Lista de obras - Marc Le Borgne - Dominio Público Uruguay

1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

artículo científico publicado en 2019

1H and 13C NMR assignments of bioactive indeno[1,2-b]indole-10-one derivatives.

artículo científico publicado en 2013

1st Joint European Conference on Therapeutic Targets and Medicinal Chemistry (TTMC 2015)

artículo científico publicado en 2015

2- and 3-[(aryl)(azolyl)methyl]indoles as potential non-steroidal aromatase inhibitors.

artículo científico publicado en 2004

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site

scientific article published on 18 February 2019

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action

artículo científico publicado en 2019

2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2.

artículo científico publicado en 2016

4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects

artículo científico publicado en 2021

A 3D-QSAR CoMSIA study on 3-azolylmethylindoles as anti-leishmanial agents

artículo científico publicado en 2006

A safe and practical method for the preparation of 7α-thioether and thioester derivatives of spironolactone

artículo científico publicado en 2012

An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2.

artículo científico publicado en 2017

Antileishmanial activities and mechanisms of action of indole-based azoles

artículo científico publicado en 2006

Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent

artículo científico publicado en 2020

Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds.

artículo científico publicado en 2014

Biomimetic synthesis of Tramadol

artículo científico publicado en 2015

Carbazole scaffolds in cancer therapy: a review from 2012 to 2018

scientific article published on 01 December 2019

Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2.

artículo científico publicado en 2014

Crystal structure of 13-phenyl-2,3,4,13-tetra-hydro-1H-indazolo[1,2-b]phthalazine-1,6,11-trione

artículo científico publicado en 2015

Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.

artículo científico publicado en 2009

Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II.

artículo científico publicado en 2009

Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

artículo científico publicado en 2008

Design, synthesis, and in vitro antifungal activity of 1-[(4-substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

artículo científico publicado en 2011

Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining

artículo científico publicado en 2017

Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α' Structures

artículo científico publicado en 2019

Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells.

artículo científico publicado en 2014

Discovery of 7-aryl-substituted (1,5-naphthyridin-4-yl)ureas as aurora kinase inhibitors.

artículo científico publicado en 2013

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

scientific article published on 04 November 2019

Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles.

artículo científico publicado en 2018

Functional display of heterotetrameric human protein kinase CK2 on Escherichia coli: a novel tool for drug discovery

artículo científico publicado en 2015

Improved Surface Display of Human Hyal1 and Identification of Testosterone Propionate and Chicoric Acid as New Inhibitors

artículo científico publicado en 2020

In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface

artículo científico publicado en 2017

In vitro activity of a new antifungal azolyl-substituted indole against Aspergillus fumigatus

artículo científico publicado en 2002

In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts

article

Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.

artículo científico publicado en 2012

Indenoindoles and cyclopentacarbazoles as bioactive compounds: synthesis and biological applications.

artículo científico

Inhibition of Shiga toxin-converting bacteriophage development by novel antioxidant compounds.

artículo científico publicado en 2018

Mechanisms of depolymerization and activation of a polysialic acid and its tetramer by hydrogen peroxide

artículo científico publicado en 2014

Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles

artículo científico publicado en 2021

New selective nonsteroidal aromatase inhibitors: synthesis and inhibitory activity of 2,3 or 5-(alpha-azolylbenzyl)-1H-indoles

scientific article published on 01 February 1999

Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion

artículo científico publicado en 2020

Occurrence of the synthetic analgesic tramadol in an African medicinal plant

artículo científico publicado en 2013

Oxidation of sialic acid using hydrogen peroxide as a new method to tune the reducing activity

artículo científico publicado en 2014

Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity

artículo científico publicado en 2015

Potential application of plant lipid transfer proteins for drug delivery.

artículo científico publicado en 2001

Preparation and characterization of CK2 inhibitor-loaded cyclodextrin nanoparticles for drug delivery

artículo científico publicado en 2012

Preparation and pharmacological profile of 7-(alpha-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors

artículo científico publicado en 2003

Proceedings of the 16th annual conference of the Groupement des Pharmacochimistes de l'Arc Atlantique (GP2A)

scientific article published on 01 October 2008

QSAR Model of Indeno[1,2-b]indole Derivatives and Identification of N-isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3-b]furan-3-carboxamide as a Potent CK2 Inhibitor

artículo científico publicado en 2019

Screening of indeno[1,2-b]indoloquinones by MALDI-MS: a new set of potential CDC25 phosphatase inhibitors brought to light

artículo científico publicado en 2016

Self-Assembled Supramolecular Nanoparticles Improve the Cytotoxic Efficacy of CK2 Inhibitor THN7.

artículo científico publicado en 2018

Sleep Disorders and Therapeutic Management: A Survey in a French Population of Prisoners.

artículo científico publicado en 2017

Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: <i>in silico</i> modelling, formulation, characterisation, and <i>in vitro</i> studies

artículo científico publicado en 2021

Structural elucidation of two photolytic degradation products of tetrabenazine

artículo científico publicado en 2014

Structure-based design and profiling of novel 17β-HSD14 inhibitors

artículo científico publicado en 2018

Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors

scientific article published on 02 August 2018

Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety

artículo científico publicado en 2007

Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives

artículo científico publicado en 2003

Synthesis and antileishmanial activity of 3-(alpha-azolylbenzyl)indoles

artículo científico publicado en 2002

Synthesis and biological evaluation of 3-(azolylmethyl)-1H-indoles and 3-(alpha-azolylbenzyl)-1H-indoles as selective aromatase inhibitors

artículo científico publicado en 2007

Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: potent and selective aromatase inhibitors

artículo científico publicado en 2005

Synthesis and biological evaluation of novel substituted pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of the human protein kinase CK2.

artículo científico publicado en 2013

Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors

scientific article published on 08 March 2019

Synthesis and in vitro evaluation of 3-(1-azolylmethyl)-1H-indoles and 3-(1-azolyl-1-phenylmethyl)-1H-indoles as inhibitors of P450 arom

artículo científico publicado en 1997

Synthesis and structure-activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents.

artículo científico publicado en 2008

Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors

artículo científico publicado en 2008

Synthesis of new steroidal inhibitors of P-glycoprotein-mediated multidrug resistance and biological evaluation on K562/R7 erythroleukemia cells

scientific article published on 11 February 2015

Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols

artículo científico publicado en 2020

Synthesis, Spectroscopic Characterization, and In Vitro Antibacterial Evaluation of Novel Functionalized Sulfamidocarbonyloxyphosphonates

artículo científico publicado en 2018

Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes

artículo científico publicado en 2018

Three-dimensional model of cytochrome P450 human aromatase.

artículo científico publicado en 2005

Toward selective CK2alpha and CK2alpha' inhibitors: Development of a novel whole-cell kinase assay by Autodisplay of catalytic CK2alpha'.

artículo científico publicado en 2016

Toxicological Risks of the Cobalt–Chromium Alloys in Dentistry: A Systematic Review

artículo científico publicado en 2022

Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2

artículo científico publicado en 2020

Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α'.

artículo científico publicado en 2017

[Synthesis and biological evaluation of indole derivatives acting as anti-inflammatory or antitumoral drugs]

scientific article published on 01 October 2000

Lista de obras de Marc Le Borgne

1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

1H and 13C NMR assignments of bioactive indeno[1,2-b]indole-10-one derivatives.

1st Joint European Conference on Therapeutic Targets and Medicinal Chemistry (TTMC 2015)

2- and 3-[(aryl)(azolyl)methyl]indoles as potential non-steroidal aromatase inhibitors.

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action

2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2.

4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects

A 3D-QSAR CoMSIA study on 3-azolylmethylindoles as anti-leishmanial agents

A safe and practical method for the preparation of 7α-thioether and thioester derivatives of spironolactone

An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2.

Antileishmanial activities and mechanisms of action of indole-based azoles

Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent

Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds.

Biomimetic synthesis of Tramadol

Carbazole scaffolds in cancer therapy: a review from 2012 to 2018

Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2.

Crystal structure of 13-phenyl-2,3,4,13-tetra-hydro-1H-indazolo[1,2-b]phthalazine-1,6,11-trione

Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.

Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II.

Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

Design, synthesis, and in vitro antifungal activity of 1-[(4-substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining

Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α' Structures

Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells.

Discovery of 7-aryl-substituted (1,5-naphthyridin-4-yl)ureas as aurora kinase inhibitors.

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles.

Functional display of heterotetrameric human protein kinase CK2 on Escherichia coli: a novel tool for drug discovery

Improved Surface Display of Human Hyal1 and Identification of Testosterone Propionate and Chicoric Acid as New Inhibitors

In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface

In vitro activity of a new antifungal azolyl-substituted indole against Aspergillus fumigatus

In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts

Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.

Indenoindoles and cyclopentacarbazoles as bioactive compounds: synthesis and biological applications.

Inhibition of Shiga toxin-converting bacteriophage development by novel antioxidant compounds.

Mechanisms of depolymerization and activation of a polysialic acid and its tetramer by hydrogen peroxide

Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles

New selective nonsteroidal aromatase inhibitors: synthesis and inhibitory activity of 2,3 or 5-(alpha-azolylbenzyl)-1H-indoles

Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion

Occurrence of the synthetic analgesic tramadol in an African medicinal plant

Oxidation of sialic acid using hydrogen peroxide as a new method to tune the reducing activity

Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity

Potential application of plant lipid transfer proteins for drug delivery.

Preparation and characterization of CK2 inhibitor-loaded cyclodextrin nanoparticles for drug delivery

Preparation and pharmacological profile of 7-(alpha-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors

Proceedings of the 16th annual conference of the Groupement des Pharmacochimistes de l'Arc Atlantique (GP2A)

QSAR Model of Indeno[1,2-b]indole Derivatives and Identification of N-isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3-b]furan-3-carboxamide as a Potent CK2 Inhibitor

Screening of indeno[1,2-b]indoloquinones by MALDI-MS: a new set of potential CDC25 phosphatase inhibitors brought to light

Self-Assembled Supramolecular Nanoparticles Improve the Cytotoxic Efficacy of CK2 Inhibitor THN7.

Sleep Disorders and Therapeutic Management: A Survey in a French Population of Prisoners.

Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: <i>in silico</i> modelling, formulation, characterisation, and <i>in vitro</i> studies

Structural elucidation of two photolytic degradation products of tetrabenazine

Structure-based design and profiling of novel 17β-HSD14 inhibitors

Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors

Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety

Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives

Synthesis and antileishmanial activity of 3-(alpha-azolylbenzyl)indoles

Synthesis and biological evaluation of 3-(azolylmethyl)-1H-indoles and 3-(alpha-azolylbenzyl)-1H-indoles as selective aromatase inhibitors

Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: potent and selective aromatase inhibitors

Synthesis and biological evaluation of novel substituted pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of the human protein kinase CK2.

Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors

Synthesis and in vitro evaluation of 3-(1-azolylmethyl)-1H-indoles and 3-(1-azolyl-1-phenylmethyl)-1H-indoles as inhibitors of P450 arom

Synthesis and structure-activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents.

Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors

Synthesis of new steroidal inhibitors of P-glycoprotein-mediated multidrug resistance and biological evaluation on K562/R7 erythroleukemia cells

Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols

Synthesis, Spectroscopic Characterization, and In Vitro Antibacterial Evaluation of Novel Functionalized Sulfamidocarbonyloxyphosphonates

Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes

Three-dimensional model of cytochrome P450 human aromatase.

Toward selective CK2alpha and CK2alpha' inhibitors: Development of a novel whole-cell kinase assay by Autodisplay of catalytic CK2alpha'.

Toxicological Risks of the Cobalt–Chromium Alloys in Dentistry: A Systematic Review

Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2

Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α'.

[Synthesis and biological evaluation of indole derivatives acting as anti-inflammatory or antitumoral drugs]