

C1q-calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of Alzheimer's disease.

artículo científico publicado en 2003

CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction

artículo científico publicado en 2009

Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET.

artículo científico publicado en 2008

Caveolae, Plasma Membrane Microdomains for α-Secretase-mediated Processing of the Amyloid Precursor Protein ⬇️

artículo científico publicado el 24 de abril de 1998

Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain

artículo científico publicado en 1998

Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer's disease?

artículo científico publicado en 2012

Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.

artículo científico publicado en 2012

Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies

artículo científico publicado en 2012

Corrigendum to "Syk and ye shall find" [EBioMedicine 2 (11) (2015) 190-1591].

artículo científico publicado en 2016

Crohn's and Parkinson's Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo

artículo científico publicado en 2020

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

artículo científico publicado en 2015

Distinct neuronal localization of microtubule-associated protein 4 in the mammalian brain

artículo científico publicado en 2010

Emerging roles of extracellular vesicles in neurodegenerative disorders

scientific article published on 20 June 2019

Extracellular Vesicle Biology in Alzheimer's Disease and Related Tauopathy

artículo científico publicado en 2017

FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders

artículo científico publicado en 2011

Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration.

artículo científico publicado en 2013

G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.

artículo científico publicado en 1997

GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia

artículo científico publicado en 2015

HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes

artículo científico publicado en 2011

Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins

artículo científico publicado en 1997

Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease

artículo científico publicado en 2016

In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins. Distinct roles of cytoplasmic domains and signal sequestration by the receptor

artículo científico publicado en 1995

Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities

scientific article published on 18 February 2020

Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia ⬇️

artículo científico publicado en 2013

Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease

scientific article published on 03 September 2021

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

artículo científico publicado en 2007

Kinetic analysis of aggregated amyloid-beta peptide clearance in adult bone-marrow-derived macrophages from APP and CCL2 transgenic mice

artículo científico publicado en 2006

Measurement of GTP gamma S binding to specific G proteins in membranes using G-protein antibodies

artículo científico publicado en 1992

Neuroimmune pharmacology as a sub-discipline of medical neuroscience in the medical school curriculum.

artículo científico publicado en 2010

OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis

artículo científico publicado en 2004

OTK18 levels in plasma and cerebrospinal fluid correlate with viral load and CD8 T-cells in normal and AIDS patients

artículo científico publicado en 2008

OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regions

artículo científico publicado en 2007

Occurrence of Crohn's disease with Parkinson's disease

artículo científico publicado en 2017

Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network

artículo científico publicado en 2017

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

artículo científico publicado en 2020

PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation

artículo científico publicado en 2014

Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers ⬇️

artículo científico publicado el 25 de noviembre de 2010

Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.

artículo científico publicado en 2008

Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands

artículo científico publicado en 2007

Potential CRE suppression by familial Alzheimer's mutants of APP independent of adenylyl cyclase regulation ⬇️

artículo científico publicado el 21 de julio de 1997

Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy

artículo científico publicado en 2016

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

artículo científico publicado en 2020

Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models

artículo científico publicado en 2013

Real-time imaging and quantification of amyloid-beta peptide aggregates by novel quantum-dot nanoprobes

artículo científico publicado en 2009

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

artículo científico publicado en 2017

Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia

artículo científico publicado en 2022

Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)

artículo científico publicado en 2006

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

artículo científico publicado en 2008

Syk and Yea Shall Find

artículo científico publicado en 2015

Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans

artículo científico publicado en 2018

Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.

artículo científico publicado en 2006

Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

artículo científico publicado en 2020

Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice

artículo científico publicado en 2010

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

artículo científico publicado en 2017

The aging of human-immunodeficiency-virus-associated neurocognitive disorders

artículo científico publicado en 2009

The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. ⬇️

artículo científico publicado en 2012

The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer's disease animal model

artículo científico publicado en 2011

The neuropathogenesis of HIV-1 infection

artículo científico publicado en 2007

Transcriptional and Epigenetic Regulation of Microglia in Health and Disease

scientific article published on 18 December 2018

Transduction of bovine adrenal chromaffin cells using a recombinant adenovirus expressing GFP.

artículo científico publicado en 2002

Using mechanical homogenization to isolate microglia from mouse brain tissue to preserve transcriptomic integrity

artículo científico publicado en 2022

miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction

artículo científico publicado en 2015

Lista de obras de Tsuneya Ikezu

AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice ⬇️

Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity

Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing

Activation of NR1a/NR2B receptors by soluble factors from APP-stimulated monocyte-derived macrophages: implications for the pathogenesis of Alzheimer's disease

Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy

Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells

Amino acids 356-372 constitute a Gi-activator sequence of the alpha 2-adrenergic receptor and have a Phe substitute in the G protein-activator sequence motif

Amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sAPP- and Abeta-mediated neurotoxicity.

Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms

Betagamma subunits mediate the NPY enhancement of ATP-stimulated inositol phosphate formation

Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product.

C1q-calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of Alzheimer's disease.

CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction

Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET.

Caveolae, Plasma Membrane Microdomains for α-Secretase-mediated Processing of the Amyloid Precursor Protein ⬇️

Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain

Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer's disease?

Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.

Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies

Corrigendum to "Syk and ye shall find" [EBioMedicine 2 (11) (2015) 190-1591].

Crohn's and Parkinson's Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Distinct neuronal localization of microtubule-associated protein 4 in the mammalian brain

Emerging roles of extracellular vesicles in neurodegenerative disorders

Extracellular Vesicle Biology in Alzheimer's Disease and Related Tauopathy

FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders

Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration.

G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.

GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia

HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes

Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins

Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease

In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins. Distinct roles of cytoplasmic domains and signal sequestration by the receptor

Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities

Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia ⬇️

Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

Kinetic analysis of aggregated amyloid-beta peptide clearance in adult bone-marrow-derived macrophages from APP and CCL2 transgenic mice

Measurement of GTP gamma S binding to specific G proteins in membranes using G-protein antibodies

Neuroimmune pharmacology as a sub-discipline of medical neuroscience in the medical school curriculum.

OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis

OTK18 levels in plasma and cerebrospinal fluid correlate with viral load and CD8 T-cells in normal and AIDS patients

OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regions

Occurrence of Crohn's disease with Parkinson's disease

Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation

Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers ⬇️

Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.

Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands

Potential CRE suppression by familial Alzheimer's mutants of APP independent of adenylyl cyclase regulation ⬇️

Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models

Real-time imaging and quantification of amyloid-beta peptide aggregates by novel quantum-dot nanoprobes

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia

Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

Syk and Yea Shall Find

Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans

Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.

Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

The aging of human-immunodeficiency-virus-associated neurocognitive disorders

The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. ⬇️

The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer's disease animal model

The neuropathogenesis of HIV-1 infection

Transcriptional and Epigenetic Regulation of Microglia in Health and Disease

Transduction of bovine adrenal chromaffin cells using a recombinant adenovirus expressing GFP.

Using mechanical homogenization to isolate microglia from mouse brain tissue to preserve transcriptomic integrity

miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction