Lista de obras - Conrad Kunick - Dominio Público Uruguay

1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: a new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines

artículo científico publicado en 2007

2-(3-aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: a new antileishmanial chemotype

artículo científico publicado en 2008

2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines

artículo científico publicado en 2012

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3

artículo científico publicado en 2013

4-Arylthieno[2,3-b]pyridine-2-carboxamides Are a New Class of Antiplasmodial Agents

scientific article published on 13 July 2020

5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms

artículo científico publicado en 2016

9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma

artículo científico publicado en 2014

A new Heck reaction modification using ketone Mannich bases as enone precursors: parallel synthesis of anti-leishmanial chalcones

artículo científico publicado en 2008

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

artículo científico publicado en 2006

Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential

artículo científico publicado en 2003

Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages

artículo científico publicado en 2017

Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer

artículo científico publicado en 2018

Darpones and water-soluble aminobutoxylated darpone derivatives are distinguished by matrix COMPARE analysis

artículo científico publicado en 2007

Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH).

artículo científico publicado en 2009

Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure

artículo científico publicado en 2011

Epoxide-containing side chains enhance antiproliferative activity of paullones

artículo científico publicado en 2005

Functional inactivation of Plasmodium falciparum glycogen synthase kinase GSK3 modulates erythrocyte invasion and blocks gametocyte maturation

artículo científico publicado en 2022

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

artículo científico publicado en 2016

Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation

artículo científico publicado en 2010

Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening

artículo científico publicado en 2016

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design.

artículo científico publicado en 2018

Inhibitors of the RET tyrosine kinase based on a 2-(alkylsulfanyl)-4-(3-thienyl)nicotinonitrile scaffold

artículo científico publicado en 2010

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

artículo científico publicado en 2020

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.

artículo científico publicado en 2018

Novel molecular targets in cancer chemotherapy waiting for discovery

artículo científico publicado en 2004

Parenteral formulation of an antileishmanial drug candidate--tackling poor solubility, chemical instability, and polymorphism

artículo científico publicado en 2013

Paullones as inhibitors of protein kinases

artículo científico publicado en 2011

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

artículo científico publicado en 2004

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

artículo científico publicado en 2009

Selective inhibitors of Plasmodium falciparum glycogen synthase-3 (PfGSK-3): New antimalarial agents?

artículo científico publicado en 2015

Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines

artículo científico publicado en 2019

Structure-aided optimization of kinase inhibitors derived from alsterpaullone.

artículo científico publicado en 2005

Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).

artículo científico publicado en 2014

[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors

scientific article published on 13 November 2019

Lista de obras de Conrad Kunick

1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: a new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines

2-(3-aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: a new antileishmanial chemotype

2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3

4-Arylthieno[2,3-b]pyridine-2-carboxamides Are a New Class of Antiplasmodial Agents

5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms

9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma

A new Heck reaction modification using ketone Mannich bases as enone precursors: parallel synthesis of anti-leishmanial chalcones

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential

Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages

Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer

Darpones and water-soluble aminobutoxylated darpone derivatives are distinguished by matrix COMPARE analysis

Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH).

Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure

Epoxide-containing side chains enhance antiproliferative activity of paullones

Functional inactivation of Plasmodium falciparum glycogen synthase kinase GSK3 modulates erythrocyte invasion and blocks gametocyte maturation

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation

Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design.

Inhibitors of the RET tyrosine kinase based on a 2-(alkylsulfanyl)-4-(3-thienyl)nicotinonitrile scaffold

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.

Novel molecular targets in cancer chemotherapy waiting for discovery

Parenteral formulation of an antileishmanial drug candidate--tackling poor solubility, chemical instability, and polymorphism

Paullones as inhibitors of protein kinases

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

Selective inhibitors of Plasmodium falciparum glycogen synthase-3 (PfGSK-3): New antimalarial agents?

Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines

Structure-aided optimization of kinase inhibitors derived from alsterpaullone.

Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).

[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors