Lista de obras - Thomas S. Peat - Dominio Público Uruguay

300-Fold Increase in Production of the Zn2+-Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme Stabilization

artículo científico publicado en 2014

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.

artículo científico publicado en 2017

A Nondenaturing Purification Scheme for the DNA-Binding Domain of Poly(ADP-Ribose) Polymerase, a Structure-Specific DNA-Binding Protein ⬇️

artículo científico publicado el 1 de octubre de 1998

A PMMA microfluidic droplet platform for in vitro protein expression using crude E. coli S30 extract

artículo científico publicado en 2009

A drunken search in crystallization space

artículo científico publicado en 2014

A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo

artículo científico publicado en 2010

A new crystal form of human vascular adhesion protein 1

artículo científico publicado en 2010

A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. strain ADP

artículo científico publicado en 2018

A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs

artículo científico publicado en 2001

A β-Alanine Catabolism Pathway Containing a Highly Promiscuous ω-Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC.

artículo científico publicado en 2016

An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets

artículo científico publicado en 2011

An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme.

artículo científico publicado en 2018

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects

artículo científico publicado en 2019

Characterization of crystals of the thermostable DNA polymerase I fromthermus aquaticus

artículo científico publicado en 1995

Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling.

artículo científico

Cryo-EM structure of the active, G-protein complexed, human CGRP receptor

artículo científico publicado en 2018

Crystal Structure of an Indole-3-Acetic Acid Amido Synthetase from Grapevine Involved in Auxin Homeostasis ⬇️

artículo científico publicado el 6 de noviembre de 2012

Crystal structure of YIGZ, a conserved hypothetical protein from Escherichia coli k12 with a novel fold

artículo científico publicado en 2004

Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC.

artículo científico publicado en 2017

Crystal structures of human ENPP1 in apo and bound forms

artículo científico publicado en 2020

Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site

artículo científico publicado en 2011

Crystallization and preliminary X-ray analysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

artículo científico publicado en 2010

Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II.

artículo científico publicado en 2009

Crystallization and preliminary X-ray diffraction analysis of the amidase domain of allophanate hydrolase from Pseudomonas sp. strain ADP.

artículo científico publicado en 2014

Crystallization of an apo form of human arginase: using all the tools in the toolbox simultaneously

artículo científico publicado en 2010

Crystallization reports are the backbone of Acta Cryst. F, but do they have any spine?

artículo científico publicado en 2013

Crystallization: digging into the past to learn lessons for the future.

artículo científico publicado en 2015

Cyanuric acid hydrolase: evolutionary innovation by structural concatenation

artículo científico publicado en 2013

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology

scientific article published on 09 April 2018

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects

artículo científico publicado en 2018

Determination of the Structure of the Catabolic N-Succinylornithine Transaminase (AstC) from Escherichia coli

artículo científico publicado en 2013

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.

artículo científico publicado en 2017

Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action

artículo científico publicado en 2020

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK

artículo científico publicado en 2013

Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit

artículo científico publicado en 2013

Fragment screening for a protein-protein interaction inhibitor to WDR5

scientific article published on 14 November 2019

From information management to protein annotation: preparing protein structures for drug discovery.

artículo científico publicado en 2002

High-Resolution X-Ray Structures of Two Functionally Distinct Members of the Cyclic Amide Hydrolase Family of Toblerone Fold Enzymes.

artículo científico publicado en 2017

How to fabricate robust microfluidic systems for a dollar

artículo científico publicado en 2013

Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation

artículo científico publicado en 2010

Identification of a Highly Conserved Allosteric Binding Site on Mnk1 and Mnk2.

artículo científico publicado en 2015

Identification of a New Zinc Binding Chemotype by Fragment Screening.

artículo científico publicado en 2017

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

artículo científico publicado en 2018

Intermolecular cleavage by UmuD-like enzymes: identification of residues required for cleavage and substrate specificity

artículo científico publicado en 1999

Interrogating HIV integrase for compounds that bind- a SAMPL challenge

artículo científico publicado en 2014

Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors.

artículo científico publicado en 2016

Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state

artículo científico publicado en 2014

On the need for an international effort to capture, share and use crystallization screening data

artículo científico publicado en 2012

Over the rainbow: structural characterization of the chromoproteins gfasPurple, amilCP, spisPink and eforRed

artículo científico publicado en 2022

Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?

artículo científico publicado en 2013

Phoenito experiments: combining the strengths of commercial crystallization automation.

artículo científico publicado en 2008

Practical aspects of the SAMPL challenge: providing an extensive experimental data set for the modeling community

artículo científico publicado en 2009

Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst.

artículo científico publicado en 2015

Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase ⬇️

artículo científico publicado el 1 de noviembre de 2001

Some of the most interesting CASP11 targets through the eyes of their authors

artículo científico publicado en 2015

Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli

artículo científico publicado en 2016

Structural analysis of a set of proteins resulting from a bacterial genomics project.

artículo científico publicado en 2005

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses

artículo científico publicado en 2010

Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase

artículo científico publicado en 2015

Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841.

artículo científico publicado en 2018

Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design

artículo científico publicado en 2011

Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae

artículo científico publicado en 2016

Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus.

artículo científico publicado en 2018

Structure of S. aureus HPPK and the Discovery of a New Substrate Site Inhibitor ⬇️

artículo científico publicado el 19 de enero de 2012

Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

artículo científico publicado en 2014

Structures of the transcriptional regulator BgaR, a lactose sensor

scientific article published on 26 June 2019

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity

artículo científico publicado en 2019

Synthesis, structure and bioactivity of primary sulfamate-containing natural products

artículo científico publicado en 2018

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.

artículo científico publicado en 2017

Tapping the Protein Data Bank for crystallization information

artículo científico publicado en 2005

The 1.59 A resolution crystal structure of TM0096, a flavin mononucleotide binding protein from Thermotoga maritima

artículo científico publicado en 2004

The DINGO dataset: a comprehensive set of data for the SAMPL challenge

artículo científico publicado en 2012

The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors—A Spin-Off Discovery from Fragment Screening

artículo científico publicado en 2021

The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein

scientific article published on 25 November 2020

The evolving story of AtzT, a periplasmic binding protein

artículo científico publicado en 2019

The nanoscience behind the art of in-meso crystallization of membrane proteins

artículo científico publicado en 2016

The structure of the hexameric atrazine chlorohydrolase AtzA

artículo científico publicado en 2015

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation

artículo científico publicado en 2014

Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits

artículo científico publicado en 2014

X-Ray Structure and Mutagenesis Studies of the N-Isopropylammelide Isopropylaminohydrolase, AtzC

artículo científico publicado en 2015

X-ray crystal structure of a malonate-semialdehyde dehydrogenase from Pseudomonas sp. strain AAC.

artículo científico publicado en 2017

X-ray crystallography of Epacadostat in adduct with Carbonic Anhydrase IX

artículo científico publicado en 2020

X-ray structure of the amidase domain of AtzF, the allophanate hydrolase from the cyanuric acid-mineralizing multienzyme complex

artículo científico publicado en 2014

Lista de obras de Thomas S. Peat

300-Fold Increase in Production of the Zn2+-Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme Stabilization

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.

A Nondenaturing Purification Scheme for the DNA-Binding Domain of Poly(ADP-Ribose) Polymerase, a Structure-Specific DNA-Binding Protein ⬇️

A PMMA microfluidic droplet platform for in vitro protein expression using crude E. coli S30 extract

A drunken search in crystallization space

A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo

A new crystal form of human vascular adhesion protein 1

A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. strain ADP

A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs

A β-Alanine Catabolism Pathway Containing a Highly Promiscuous ω-Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC.

An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets

An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme.

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects

Characterization of crystals of the thermostable DNA polymerase I fromthermus aquaticus

Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling.

Cryo-EM structure of the active, G-protein complexed, human CGRP receptor

Crystal Structure of an Indole-3-Acetic Acid Amido Synthetase from Grapevine Involved in Auxin Homeostasis ⬇️

Crystal structure of YIGZ, a conserved hypothetical protein from Escherichia coli k12 with a novel fold

Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC.

Crystal structures of human ENPP1 in apo and bound forms

Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site

Crystallization and preliminary X-ray analysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II.

Crystallization and preliminary X-ray diffraction analysis of the amidase domain of allophanate hydrolase from Pseudomonas sp. strain ADP.

Crystallization of an apo form of human arginase: using all the tools in the toolbox simultaneously

Crystallization reports are the backbone of Acta Cryst. F, but do they have any spine?

Crystallization: digging into the past to learn lessons for the future.

Cyanuric acid hydrolase: evolutionary innovation by structural concatenation

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects

Determination of the Structure of the Catabolic N-Succinylornithine Transaminase (AstC) from Escherichia coli

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.

Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK

Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit

Fragment screening for a protein-protein interaction inhibitor to WDR5

From information management to protein annotation: preparing protein structures for drug discovery.

High-Resolution X-Ray Structures of Two Functionally Distinct Members of the Cyclic Amide Hydrolase Family of Toblerone Fold Enzymes.

How to fabricate robust microfluidic systems for a dollar

Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation

Identification of a Highly Conserved Allosteric Binding Site on Mnk1 and Mnk2.

Identification of a New Zinc Binding Chemotype by Fragment Screening.

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Intermolecular cleavage by UmuD-like enzymes: identification of residues required for cleavage and substrate specificity

Interrogating HIV integrase for compounds that bind- a SAMPL challenge

Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors.

Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state

On the need for an international effort to capture, share and use crystallization screening data

Over the rainbow: structural characterization of the chromoproteins gfasPurple, amilCP, spisPink and eforRed

Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?

Phoenito experiments: combining the strengths of commercial crystallization automation.

Practical aspects of the SAMPL challenge: providing an extensive experimental data set for the modeling community

Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst.

Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase ⬇️

Some of the most interesting CASP11 targets through the eyes of their authors

Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli

Structural analysis of a set of proteins resulting from a bacterial genomics project.

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses

Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase

Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841.

Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design

Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae

Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus.

Structure of S. aureus HPPK and the Discovery of a New Substrate Site Inhibitor ⬇️

Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

Structures of the transcriptional regulator BgaR, a lactose sensor

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity

Synthesis, structure and bioactivity of primary sulfamate-containing natural products

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.

Tapping the Protein Data Bank for crystallization information

The 1.59 A resolution crystal structure of TM0096, a flavin mononucleotide binding protein from Thermotoga maritima

The DINGO dataset: a comprehensive set of data for the SAMPL challenge

The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors—A Spin-Off Discovery from Fragment Screening

The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein

The evolving story of AtzT, a periplasmic binding protein

The nanoscience behind the art of in-meso crystallization of membrane proteins

The structure of the hexameric atrazine chlorohydrolase AtzA

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation

Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits