Lista de obras - Florian Nigsch - Dominio Público Uruguay

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi.

artículo científico publicado en 2017

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space

artículo científico publicado en 2010

A novel hybrid ultrafast shape descriptor method for use in virtual screening.

artículo científico publicado en 2008

Activity-aware clustering of high throughput screening data and elucidation of orthogonal structure-activity relationships

artículo científico publicado en 2011

Analysis of Iterative Screening with Stepwise Compound Selection Based on Novartis In-house HTS Data

artículo científico publicado en 2016

Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer

artículo científico publicado en 2014

CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data

artículo científico publicado en 2019

Classifying large chemical data sets: using a regularized potential function method

artículo científico publicado en 2010

Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia.

artículo científico publicado en 2016

Computational methods for early predictive safety assessment from biological and chemical data

artículo científico publicado en 2011

Computational toxicology: an overview of the sources of data and of modelling methods

article

Corrigendum: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size

artículo científico publicado en 2016

Data-Driven Derivation of an "Informer Compound Set" for Improved Selection of Active Compounds in High-Throughput Screening

artículo científico publicado en 2016

Determination of minimal transcriptional signatures of compounds for target prediction

artículo científico publicado en 2012

Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery

artículo científico publicado en 2016

Farnesoid X Receptor Agonism, Acetyl-Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model

artículo científico publicado en 2019

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy

artículo científico publicado en 2017

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

artículo científico publicado en 2014

How to winnow actives from inactives: introducing molecular orthogonal sparse bigrams (MOSBs) and multiclass Winnow.

artículo científico publicado en 2008

IRF2 is a master regulator of human keratinocyte stem cell fate

artículo científico publicado en 2019

In vitro models for processes involved in intestinal absorption

artículo científico publicado en 2007

Ligand-target prediction using Winnow and naive Bayesian algorithms and the implications of overall performance statistics

artículo científico publicado en 2008

Melting point prediction employing k-nearest neighbor algorithms and genetic parameter optimization

artículo científico publicado en 2006

Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization

artículo científico publicado en 2017

Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information

artículo científico publicado en 2011

Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information

artículo científico publicado en 2011

Predicting the mechanism of phospholipidosis

artículo científico publicado en 2012

Recent trends and observations in the design of high-quality screening collections

artículo científico publicado en 2011

Rethinking molecular similarity: comparing compounds on the basis of biological activity.

artículo científico

Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology

scholarly article published 6 January 2017

Simultaneous feature selection and parameter optimisation using an artificial ant colony: case study of melting point prediction.

artículo científico publicado en 2008

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis

artículo científico publicado en 2021

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

artículo científico publicado en 2016

The multidimensional perturbation value: a single metric to measure similarity and activity of treatments in high-throughput multidimensional screens

artículo científico publicado en 2012

Total synthesis of (+)-crocacin D.

artículo científico publicado en 2005

Toxicological relationships between proteins obtained from protein target predictions of large toxicity databases

artículo científico publicado en 2008

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite during progression into dormancy

artículo científico publicado en 2018

Why are some properties more difficult to predict than others? A study of QSPR models of solubility, melting point, and Log P.

artículo científico publicado en 2008

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

scientific article published on 09 May 2019

Lista de obras de Florian Nigsch

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi.

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space

A novel hybrid ultrafast shape descriptor method for use in virtual screening.

Activity-aware clustering of high throughput screening data and elucidation of orthogonal structure-activity relationships

Analysis of Iterative Screening with Stepwise Compound Selection Based on Novartis In-house HTS Data

Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer

CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data

Classifying large chemical data sets: using a regularized potential function method

Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia.

Computational methods for early predictive safety assessment from biological and chemical data

Computational toxicology: an overview of the sources of data and of modelling methods

Corrigendum: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size

Data-Driven Derivation of an "Informer Compound Set" for Improved Selection of Active Compounds in High-Throughput Screening

Determination of minimal transcriptional signatures of compounds for target prediction

Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery

Farnesoid X Receptor Agonism, Acetyl-Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

How to winnow actives from inactives: introducing molecular orthogonal sparse bigrams (MOSBs) and multiclass Winnow.

IRF2 is a master regulator of human keratinocyte stem cell fate

In vitro models for processes involved in intestinal absorption

Ligand-target prediction using Winnow and naive Bayesian algorithms and the implications of overall performance statistics

Melting point prediction employing k-nearest neighbor algorithms and genetic parameter optimization

Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization

Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information

Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information

Predicting the mechanism of phospholipidosis

Recent trends and observations in the design of high-quality screening collections

Rethinking molecular similarity: comparing compounds on the basis of biological activity.

Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology

Simultaneous feature selection and parameter optimisation using an artificial ant colony: case study of melting point prediction.

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

The multidimensional perturbation value: a single metric to measure similarity and activity of treatments in high-throughput multidimensional screens

Total synthesis of (+)-crocacin D.

Toxicological relationships between proteins obtained from protein target predictions of large toxicity databases

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite during progression into dormancy

Why are some properties more difficult to predict than others? A study of QSPR models of solubility, melting point, and Log P.

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury