Lista de obras - Arwen Pearson - Dominio Público Uruguay

3D-MiXD: 3D-printed X-ray-compatible microfluidic devices for rapid, low-consumption serial synchrotron crystallography data collection in flow

artículo científico publicado en 2020

A comparative analysis of the fluorescence properties of the wild-type and active site mutants of the hepatitis C virus autoprotease NS2-3

artículo científico publicado en 2010

A new on-axis multimode spectrometer for the macromolecular crystallography beamlines of the Swiss Light Source

artículo científico publicado en 2009

Active site aspartate residues are critical for tryptophan tryptophylquinone biogenesis in methylamine dehydrogenase

artículo científico publicado en 2005

All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding

artículo científico publicado en 2010

Applying broadband terahertz time-domain spectroscopy to the analysis of crystalline proteins: a dehydration study

Calculation of terahertz active normal modes in organic crystals

Catching catalysis in the act: using single crystal kinetics to trap methylamine dehydrogenase reaction intermediates

artículo científico publicado en 2003

Combining X-ray crystallography and single-crystal spectroscopy to probe enzyme mechanisms

artículo científico publicado en 2009

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.

artículo científico publicado en 2018

Cryocrystallography of metalloprotein reaction intermediates

artículo científico publicado en 2002

Crystal structure of a domain-swapped photoactivatable sfGFP variant provides evidence for GFP folding pathway

artículo científico publicado en 2019

Crystallization and preliminary X-ray analysis of a bifunctional catalase-phenol oxidase from Scytalidium thermophilum

artículo científico publicado en 2009

Directed Assembly of Homopentameric Cholera Toxin B-Subunit Proteins into Higher-Order Structures Using Coiled-Coil Appendages

scientific article published on 21 March 2019

Dissecting the mechanism of oxygen trafficking in a metalloenzyme

artículo científico publicado en 2011

Dynamic structural science: recent developments in time-resolved spectroscopy and X-ray crystallography.

artículo científico publicado en 2013

Effect of molecular size and particle shape on the terahertz absorption of a homologous series of tetraalkylammonium salts

artículo científico publicado en 2013

Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity ⬇️

artículo científico publicado en 2015

Exploring Molecular Oxygen Pathways in Hansenula polymorpha Copper-containing Amine Oxidase

artículo científico publicado en 2007

Exploring the Roles of the Metal Ions in Escherichia coli Copper Amine Oxidase ,

artículo científico publicado en 2010

Expression, purification, crystallization and preliminary X-ray diffraction of a novel Nitrosomonas europaea cytochrome, cytochrome P460.

artículo científico publicado en 2006

Extending enzyme molecular recognition with an expanded amino acid alphabet ⬇️

artículo científico publicado en 2017

Fixed target combined with spectral mapping: approaching 100% hit rates for serial crystallography

artículo científico publicado en 2016

Fixed target matrix for femtosecond time-resolved and in situ serial micro-crystallography

artículo científico publicado en 2015

Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation

artículo científico publicado en 2004

Human Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9- cis -Retinal Isomerase Activity

artículo científico publicado en 2014

Identification of the site of oxidase substrate binding in Scytalidium thermophilum catalase ⬇️

artículo científico publicado en 2018

Improving Escherichia coli alkaline phosphatase efficacy by additional mutations inside and outside the catalytic pocket.

artículo científico publicado en 2001

In pursuit of an accurate spatial and temporal model of biomolecules at the atomistic level: a perspective on computer simulation

artículo científico publicado en 2015

Investigating the active centre of theScytalidium thermophilumcatalase

artículo científico publicado en 2013

Isolation of an Asymmetric RNA Uncoating Intermediate for a Single-Stranded RNA Plant Virus

artículo científico publicado en 2012

Isotope labeling studies reveal the order of oxygen incorporation into the tryptophan tryptophylquinone cofactor of methylamine dehydrogenase

artículo científico publicado en 2006

Light-induced Trpin/Metout Switching During BLUF Domain Activation in ATP-bound Photoactivatable Adenylate Cyclase OaPAC

artículo científico publicado en 2024

Limits of Structural Plasticity in a Picornavirus Capsid Revealed by a Massively Expanded Equine Rhinitis A Virus Particle ⬇️

artículo científico publicado en 2014

Liquid application method for time-resolved analyses by serial synchrotron crystallography

artículo científico publicado en 2019

MauG, a novel diheme protein required for tryptophan tryptophylquinone biogenesis

artículo científico publicado en 2003

MauG-dependent in vitro biosynthesis of tryptophan tryptophylquinone in methylamine dehydrogenase

artículo científico publicado en 2005

Mechanistic Possibilities in MauG-Dependent Tryptophan Tryptophylquinone Biosynthesis†

artículo científico publicado en 2006

Microspectrophotometry for structural enzymology

artículo científico publicado en 2004

Multi and serial data collection and processing

scientific article published on 26 February 2019

Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design

artículo científico publicado en 2024

Nature of the Ferryl Heme in Compounds I and II

artículo científico publicado en 2011

Nature of the ferryl heme in Compounds I and II.

artículo científico publicado en 2011

Oxygen Activation Switch in the Copper Amine Oxidase of Escherichia coli ⬇️

artículo científico publicado en 2018

Packaging signals in single-stranded RNA viruses: nature's alternative to a purely electrostatic assembly mechanism ⬇️

artículo científico publicado en 2013

Pathological macromolecular crystallographic data affected by twinning, partial-disorder and exhibiting multiple lattices for testing of data processing and refinement tools

artículo científico publicado en 2018

Preface to Special Topic: Transactions from the 66th Annual Meeting of the American Crystallographic Association

artículo científico publicado en 2017

Probing temperature- and solvent-dependent protein dynamics using terahertz time-domain spectroscopy ⬇️

article

Probing the molecular mechanisms in copper amine oxidases by generating heterodimers ⬇️

artículo científico publicado en 2015

Reaction Mechanism of N -Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis ⬇️

artículo científico publicado en 2014

Revealing low-dose radiation damage using single-crystal spectroscopy

artículo científico publicado en 2011

Sequence-Specific, RNA–Protein Interactions Overcome Electrostatic Barriers Preventing Assembly of Satellite Tobacco Necrosis Virus Coat Protein

artículo científico publicado en 2013

Structural Insight into Methyl-Coenzyme M Reductase Chemistry Using Coenzyme B Analogues,

artículo científico publicado en 2010

Structural Insights into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution

artículo científico publicado en 2010

Structural Insights into the Recovery of Aldolase Activity inN-Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with γ-Thialysine by Using a Chemical Mutagenesis Strategy

artículo científico publicado en 2013

Structural Kinetics of MsbA Investigated by Stopped-Flow Time-Resolved Small-Angle X-Ray Scattering

scientific article published on 30 December 2019

Structure of a xenon derivative ofEscherichia colicopper amine oxidase: confirmation of the proposed oxygen-entry pathway

artículo científico publicado en 2008

Structure of anEscherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 Å resolution

artículo científico publicado en 2009

Structure, recombinant expression and mutagenesis studies of the catalase with oxidase activity from Scytalidium thermophilum ⬇️

artículo científico publicado en 2013

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

artículo científico publicado en 2014

Terahertz spectral measurements of a homologous organic series

Terahertz time-domain spectroscopy of lysozyme and mouse urinary protein single crystals ⬇️

Terahertz time-domain spectroscopy of protein single crystals

The Crystal Structure of Cytochrome P460 of Nitrosomonas europaea Reveals a Novel Cytochrome Fold and Heme−Protein Cross-link † , ‡

artículo científico publicado en 2007

The HARE chip for efficient time-resolved serial synchrotron crystallography

scientific article published on 27 February 2020

The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD-PanZ·AcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N-Pentyl Pantothenamide (N5-Pan). ⬇️

artículo científico publicado en 2017

The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A. ⬇️

artículo científico publicado en 2015

Threonine 57 is required for the post-translational activation ofEscherichia coliaspartate α-decarboxylase ⬇️

artículo científico publicado en 2014

Time-resolved crystallography using the Hadamard transform

artículo científico publicado en 2014

Topological Dissection of the Membrane Transport Protein Mhp1 Derived from Cysteine Accessibility and Mass Spectrometry ⬇️

artículo científico publicado en 2017

Tracking X-ray-derived redox changes in crystals of a methylamine dehydrogenase/amicyanin complex using single-crystal UV/Vis microspectrophotometry

artículo científico publicado en 2007

Understanding quinone cofactor biogenesis in methylamine dehydrogenase through novel cofactor generation

artículo científico publicado en 2003

Understanding the influence of morphology on the terahertz spectra of a powdered ionic crystalline system ⬇️

Using synchrotrons and XFELs for time-resolved X-ray crystallography and solution scattering experiments on biomolecules

artículo científico publicado en 2015

X-ray crystallography marries spectroscopy to unveil structure and function of biological macromolecules

artículo científico publicado en 2011

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

artículo científico publicado en 2021

X-ray-excited optical luminescence of protein crystals: a new tool for studying radiation damage during diffraction data collection

artículo científico publicado en 2012

Lista de obras de Arwen Pearson

3D-MiXD: 3D-printed X-ray-compatible microfluidic devices for rapid, low-consumption serial synchrotron crystallography data collection in flow

A comparative analysis of the fluorescence properties of the wild-type and active site mutants of the hepatitis C virus autoprotease NS2-3

A new on-axis multimode spectrometer for the macromolecular crystallography beamlines of the Swiss Light Source

Active site aspartate residues are critical for tryptophan tryptophylquinone biogenesis in methylamine dehydrogenase

All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding

Applying broadband terahertz time-domain spectroscopy to the analysis of crystalline proteins: a dehydration study

Calculation of terahertz active normal modes in organic crystals

Catching catalysis in the act: using single crystal kinetics to trap methylamine dehydrogenase reaction intermediates

Combining X-ray crystallography and single-crystal spectroscopy to probe enzyme mechanisms

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.

Cryocrystallography of metalloprotein reaction intermediates

Crystal structure of a domain-swapped photoactivatable sfGFP variant provides evidence for GFP folding pathway

Crystallization and preliminary X-ray analysis of a bifunctional catalase-phenol oxidase from Scytalidium thermophilum

Directed Assembly of Homopentameric Cholera Toxin B-Subunit Proteins into Higher-Order Structures Using Coiled-Coil Appendages

Dissecting the mechanism of oxygen trafficking in a metalloenzyme

Dynamic structural science: recent developments in time-resolved spectroscopy and X-ray crystallography.

Effect of molecular size and particle shape on the terahertz absorption of a homologous series of tetraalkylammonium salts

Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity ⬇️

Exploring Molecular Oxygen Pathways in Hansenula polymorpha Copper-containing Amine Oxidase

Exploring the Roles of the Metal Ions in Escherichia coli Copper Amine Oxidase ,

Expression, purification, crystallization and preliminary X-ray diffraction of a novel Nitrosomonas europaea cytochrome, cytochrome P460.

Extending enzyme molecular recognition with an expanded amino acid alphabet ⬇️

Fixed target combined with spectral mapping: approaching 100% hit rates for serial crystallography

Fixed target matrix for femtosecond time-resolved and in situ serial micro-crystallography

Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation

Human Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9- cis -Retinal Isomerase Activity

Identification of the site of oxidase substrate binding in Scytalidium thermophilum catalase ⬇️

Improving Escherichia coli alkaline phosphatase efficacy by additional mutations inside and outside the catalytic pocket.

In pursuit of an accurate spatial and temporal model of biomolecules at the atomistic level: a perspective on computer simulation

Investigating the active centre of theScytalidium thermophilumcatalase

Isolation of an Asymmetric RNA Uncoating Intermediate for a Single-Stranded RNA Plant Virus

Isotope labeling studies reveal the order of oxygen incorporation into the tryptophan tryptophylquinone cofactor of methylamine dehydrogenase

Light-induced Trpin/Metout Switching During BLUF Domain Activation in ATP-bound Photoactivatable Adenylate Cyclase OaPAC

Limits of Structural Plasticity in a Picornavirus Capsid Revealed by a Massively Expanded Equine Rhinitis A Virus Particle ⬇️

Liquid application method for time-resolved analyses by serial synchrotron crystallography

MauG, a novel diheme protein required for tryptophan tryptophylquinone biogenesis

MauG-dependent in vitro biosynthesis of tryptophan tryptophylquinone in methylamine dehydrogenase

Mechanistic Possibilities in MauG-Dependent Tryptophan Tryptophylquinone Biosynthesis†

Microspectrophotometry for structural enzymology

Multi and serial data collection and processing

Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design

Nature of the Ferryl Heme in Compounds I and II

Nature of the ferryl heme in Compounds I and II.

Oxygen Activation Switch in the Copper Amine Oxidase of Escherichia coli ⬇️

Packaging signals in single-stranded RNA viruses: nature's alternative to a purely electrostatic assembly mechanism ⬇️

Pathological macromolecular crystallographic data affected by twinning, partial-disorder and exhibiting multiple lattices for testing of data processing and refinement tools

Preface to Special Topic: Transactions from the 66th Annual Meeting of the American Crystallographic Association

Probing temperature- and solvent-dependent protein dynamics using terahertz time-domain spectroscopy ⬇️

Probing the molecular mechanisms in copper amine oxidases by generating heterodimers ⬇️

Reaction Mechanism of N -Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis ⬇️

Revealing low-dose radiation damage using single-crystal spectroscopy

Sequence-Specific, RNA–Protein Interactions Overcome Electrostatic Barriers Preventing Assembly of Satellite Tobacco Necrosis Virus Coat Protein

Structural Insight into Methyl-Coenzyme M Reductase Chemistry Using Coenzyme B Analogues,

Structural Insights into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution

Structural Insights into the Recovery of Aldolase Activity inN-Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with γ-Thialysine by Using a Chemical Mutagenesis Strategy

Structural Kinetics of MsbA Investigated by Stopped-Flow Time-Resolved Small-Angle X-Ray Scattering

Structure of a xenon derivative ofEscherichia colicopper amine oxidase: confirmation of the proposed oxygen-entry pathway

Structure of anEscherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 Å resolution

Structure, recombinant expression and mutagenesis studies of the catalase with oxidase activity from Scytalidium thermophilum ⬇️

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

Terahertz spectral measurements of a homologous organic series

Terahertz time-domain spectroscopy of lysozyme and mouse urinary protein single crystals ⬇️

Terahertz time-domain spectroscopy of protein single crystals

The Crystal Structure of Cytochrome P460 of Nitrosomonas europaea Reveals a Novel Cytochrome Fold and Heme−Protein Cross-link † , ‡

The HARE chip for efficient time-resolved serial synchrotron crystallography

The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD-PanZ·AcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N-Pentyl Pantothenamide (N5-Pan). ⬇️

The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A. ⬇️

Threonine 57 is required for the post-translational activation ofEscherichia coliaspartate α-decarboxylase ⬇️

Time-resolved crystallography using the Hadamard transform

Topological Dissection of the Membrane Transport Protein Mhp1 Derived from Cysteine Accessibility and Mass Spectrometry ⬇️

Tracking X-ray-derived redox changes in crystals of a methylamine dehydrogenase/amicyanin complex using single-crystal UV/Vis microspectrophotometry

Understanding quinone cofactor biogenesis in methylamine dehydrogenase through novel cofactor generation

Understanding the influence of morphology on the terahertz spectra of a powdered ionic crystalline system ⬇️

Using synchrotrons and XFELs for time-resolved X-ray crystallography and solution scattering experiments on biomolecules

X-ray crystallography marries spectroscopy to unveil structure and function of biological macromolecules

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

X-ray-excited optical luminescence of protein crystals: a new tool for studying radiation damage during diffraction data collection